{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:20:52Z","timestamp":1787790052199,"version":"build-2784847793"},"reference-count":15,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19AI162568"],"award-info":[{"award-number":["U19AI162568"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI161013"],"award-info":[{"award-number":["R01AI161013"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bacille Calmette\u2013Gu\u00e9rin (BCG) provides limited protection against tuberculosis relapse. We investigated whether adjunctive immunotherapy targeting B cells enhances BCG-mediated protection in a murine model of latent tuberculosis. While BCG alone had modest effects, adjunctive immunotherapy with recombinant A proliferation\u2013inducing ligand significantly reduced relapse. Protection was associated with selective remodeling and activation of marginal-zone B-cell compartments, whereas effects on T-cell populations were comparatively modest. These findings support further investigation of B-cell\u2013targeted immunomodulation to improve durable immune control and reduce tuberculosis relapse.<\/jats:p>","DOI":"10.1093\/infdis\/jiag416","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T11:52:14Z","timestamp":1786189934000},"source":"Crossref","is-referenced-by-count":0,"title":["Bacille Calmette\u2013Gu\u00e9rin Vaccination With Adjunctive A Proliferation\u2013Inducing Ligand Immunotherapy Reduces Tuberculosis Relapse in Mice"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3943-9061","authenticated-orcid":false,"given":"Chen-Yu","family":"Tsai","sequence":"first","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey 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