{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:33:59Z","timestamp":1786113239965,"version":"build-2736575974"},"reference-count":44,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["33FI-0_229621"],"award-info":[{"award-number":["33FI-0_229621"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SHCS project"},{"name":"SHCS research foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clonal hematopoiesis (CH), defined by the expansion of hematopoietic cells with somatic mutations in leukemogenic genes (CH of indeterminate potential [CHIP]) or with mosaic chromosomal alterations (mCAs), is associated with aging and adverse health outcomes in the general population. Clonal hematopoiesis of indeterminate potential prevalence is higher in people with human immunodeficiency virus (PWH) than in controls. However, the full spectrum, prevalence, and clinical consequences of CH in PWH remain incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assessed CHIP and mCAs in a large sample of PWH (N\u223c2500) from the Swiss HIV Cohort Study. Using high-depth targeted sequencing of CHIP genes and genome-wide genotyping to call mCAs, we quantified the prevalence and clone size of both CH types and investigated an association of CH with clinical variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Clonal hematopoiesis of indeterminate potential (25% of individuals) and mCAs (16% of individuals) were common, positively correlated with age, often co-occurring (odds ratio = 1.7, P = .02 for autosomal mCAs), and associated with various clinical outcomes, including all-cause mortality (hazard ratio [HR] = 1.3, P = .02 for CHIP) and hematologic malignancies (HR = 9.4, P = .01 for the effect of CHIP on the risk of myeloid cancer; HR &amp;gt; 20, P &amp;lt; .001 for the effect of co-occurring CHIP and mCAs on the risk of lymphoid cancer). We also observed associations of CH with several proxies of inflammatory status (CD4:CD8 ratio, HIV load, late initiation of antiretroviral therapy, and toxicity of antiretroviral drugs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study provides a comprehensive assessment of the CH landscape in PWH, highlighting potential causes and consequences in this population and suggesting an interaction between CH and chronic immune activation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag393","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T11:33:27Z","timestamp":1785065607000},"source":"Crossref","is-referenced-by-count":0,"title":["Epidemiology and Clinical Impact of Clonal Hematopoiesis in People With HIV"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4235-9102","authenticated-orcid":false,"given":"Valeriia","family":"Timonina","sequence":"first","affiliation":[{"name":"School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne , Lausanne ,","place":["Switzerland"]},{"name":"Swiss Institute of Bioinformatics Host-Pathogen Genomics Group, , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Popadin","sequence":"additional","affiliation":[{"name":"Immanuel Kant Baltic Federal University Center for Mitochondrial Functional Genomics, , Kaliningrad ,","place":["Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Ait Oumelloul","sequence":"additional","affiliation":[{"name":"School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne , Lausanne ,","place":["Switzerland"]},{"name":"Swiss Institute of Bioinformatics 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