{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:34:07Z","timestamp":1793190847769,"version":"4.5.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["1FI-2GM150424"],"award-info":[{"award-number":["1FI-2GM150424"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gut dysbiosis is associated with chronic immune activation in people with HIV (PWH) but is not well-characterized in elite controllers (ECs) or PWH receiving aspirin or statins. We analyzed gut microbiota among 22 virally suppressed PWH and 12 ECs before and 9 months after randomization to aspirin or atorvastatin. There were no differences in microbiota between PWH and ECs at baseline. There was a significant change in beta diversity after aspirin administration, but no difference in microbiota after atorvastatin. These findings suggest that ECs have gut microbiota resembling virally suppressed PWH, and aspirin, but not atorvastatin, may impact gut microbiota diversity in PWH.<\/jats:p>","DOI":"10.1093\/infdis\/jiag508","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:51:43Z","timestamp":1791373903000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Gut Microbiota Composition in Elite Controllers and Antiretroviral-treated People With HIV After Aspirin Versus Atorvastatin Administration"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4447-6506","authenticated-orcid":false,"given":"Mia","family":"Marotti","sequence":"first","affiliation":[{"name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7434-942X","authenticated-orcid":false,"given":"Brian P","family":"Epling","sequence":"additional","affiliation":[{"name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2923-0072","authenticated-orcid":false,"given":"Angelina","family":"Angelova","sequence":"additional","affiliation":[{"name":"Bioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisha","family":"Segrist","sequence":"additional","affiliation":[{"name":"National Institute for General Medical Sciences, National Institutes of Health , Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Laidlaw","sequence":"additional","affiliation":[{"name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April","family":"Poole","sequence":"additional","affiliation":[{"name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0991-0011","authenticated-orcid":false,"given":"Maura","family":"Manion","sequence":"additional","affiliation":[{"name":"Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6062-8022","authenticated-orcid":false,"given":"Stephen","family":"Migueles","sequence":"additional","affiliation":[{"name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5542-1545","authenticated-orcid":false,"given":"Jason","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Minnesota , Minneapolis, Minnesota"},{"name":"Division of Infectious Diseases, Hennepin Healthcare Research Institute , Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0076-0224","authenticated-orcid":false,"given":"Irini","family":"Sereti","sequence":"additional","affiliation":[{"name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"2026102808162692600_jiag508-B1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1056\/NEJMoa2304146","article-title":"Pitavastatin to prevent cardiovascular disease in HIV infection","volume":"389","author":"Grinspoon","year":"2023","journal-title":"N Engl J Med"},{"key":"2026102808162692600_jiag508-B2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S2055-6640(20)30488-X","article-title":"Clinical outcomes and antiretroviral therapy in 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