{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:19:03Z","timestamp":1787789943396,"version":"build-2784847793"},"reference-count":28,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Basic Science Research Program"},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020930","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2019R1I1A3A01060465"],"award-info":[{"award-number":["NRF-2019R1I1A3A01060465"]}],"id":[{"id":"10.13039\/501100020930","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020930","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2020R1I1A3073530"],"award-info":[{"award-number":["NRF-2020R1I1A3073530"]}],"id":[{"id":"10.13039\/501100020930","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020930","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2020R1A6A1A03043026"],"award-info":[{"award-number":["NRF-2020R1A6A1A03043026"]}],"id":[{"id":"10.13039\/501100020930","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003661","name":"Korea Institute for Advancement of Technology","doi-asserted-by":"publisher","award":["P0020622"],"award-info":[{"award-number":["P0020622"]}],"id":[{"id":"10.13039\/501100003661","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bio & Medical Technology Development Program"},{"DOI":"10.13039\/501100012266","name":"NRF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"publisher","award":["2021M3A9I4023974"],"award-info":[{"award-number":["2021M3A9I4023974"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korea National Institute of Infectious Diseases"},{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["2023-ER2107-02"],"award-info":[{"award-number":["2023-ER2107-02"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Persistent intestinal carbapenemase-producing Enterobacterales (CPE) carriage challenges infection prevention and antimicrobial stewardship. We evaluated fecal microbiota transplantation (FMT) for decolonization and response-associated recipient microbiome features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study assessed intestinal CPE clearance in 131 adult carriers (68 receiving FMT and 63 under observation). Responders achieved clearance, defined as 3 consecutive negative rectal surveillance cultures for CPE obtained at 3-day intervals within 1 month after FMT. Following least absolute shrinkage and selection operator (LASSO)\u2013based covariate selection, Cox proportional hazards models estimated associations between FMT and time to successful decolonization within prespecified 0\u201330-day and 0\u201390-day windows. A longitudinal metagenomic subcohort of 21 FMT recipients (102 fecal samples) underwent shotgun sequencing to characterize taxonomic composition, microbial network organization, functional pathways, antimicrobial resistance genes (ARGs), and donor engraftment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After LASSO-based covariate selection, FMT was associated with faster CPE clearance than observation at 1 month (hazard ratio, 4.02; 95% CI, 1.84\u20138.79), with effects sustained at 3 months. Responders showed relatively preserved baseline microbial network organization and enrichment of taxa annotated with arginine-related pathway features, suggesting metabolic relevance to microbial niche competition. After FMT, responders had greater engraftment of donor-associated taxa and donor-like ecological reassembly, with reduced Klebsiella pneumoniae dominance and ARG abundance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fecal microbiota transplantation may accelerate intestinal decolonization in CPE carriers; response variability was associated with recipient gut-microbiome ecology, suggesting that microbiome-guided patient selection could optimize microbiota-based strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag414","type":"journal-article","created":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T11:33:59Z","timestamp":1786275239000},"source":"Crossref","is-referenced-by-count":0,"title":["Fecal Microbiota Transplantation Accelerates Clearance of Carbapenemase-Producing Enterobacterales Intestinal Carriage: Influence of Recipient Gut Microbiome Ecology"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4509-2936","authenticated-orcid":false,"given":"Imchang","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine , Chuncheon ,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9206-9245","authenticated-orcid":false,"given":"Ki Tae","family":"Suk","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine , Chuncheon ,","place":["South Korea"]},{"name":"Institute for Liver and Digestive Diseases, Hallym University , Chuncheon ,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7077-0807","authenticated-orcid":false,"given":"Joon-Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Life Science, Multidisciplinary Genome Institute, Hallym University , Chuncheon ,","place":["South Korea"]},{"name":"Department of Nutritional Science and Food Management, Ewha Womans University , Seoul ,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1225-8477","authenticated-orcid":false,"given":"Dongeun","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine , Seoul ,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5792-1500","authenticated-orcid":false,"given":"Dong Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine , Chuncheon ,","place":["South Korea"]},{"name":"Institute for Liver and Digestive Diseases, Hallym University , Chuncheon ,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1243-8280","authenticated-orcid":false,"given":"Bong-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science and Food Management, Ewha Womans University , Seoul ,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1797-3426","authenticated-orcid":false,"given":"Seung Soon","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, 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