{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:11:58Z","timestamp":1790194318651,"version":"4.1.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Takeda Manufacturing Austria AG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to investigate the potentially underappreciated circulation of Bourbon virus (BRBV) and related Thogotoviruses by analyzing neutralizing antibodies in US and EU human plasma-derived immunoglobulin (IG) lots. Using live virus neutralization assays on 71 IG lots manufactured from 2006 to 2024, we quantified BRBV, Thogotovirus, and Dhori virus (DHOV) neutralization. Thogotovirus and DHOV antibodies were undetectable in all lots, while BRBV-neutralizing titers in US IG showed a borderline-significant increase over time; EU IG was largely nonreactive. These findings suggest wider-than-recognized BRBV circulation in the US and support IG-based sero-epidemiology as sensitive tool for detecting evidence of past infection by emerging viruses.<\/jats:p>","DOI":"10.1093\/infdis\/jiag442","type":"journal-article","created":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T11:32:47Z","timestamp":1787484767000},"source":"Crossref","is-referenced-by-count":2,"title":["Serosurvey for Antibodies to Bourbon Virus and Related Thogotoviruses in Immunoglobulin Lots Obtained From Human Plasma Collected in the United States and Europe"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2335-8609","authenticated-orcid":false,"given":"Maria R","family":"Farcet","sequence":"first","affiliation":[{"name":"Global Pathogen Safety, Takeda Manufacturing Austria AG , Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8064-2489","authenticated-orcid":false,"given":"Michael","family":"Karbiener","sequence":"additional","affiliation":[{"name":"Global Pathogen Safety, Takeda Manufacturing Austria AG , Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9970-0987","authenticated-orcid":false,"given":"Thomas R","family":"Kreil","sequence":"additional","affiliation":[{"name":"Global Pathogen Safety, Takeda Manufacturing Austria AG , Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"2026091710221180400_jiag442-B1","doi-asserted-by":"crossref","first-page":"760","DOI":"10.3201\/eid2105.150150","article-title":"Novel thogotovirus associated with febrile illness and death, United States, 2014","volume":"21","author":"Kosoy","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"2026091710221180400_jiag442-B2","doi-asserted-by":"crossref","DOI":"10.1128\/msphere.00164-22","article-title":"Detection of Bourbon virus-specific serum neutralizing antibodies in human serum in Missouri, USA","volume":"7","author":"Bamunuarachchi","year":"2022","journal-title":"mSphere"},{"key":"2026091710221180400_jiag442-B3","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.3201\/eid3011.240499","article-title":"Evidence of human Bourbon virus infections, North Carolina, USA","volume":"30","author":"Zychowski","year":"2024","journal-title":"Emerg Infect Dis"},{"key":"2026091710221180400_jiag442-B4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3201\/eid2901.220283","article-title":"Bourbon virus transmission, New York, USA","volume":"29","author":"Dupuis","year":"2023","journal-title":"Emerg Infect Dis"},{"key":"2026091710221180400_jiag442-B5","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1093\/jme\/tjab047","article-title":"The contribution of wildlife hosts to the rise of ticks and tick-borne diseases in North America","volume":"58","author":"Tsao","year":"2021","journal-title":"J Med Entomol"},{"key":"2026091710221180400_jiag442-B6","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/jme\/tjaa094","article-title":"A survey of tick surveillance and control practices in the United States","volume":"58","author":"Mader","year":"2021","journal-title":"J Med Entomol"},{"key":"2026091710221180400_jiag442-B7","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1093\/cid\/ciac766","article-title":"Severe arboviral neuroinvasive disease in patients on rituximab therapy: a review","volume":"76","author":"Kapadia","year":"2023","journal-title":"Clin Infect Dis"},{"key":"2026091710221180400_jiag442-B8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007790","article-title":"Therapeutic efficacy of favipiravir against Bourbon virus in mice","volume":"15","author":"Bricker","year":"2019","journal-title":"PLoS Pathog"},{"key":"2026091710221180400_jiag442-B9","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.3201\/eid1510.081668","article-title":"West Nile virus infection in plasma of blood and plasma donors, United States","volume":"15","author":"Planitzer","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"2026091710221180400_jiag442-B10","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01556-21","article-title":"Comparative study of ten thogotovirus isolates and their distinct in vivo characteristics","volume":"96","author":"Fuchs","year":"2022","journal-title":"J Virol"},{"key":"2026091710221180400_jiag442-B11","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1016\/j.vaccine.2019.04.022","article-title":"Measles virus neutralizing antibodies in immunoglobulin lots produced from plasma collected in Europe or the United States","volume":"37","author":"Farcet","year":"2019","journal-title":"Vaccine"},{"key":"2026091710221180400_jiag442-B12","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1093\/infdis\/jiab142","article-title":"Rapidly increasing severe acute respiratory syndrome coronavirus 2 neutralization by intravenous immunoglobulins produced from plasma collected during the 2020 pandemic","volume":"226","author":"Farcet","year":"2021","journal-title":"J Infect Dis"},{"key":"2026091710221180400_jiag442-B13","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1086\/519392","article-title":"West Nile virus neutralization by US plasma-derived immunoglobulin products","volume":"196","author":"Planitzer","year":"2007","journal-title":"J Infect Dis"},{"key":"2026091710221180400_jiag442-B14","doi-asserted-by":"crossref","DOI":"10.1099\/jgv.0.001887","article-title":"Bourbon virus, a newly discovered zoonotic thogotovirus","volume":"104","author":"Bendl","year":"2023","journal-title":"J Gen Virol"},{"key":"2026091710221180400_jiag442-B15","doi-asserted-by":"crossref","DOI":"10.2807\/ese.16.10.19812-en","article-title":"Increasing West Nile virus antibody titres in central European plasma donors from 2006 to 2010","volume":"16","author":"Rabel","year":"2011","journal-title":"Eurosurv"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiag442\/70769034\/jiag442.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiag442\/70769034\/jiag442.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:22:20Z","timestamp":1789654940000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/advance-article\/doi\/10.1093\/infdis\/jiag442\/8769286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":15,"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiag442","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,24]]},"article-number":"jiag442"}}