{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:47:37Z","timestamp":1791049657146,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,5,15]]},"DOI":"10.1093\/infdis\/jir048","type":"journal-article","created":{"date-parts":[[2011,3,13]],"date-time":"2011-03-13T20:39:34Z","timestamp":1300048774000},"page":"1415-1424","source":"Crossref","is-referenced-by-count":142,"title":["Impaired Interferon Signaling in Dendritic Cells From Older Donors Infected In Vitro With West Nile Virus"],"prefix":"10.1093","volume":"203","author":[{"given":"Feng","family":"Qian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Fikrig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth R.","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,5,15]]},"reference":[{"key":"key\n\t\t\t\t20170702153523_bib1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev.micro.56.012302.160654","article-title":"The molecular biology of West Nile Virus: a new invader of the western hemisphere","volume":"56","author":"Brinton","year":"2002","journal-title":"Annu Rev Microbiol"},{"key":"key\n\t\t\t\t20170702153523_bib2","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1086\/521911","article-title":"The continuing spread of West Nile virus in the western hemisphere","volume":"45","author":"Gubler","year":"2007","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170702153523_bib3","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/ncpneuro0176","article-title":"West Nile virus meningoencephalitis","volume":"2","author":"Debiasi","year":"2006","journal-title":"Nat Clin Pract Neurol"},{"key":"key\n\t\t\t\t20170702153523_bib4","first-page":"3266","article-title":"Tregs control the development of symptomatic West Nile virus infection in humans and mice","volume":"119","author":"Lanteri","year":"2009","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170702153523_bib5","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.4049\/jimmunol.177.3.1825","article-title":"Gamma delta T cells facilitate adaptive immunity against West Nile virus infection in mice","volume":"177","author":"Wang","year":"2006","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702153523_bib6","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1084\/jem.20031223","article-title":"A critical role for induced IgM in the protection against West Nile virus infection","volume":"198","author":"Diamond","year":"2003","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170702153523_bib7","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1128\/JVI.77.4.2578-2586.2003","article-title":"B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus","volume":"77","author":"Diamond","year":"2003","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170702153523_bib8","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/BF01718310","article-title":"West Nile virus neuroinvasion and encephalitis induced by macrophage depletion in mice","volume":"141","author":"Ben-Nathan","year":"1996","journal-title":"Arch Virol"},{"key":"key\n\t\t\t\t20170702153523_bib9","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/nm1140","article-title":"Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis","volume":"10","author":"Wang","year":"2004","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170702153523_bib10","doi-asserted-by":"crossref","first-page":"8978","DOI":"10.1128\/JVI.00314-08","article-title":"Matrix metalloproteinase 9 facilitates West Nile Virus entry into the brain","volume":"82","author":"Wang","year":"2008","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170702153523_bib11","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.1128\/JVI.02621-07","article-title":"ICAM-1 participates in the entry of West Nile virus into the central nervous system","volume":"82","author":"Dai","year":"2008","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170702153523_bib12","doi-asserted-by":"crossref","first-page":"e1000610","DOI":"10.1371\/journal.ppat.1000610","article-title":"IL-10 signaling blockade controls murine West Nile virus infection","volume":"5","author":"Bai","year":"2009","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20170702153523_bib13","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.immuni.2008.11.012","article-title":"Tlr7 mitigates lethal West Nile encephalitis by affecting interleukin 23-dependent immune cell infiltration and homing","volume":"30","author":"Town","year":"2009","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20170702153523_bib14","doi-asserted-by":"crossref","first-page":"e1000757","DOI":"10.1371\/journal.ppat.1000757","article-title":"IPS-1 is essential for the control of West Nile virus infection and immunity","volume":"6","author":"Suthar","year":"2010","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20170702153523_bib15","doi-asserted-by":"crossref","DOI":"10.1086\/657416","article-title":"A paradoxical role for neutrophils in the pathogenesis of West Nile virus","author":"Bai","year":"2010","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702153523_bib16","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/jlb.64.6.703","article-title":"Impact of aging on innate immunity","volume":"64","author":"Pawelec","year":"1998","journal-title":"J Leukoc Biol"},{"key":"key\n\t\t\t\t20170702153523_bib17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/ni1033","article-title":"Age-related changes in lymphocyte development and function","volume":"5","author":"Linton","year":"2004","journal-title":"Nat