{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:05:47Z","timestamp":1792785947951,"version":"4.5.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005744","name":"Foundation for Pediatric Research","doi-asserted-by":"publisher","award":["220131"],"award-info":[{"award-number":["220131"]}],"id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005744","name":"Foundation for Pediatric Research","doi-asserted-by":"publisher","award":["240013"],"award-info":[{"award-number":["240013"]}],"id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wellbeing Services County of Southwest Finland","award":["30015"],"award-info":[{"award-number":["30015"]}]},{"DOI":"10.13039\/501100006706","name":"Tampere Tuberculosis Foundation","doi-asserted-by":"publisher","award":["26006205"],"award-info":[{"award-number":["26006205"]}],"id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sigrid Juselius Foundation","award":["260050"],"award-info":[{"award-number":["260050"]}],"id":[{"id":"https:\/\/ror.org\/00ckakm23","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pertussis vaccination during pregnancy protects young infants but blunts their antibody responses to primary immunization; the duration of this effect beyond infancy is unknown. In a clinical trial, we followed children born to tetanus-diphtheria-acellular pertussis-vaccinated (n = 47) and unvaccinated (n = 22) mothers to 4 years of age. At both 3 and 4 years, children born to Tdap-vaccinated mothers had lower anti-pertussis toxin and anti-diphtheria toxin IgG concentrations than control children, and pertussis toxin seropositivity and diphtheria seroprotection rates were low in both groups. After a preschool acellular pertussis booster at 4 years, antibody concentrations increased to comparable levels in both groups.<\/jats:p>\n                  <jats:p>Clinical Trials Registration . MIFI\u2014EudraCT 2019-001986-34; MIFI-4Y\u2014EU Clinical Trials Information System (CTIS) EU CT 2024-510787-23-00.<\/jats:p>","DOI":"10.1093\/infdis\/jiag472","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:38:56Z","timestamp":1790077136000},"source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Pertussis Vaccination During Pregnancy on Pertussis and Diphtheria Immunity in Children at 3 and 4 Years of Age"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9391-3137","authenticated-orcid":false,"given":"Milja","family":"Miettinen","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku , Turku ,","place":["Finland"]},{"name":"Institute of Biomedicine, Centre for Infections and Immunity, University of Turku , Turku ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Lehtosalo","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Centre for Infections and Immunity, University of Turku , Turku ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0742-1580","authenticated-orcid":false,"given":"Alex-Mikael","family":"Barkoff","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Centre for Infections and Immunity, University of Turku , Turku ,","place":["Finland"]},{"name":"InFLAMES Research Flagship Centre, University of Turku , Turku ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Anabe","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Centre for Infections and Immunity, University of Turku , Turku ,","place":["Finland"]},{"name":"InFLAMES Research Flagship Centre, University of Turku , Turku ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Ter\u00e4sj\u00e4rvi","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Centre for Infections and Immunity, University of Turku , Turku ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0622-5043","authenticated-orcid":false,"given":"Aapo","family":"Knuutila","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Centre for Infections and Immunity, University of Turku , Turku ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7746-3949","authenticated-orcid":false,"given":"Jussi","family":"Mertsola","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Centre for Infections and Immunity, University of Turku , Turku ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushui","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Centre for Infections and Immunity, University of Turku , Turku ,","place":["Finland"]},{"name":"InFLAMES Research Flagship Centre, University of Turku , Turku ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8935-5032","authenticated-orcid":false,"given":"Lauri","family":"Ivaska","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku , Turku ,","place":["Finland"]},{"name":"InFLAMES Research Flagship Centre, University of Turku , Turku ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"2026092902012692500_jiag472-B1","volume-title":"ECDC. 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