{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:58:13Z","timestamp":1791543493231,"version":"4.3.4"},"reference-count":40,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Institutes of Allergy and Infectious Diseases","award":["K23AI141764"],"award-info":[{"award-number":["K23AI141764"]}],"id":[{"id":"https:\/\/ror.org\/043z4tv69","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","award":["2015213"],"award-info":[{"award-number":["2015213"]}],"id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]},{"name":"North Carolina Translational and Clinical Sciences"},{"name":"Institute"},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR002489"],"award-info":[{"award-number":["UL1TR002489"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Larval source management (LSM) has been a core strategy of malaria control but is difficult to implement in holoendemic regions of rural sub-Saharan Africa. More targeted approaches that reduce the burden of effort but maintain impact are needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The prospective cohort study examined the spatial relationship between mosquito breeding sites and malaria cases to guide targeted LSM. After enrolling households across 3 villages, we recorded malaria cases from neighboring health facilities and conducted larval and adult mosquito surveillance. Breeding site density was assessed within different search radii from malaria cases using GIS. Households were grouped by environmental similarity using factor analysis of mixed data and k-means clustering, and clusters were compared in terms of malaria incidence and mosquito abundance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified and surveyed 69 breeding sites (March\u2013May 2023, 90% larva positive) in the study area and documented 56 clinical malaria cases among 366 households (April\u2013June 2023). Malaria incidence was higher within 200\u2005m of breeding sites than in households outside 200\u2005m (0.20 vs 0.09 cases per household, P = .005). When the search spread outward from cases, the number of covered breeding sites increased rapidly, reaching 60% within 200\u2005m and 75% within 300\u2005m before plateauing. Malaria risk and mosquito abundance varied across clusters, particularly near the hydroelectric station spillway and in areas with different house construction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings support the potential of reactive LSM by targeting breeding sites near malaria cases. Further research is needed to assess its effectiveness and its added value in malaria control programs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag481","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:01:54Z","timestamp":1790164914000},"source":"Crossref","is-referenced-by-count":0,"title":["Spatial Relationships Between Mosquito Breeding Sites and Malaria Cases in Rural Uganda: Implications for Larval Source Management"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9072-4317","authenticated-orcid":false,"given":"Huipeng","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health"},{"name":"Carolina Population Center, University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Bwambale","sequence":"additional","affiliation":[{"name":"Department of Community 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Raleigh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Barber","sequence":"additional","affiliation":[{"name":"Carolina Population Center, University of North Carolina at Chapel Hill"},{"name":"Department of Hospital Medicine, Northern Light Mercy Hospital , Portland, Maine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Reyes","sequence":"additional","affiliation":[{"name":"Division of Hospital Medicine, University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0591-0850","authenticated-orcid":false,"given":"Jonathan J","family":"Juliano","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health"},{"name":"Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel 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