{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:39:23Z","timestamp":1772138363408,"version":"3.50.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3,1]]},"DOI":"10.1093\/infdis\/jiq099","type":"journal-article","created":{"date-parts":[[2011,1,3]],"date-time":"2011-01-03T22:45:19Z","timestamp":1294094719000},"page":"707-714","source":"Crossref","is-referenced-by-count":29,"title":["Tissue Inhibitor of Matrix-Metalloprotease\u20131 Predicts Risk of Hepatic Fibrosis in Human Schistosoma japonicum Infection"],"prefix":"10.1093","volume":"203","author":[{"given":"Valeria","family":"Fabre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiwei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunthorn","family":"PondTor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz","family":"Acosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Jiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remigio","family":"Olveda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric S.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Jarilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen T.","family":"McGarvey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer F.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D.","family":"Kurtis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,1,3]]},"reference":[{"key":"key\n\t\t\t\t20170702152505_bib1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0001-706X(00)00122-4","article-title":"The global status of schistosomiasis and its control","volume":"77","author":"Chitsulo","year":"2000","journal-title":"Acta Trop"},{"key":"key\n\t\t\t\t20170702152505_bib2","volume-title":"The Global Burden of Disease: a comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020","author":"Murray","year":"1996"},{"key":"key\n\t\t\t\t20170702152505_bib3","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0140-6736(06)69440-3","article-title":"Human schistosomiasis","volume":"368","author":"Gryseels","year":"2006","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702152505_bib4","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(05)66457-4","article-title":"Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis","volume":"365","author":"King","year":"2005","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702152505_bib5","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1086\/588826","article-title":"Regulatory role of interleukin-10 and interferon-gamma in severe hepatic central and peripheral fibrosis in humans infected with Schistosoma japonicum","volume":"198","author":"Arnaud","year":"2008","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702152505_bib6","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1172\/JCI31487","article-title":"Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases","volume":"117","author":"Wynn","year":"2007","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170702152505_bib7","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1086\/510313","article-title":"Th2 cytokines are associated with persistent hepatic fibrosis in human Schistosoma japonicum infection","volume":"195","author":"Coutinho","year":"2007","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702152505_bib8","doi-asserted-by":"crossref","first-page":"753","DOI":"10.4049\/jimmunol.153.2.753","article-title":"Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis","volume":"153","author":"Cheever","year":"1994","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702152505_bib9","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1172\/JCI7325","article-title":"An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response","volume":"104","author":"Chiaramonte","year":"1999","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170702152505_bib10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0167-4889(00)00084-7","article-title":"TIMP-1\/MMP-9 imbalance in an EBV-immortalized B lymphocyte cellular model: evidence for TIMP-1 multifunctional properties","volume":"1499","author":"Gaudin","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20170702152505_bib11","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J Pathol"},{"key":"key\n\t\t\t\t20170702152505_bib12","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.0019-2805.2004.01817.x","article-title":"Expression of matrix metalloproteinases and their inhibitors during the resorption of schistosome egg-induced fibrosis in praziquantel-treated mice","volume":"111","author":"Singh","year":"2004","journal-title":"Immunology"},{"key":"key\n\t\t\t\t20170702152505_bib13","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI30542","article-title":"Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ","volume":"117","author":"Iredale","year":"2007","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170702152505_bib14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0065-308X(02)52014-5","article-title":"Cytokine-mediated host responses during schistosome infections; walking the fine line between immunological control and immunopathology","volume":"52","author":"Hoffmann","year":"2002","journal-title":"Adv Parasitol"},{"key":"key\n\t\t\t\t20170702152505_bib15","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1128\/CDLI.11.3.627-630.2004","article-title":"Gender-related cytokine patterns in sera of schistosomiasis patients with Symmers' fibrosis","volume":"11","author":"Silva-Teixeira","year":"2004","journal-title":"Clin Diagn Lab Immunol"},{"key":"key\n\t\t\t\t20170702152505_bib16","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1128\/IAI.74.2.1215-1221.2006","article-title":"Cytokine production associated with periportal fibrosis during chronic schistosomiasis mansoni in humans","volume":"74","author":"Alves