{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:24:43Z","timestamp":1786969483712,"version":"build-2736575974"},"reference-count":13,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"European Partnership","award":["JTC2024"],"award-info":[{"award-number":["JTC2024"]}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"FWO","doi-asserted-by":"publisher","award":["G053121N"],"award-info":[{"award-number":["G053121N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009091","name":"FCT","doi-asserted-by":"publisher","award":["UID\/06304\/2023"],"award-info":[{"award-number":["UID\/06304\/2023"]}],"id":[{"id":"10.13039\/501100009091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009091","name":"FCT","doi-asserted-by":"publisher","award":["LA\/P\/0050\/2020"],"award-info":[{"award-number":["LA\/P\/0050\/2020"]}],"id":[{"id":"10.13039\/501100009091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009091","name":"FCT","doi-asserted-by":"publisher","award":["2022.06674.PTDC"],"award-info":[{"award-number":["2022.06674.PTDC"]}],"id":[{"id":"10.13039\/501100009091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009091","name":"FCT","doi-asserted-by":"publisher","award":["LCF\/PR\/HR24\/52440014"],"award-info":[{"award-number":["LCF\/PR\/HR24\/52440014"]}],"id":[{"id":"10.13039\/501100009091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009091","name":"FCT","doi-asserted-by":"publisher","award":["LCF\/PR\/HR22\/52420003"],"award-info":[{"award-number":["LCF\/PR\/HR22\/52420003"]}],"id":[{"id":"10.13039\/501100009091","id-type":"DOI","asserted-by":"publisher"}]},{"name":"la Caixa\u201d Foundation"},{"name":"EU Horizon 2020","award":["847507"],"award-info":[{"award-number":["847507"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this multicentric study, we found no association regarding incidence or outcome between common single-nucleotide polymorphisms in PTX3 and CLEC7A and invasive pulmonary aspergillosis in patients with severe viral pneumonia. The distinct pathophysiology of virus-associated pulmonary aspergillosis warrants exploration of genetic variation in novel candidates.<\/jats:p>","DOI":"10.1093\/infdis\/jiag403","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:49:13Z","timestamp":1785930553000},"source":"Crossref","is-referenced-by-count":0,"title":["Genetic Variation in the Long Pentraxin PTX3 and Dectin-1 Does Not Predispose to Influenza- or COVID-19\u2013Associated Pulmonary Aspergillosis"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7516-9471","authenticated-orcid":false,"given":"Simon","family":"Feys","sequence":"first","affiliation":[{"name":"Medical Intensive Care Unit, Department of General Internal Medicine, University Hospitals Leuven , Leuven ,","place":["Belgium"]},{"name":"Department of Microbiology, Immunology and Transplantation, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5207-2159","authenticated-orcid":false,"given":"Jannes","family":"Heylen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, KU Leuven , Leuven ,","place":["Belgium"]},{"name":"Department of Respiratory Diseases, University Hospitals Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5056-4718","authenticated-orcid":false,"given":"Samuel M","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho , Braga ,","place":["Portugal"]},{"name":"ICVS\/3B's-PT Government Associate Laboratory , University of Minho, Braga\/Guimar\u00e3es ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0209-8175","authenticated-orcid":false,"given":"In\u00eas","family":"Pereira","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho , Braga ,","place":["Portugal"]},{"name":"ICVS\/3B's-PT Government Associate Laboratory , University of Minho, Braga\/Guimar\u00e3es ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cato","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Department of General Internal Medicine, University Hospitals Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne Moon","family":"Lauwers","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Department of General Internal Medicine, University Hospitals Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6176-0404","authenticated-orcid":false,"given":"Hanne","family":"Beeckmans","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, University Hospitals Leuven , Leuven ,","place":["Belgium"]},{"name":"Department of Chronic Diseases and Metabolism, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bourgeois","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Algemeen Ziekenhuis Sint-Jan Brugge , Bruges ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Debaveye","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, University Hospitals Leuven , Leuven ,","place":["Belgium"]},{"name":"Department of Cellular and Molecular Medicine, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Depuydt","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Ghent University