{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:48:39Z","timestamp":1791881319451,"version":"4.3.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100003896","name":"Henry M. Jackson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003896","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Advancement of Military Medicine, Inc"},{"name":"US Department of War"},{"name":"Thai Red Cross AIDS Research Centre"},{"name":"US NIAID"},{"DOI":"10.13039\/100000025","name":"NIMH","doi-asserted-by":"publisher","award":["R01MH106466"],"award-info":[{"award-number":["R01MH106466"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["R01NS084911"],"award-info":[{"award-number":["R01NS084911"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"name":"International NeuroHIV Cure Consortium"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01MH130197"],"award-info":[{"award-number":["R01MH130197"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["RV254\/SEARCH 010"],"award-info":[{"award-number":["RV254\/SEARCH 010"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Thai Government Pharmaceutical Organization"},{"name":"Gilead, Merck and ViiV Healthcare"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vascular activation occurs during human immunodeficiency virus (HIV) infection and is a risk factor for cardiovascular disease (CVD). This study investigates whether vascular endothelial and hemostatic perturbations emerge during acute HIV infection (AHI) and persist despite immediate antiretroviral therapy (ART) initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirteen plasma biomarkers indicative of endothelial and hemostatic perturbations were measured in 83 RV254 AHI cohort participants during pre-ART AHI and at week 288 post-ART, compared with cross-sectional measures from 32 people without HIV (PWoH). Hierarchical clustering was applied to week 288 biomarker profiles of RV254 participants and PWoH to identify distinct biomarker phenotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During pre-ART AHI, RV254 participants exhibited higher intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), tissue factor, neopterin, and myeloperoxidase than PWoH (P &amp;lt; .05), independent of age, sex, and body mass index (BMI). These markers correlated with plasma HIV RNA or the CD4\/CD8 ratio (P &amp;lt; .05). At week 288, significant reductions in ICAM-1, VCAM-1, vascular endothelial growth factor (VEGF)\u2013C, VEGF-D, neopterin, and myeloperoxidase and a significant increase in tissue plasminogen activator were observed in RV254 (P &amp;lt; .05). However, VCAM-1 and thrombomodulin remained higher, and VEGF-A remained lower in RV254 participants compared to PWoH (P &amp;lt; .05). Hierarchical clustering identified 2 distinct clusters. Despite comparable 10-year CVD risk, 1 cluster exhibited concomitant elevation of ICAM-1, ICAM-2, VCAM-1, and E-selectin. Notably, 45% of RV254 participants vs 13% of PWoH were classified into this phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Endothelial and hemostatic perturbations emerge during AHI and correlate with HIV-related parameters. Despite suppressive ART, RV254 participants remained approximately 3.5 times more likely than PWoH to exhibit an endothelial activation biomarker phenotype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag495","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:47:14Z","timestamp":1791546434000},"source":"Crossref","is-referenced-by-count":0,"title":["Soluble Indicators of Endothelial Injury and Activation Emerge During Acute HIV Infection and Persist Despite Rapid Antiretroviral Therapy Initiation"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4071-4409","authenticated-orcid":false,"given":"Phillip","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Neurology, Yale University School of Medicine , New Haven, Connecticut ,","place":["USA"]},{"name":"Yale Center for Brain and Mind Health, Yale University School of Medicine , New Haven, Connecticut ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirati","family":"Tayutivutikul","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale University School of Medicine , New Haven, Connecticut ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie M","family":"Slike","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research , Silver Spring, Maryland ,","place":["USA"]},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. , Bethesda, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3880-4381","authenticated-orcid":false,"given":"Suteeraporn","family":"Pinyakorn","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research , Silver Spring, Maryland ,","place":["USA"]},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. , Bethesda, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5884-9734","authenticated-orcid":false,"given":"Kathryn B","family":"Holroyd","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University Irving Medical Center , New York, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5839-4837","authenticated-orcid":false,"given":"Carlo","family":"Sacdalan","sequence":"additional","affiliation":[{"name":"SEARCH