{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:39:10Z","timestamp":1792715950636,"version":"4.5.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We retrospectively analyzed 36 children with Epstein-Barr virus-related lymphoproliferative disorder (EBV-LPD) from the Japan Children's Cancer Group (2006-2021), focusing on diagnostically challenging lesions not definitively classified as lymphoma. Using EBER in situ hybridization double-staining, we confirmed EBV infection primarily in T\/NK cells (EBV-T\/NK-LPD, n\u2009=\u200917) or B cells (EBV-B-LPD, n\u2009=\u200916). Lymphoid follicle architecture was effaced in EBV-T\/NK-LPD (89%) and EBV-B-LPD (54%). 5-year overall survival was lower for EBV-T\/NK-LPD (59%) than EBV-B-LPD (93%). Determining the EBV-infected cell lineage enables clinically relevant classification and risk stratification, and can be applied to archival specimens, including lesions initially interpreted as reactive.<\/jats:p>","DOI":"10.1093\/infdis\/jiag523","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:01:33Z","timestamp":1792713693000},"source":"Crossref","is-referenced-by-count":0,"title":["EBV-infected cell lineage by EBER double-staining as a diagnostic and prognostic clue in pediatric EBV-related lymphoproliferative disorders: a Japanese central pathology cohort study"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8847-2528","authenticated-orcid":false,"given":"Rintaro","family":"Ono","sequence":"first","affiliation":[{"name":"Department of Pediatrics, St. Luke's International Hospital , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1499-538X","authenticated-orcid":false,"given":"Kenichi","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shinshu University School of Medicine , Matsumoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0418-5132","authenticated-orcid":false,"given":"Kunihiko","family":"Moriya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Defense Medical College , Saitama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Child Health and Development, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Ohki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Research, National Center for Child health and Development , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutaka","family":"Kiyokawa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Research, National Center for Child health and Development , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideto","family":"Iwafuchi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shizuoka Children's Hospital , Shizuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Center for Child Health and Development , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Kanegane","sequence":"additional","affiliation":[{"name":"Department of Child Health and Development, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-Ichi","family":"Imadome","sequence":"additional","affiliation":[{"name":"Division of Advanced Medicine for Virus infections. Akiru Municipal Medical Center , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Sekimizu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Hospital Organization Nagoya Medical Center , Nagoya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Shioda","sequence":"additional","affiliation":[{"name":"Children's Cancer Center, National Center for Child Health and Development , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Saitama Children's Medical Center , Saitama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,23]]},"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiag523\/72372689\/jiag523.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiag523\/72372689\/jiag523.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:01:33Z","timestamp":1792713693000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/advance-article\/doi\/10.1093\/infdis\/jiag523\/8979757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiag523","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,23]]},"article-number":"jiag523"}}