Hospital , Ghent ,","place":["Belgium"]},{"name":"Department of Internal Medicine and Pediatrics, Ghent University , Ghent ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7580-9718","authenticated-orcid":false,"given":"Pascal","family":"Frederiks","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, University Hospitals Leuven , Leuven ,","place":["Belgium"]},{"name":"Department of Cardiovascular Sciences, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5340-1500","authenticated-orcid":false,"given":"Greet","family":"Hermans","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Department of General Internal Medicine, University Hospitals Leuven , Leuven ,","place":["Belgium"]},{"name":"Department of Chronic Diseases and Metabolism, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hoenigl","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Medical University of Graz , Graz ,","place":["Austria"]},{"name":"Translational Mycology Unit, Medical University of Graz , Graz ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7602-1980","authenticated-orcid":false,"given":"Lenn","family":"Maessen","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Department of General Internal Medicine, University Hospitals Leuven , Leuven ,","place":["Belgium"]},{"name":"Department of Microbiology, Immunology and Transplantation, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Meersseman","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Department of General Internal Medicine, University Hospitals Leuven , Leuven ,","place":["Belgium"]},{"name":"Department of Microbiology, Immunology and Transplantation, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8668-1350","authenticated-orcid":false,"given":"Katrien","family":"Lagrou","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, KU Leuven , Leuven ,","place":["Belgium"]},{"name":"Department of Laboratory Medicine, National Reference Centre for Mycosis and Excellence Centre for Medical Mycology, University Hospitals Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet","family":"Lormans","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Algemeen Ziekenhuis Delta , Roeselare ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9230-1403","authenticated-orcid":false,"given":"Marijke","family":"Peetermans","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Department of General Internal Medicine, University Hospitals Leuven , Leuven ,","place":["Belgium"]},{"name":"Department of Microbiology, Immunology and Transplantation, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4227-7852","authenticated-orcid":false,"given":"Marick R","family":"Starick","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Thevissen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, KU Leuven , Leuven ,","place":["Belgium"]},{"name":"Department of Microbial and Molecular Systems, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lore","family":"Vanderbeke","sequence":"additional","affiliation":[{"name":"Department of Infectiology, AZORG Ziekenhuis , Aalst ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3468-9251","authenticated-orcid":false,"given":"Robin","family":"Vos","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, University Hospitals Leuven , Leuven ,","place":["Belgium"]},{"name":"Department of Chronic Diseases and Metabolism, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4176-3608","authenticated-orcid":false,"given":"Alexander","family":"Wilmer","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Department of General Internal Medicine, University Hospitals Leuven , Leuven ,","place":["Belgium"]},{"name":"Department of Microbiology, Immunology and Transplantation, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1121-4894","authenticated-orcid":false,"given":"Frank L","family":"van de Veerdonk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center , Nijmegen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Van Weyenbergh","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the GALACTIC consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Sedik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Prattes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Wolfgruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Huguet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina Thomas","family":"Villikudathil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Cunha","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho , Braga ,","place":["Portugal"]},{"name":"ICVS\/3B's-PT Government Associate Laboratory , University of Minho, Braga\/Guimar\u00e3es ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5983-3897","authenticated-orcid":false,"given":"Joost","family":"Wauters","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Department of General Internal Medicine, University Hospitals Leuven , Leuven ,","place":["Belgium"]},{"name":"Department of Microbiology, Immunology