{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:45:02Z","timestamp":1792025102281,"version":"4.4.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2020606"],"award-info":[{"award-number":["2020606"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Antibody Fc regions have important roles in clearance of Plasmodium falciparum-infected erythrocytes. One such role is engagement with Fc\u03b3 receptors on host leukocytes. In the case of Fc\u03b3RIIIa and b, this interaction is greatly enhanced when the IgG glycan is afucosylated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we used a fucose-sensitive enzyme-linked immunosorbent assay (FEASI) to assess afucosylation in IgG specific for placental malaria protein VAR2CSA from n = 139 malaria-exposed pregnant Malawian women, correlating these data with mass spectrometry-based analysis. Furthermore, we measured the effect of afucosylation on Fc-mediated leukocyte functions, using both plasma and a monoclonal antibody, PAM2.8, with varying levels of afucosylation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were significantly higher levels of VAR2CSA-specific IgG afucosylation in women with no placental malaria measured by FEASI (P &amp;lt; .0001), which correlated strongly with mass spectrometry analysis (R = 0.8, P &amp;lt; .0001). In addition, highly afucosylated IgG mediated significantly greater neutrophil phagocytosis of antigen-coated beads and induction of NK cell degranulation by infected erythrocytes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Afucosylated IgG to VAR2CSA, measured by FEASI or mass spectrometry, was a correlate of protection from placental malaria, and afucosylated IgG activated NK cells and neutrophils. Naturally acquired or therapeutic afucosylated IgG antibody could have a role in protection from malaria infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag344","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:01:40Z","timestamp":1784037700000},"page":"e975-e984","source":"Crossref","is-referenced-by-count":0,"title":["Afucosylated VAR2CSA-Specific IgG Reduces Risks of Placental Malaria"],"prefix":"10.1093","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9738-5423","authenticated-orcid":false,"given":"Honghua","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, The University of Melbourne, The Peter Doherty Institute , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5638-7569","authenticated-orcid":false,"given":"Oscar H","family":"Lloyd Williams","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The University of Melbourne, The Peter Doherty Institute , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The University of Melbourne, The Peter Doherty Institute , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wina","family":"Hasang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The University of Melbourne, The Peter Doherty Institute , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4108-375X","authenticated-orcid":false,"given":"Bruce D","family":"Wines","sequence":"additional","affiliation":[{"name":"Immune Therapies Group, Burnet Institute , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9876-0248","authenticated-orcid":false,"given":"Mary","family":"Lopez-Perez","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6190-3324","authenticated-orcid":false,"given":"Maria del Pilar","family":"Quintana","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1698-4927","authenticated-orcid":false,"given":"Lars","family":"Hviid","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5593-9387","authenticated-orcid":false,"given":"Adam","family":"Wheatley","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mwayiwawo","family":"Madanitsa","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Academy of Medical Sciences, Malawi University of Science and Technology , Limbe ,","place":["Malawi"]},{"name":"Department of Clinical Sciences, Liverpool School of Tropical Medicine , Liverpool ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2748-8902","authenticated-orcid":false,"given":"Victor","family":"Mwapasa","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Global and Public Health, Kamuzu University of Health Sciences , Blantyre ,","place":["Malawi"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1753-2727","authenticated-orcid":false,"given":"Kamija S","family":"Phiri","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Global and Public Health, Kamuzu University of Health Sciences , Blantyre ,","place":["Malawi"]},{"name":"Training and Research Unit of Excellence , Blantyre ,","place":["Malawi"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3663-5617","authenticated-orcid":false,"given":"Feiko O","family":"ter Kuile","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Liverpool School of Tropical Medicine , Liverpool ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2556-8316","authenticated-orcid":false,"given":"Nichollas","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2677-6208","authenticated-orcid":false,"given":"Elizabeth H","family":"Aitken","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The 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