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This study evaluated 3 intranasal live-attenuated candidate RSV vaccines, RSV\/\u0394NS2\/\u03941313\/I1314L, RSV\/6120\/\u0394NS2\/1030s, and RSV\/276 to placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Healthy, RSV-seronegative children aged 6\u201324 monthswere randomized to receive 1 of 3 candidate vaccines or placebo. Participants were monitored for vaccine reactogenicity and RSV serum antibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between years 2019 and 2023, 67 participants were randomized, 20 each to RSV\/\u0394NS2\/\u03941313\/I1314L, RSV\/6120\/\u0394NS2\/1030s, and placebo and 7 to RSV\/276. The RSV\/276 arm closed early due to an excess of mild cough in another study. The proportion (95% CI) of children experiencing at least 1 solicited adverse event during the 28 days after inoculation was 55% (32%, 77%) in RSV\/\u0394NS2\/\u03941313\/I1314L, 40% (19%, 64%) in RSV\/6120\/\u0394NS2\/1030s, 71% (29%, 96%) in RSV\/276, and 55% (32%, 77%) in placebo. Events were mostly Grade 1 and often associated with other viruses. The proportion of children with \u22654-fold increase in serum RSV-neutralizing antibody titer in each vaccine arm (&amp;gt;70%) was significantly greater than the placebo arm (15%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RSV\/\u0394NS2\/\u03941313\/I1314L and RSV\/6120\/\u0394NS2\/1030s had excellent safety and immunogenicity;assessment of RSV\/276 was limited by the small sample size. RSV\/\u0394NS2\/\u03941313\/I1314L and RSV\/6120\/\u0394NS2\/1030s were deemed suitable for further evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trials Registration<\/jats:title>\n                    <jats:p>NCT03916185.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag489","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:56:04Z","timestamp":1790855764000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Three Recombinant Live-Attenuated Respiratory Syncytial Virus Vaccines RSV\/\u0394NS2\/\u03941313\/I1314L, RSV\/6120\/\u0394NS2\/1030s, and RSV\/276 in RSV Seronegative Children"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7725-3052","authenticated-orcid":false,"given":"Coleen K","family":"Cunningham","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of California , Irvine, California ,","place":["USA"]},{"name":"Department of Pediatrics, Children's Hospital of Orange County , Orange, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth A","family":"Karron","sequence":"additional","affiliation":[{"name":"Center for Immunization Research, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0653-8955","authenticated-orcid":false,"given":"Elizabeth J","family":"McFarland","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado , Aurora, Colorado ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2255-9756","authenticated-orcid":false,"given":"Mark 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,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haley","family":"Brozik","sequence":"additional","affiliation":[{"name":"Science Facilitation Department, FHI 360 , Durham, NC\/Washington, DC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7564-4271","authenticated-orcid":false,"given":"Jennifer","family":"Oliva","sequence":"additional","affiliation":[{"name":"Center for Immunization Research, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8599-1004","authenticated-orcid":false,"given":"Dwight E","family":"Yin","sequence":"additional","affiliation":[{"name":"Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 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