and Transplantation, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8935-8030","authenticated-orcid":false,"given":"Agostinho","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho , Braga ,","place":["Portugal"]},{"name":"ICVS\/3B's-PT Government Associate Laboratory , University of Minho, Braga\/Guimar\u00e3es ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"2026081707263878800_jiag403-B1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/S2213-2600(24)00151-6","article-title":"Influenza-associated and COVID-19-associated pulmonary aspergillosis in critically ill patients","volume":"12","author":"Feys","year":"2024","journal-title":"Lancet Respir Med"},{"key":"2026081707263878800_jiag403-B2","doi-asserted-by":"crossref","first-page":"e0009421","DOI":"10.1128\/CMR.00094-21","article-title":"Pathogenesis of respiratory viral and fungal coinfections","volume":"35","author":"Salazar","year":"2022","journal-title":"Clin Microbiol Rev"},{"key":"2026081707263878800_jiag403-B3","doi-asserted-by":"crossref","first-page":"e0198223","DOI":"10.1128\/mbio.01982-23","article-title":"Integrating genetic and immune factors to uncover pathogenetic mechanisms of viral-associated pulmonary aspergillosis","volume":"15","author":"Gon\u00e7alves","year":"2024","journal-title":"mBio"},{"key":"2026081707263878800_jiag403-B4","doi-asserted-by":"crossref","first-page":"5394","DOI":"10.1182\/blood-2010-04-279307","article-title":"Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity","volume":"116","author":"Cunha","year":"2010","journal-title":"Blood"},{"key":"2026081707263878800_jiag403-B5","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1056\/NEJMoa1211161","article-title":"Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation","volume":"370","author":"Cunha","year":"2014","journal-title":"N Engl J Med"},{"key":"2026081707263878800_jiag403-B6","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1182\/blood-2016-10-743294","article-title":"Validation of single nucleotide polymorphisms in invasive aspergillosis following hematopoietic cell transplantation","volume":"129","author":"Fisher","year":"2017","journal-title":"Blood"},{"key":"2026081707263878800_jiag403-B7","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41577-022-00826-w","article-title":"Immune responses to human fungal pathogens and therapeutic prospects","volume":"23","author":"Lionakis","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"2026081707263878800_jiag403-B8","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1007\/s00134-020-06091-6","article-title":"International expert review of influenza-associated pulmonary aspergillosis in ICU patients and recommendations for a case definition","volume":"46","author":"Verweij","year":"2020","journal-title":"Intensive Care Med"},{"key":"2026081707263878800_jiag403-B9","doi-asserted-by":"crossref","first-page":"e149","DOI":"10.1016\/S1473-3099(20)30847-1","article-title":"Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM\/ISHAM consensus criteria for research and clinical guidance","volume":"21","author":"Koehler","year":"2021","journal-title":"Lancet Infect Dis"},{"key":"2026081707263878800_jiag403-B10","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S2213-2600(22)00259-4","article-title":"Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study","volume":"10","author":"Feys","year":"2022","journal-title":"Lancet Respir Med"},{"key":"2026081707263878800_jiag403-B11","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/cid\/civ386","article-title":"PTX3 polymorphisms and invasive mold infections after solid organ transplant: figure 1","volume":"61","author":"W\u00f3jtowicz","year":"2015","journal-title":"Clin Infect Dis"},{"key":"2026081707263878800_jiag403-B12","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/cid\/ciz1008","article-title":"Revision and update of the consensus definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium","volume":"71","author":"Donnelly","year":"2020","journal-title":"Clin Infect Dis"},{"key":"2026081707263878800_jiag403-B13","doi-asserted-by":"crossref","first-page":"e1333215","DOI":"10.1080\/2162402X.2017.1333215","article-title":"Epigenetic regulation of the extrinsic oncosuppressor PTX3 gene in inflammation and cancer","volume":"6","author":"Rubino","year":"2017","journal-title":"Oncoimmunology"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiag403\/70535811\/jiag403.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiag403\/70535811\/jiag403.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:26:51Z","timestamp":1786966011000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/advance-article\/doi\/10.1093\/infdis\/jiag403\/8754520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,7]]},"references-count":13,"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiag403","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,7]]},"article-number":"jiag403"}}