Oliveira","year":"2006","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170702152505_bib17","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.4049\/jimmunol.172.2.1295","article-title":"Periportal fibrosis in human Schistosoma mansoni infection is associated with low IL-10, low IFN-gamma, high TNF-alpha, or low RANTES, depending on age and gender","volume":"172","author":"Booth","year":"2004","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702152505_bib18","doi-asserted-by":"crossref","first-page":"929","DOI":"10.4049\/jimmunol.169.2.929","article-title":"Cytokine regulation of periportal fibrosis in humans infected with Schistosoma mansoni: IFN-gamma is associated with protection against fibrosis and TNF-alpha with aggravation of disease","volume":"169","author":"Henri","year":"2002","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702152505_bib19","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1086\/302526","article-title":"Severe hepatic fibrosis in Schistosoma mansoni infection is controlled by a major locus that is closely linked to the interferon-gamma receptor gene","volume":"65","author":"Dessein","year":"1999","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t20170702152505_bib20","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1086\/430929","article-title":"Nutritional status and serum cytokine profiles in children, adolescents, and young adults with Schistosoma japonicum-associated hepatic fibrosis, in Leyte, Philippines","volume":"192","author":"Coutinho","year":"2005","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702152505_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4269\/ajtmh.1999.61.9","article-title":"Expression of metalloproteinases (MMP-1, MMP-2, and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in schistosomal portal fibrosis","volume":"61","author":"Gomez","year":"1999","journal-title":"Am J Trop Med Hyg"},{"key":"key\n\t\t\t\t20170702152505_bib22","doi-asserted-by":"crossref","first-page":"527","DOI":"10.4269\/ajtmh.2005.72.527","article-title":"Relationship between Schistosoma japonicum and nutritional status among children and young adults in leyte, the Philippines","volume":"72","author":"Friedman","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"key\n\t\t\t\t20170702152505_bib23","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1128\/IAI.74.1.370-381.2006","article-title":"T-Helper-2 cytokine responses to Sj97 predict resistance to reinfection with Schistosoma japonicum","volume":"74","author":"Leenstra","year":"2006","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170702152505_bib24","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0895-4356(01)00476-0","article-title":"Attrition in longitudinal studies: how to deal with missing data","volume":"55","author":"Twisk","year":"2002","journal-title":"J Clin Epidemiol"},{"key":"key\n\t\t\t\t20170702152505_bib25","first-page":"8","volume-title":"Prevention and control of intestinal parasitic infections. WHO Technical Report Series 749","author":"WHO","year":"1987"},{"key":"key\n\t\t\t\t20170702152505_bib26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.actatropica.2004.06.009","article-title":"Ultrasound organometry: the importance of body height adjusted normal ranges in assessing liver and spleen parameters among Chinese subjects with Schistosoma japonicum infection","volume":"92","author":"Li","year":"2004","journal-title":"Acta Trop"},{"key":"key\n\t\t\t\t20170702152505_bib27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4269\/ajtmh.1989.41.63","article-title":"Sonomorphological abnormalities in Sudanese children with Schistosoma mansoni infection: a proposed staging-system for field diagnosis of periportal fibrosis","volume":"41","author":"Doehring-Schwerdtfeger","year":"1989","journal-title":"Am J Trop Med Hyg"},{"key":"key\n\t\t\t\t20170702152505_bib28","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1084\/jem.132.3.488","article-title":"Delayed hypersensitivity-type granuloma formation and dermal reaction induced and elicited by a soluble factor isolated from Schistosoma mansoni eggs","volume":"132","author":"Boros","year":"1970","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170702152505_bib29","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0001-706X(02)00177-8","article-title":"Immune correlate study on human Schistosoma japonicum in a well-defined population in Leyte, Philippines. II. Cellular immune responses to S. japonicum recombinant and native antigens","volume":"84","author":"Acosta","year":"2002","journal-title":"Acta Trop"},{"key":"key\n\t\t\t\t20170702152505_bib30","doi-asserted-by":"crossref","first-page":"E81","DOI":"10.1542\/peds.105.6.e81","article-title":"Prolonged hepatitis B surface antigenemia after vaccination","volume":"105","author":"Lunn","year":"2000","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t20170702152505_bib31","first-page":"756","article-title":"Cirrhosis and chronic liver failure: part I. Diagnosis and evaluation","volume":"74","author":"Heidelbaugh","year":"2006","journal-title":"Am Fam Physician"},{"key":"key\n\t\t\t\t20170702152505_bib32","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1111\/j.1582-4934.2007.00092.x","article-title":"Biomarkers of hepatic fibrosis, fibrogenesis and genetic pre-disposition pending between fiction and reality","volume":"11","author":"Gressner","year":"2007","journal-title":"J Cell Mol Med"},{"key":"key\n\t\t\t\t20170702152505_bib33","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nm1332","article-title":"IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis","volume":"12","author":"Fichtner-Feigl","year":"2006","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170702152505_bib34","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/j.1478-3231.2008.01826.x","article-title":"Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases","volume":"28","author":"Gressner","year":"2008","journal-title":"Liver