{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:50:00Z","timestamp":1782895800514,"version":"3.54.5"},"reference-count":48,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473693"],"award-info":[{"award-number":["82473693"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Congenital human cytomegalovirus (HCMV) infection, caused by maternal transmission, is a leading cause of congenital disabilities and poses a substantial global disease burden. Accumulating evidence indicates that the majority of HCMV infections in newborns stem from nonprimary infections. But the relationship between viral shedding and host immune status in seropositive individuals remains poorly elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 142 HCMV-seropositive women of reproductive age were enrolled from Taizhou, China. Serum samples and cervical secretions were collected, and antibody levels and HCMV DNA loads were detected, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum IgG binding to postfusion glycoprotein B (gB), cell-surface-expressed gB, and pentameric complex (PC) was significantly associated with HCMV shedding in cervical secretions. In contrast, no significant associations were observed between cervical shedding and serum IgG binding to prefusion gB or the structural antigen pp150 nor with neutralizing antibody (NAb) titers against Towne and ADR131 strains in MRC-5 cells or ADR131 strain in ARPE-19 cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings advance the current understanding of the interplay between viral shedding and humoral immunity in HCMV-seropositive individuals. Importantly, they provide novel evidence supporting site-specific HCMV shedding as a potential biomarker for reinfection\/reactivation, and a potential exploratory surrogate marker for subsequent vaccine endpoint validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag317","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T11:44:27Z","timestamp":1781783067000},"source":"Crossref","is-referenced-by-count":0,"title":["Correlates of Human Cytomegalovirus Cervical Shedding in Seropositive Women: Implications for Vaccine Development"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7300-0130","authenticated-orcid":false,"given":"Jinting","family":"Li","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Key Laboratory of Public Health Safety and Emergency, Prevention and Control Technology of Higher Education Institutions in Jiangsu Province, Center for Global Health, School of Public Health, Nanjing Medical University , Nanjing ,","place":["China"]},{"name":"National Vaccine Innovation Platform, Nanjing Medical University , Nanjing ,","place":["China"]},{"name":"Taizhou Laboratory, Jiangsu Recbio Technology Co., Ltd , Taizhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Key Laboratory of Public Health Safety and Emergency, Prevention and Control Technology of Higher Education Institutions in Jiangsu Province, Center for Global Health, School of Public Health, Nanjing Medical University , Nanjing ,","place":["China"]},{"name":"National Vaccine Innovation Platform, Nanjing Medical University , Nanjing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Li","sequence":"additional","affiliation":[{"name":"Taizhou Laboratory, Jiangsu Recbio Technology Co., Ltd , Taizhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Taizhou Laboratory, Jiangsu Recbio Technology Co., Ltd , Taizhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbing","family":"Xu","sequence":"additional","affiliation":[{"name":"Taizhou Laboratory, Jiangsu Recbio Technology Co., Ltd , Taizhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Taizhou People\u2019s Hospital , Taizhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"Taizhou Laboratory, Jiangsu Recbio Technology Co., Ltd , Taizhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9151-284X","authenticated-orcid":false,"given":"Jianming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Key Laboratory of Public Health Safety and Emergency, Prevention and Control Technology of Higher Education Institutions in Jiangsu Province, Center for Global Health, School of Public Health, Nanjing Medical University , Nanjing ,","place":["China"]},{"name":"National Vaccine Innovation Platform, Nanjing Medical University , Nanjing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"2026063015134795400_jiag317-B1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.virusres.2006.01.002","article-title":"Topics in herpesvirus genomics and evolution","volume":"117","author":"McGeoch","year":"2006","journal-title":"Virus Res"},{"key":"2026063015134795400_jiag317-B2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000149269","article-title":"Herpesviridae. 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