Research Foundation , Bangkok ,","place":["Thailand"]},{"name":"Faculty of Medicine, Chulalongkorn University , Bangkok ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Metzger","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research , Silver Spring, Maryland ,","place":["USA"]},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. , Bethesda, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1175-4679","authenticated-orcid":false,"given":"Pathariya","family":"Promsena","sequence":"additional","affiliation":[{"name":"SEARCH Research Foundation , Bangkok ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eug\u00e8ne","family":"Kroon","sequence":"additional","affiliation":[{"name":"SEARCH Research Foundation , Bangkok ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donn","family":"Colby","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research , Silver Spring, Maryland ,","place":["USA"]},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. , Bethesda, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somchai","family":"Sriplienchan","sequence":"additional","affiliation":[{"name":"SEARCH Research Foundation , Bangkok ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nittaya","family":"Phanuphak","sequence":"additional","affiliation":[{"name":"Institute of HIV Research and Innovation (IHRI) , Bangkok ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Paul","sequence":"additional","affiliation":[{"name":"Faculty of Psychological Sciences, Missouri Institute of Mental Health, University of Missouri-St. Louis , St. Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Valcour","sequence":"additional","affiliation":[{"name":"Global Brain Health Institute (GBHI), University of California , San Francisco, California ,","place":["USA"]},{"name":"Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California , San Francisco, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5427-4187","authenticated-orcid":false,"given":"Lishomwa","family":"Ndhlovu","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine , New York, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydie","family":"Trautmann","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research , Silver Spring, Maryland ,","place":["USA"]},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. , Bethesda, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1136-1760","authenticated-orcid":false,"given":"Shelly J","family":"Krebs","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research , Silver Spring, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6032-3950","authenticated-orcid":false,"given":"Serena","family":"Spudich","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale University School of Medicine , New Haven, Connecticut ,","place":["USA"]},{"name":"Yale Center for Brain and Mind Health, Yale University School of Medicine , New Haven, Connecticut ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"2026101304062927700_jiag495-B1","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/hiv.13077","article-title":"The burden of non-communicable diseases and mortality in people living with HIV (PLHIV) in the pre-, early- and late-HAART era","volume":"22","author":"Jespersen","year":"2021","journal-title":"HIV Med"},{"key":"2026101304062927700_jiag495-B2","doi-asserted-by":"crossref","first-page":"ofw032","DOI":"10.1093\/ofid\/ofw032","article-title":"START or SMART? Timing of antiretroviral therapy initiation and cardiovascular risk for people with human immunodeficiency virus infection","volume":"3","author":"Siedner","year":"2016","journal-title":"Open Forum Infect Dis"},{"key":"2026101304062927700_jiag495-B3","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1506816","article-title":"Initiation of antiretroviral therapy in early asymptomatic HIV infection","volume":"373","author":"Group","year":"2015","journal-title":"N Engl J Med"},{"key":"2026101304062927700_jiag495-B4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1161\/CIRCULATIONAHA.122.057443","article-title":"Cardiovascular disease among persons living with HIV: new insights into pathogenesis and clinical manifestations in a global context","volume":"147","author":"Ntsekhe","year":"2023","journal-title":"Circulation"},{"key":"2026101304062927700_jiag495-B5","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1161\/CIRCULATIONAHA.117.033369","article-title":"Global burden of atherosclerotic cardiovascular disease in people living with HIV: systematic review and meta-analysis","volume":"138","author":"Shah","year":"2018","journal-title":"Circulation"},{"key":"2026101304062927700_jiag495-B6","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1161\/STROKEAHA.123.043410","article-title":"Global and regional estimate of HIV-associated stroke burden: a meta-analysis and population attributable modeling study","volume":"54","author":"Yang","year":"2023","journal-title":"Stroke"},{"key":"2026101304062927700_jiag495-B7","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1161\/CIR.0000000000000695","article-title":"Characteristics, prevention, and