{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:06:21Z","timestamp":1785326781712,"version":"3.55.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Programme Hospitalier de Recherche Clinique"},{"name":"PHRC"},{"name":"French Ministry of Health"},{"name":"Assistance Publique \u2013 H\u00f4pitaux de Paris"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In the OPTIFIL study that included 39 patients with localized invasive pulmonary aspergillosis complicating hematological malignancies, Aspergillus-specific IFN-\u03b3-producing T cells were detectable in 41% of the patients and predicted better 6-week outcomes, while their absence correlated with uncontrolled disease. Lymphopenia was the main limitation to Aspergillus ELISpot assay interpretation.<\/jats:p>","DOI":"10.1093\/infdis\/jiag356","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:27:11Z","timestamp":1784633231000},"source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of\n                    <i>Aspergillus<\/i>\n                    -Specific T Cells in Invasive Pulmonary Aspergillosis Among Patients With Hematologic Malignancies"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7444-4662","authenticated-orcid":false,"given":"Alexandra","family":"Serris","sequence":"first","affiliation":[{"name":"Infectious Diseases Department, University Hospital Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, Paris Cit\u00e9 University , Paris ,","place":["France"]},{"name":"Translational Immunology Unit, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amani","family":"Ouedrani","sequence":"additional","affiliation":[{"name":"Immunology Department, University Hospital Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, Paris Cit\u00e9 University , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9346-5848","authenticated-orcid":false,"given":"Blandine","family":"Rammaert","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, CHU Poitiers , Medicine and pharmacy university of Poitiers, Poitiers ,","place":["France"]},{"name":"Pharmacology of Antimicrobial Agents and Resistance unit, INSERM U1070 , Poitiers ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Vendrame","sequence":"additional","affiliation":[{"name":"Immunology Department, University Hospital Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, Paris Cit\u00e9 University , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4778-4338","authenticated-orcid":false,"given":"Florence","family":"Ader","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospices Civils de Lyon , Lyon ,","place":["France"]},{"name":"Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308 , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5445-9122","authenticated-orcid":false,"given":"Elodie","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Pneumology Department, Bordeaux University Hospital, H\u00f4pital Haut-L\u00e9v\u00eaque , Bordeaux ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Robin","sequence":"additional","affiliation":[{"name":"Hematology Department, Henri Mondor University Hospital, Assistance Publique-H\u00f4pitaux de Paris , Cr\u00e9teil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Thiebaut-Bertrand","sequence":"additional","affiliation":[{"name":"Hematology Department, Centre Hospitalier Universitaire Grenoble Alpes , Grenoble ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Risso","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nice University Hospital , Nice ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prissile","family":"Bakouboula","sequence":"additional","affiliation":[{"name":"APHP, URC Necker-Cochin , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Lortholary","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University Hospital Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, Paris Cit\u00e9 University , Paris ,","place":["France"]},{"name":"National Reference Center for Invasive Mycoses and Antifungals, Translational Mycology Research Group, Mycology Department, Institut Pasteur, Paris Cit\u00e9 University , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7060-2275","authenticated-orcid":false,"given":"Sophie","family":"Candon","sequence":"additional","affiliation":[{"name":"Department of Immunology and Biotherapy, Univ Rouen Normandie, Inserm, UMR 1234, CHU de Rouen , Rouen ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Lanternier","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University Hospital Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, Paris Cit\u00e9 University , Paris ,","place":["France"]},{"name":"National Reference Center for Invasive Mycoses and Antifungals, Translational Mycology Research Group, Mycology Department, Institut Pasteur, Paris Cit\u00e9 University , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Optifil study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Elisabeth","family":"Bougnoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Suarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Alanio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regis Peffault","family":"de la Tour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Raffoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Boissel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Sebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Malphettes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Botterel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Cordonnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Chachaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"De Botton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Paugam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Deau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Herbrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Letscher-Bru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cendrine","family":"Godet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Kauffman-Lacroix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Pilar","family":"Gallego Hernanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natacha","family":"Maillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taieb","family":"Chouaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9reng\u00e8re","family":"Gruson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"2026072907262672400_jiag356-B1","first-page":"1068","article-title":"The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study","volume":"91","author":"Pagano","year":"2006","journal-title":"Haematologica"},{"key":"2026072907262672400_jiag356-B2","doi-asserted-by":"crossref","first-page":"e0186422","DOI":"10.1371\/journal.pone.0186422","article-title":"Clinical outcome and prognostic factors associated with invasive pulmonary aspergillosis: an 11-year follow-up report from Taiwan","volume":"12","author":"Sun","year":"2017","journal-title":"PLoS One"},{"key":"2026072907262672400_jiag356-B3","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/ciw326","article-title":"Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the Infectious Diseases Society of America","volume":"63","author":"Patterson","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2026072907262672400_jiag356-B4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3324\/haematol.2016.152900","article-title":"ECIL-6 guidelines for the treatment of invasive candidiasis, aspergillosis and mucormycosis in leukemia and hematopoietic stem cell transplant patients","volume":"102","author":"Tissot","year":"2017","journal-title":"Haematologica. mars"},{"key":"2026072907262672400_jiag356-B5","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.cmi.2018.01.002","article-title":"Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline","volume":"24","author":"Ullmann","year":"2018","journal-title":"Clin Microbiol Infect"},{"key":"2026072907262672400_jiag356-B6","doi-asserted-by":"crossref","first-page":"e74326","DOI":"10.1371\/journal.pone.0074326","article-title":"Characterization of specific immune responses to different Aspergillus antigens during the course of invasive aspergillosis in hematologic patients","volume":"8","author":"Potenza","year":"2013","journal-title":"PLoS One"},{"key":"2026072907262672400_jiag356-B7","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.1182\/blood-2002-01-0265","article-title":"Analysis of T-cell responses to Aspergillus fumigatus antigens in healthy individuals and patients with hematologic malignancies","volume":"100","author":"Hebart","year":"2002","journal-title":"Blood"},{"key":"2026072907262672400_jiag356-B8","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1086\/315142","article-title":"Interleukin-4 causes susceptibility to invasive pulmonary aspergillosis through suppression of protective type I responses","volume":"180","author":"Cenci","year":"1999","journal-title":"J Infect Dis"},{"key":"2026072907262672400_jiag356-B9","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1086\/590566","article-title":"Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: mycoses study group and European organization for research and treatment of cancer consensus criteria","volume":"47","author":"Segal","year":"2008","journal-title":"Clin Infect Dis"},{"key":"2026072907262672400_jiag356-B10","doi-asserted-by":"crossref","first-page":"101272","DOI":"10.1016\/j.lanmic.2025.101272","article-title":"Invasive aspergillosis in liver transplant recipients in France (2007-21): a nationwide, retrospective, matched case-control study","volume":"7","author":"Le Hyaric","year":"2026","journal-title":"Lancet Microbe"},{"key":"2026072907262672400_jiag356-B11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0002-9343(93)90258-Q","article-title":"Invasive aspergillosis in patients with acquired immunodeficiency syndrome: report of 33 cases. French cooperative study group on aspergillosis in AIDS","volume":"95","author":"Lortholary","year":"1993","journal-title":"Am J Med"},{"key":"2026072907262672400_jiag356-B12","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.4049\/jimmunol.1400776","article-title":"Identification of immunogenic antigens from Aspergillus fumigatus by direct multiparameter characterization of specific conventional and regulatory CD4+ T cells","volume":"193","author":"Bacher","year":"2014","journal-title":"J Immunol"},{"key":"2026072907262672400_jiag356-B13","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.3324\/haematol.2013.098830","article-title":"Induction of A. fumigatus-specific CD4-positive T cells in patients recovering from invasive aspergillosis","volume":"99","author":"Jolink","year":"2014","journal-title":"Haematologica"},{"key":"2026072907262672400_jiag356-B14","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/infdis\/jit237","article-title":"Characterization of the T-cell-mediated immune response against the Aspergillus fumigatus proteins Crf1 and catalase 1 in healthy individuals","volume":"208","author":"Jolink","year":"2013","journal-title":"J Infect Dis"},{"key":"2026072907262672400_jiag356-B15","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1182\/blood-2005-05-1775","article-title":"Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation","volume":"106","author":"Perruccio","year":"2005","journal-title":"Blood"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiag356\/69850514\/jiag356.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiag356\/69850514\/jiag356.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:26:36Z","timestamp":1785324396000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/advance-article\/doi\/10.1093\/infdis\/jiag356\/8740286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":15,"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiag356","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]},"article-number":"jiag356"}}