{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:57:24Z","timestamp":1792598244570,"version":"4.5.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Association pour la Recherche en M\u00e9decine Interne et en Immunologie Clinique"},{"name":"ARMIIC"},{"name":"French Ministry of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Autoantibody profiles in HIV-associated pulmonary arterial hypertension (HIV-PAH) remain poorly characterized. Using a validated proteomic pipeline (two-dimensional immunoblot, mass spectrometry, ELISA), we compared 20 HIV-PAH patients with 20 HIV controls without PAH. Anti-annexin A5 (AnxA5) autoantibodies were present in 55% of HIV-PAH patients versus 0% of controls (P &amp;lt; .001) and anti-14-3-3\u03b5 in 35% versus 5% (P = .04), despite comparable HIV duration, CD4 counts, and virological control. Both remained associated with PAH after adjustment for coinfections. These autoantibodies mirror those described in connective-tissue-disease-PAH, suggesting a possible overlap in autoimmune features and a research biomarker warranting prospective validation.<\/jats:p>","DOI":"10.1093\/infdis\/jiag470","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T11:39:18Z","timestamp":1792323558000},"source":"Crossref","is-referenced-by-count":0,"title":["Anti-annexin A5 Autoantibodies in Pulmonary Arterial Hypertension Related to Human Immunodeficiency Virus Infection (HIV-PAH): A Case-Control Study"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9046-4524","authenticated-orcid":false,"given":"Benjamin","family":"Thoreau","sequence":"first","affiliation":[{"name":"INSERM U1016, Institut Cochin , Paris ,","place":["France"]},{"name":"CNRS UMR 8104, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]},{"name":"Service de M\u00e9decine Interne, Centre de R\u00e9f\u00e9rence Maladies Autoimmunes et Autoinflammatoires Syst\u00e9miques Rares D'Ile de France, de L\u2019Est et de L\u2019Ouest, H\u00f4pital Cochin, Assistance Publique- H\u00f4pitaux de Paris (AP-HP) , Paris ,","place":["France"]},{"name":"APHP-CUP, H\u00f4pital Cochin, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8029-9417","authenticated-orcid":false,"given":"Arthur","family":"Renaud","sequence":"additional","affiliation":[{"name":"INSERM U1016, Institut Cochin , Paris ,","place":["France"]},{"name":"CNRS UMR 8104, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]},{"name":"Service de M\u00e9decine Interne, Centre de R\u00e9f\u00e9rence Maladies Autoimmunes et Autoinflammatoires Syst\u00e9miques Rares D'Ile de France, de L\u2019Est et de L\u2019Ouest, CHU de Nantes , Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Chafey","sequence":"additional","affiliation":[{"name":"Proteom\u2019IC Facility, Universit\u00e9 Paris Cit\u00e9, CNRS, Inserm, Institut Cochin , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilhem","family":"Clary","sequence":"additional","affiliation":[{"name":"Proteom\u2019IC Facility, Universit\u00e9 Paris Cit\u00e9, CNRS, Inserm, Institut Cochin , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4935-7065","authenticated-orcid":false,"given":"Morgane","family":"Le Gall","sequence":"additional","affiliation":[{"name":"Proteom\u2019IC Facility, Universit\u00e9 Paris Cit\u00e9, CNRS, Inserm, Institut Cochin , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Broussard","sequence":"additional","affiliation":[{"name":"Proteom\u2019IC Facility, Universit\u00e9 Paris Cit\u00e9, CNRS, Inserm, Institut Cochin , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3242-7247","authenticated-orcid":false,"given":"Odile","family":"Launay","sequence":"additional","affiliation":[{"name":"CIC Cochin Pasteur, H\u00f4pital Cochin, AP-HP, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1840-1817","authenticated-orcid":false,"given":"David","family":"Launay","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology, Referral Centre for Centre for Rare Systemic Autoimmune Diseases North of France, North-West, Mediterranean and Guadeloupe (CeRAINOM) , Lille ,","place":["France"]},{"name":"CHU Lille, Univ. Lille, Inserm, U1286 \u2013 INFINITE\u2014Institute for Translational Research in Inflammation , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7432-847X","authenticated-orcid":false,"given":"Eric","family":"Hachulla","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology, Referral Centre for Centre for Rare Systemic Autoimmune Diseases North of France, North-West, Mediterranean and Guadeloupe (CeRAINOM) , Lille ,","place":["France"]},{"name":"CHU Lille, Univ. Lille, Inserm, U1286 \u2013 INFINITE\u2014Institute for Translational Research in Inflammation , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Deligny","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne et Immunologie Clinique, H\u00f4pital Pierre Zobda-Quitman, CHU de Martinique , Fort de France ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2548-7858","authenticated-orcid":false,"given":"Alban-Elouen","family":"Baruteau","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and Pediatric Cardiac Surgery, FHU PRECICARE, Nantes Universit\u00e9, CHU Nantes , Nantes ,","place":["France"]},{"name":"INSERM, CIC FEA 1413, Nantes Universit\u00e9, CHU Nantes , Nantes ,","place":["France"]},{"name":"CNRS, INSERM, l\u2019Institut du Thorax, Nantes Universit\u00e9, CHU Nantes , Nantes 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