management of cardiovascular disease in people living with HIV: a scientific statement from the American Heart Association","volume":"140","author":"Feinstein","year":"2019","journal-title":"Circulation"},{"key":"2026101304062927700_jiag495-B8","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1093\/cid\/ciad728","article-title":"Cardiovascular disease risk factor control in people with and without HIV","volume":"78","author":"Silverberg","year":"2024","journal-title":"Clin Infect Dis"},{"key":"2026101304062927700_jiag495-B9","doi-asserted-by":"crossref","first-page":"e029228","DOI":"10.1161\/JAHA.123.029228","article-title":"Cardiovascular risk estimation is suboptimal in people with HIV","volume":"13","author":"Triant","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"2026101304062927700_jiag495-B10","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1161\/CIRCULATIONAHA.117.028975","article-title":"Cardiovascular risk prediction functions underestimate risk in HIV infection","volume":"137","author":"Triant","year":"2018","journal-title":"Circulation"},{"key":"2026101304062927700_jiag495-B11","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.3390\/ijms22083850","article-title":"Endothelial dysfunction, inflammation and coronary artery disease: potential biomarkers and promising therapeutical approaches","volume":"22","author":"Medina-Leyte","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026101304062927700_jiag495-B12","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","article-title":"Endothelial cell dysfunction and the pathobiology of atherosclerosis","volume":"118","author":"Gimbrone MA","year":"2016","journal-title":"Circ Res"},{"key":"2026101304062927700_jiag495-B13","doi-asserted-by":"crossref","first-page":"107812","DOI":"10.1016\/j.phrs.2025.107812","article-title":"HIV infection, antiretroviral therapy and vascular dysfunction: effects, mechanisms and treatments","volume":"217","author":"Wei","year":"2025","journal-title":"Pharmacol Res"},{"key":"2026101304062927700_jiag495-B14","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1097\/QAD.0b013e328360e9fb","article-title":"Endothelial activation biomarkers increase after HIV-1 acquisition: plasma vascular cell adhesion molecule-1 predicts disease progression","volume":"27","author":"Graham","year":"2013","journal-title":"AIDS"},{"key":"2026101304062927700_jiag495-B15","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.13615","article-title":"Association of endothelial dysfunction and antiretroviral therapy in early HIV infection","volume":"2","author":"Bush","year":"2019","journal-title":"JAMA Netw Open"},{"key":"2026101304062927700_jiag495-B16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.5830\/CVJA-2018-003","article-title":"HIV disease is associated with increased biomarkers of endothelial dysfunction despite viral suppression on long-term antiretroviral therapy in Botswana","volume":"29","author":"Mosepele","year":"2018","journal-title":"Cardiovasc J Afr"},{"key":"2026101304062927700_jiag495-B17","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1097\/QAD.0000000000003675","article-title":"Vascular injury markers associated with cognitive impairment in people with HIV on suppressive antiretroviral therapy","volume":"37","author":"Guha","year":"2023","journal-title":"AIDS"},{"key":"2026101304062927700_jiag495-B18","doi-asserted-by":"crossref","first-page":"117487","DOI":"10.1016\/j.cca.2023.117487","article-title":"ICAM-1 and VCAM-1: gatekeepers in various inflammatory and cardiovascular disorders","volume":"548","author":"Singh","year":"2023","journal-title":"Clin Chim Acta"},{"key":"2026101304062927700_jiag495-B19","doi-asserted-by":"crossref","first-page":"100560","DOI":"10.1016\/j.bbih.2022.100560","article-title":"Plasma biomarkers of vascular dysfunction uniquely relate to a vascular-risk profile of neurocognitive deficits in virally-suppressed adults with HIV","volume":"26","author":"Saloner","year":"2022","journal-title":"Brain Behav Immun Health"},{"key":"2026101304062927700_jiag495-B20","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1097\/00002030-200309050-00005","article-title":"Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection","volume":"17","author":"Fiebig","year":"2003","journal-title":"AIDS"},{"key":"2026101304062927700_jiag495-B21","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1097\/QAD.0000000000000616","article-title":"Impact of nucleic acid testing relative to antigen\/antibody combination immunoassay on the detection of acute HIV infection","volume":"29","author":"De Souza","year":"2015","journal-title":"AIDS"},{"key":"2026101304062927700_jiag495-B22","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCULATIONAHA.107.699579","article-title":"General cardiovascular risk profile for use in primary care: the Framingham heart study","volume":"117","author":"D'Agostino RB","year":"2008","journal-title":"Circulation"},{"key":"2026101304062927700_jiag495-B23","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.cell.2019.01.021","article-title":"VEGF