{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:20:24Z","timestamp":1787793624051,"version":"build-2784847793"},"reference-count":25,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Emory Vaccine and Treatment Evaluation Units","award":["HHSN272201300018I"],"award-info":[{"award-number":["HHSN272201300018I"]}]},{"name":"Baylor VTEU","award":["HHSN272201300015I"],"award-info":[{"award-number":["HHSN272201300015I"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prior dengue virus (DENV) infection is common in regions affected by Zika virus (ZIKV) and may shape immune responses to subsequent ZIKV infection. Although cross-reactive neutralizing and disease-enhancing antibodies have been extensively studied, the effect of prior DENV immunity on antibody-dependent cellular cytotoxicity (ADCC) responses to ZIKV remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Longitudinal serum samples were obtained and analyzed from a prospective cohort of 46 PCR-confirmed ZIKV cases enrolled at two U.S. sites between 2016 and 2018 (follow-up visits 6\u2013409 days). ZIKV cases were classified as DENV-experienced (n = 13) or DENV-naive groups (n = 33) based on detection of DENV neutralizing antibodies at baseline. ZIKV-specific ADCC activity was measured using a natural killer cell cytotoxicity assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>DENV-experienced individuals had significantly higher peak ZIKV-specific ADCC responses (geometric mean titers [GMT] 15 104 vs 1819; P &amp;lt; .0001) and greater cumulative ADCC responses during early (\u226480 days, AUC 918 540 vs 42 752; P = .0012) and late convalescent phases (&amp;gt;80 days, AUC 953 694 vs 182 004; P = .0037). Peak ZIKV ADCC magnitude did not correlate with peak DENV or ZIKV antibody neutralizing titers, and ZIKV neutralization efficiency at the time of peak ZIKV ADCC did not differ between groups. However, ZIKV ADCC normalized to ZIKV IgG was significantly higher among DENV-experienced individuals (GMT 2230 vs 735.6; P = .0107).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prior DENV infection was associated with greater ZIKV-specific ADCC magnitude, despite similar ZIKV neutralization, suggesting that prior DENV exposure shapes Fc-mediated flavivirus immunity beyond neutralization. Future studies are needed to assess the clinical implications of these antibodies in immunopathology and protection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag429","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T12:49:54Z","timestamp":1786798194000},"source":"Crossref","is-referenced-by-count":0,"title":["Prior Dengue Virus Exposure is Associated with Enhanced Zika Virus-Specific ADCC Activity in a Longitudinal Human Cohort"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7189-8706","authenticated-orcid":false,"given":"Jessica N","family":"McCaffery","sequence":"first","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemin","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Pediatric 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,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilin","family":"Lai","sequence":"additional","affiliation":[{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]},{"name":"Emory Vaccine Center, Emory University , Atlanta, Georgia ,","place":["USA"]},{"name":"Emory National Primate Research Center , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0217-332X","authenticated-orcid":false,"given":"Wendy A","family":"Keitel","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology & Microbiology, Baylor College of Medicine , Houston, Texas ,","place":["USA"]},{"name":"Department of Medicine, Baylor College of Medicine , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2512-7919","authenticated-orcid":false,"given":"Nadine","family":"Rouphael","sequence":"additional","affiliation":[{"name":"The Hope Clinic, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0652-6834","authenticated-orcid":false,"given":"Larry J","family":"Anderson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1576-4420","authenticated-orcid":false,"given":"Evan J","family":"Anderson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J","family":"Mulligan","sequence":"additional","affiliation":[{"name":"The Hope Clinic, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0489-0074","authenticated-orcid":false,"given":"Hana M","family":"El 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