{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:13:27Z","timestamp":1792858407366,"version":"4.5.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Medical Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]},{"name":"French National Center for Scientific Research"},{"DOI":"10.13039\/501100007175","name":"CNRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007175","id-type":"DOI","asserted-by":"publisher"}]},{"name":"La Fondation de l\u2019Assistance Publique-H\u00f4pitaux de Paris"},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pneumococcal nasopharyngeal colonization is the first step toward invasive pneumococcal disease (IPD). Respiratory syncytial virus (RSV) may trigger IPD, particularly for serotypes with low disease potential. We aimed to analyze the distribution of pneumococcal serotypes among pediatric IPD according to RSV circulation level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used data from 3 continuous French surveillance systems on IPD, pneumococcal carriage and RSV infections from 2008 to 2023. Based on the RSV epidemic threshold, we assessed the proportion of each serotype among IPD, depending on \u201cRSV season\u201d and \u201cnon-RSV season.\u201d We assessed the correlation between the likelihood of serotype-specific involvement in IPD according to non-RSV season versus RSV season and the estimated disease potential of each serotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 4574 IPD cases, the serotype distribution strongly varied during non-RSV season versus RSV season. The lower the disease potential of serotypes, the more RSV circulation enhanced their involvement in IPD (Rho=0.60, CI95% .28\u2013.80, P = .0012).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The role of RSV in triggering IPD strongly varies across pneumococcal serotypes. The impact of RSV-targeted interventions should be evaluated in light of these data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag401","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:46:56Z","timestamp":1785498416000},"source":"Crossref","is-referenced-by-count":1,"title":["Respiratory Syncytial Virus Shapes Serotype-Specific Invasive Pneumococcal Disease Dynamics in Children: An Observational Study"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2516-2175","authenticated-orcid":false,"given":"In\u00e8s","family":"Fafi","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, IAME UMR 1137 , Paris ,","place":["France"]},{"name":"Department of General Paediatrics, Paediatric Infectious Disease and Internal Medicine, Robert Debr\u00e9 University Hospital, Assistance Publique-H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"Clinical Investigation Centre, INSERM CIC1426, Robert Debr\u00e9 University Hospital, Assistance Publique-H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1927-6360","authenticated-orcid":false,"given":"Corinne","family":"Levy","sequence":"additional","affiliation":[{"name":"French Paediatric Infectious Disease Group , Nice ,","place":["France"]},{"name":"Association Clinique et Th\u00e9rapeutique Infantile du Val-de-Marne France (ACTIV) , Cr\u00e9teil ,","place":["France"]},{"name":"Centre Hospitalier Intercommunal de Cr\u00e9teil, Clinical Research Centre, Universit\u00e9 Paris Est, IMRB-GRC GEMINI , Cr\u00e9teil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3043-2838","authenticated-orcid":false,"given":"Emmanuelle","family":"Varon","sequence":"additional","affiliation":[{"name":"French Paediatric Infectious Disease Group , Nice ,","place":["France"]},{"name":"National Reference Center for Pneumococci, Centre Hospitalier Intercommunal de Cr\u00e9teil , Cr\u00e9teil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6151-0686","authenticated-orcid":false,"given":"Robert","family":"Cohen","sequence":"additional","affiliation":[{"name":"French Paediatric Infectious Disease Group , Nice ,","place":["France"]},{"name":"Association Clinique et Th\u00e9rapeutique Infantile du Val-de-Marne France (ACTIV) , Cr\u00e9teil ,","place":["France"]},{"name":"Centre Hospitalier Intercommunal de Cr\u00e9teil, Clinical Research Centre, Universit\u00e9 Paris Est, IMRB-GRC GEMINI , Cr\u00e9teil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"B\u00e9chet","sequence":"additional","affiliation":[{"name":"Association Clinique et Th\u00e9rapeutique Infantile du Val-de-Marne France (ACTIV) , Cr\u00e9teil ,","place":["France"]},{"name":"Centre Hospitalier Intercommunal de Cr\u00e9teil, Clinical Research Centre, Universit\u00e9 Paris Est, IMRB-GRC GEMINI , Cr\u00e9teil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaba","family":"Valtuille","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, IAME UMR 1137 , Paris ,","place":["France"]},{"name":"Clinical Investigation Centre, INSERM CIC1426, Robert Debr\u00e9 University Hospital, Assistance Publique-H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Birgy","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, IAME UMR 1137 , Paris ,","place":["France"]},{"name":"Service de Microbiologie, Assistance Publique-H\u00f4Pitaux de Paris, H\u00f4Pital Robert-Debr\u00e9 