{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:44:59Z","timestamp":1792025099738,"version":"4.4.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100018493","name":"Taipei Medical University-Shuang Ho Hospital","doi-asserted-by":"publisher","award":["109TMU-SHH-18"],"award-info":[{"award-number":["109TMU-SHH-18"]}],"id":[{"id":"10.13039\/100018493","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112-2320-B-038-055-MY3"],"award-info":[{"award-number":["NSTC 112-2320-B-038-055-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 113-2314-B-038-040"],"award-info":[{"award-number":["NSTC 113-2314-B-038-040"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 114-2314-B-038-103"],"award-info":[{"award-number":["NSTC 114-2314-B-038-103"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cutibacterium acnes strains vary in virulence and inflammatory potential in acne vulgaris, but the role of the bacterial ability to induce neutrophil extracellular traps (NETs) in acne is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We collected 18 clinical isolates from acne patients and healthy controls and analyzed the correlation between C. acnes NET-inducing ability and bacterial virulence involved in acne vulgaris pathogenicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighteen clinical strains were classified into 17 IA1 and 1 IA2 phylotypes. Supernatants from 5 acne-associated strains exhibited marked NET-inducing activity, which was strongly correlated with cytokine production and reactive oxygen species generation. The NET-inducing capacity of supernatants was also positively correlated with bacterial hemolytic activity against human erythrocytes and biofilm formation. In a mouse ear model, NET-inducing strains caused more-severe lesions than NET-noninducing strains. Whole-genome sequencing revealed substantial genetic variation between the NET-inducing strain (C009) and NET-noninducing ATCC strain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that NET induction represents one of virulence-associated phenotypes linked to pathogenicity in C. acnes\u2013induced acne vulgaris.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag343","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T01:03:22Z","timestamp":1782867802000},"page":"598-608","source":"Crossref","is-referenced-by-count":0,"title":["NET-Inducing Ability of\n                    <i>Cutibacterium acnes<\/i>\n                    Clinical Isolates Is Associated With Pathogenicity in Acne Vulgaris"],"prefix":"10.1093","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2095-7064","authenticated-orcid":false,"given":"Yi-Hsien","family":"Shih","sequence":"first","affiliation":[{"name":"Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University , Taipei ,","place":["Taiwan"]},{"name":"Department of Dermatology, Taipei Medical University Shuang Ho Hospital , New Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Chieh","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Soochow University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Che-Hao","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University , Taipei ,","place":["Taiwan"]},{"name":"Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3905-3105","authenticated-orcid":false,"given":"Pei-Yun","family":"Kuo","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Immunology, College of Life Science, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Hsiang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, Taipei Medical University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woan-Ruoh","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Taipei Medical University Shuang Ho Hospital , New Taipei ,","place":["Taiwan"]},{"name":"Graduate Institute of Medical Sciences, College of Medicine, 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