Int"},{"key":"key\n\t\t\t\t20170702152505_bib35","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nri1733","article-title":"Monocyte and macrophage heterogeneity","volume":"5","author":"Gordon","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20170702152505_bib36","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.4049\/jimmunol.173.6.4020","article-title":"IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent","volume":"173","author":"Kaviratne","year":"2004","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702152505_bib37","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1053\/j.gastro.2004.03.009","article-title":"Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking","volume":"126","author":"Issa","year":"2004","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170702152505_bib38","doi-asserted-by":"crossref","first-page":"re6","DOI":"10.1126\/scisignal.127re6","article-title":"Tissue inhibitors of metalloproteinases in cell signaling: metalloproteinase-independent biological activities","volume":"1","author":"Stetler-Stevenson","year":"2008","journal-title":"Sci Signal"},{"key":"key\n\t\t\t\t20170702152505_bib39","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1179\/000349804225021316","article-title":"Dynamics of collagen, MMP and TIMP gene expression during the granulomatous, fibrotic process induced by Schistosoma mansoni eggs","volume":"98","author":"Singh","year":"2004","journal-title":"Ann Trop Med Parasitol"},{"key":"key\n\t\t\t\t20170702152505_bib40","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/hep.510240129","article-title":"Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis","volume":"24","author":"Iredale","year":"1996","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170702152505_bib41","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s004280050149","article-title":"Comparison of matrix metalloproteinase expression in normal and cirrhotic human liver","volume":"432","author":"Lichtinghagen","year":"1998","journal-title":"Virchows Arch"},{"key":"key\n\t\t\t\t20170702152505_bib42","doi-asserted-by":"crossref","first-page":"7017","DOI":"10.4049\/jimmunol.167.12.7017","article-title":"Regulation of hepatic fibrosis and extracellular matrix genes by the th response: new insight into the role of tissue inhibitors of matrix metalloproteinases","volume":"167","author":"Vaillant","year":"2001","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702152505_bib43","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/infdis\/174.1.163","article-title":"Schistosomiasis japonica in the Philippines: the long-term impact of population-based chemotherapy on infection, transmission, and morbidity","volume":"174","author":"Olveda","year":"1996","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702152505_bib44","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/ng1096-181","article-title":"Genetic localization of a locus controlling the intensity of infection by Schistosoma mansoni on chromosome 5q31-q33","volume":"14","author":"Marquet","year":"1996","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170702152505_bib45","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1086\/515299","article-title":"Glycine-valine dimorphism at the 86th amino acid of HLA-DRB1 influenced the prognosis of postschistosomal hepatic fibrosis","volume":"177","author":"Hirayama","year":"1998","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702152505_bib46","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/327426a0","article-title":"HLA-DQ is epistatic to HLA-DR in controlling the immune response to schistosomal antigen in humans","volume":"327","author":"Hirayama","year":"1987","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170702152505_bib47","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1084\/jem.20090383","article-title":"Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with schistosomes","volume":"206","author":"Dessein","year":"2009","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170702152505_bib48","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1136\/thx.2004.026930","article-title":"A novel tissue inhibitor of metalloproteinase-1 (TIMP-1) polymorphism associated with asthma in Australian women","volume":"60","author":"Lose","year":"2005","journal-title":"Thorax"},{"key":"key\n\t\t\t\t20170702152505_bib49","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2471\/BLT.06.033365","article-title":"The prevalence of HIV, HBV and HCV among Filipino blood donors and overseas work visa applicants","volume":"85","author":"Yanase","year":"2007","journal-title":"Bull World Health Organ"},{"key":"key\n\t\t\t\t20170702152505_bib50","first-page":"797","article-title":"The world health surveys","volume-title":"Health systems performance assessment: debates, methods and empiricism","author":"Ustun","year":"2003"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/203\/5\/707\/18064575\/jiq099.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T14:36:31Z","timestamp":1685889391000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jiq099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,3]]},"references-count":50,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2011,1,3]]},"published-print":{"date-parts":[[2011,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiq099","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13150956.14482054","asserted-by":"object"}]},"ISSN":["1537-6613","0022-1899"],"issn-type":[{"value":"1537-6613","type":"electronic"},{"value":"0022-1899","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1,3]]}}}