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6447-6874","authenticated-orcid":false,"given":"St\u00e9phane","family":"Bonacorsi","sequence":"additional","affiliation":[{"name":"Service de Microbiologie, Assistance Publique-H\u00f4Pitaux de Paris, H\u00f4Pital Robert-Debr\u00e9 , Paris ,","place":["France"]},{"name":"Universit\u00e9 Paris Diderot , Sorbonne Paris Cit\u00e9 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Delobbe","sequence":"additional","affiliation":[{"name":"Association Fran\u00e7aise de P\u00e9diatre Ambulatoire , Villeneuve les Avignons ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Batard","sequence":"additional","affiliation":[{"name":"Association Clinique et Th\u00e9rapeutique Infantile du Val-de-Marne France (ACTIV) , Cr\u00e9teil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6168-1351","authenticated-orcid":false,"given":"Zein","family":"Assad","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, IAME UMR 1137 , Paris ,","place":["France"]},{"name":"French Paediatric Infectious Disease Group , Nice ,","place":["France"]},{"name":"General Paediatrics and Paediatric Emergency Departments, Jean Verdier University Hospital, Assistance Publique-H\u00f4pitaux de Paris, Sorbonne Paris Nord University , Bondy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0063-1510","authenticated-orcid":false,"given":"Manon","family":"Jaboyedoff","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, IAME UMR 1137 , Paris ,","place":["France"]},{"name":"Department Women-Mother-Child, Service of Paediatrics, Lausanne University Hospital and University of Lausanne , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"Lenglart","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, IAME UMR 1137 , Paris ,","place":["France"]},{"name":"Paediatric Emergency Department, Robert Debr\u00e9 University Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris Cit\u00e9 University , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5277-0002","authenticated-orcid":false,"given":"Romain","family":"Basmaci","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, IAME UMR 1137 , Paris ,","place":["France"]},{"name":"French Paediatric Infectious Disease Group , Nice ,","place":["France"]},{"name":"General Paediatrics and Paediatric Emergency Departments, Louis Mourier University Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris Cit\u00e9 Universit\u00e9 , Colombes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4996-9640","authenticated-orcid":false,"given":"Na\u00efm","family":"Ouldali","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, IAME UMR 1137 , Paris ,","place":["France"]},{"name":"Department of General Paediatrics, Paediatric Infectious Disease and Internal Medicine, Robert Debr\u00e9 University Hospital, Assistance Publique-H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"French Paediatric Infectious Disease Group , Nice ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"2026081021320107200_jiag401-B1","doi-asserted-by":"crossref","first-page":"e744","DOI":"10.1016\/S2214-109X(18)30247-X","article-title":"Burden of Streptococcus pneumoniae and Haemophilus influenzae 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Respir Med"},{"key":"2026081021320107200_jiag401-B9","doi-asserted-by":"crossref","first-page":"e2218959","DOI":"10.1001\/jamanetworkopen.2022.18959","article-title":"Association of nonpharmaceutical interventions during the COVID-19 pandemic with invasive pneumococcal disease, pneumococcal carriage, and respiratory viral infections among children in France","volume":"5","author":"Rybak","year":"2022","journal-title":"JAMA Netw Open"},{"key":"2026081021320107200_jiag401-B10"},{"key":"2026081021320107200_jiag401-B11","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.3390\/antibiotics12061020","article-title":"Dynamics of antibiotic resistance of Streptococcus pneumoniae in France: a pediatric prospective nasopharyngeal carriage study from 2001 to 2022","volume":"12","author":"Rybak","year":"2023","journal-title":"Antibiotics"},{"key":"2026081021320107200_jiag401-B12","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/cid\/ciaa917","article-title":"Invasive disease potential of pneumococcal serotypes in children after PCV13 implementation","volume":"72","author":"Cohen","year":"2021","journal-title":"Clin Infect Dis"},{"key":"2026081021320107200_jiag401-B13","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1093\/cid\/cix941","article-title":"Dynamics of bacterial colonization with Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis during symptomatic and asymptomatic viral upper respiratory tract infection","volume":"66","author":"DeMuri","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2026081021320107200_jiag401-B14","doi-asserted-by":"crossref","first-page":"104493","DOI":"10.1016\/j.ebiom.2023.104493","article-title":"The COVID-19 pandemic as an opportunity for unravelling the causative association between respiratory viruses and pneumococcus-associated disease in young children: a prospective study","volume":"90","author":"Dagan","year":"2023","journal-title":"EBioMedicine"}],"container-title":["The Journal of Infectious 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