{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:05:48Z","timestamp":1792785948437,"version":"4.5.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100003896","name":"Henry M. Jackson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003896","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Advancement of Military Medicine, Inc."},{"name":"US Department of the Army","award":["W81XWH-18-2-0040"],"award-info":[{"award-number":["W81XWH-18-2-0040"]}],"id":[{"id":"https:\/\/ror.org\/035w1gb98","id-type":"ROR","asserted-by":"crossref"}]},{"name":"US Public Health Service"},{"DOI":"10.13039\/100029382","name":"HIV Vaccine Trials Network","doi-asserted-by":"publisher","award":["UM1 AI068614"],"award-info":[{"award-number":["UM1 AI068614"]}],"id":[{"id":"10.13039\/100029382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100029382","name":"HIV Vaccine Trials Network","doi-asserted-by":"publisher","award":["UM1 AI06818"],"award-info":[{"award-number":["UM1 AI06818"]}],"id":[{"id":"10.13039\/100029382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100029382","name":"HIV Vaccine Trials Network","doi-asserted-by":"publisher","award":["UM1 AI068635"],"award-info":[{"award-number":["UM1 AI068635"]}],"id":[{"id":"10.13039\/100029382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Antibody Mediated Prevention trials (HVTN 703 and HVTN 704) demonstrated that infusions of the broadly neutralizing antibody (bnAb) VRC01 prevented human immunodeficiency virus-1 (HIV-1) acquisition with viruses sensitive to VRC01 neutralization. We evaluated how VRC01 epitope distances differed across groups in the trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We calculated VRC01 epitope distances (a 3D structure-informed measure of how the VRC01 epitope in a sequence differs from that epitope in known VRC01-sensitive strains) to compare &amp;gt;35,000 Envelopes sampled from 172 participants with mostly subtype C viruses in HVTN 703 and subtype B in HVTN 704.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At the first visit with detectable HIV-1, we found fewer distinct VRC01 epitopes in the sequences from participants in the VRC01 high-dose group in HVTN 704 (P = .054), suggesting that some epitope variants were blocked in these participants who harbored subtype B viruses. In both trials, VRC01 epitope distances were significantly larger in the VRC01 high-dose groups than in the placebo groups (P \u2264 .010). Moreover, sequences sampled in the first month after diagnosis showed that the rate of change in VRC01 epitope distances was significantly higher in the VRC01 groups than in the placebo group in the HVTN 703 trial (P \u2264 .036).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings show the impact of sieve acquisition (variants blocked among subtype B viruses) and postacquisition (stronger impact of VRC01-mediated escape in subtype C) effects, highlighting a complex intersection between HIV-1 subtypes, escape pathways, and antibody-mediated prevention. The differential pressure exerted by VRC01 on subtype B versus C viruses emphasizes that escape pathways need to be considered when selecting bnAbs for clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag454","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:36:06Z","timestamp":1788521766000},"source":"Crossref","is-referenced-by-count":0,"title":["VRC01 Exerted Differential Pressure on HIV-1 Envelope From Subtypes B and C That Continued in the First Weeks Postdiagnosis in the Antibody Mediated Prevention Trials"],"prefix":"10.1093","author":[{"given":"Hongjun","family":"Bai","sequence":"first","affiliation":[{"name":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research , Silver Spring, Maryland ,","place":["USA"]},{"name":"Henry M. 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