{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:05:47Z","timestamp":1792785947952,"version":"4.5.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"New Vaccine Surveillance Network"},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["IP-16-004"],"award-info":[{"award-number":["IP-16-004"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["IP21-002)"],"award-info":[{"award-number":["IP21-002)"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pandemic Threat Technology Center","id":[{"id":"https:\/\/ror.org\/046wj6g23","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007915","name":"Baylor College of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Infants are at risk of severe respiratory syncytial virus (RSV) infection. We characterized the humoral immune response of infants with primary RSV infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Term infants hospitalized for RSV acute respiratory infection (ARI) or non-RSV ARI (controls) were enrolled from November 2018 through March 2020 at 5 pediatric medical institutions. Adult controls were women aged 18\u201345 years without acute RSV infection. Acute and convalescent sera were tested for homologous and heterologous neutralizing antibodies (NtAbs), competitive antibodies (CAs) to sites \u00d8, II, IV, and I on the fusion (F) glycoprotein, and anti-postF and 27-amino acid peptide (p27) immunoglobulin G (IgG). Geometric mean titer or CA concentrations of acute and convalescent sera were compared between and within groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty-six infants (49 RSV infected and 17 controls) were enrolled. Median age was 76 (interquartile range [IQR], 45\u2013179) days and 151 (IQR, 72\u2013207) days for the RSV and control groups, respectively. NtAb and CA at hospitalization were low among infant groups. Postinfection, RSV\/A induced robust homologous and heterologous NtAb responses while RSV\/B caused a robust NtAb response only to RSV\/B. RSV\/A infection generated significant CA rise to sites IV and II, while RSV\/B infection resulted in only site II CA rise. Rises in postF and p27 IgG were not detected. Postinfection RSV antibody levels in infants were markedly lower compared to those in control adult women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RSV-infected infants had low preinfection levels of protective antibodies. Infants infected with RSV\/A compared to RSV\/B generated a more robust NtAb response, highlighted by a broader CA response to sites II and IV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag418","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T11:52:15Z","timestamp":1786189935000},"source":"Crossref","is-referenced-by-count":0,"title":["The Humoral Immune Profiles of Infants Before and After Severe Primary Respiratory Syncytial Virus A and B Infection"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4016-7588","authenticated-orcid":false,"given":"Vasanthi","family":"Avadhanula","sequence":"first","affiliation":[{"name":"Department of Molecular Virology and Microbiology, Baylor College of Medicine , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila C","family":"Sahni","sequence":"additional","affiliation":[{"name":"Immunization Project, Texas Children's Hospital , Houston, Texas ,","place":["USA"]},{"name":"Department of Pediatrics, Baylor College of Medicine , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4860-843X","authenticated-orcid":false,"given":"Laura","family":"Ferlic Stark","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology and Microbiology, Baylor College of Medicine , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-0544","authenticated-orcid":false,"given":"Marian G","family":"Michaels","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John V","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania ,","place":["USA"]},{"name":"Department of Pediatrics, University of Wisconsin School of Medicine and Public Health , Madison, Wisconsin ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8582-3609","authenticated-orcid":false,"given":"Eileen J","family":"Klein","sequence":"additional","affiliation":[{"name":"Seattle Children's Research Institute, University of Washington School of Medicine , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1134-4178","authenticated-orcid":false,"given":"Janet A","family":"Englund","sequence":"additional","affiliation":[{"name":"Seattle Children's Research Institute, University of Washington School of Medicine , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-911X","authenticated-orcid":false,"given":"Daniel C","family":"Payne","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, Ohio ,","place":["USA"]},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1788-8037","authenticated-orcid":false,"given":"Mary Allen","family":"Staat","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, Ohio ,","place":["USA"]},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth P","family":"Schlaudecker","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, Ohio ,","place":["USA"]},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Halasa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Vanderbilt University Medical Center , Nashville, Tennessee ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Vanderbilt University Medical Center , Nashville, Tennessee ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3900-379X","authenticated-orcid":false,"given":"Geoffrey A","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Rochester School of Medicine and Dentistry , Rochester, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G","family":"Szilagyi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California, Los Angeles , Los Angeles, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3275-6657","authenticated-orcid":false,"given":"Rangaraj","family":"Selvarangan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Mercy Kansas City , Kansas City, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4281-1824","authenticated-orcid":false,"given":"Christopher","family":"Harrison","sequence":"additional","affiliation":[{"name":"University of Missouri\u2013Kansas City School of Medicine Department of Pathology and Laboratory Medicine, , Kansas City, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Moline","sequence":"additional","affiliation":[{"name":"Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3523-3616","authenticated-orcid":false,"given":"Natalie","family":"Thornburg","sequence":"additional","affiliation":[{"name":"Coronavirus and Other Respiratory Viruses Division, 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