{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:17:07Z","timestamp":1792441027248,"version":"4.5.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1,1]]},"DOI":"10.1093\/infdis\/jiq020","type":"journal-article","created":{"date-parts":[[2010,12,7]],"date-time":"2010-12-07T23:05:02Z","timestamp":1291763102000},"page":"85-94","source":"Crossref","is-referenced-by-count":70,"title":["RSV-Induced Bronchial Epithelial Cell PD-L1 Expression Inhibits CD8+ T Cell Nonspecific Antiviral Activity"],"prefix":"10.1093","volume":"203","author":[{"given":"Aurica G.","family":"Telcian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasile","family":"Laza-Stanca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Harker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan W.","family":"Bartlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Mallia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihnea T.","family":"Zdrenghea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Kebadze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Coyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.M.","family":"Openshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luminita A.","family":"Stanciu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian L.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,1,1]]},"reference":[{"key":"key\n\t\t\t\t20170702153629_bib1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/ni1443","article-title":"The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection","volume":"8","author":"Sharpe","year":"2007","journal-title":"Nat Immunol"},{"key":"key\n\t\t\t\t20170702153629_bib2","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature05115","article-title":"PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression","volume":"443","author":"Day","year":"2006","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170702153629_bib3","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/hep.21541","article-title":"Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection","volume":"45","author":"Penna","year":"2007","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170702153629_bib4","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1128\/JVI.02844-06","article-title":"Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection","volume":"81","author":"Boni","year":"2007","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170702153629_bib5","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nature04444","article-title":"Restoring function in exhausted CD8 T cells during chronic viral infection","volume":"439","author":"Barber","year":"2006","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170702153629_bib6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1084\/jem.20022235","article-title":"PD-1 inhibits antiviral immunity at the effector phase in the liver","volume":"198","author":"Iwai","year":"2003","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170702153629_bib7","doi-asserted-by":"crossref","first-page":"7506","DOI":"10.4049\/jimmunol.180.11.7506","article-title":"Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis","volume":"180","author":"Lafon","year":"2008","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702153629_bib8","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1056\/NEJMoa0804877","article-title":"The burden of respiratory syncytial virus infection in young children","volume":"360","author":"Hall","year":"2009","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170702153629_bib9","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1056\/NEJMoa043951","article-title":"Respiratory syncytial virus infection in elderly and high-risk adults","volume":"352","author":"Falsey","year":"2005","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170702153629_bib10","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1164\/rccm.200308-1203OC","article-title":"Latency and persistence of respiratory syncytial virus despite T cell immunity","volume":"169","author":"Schwarze","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20170702153629_bib11","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1378\/chest.105.6.1848","article-title":"Persistence of respiratory syncytial virus genome and protein after acute bronchiolitis in guinea pigs","volume":"105","author":"Hegele","year":"1994","journal-title":"Chest"},{"key":"key\n\t\t\t\t20170702153629_bib12","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1067\/mai.2002.128241","article-title":"Persistence of viral RNA in 2 rat strains differing in susceptibility to postbronchiolitis airway dysfunction","volume":"110","author":"Sorkness","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"key\n\t\t\t\t20170702153629_bib13","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1164\/rccm.200509-1489OC","article-title":"Respiratory syncytial virus, airway inflammation, and FEV1 decline in patients with chronic obstructive pulmonary disease","volume":"173","author":"Wilkinson","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20170702153629_bib14","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.4049\/jimmunol.170.3.1423","article-title":"Nonspecific recruitment of memory CD8+ T cells to the lung airways during respiratory virus infections","volume":"170","author":"Ely","year":"2003","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702153629_bib15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.immunol.021908.132625","article-title":"Immunity to respiratory viruses","volume":"27","author":"Kohlmeier","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"key\n\t\t\t\t20170702153629_bib16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.0105-2896.2006.00385.x","article-title":"T-cell memory and recall responses to respiratory virus infections","volume":"211","author":"Hikono","year":"2006","journal-title":"Immunol Rev"},{"key":"key\n\t\t\t\t20170702153629_bib17","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1086\/315463","article-title":"Rhinovirus infection induces major histocompatibility complex class I and costimulatory molecule upregulation on respiratory epithelial cells","volume":"181","author":"Papi","year":"2000","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702153629_bib18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1165\/rcmb.2004-0129OC","article-title":"Constitutive and inducible expression of b7 family of ligands by human airway epithelial cells","volume":"33","author":"Kim","year":"2005","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key\n\t\t\t\t20170702153629_bib19","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1086\/499275","article-title":"Expression of programmed death-1 ligand (PD-L) 1, PD-L2, B7-H3, and inducible costimulator ligand on human respiratory tract epithelial cells and regulation by respiratory syncytial virus and type 1 and 2 cytokines","volume":"193","author":"Stanciu","year":"2006","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702153629_bib20","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1165\/rcmb.2005-0385OC","article-title":"Combination therapy: Synergistic suppression of virus-induced chemokines in airway epithelial cells","volume":"34","author":"Edwards","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key\n\t\t\t\t20170702153629_bib21","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1084\/jem.20020943","article-title":"Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood","volume":"196","author":"Culley","year":"2002","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170702153629_bib22","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0022-1759(00)00231-3","article-title":"Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution","volume":"243","author":"Lyons","year":"2000","journal-title":"J Immunol Methods"},{"key":"key\n\t\t\t\t20170702153629_bib23","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1046\/j.1365-2222.2002.01281.x","article-title":"Peripheral blood CD4+ and CD8+ T cell type 1 and type 2 cytokine production in atopic asthmatic and normal subjects","volume":"32","author":"Cho","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"key\n\t\t\t\t20170702153629_bib24","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions","volume":"401","author":"Sallusto","year":"1999","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170702153629_bib25","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.jaci.2008.02.009","article-title":"Induction of B7-H1 and B7-DC expression on airway epithelial cells by the Toll-like receptor 3 agonist double-stranded RNA and human rhinovirus infection: In vivo and in vitro studies","volume":"121","author":"Heinecke","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"key\n\t\t\t\t20170702153629_bib26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0022-1759(97)00143-9","article-title":"Temporal dynamics of CD69 expression on lymphoid cells","volume":"209","author":"Craston","year":"1997","journal-title":"J Immunol Methods"},{"key":"key\n\t\t\t\t20170702153629_bib27","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1136\/thx.2007.094870","article-title":"Healthy but not RSV-infected lung epithelial cells profoundly inhibit T cell activation","volume":"64","author":"Wang","year":"2009","journal-title":"Thorax"},{"key":"key\n\t\t\t\t20170702153629_bib28","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1183\/09031936.00096407","article-title":"NKG2D-dependent effector function of bronchial epithelium-activated alloreactive T-cells","volume":"32","author":"Kraetzel","year":"2008","journal-title":"Eur Respir J"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/203\/1\/85\/18064005\/jiq020.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T13:04:45Z","timestamp":1503493485000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jiq020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,1]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,1,1]]},"published-print":{"date-parts":[[2011,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiq020","relation":{},"ISSN":["1537-6613","0022-1899"],"issn-type":[{"value":"1537-6613","type":"electronic"},{"value":"0022-1899","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1,1]]}}}