{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:49:54Z","timestamp":1791539394796,"version":"4.3.4"},"reference-count":43,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Institutes of Health","award":["AI162150"],"award-info":[{"award-number":["AI162150"]}]},{"name":"National Institutes of Health","award":["AI192237"],"award-info":[{"award-number":["AI192237"]}]},{"name":"National Institutes of Health","award":["TR001444"],"award-info":[{"award-number":["TR001444"]}]},{"name":"National Institutes of Health","award":["AI145806"],"award-info":[{"award-number":["AI145806"]}]},{"name":"National Institutes of Health","award":["HL180319"],"award-info":[{"award-number":["HL180319"]}]},{"name":"National Institutes of Health","award":["HL152957"],"award-info":[{"award-number":["HL152957"]}]},{"name":"National Institutes of Health","award":["AI147821"],"award-info":[{"award-number":["AI147821"]}]},{"name":"National Institutes of Health","award":["AI036219"],"award-info":[{"award-number":["AI036219"]}]},{"name":"National Institutes of Health","award":["AI036214"],"award-info":[{"award-number":["AI036214"]}]},{"name":"Richard J. Fasenmyer Foundation"},{"DOI":"10.13039\/100010296","name":"James B. Pendleton Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010296","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cytomegalovirus (CMV) is highly prevalent and associated with comorbidities in people with HIV-1 (PWH). Cytomegalovirus contributes to systemic inflammation, but comprehensive analyses of the plasma proteome in PWH with or without CMV are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Plasma proteomes from 59 age- and CD4 count-matched PWH on suppressive antiretroviral therapy with (CMV+) or without (CMV\u2212) CMV were characterized by inflammation- and cardiometabolic-focused proteomics proximity extension assays. Normalized protein expression values were analyzed using linear mixed-effects models, partial least squares-discriminant analysis, and gene set enrichment analysis. T-cell phenotypes were assessed by flow cytometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In covariate-unadjusted linear mixed-effects models, 118\/350 (33.7%) inflammatory and 27\/363 (7.4%) cardiometabolic proteins were differentially expressed (false discovery rate-adjusted P &amp;lt; .05). Proteins most significantly upregulated in CMV+ participants were associated with immune inhibition (eg, FcRL6, LY9, and HLA-DRA), cytotoxic differentiation (eg, KLRD1, CD70, and SLAMF7), and interferon-associated chemotaxis (eg, CXCL9 and CXCL10). Several of the most significantly downregulated proteins in CMV+ PWH were associated with apoptosis (eg, CASP2, TRIM21, and TRAF2). Surface FcRL6 expression was significantly elevated on CD57+CD28\u2212 CD8 T cells of CMV+ PWH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These data identify a CMV-associated plasma proteomic signature in treated HIV, characterized by immunoinhibitory\/cytotoxic programs, supporting targeting CMV to reduce immune dysregulation and related comorbidities in PWH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag498","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:26:37Z","timestamp":1791113197000},"source":"Crossref","is-referenced-by-count":0,"title":["Plasma Proteome Signature of Immune Inhibition Is Associated With Cytomegalovirus in People With HIV-1"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7690-5258","authenticated-orcid":false,"given":"Michael 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Health, Department of Medicine, University of California San Diego , La Jolla, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4046-125X","authenticated-orcid":false,"given":"Brian M","family":"Clagett","sequence":"additional","affiliation":[{"name":"Rustbelt Center for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine , Cleveland, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Huang-Gao","sequence":"additional","affiliation":[{"name":"Rustbelt Center for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine , Cleveland, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2870-8468","authenticated-orcid":false,"given":"Patricia K","family":"Riggs","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego , La Jolla, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3490-4975","authenticated-orcid":false,"given":"Scott L","family":"Letendre","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego , La Jolla, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9159-5414","authenticated-orcid":false,"given":"Celestine 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