in signaling and disease: beyond discovery and development","volume":"176","author":"Apte","year":"2019","journal-title":"Cell"},{"key":"2026101304062927700_jiag495-B24","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2022248118","article-title":"Thrombomodulin is essential for maintaining quiescence in vascular endothelial cells","volume":"118","author":"Giri","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026101304062927700_jiag495-B25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12981-019-0257-8","article-title":"Neuropsychiatric outcomes before and after switching to dolutegravir-based therapy in an acute HIV cohort","volume":"17","author":"Chan","year":"2020","journal-title":"AIDS Res Ther"},{"key":"2026101304062927700_jiag495-B26","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/HJR.0b013e328336a150","article-title":"Predicting the risk of cardiovascular disease in HIV-infected patients: the data collection on adverse effects of anti-HIV drugs study","volume":"17","author":"Friis-Moller","year":"2010","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"2026101304062927700_jiag495-B27","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1093\/cid\/ciw615","article-title":"Cardiovascular disease risk prediction in the HIV outpatient study","volume":"63","author":"Thompson-Paul","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2026101304062927700_jiag495-B28","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1161\/01.CIR.96.12.4219","article-title":"Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: the Atherosclerosis Risk In Communities (ARIC) study","volume":"96","author":"Hwang","year":"1997","journal-title":"Circulation"},{"key":"2026101304062927700_jiag495-B29","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1161\/STROKEAHA.123.044172","article-title":"Soluble biomarkers of cerebrovascular pathologies","volume":"55","author":"Foley","year":"2024","journal-title":"Stroke"},{"key":"2026101304062927700_jiag495-B30","doi-asserted-by":"crossref","first-page":"e496","DOI":"10.1016\/S2352-3018(25)00043-8","article-title":"Effects of antiretrovirals on major adverse cardiovascular events in the REPRIEVE trial: a longitudinal cohort analysis","volume":"12","author":"Fichtenbaum","year":"2025","journal-title":"Lancet HIV"},{"key":"2026101304062927700_jiag495-B31","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1097\/QAD.0b013e32832e7140","article-title":"Association of abacavir and impaired endothelial function in treated and suppressed HIV-infected patients","volume":"23","author":"Hsue","year":"2009","journal-title":"AIDS"},{"key":"2026101304062927700_jiag495-B32","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1161\/CIRCRESAHA.119.316477","article-title":"HIV antivirals affect endothelial activation and endothelial-platelet crosstalk","volume":"127","author":"Khawaja","year":"2020","journal-title":"Circ Res"},{"key":"2026101304062927700_jiag495-B33","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/cid\/ciw683","article-title":"Persistent, albeit reduced, chronic inflammation in persons starting antiretroviral therapy in acute HIV infection","volume":"64","author":"Sereti","year":"2017","journal-title":"Clin Infect Dis"},{"key":"2026101304062927700_jiag495-B34","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1097\/PSY.0000000000001129","article-title":"Individual differences in CD4\/CD8 T-cell ratio trajectories and associated risk profiles modeled from acute HIV infection","volume":"84","author":"Paul","year":"2022","journal-title":"Psychosom Med"},{"key":"2026101304062927700_jiag495-B35","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000213591","article-title":"Greater accumulation of brain white matter hyperintensities in people diagnosed and treated during acute HIV compared with people without HIV","volume":"104","author":"Holroyd","year":"2025","journal-title":"Neurology"},{"key":"2026101304062927700_jiag495-B36","doi-asserted-by":"crossref","first-page":"e913","DOI":"10.1093\/infdis\/jiaf583","article-title":"Neuroaxonal injury in acute HIV infection and following immediate antiretroviral therapy","volume":"233","author":"Chan","year":"2025","journal-title":"J Infect Dis"},{"key":"2026101304062927700_jiag495-B37","first-page":"100216","article-title":"Fluid biomarkers of the neurovascular unit in cerebrovascular disease and vascular cognitive disorders: a systematic review and meta-analysis","volume":"6","author":"Hansra","year":"2024","journal-title":"Cereb Circ Cogn Behav"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiag495\/71894584\/jiag495.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiag495\/71894584\/jiag495.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:06:37Z","timestamp":1791878797000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/advance-article\/doi\/10.1093\/infdis\/jiag495\/8912393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,13]]},"references-count":37,"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiag495","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,13]]},"article-number":"jiag495"}}