Immunol"},{"key":"key\n\t\t\t\t20170702153523_bib18","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.micinf.2003.09.001","article-title":"Ineffective humoral immunity in the elderly","volume":"5","author":"McGlauchlen","year":"2003","journal-title":"Microbes Infect"},{"key":"key\n\t\t\t\t20170702153523_bib19","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.it.2009.05.004","article-title":"Human innate immunosenescence: causes and consequences for immunity in old age","volume":"30","author":"Panda","year":"2009","journal-title":"Trends Immunol"},{"key":"key\n\t\t\t\t20170702153523_bib20","doi-asserted-by":"crossref","first-page":"970","DOI":"10.4049\/jimmunol.178.2.970","article-title":"Age-associated defect in human TLR1 function and expression","volume":"178","author":"van Duin","year":"2007","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702153523_bib21","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.4049\/jimmunol.0901022","article-title":"Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response","volume":"184","author":"Panda","year":"2010","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702153523_bib22","doi-asserted-by":"crossref","first-page":"7613","DOI":"10.1128\/JVI.00618-08","article-title":"Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly","volume":"82","author":"Kong","year":"2008","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170702153523_bib23","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0092-8674(01)00449-4","article-title":"Dendritic cells: specialized and regulated antigen processing machines","volume":"106","author":"Mellman","year":"2001","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170702153523_bib24","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1182\/blood-2003-07-2314","article-title":"HIV-1-infected dendritic cells up-regulate cell surface markers but fail to produce IL-12 p70 in response to CD40 ligand stimulation","volume":"104","author":"Smed-Sorensen","year":"2004","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170702153523_bib25","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1126\/science.286.5448.2331","article-title":"Isolation of West Nile virus from mosquitoes, crows, and a Cooper's hawk in Connecticut","volume":"286","author":"Anderson","year":"1999","journal-title":"Science"},{"key":"key\n\t\t\t\t20170702153523_bib26","doi-asserted-by":"crossref","first-page":"6872","DOI":"10.4049\/jimmunol.181.10.6872","article-title":"Antiviral-activated dendritic cells: a paracrine-induced response state","volume":"181","author":"Borderia","year":"2008","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702153523_bib27","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.biochi.2007.04.018","article-title":"The role of type I interferon production by dendritic cells in host defense","volume":"89","author":"Fitzgerald-Bocarsly","year":"2007","journal-title":"Biochimie"},{"key":"key\n\t\t\t\t20170702153523_bib28","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.immuni.2006.08.009","article-title":"Type I interferon gene induction by the interferon regulatory factor family of transcription factors","volume":"25","author":"Honda","year":"2006","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20170702153523_bib29","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/sj.cr.7310018","article-title":"IRF family proteins and type I interferon induction in dendritic cells","volume":"16","author":"Tailor","year":"2006","journal-title":"Cell Res"},{"key":"key\n\t\t\t\t20170702153523_bib30","doi-asserted-by":"crossref","first-page":"6208","DOI":"10.4049\/jimmunol.178.10.6208","article-title":"Sensitization to TLR7 agonist in IFN-beta-preactivated dendritic cells","volume":"178","author":"Severa","year":"2007","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702153523_bib31","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.cell.2007.10.034","article-title":"TAM receptors are pleiotropic inhibitors of the innate immune response","volume":"131","author":"Rothlin","year":"2007","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170702153523_bib32","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","article-title":"Oxidants, oxidative stress and the biology of ageing","volume":"408","author":"Finkel","year":"2000","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170702153523_bib33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.mam.2004.02.003","article-title":"Aging and oxidative stress","volume":"25","author":"Junqueira","year":"2004","journal-title":"Mol Aspects Med"},{"key":"key\n\t\t\t\t20170702153523_bib34","doi-asserted-by":"crossref","first-page":"28766","DOI":"10.1074\/jbc.M401977200","article-title":"Hydrogen peroxide activates the Gas6-Axl pathway in vascular smooth muscle cells","volume":"279","author":"Konishi","year":"2004","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170702153523_bib35","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1084\/jem.20070763","article-title":"PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation","volume":"205","author":"Guiducci","year":"2008","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170702153523_bib36","doi-asserted-by":"crossref","first-page":"6912","DOI":"10.4049\/jimmunol.178.11.6912","article-title":"Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway","volume":"178","author":"Agrawal","year":"2007","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702153523_bib37","doi-asserted-by":"crossref","first-page":"6747","DOI":"10.4049\/jimmunol.181.10.6747","article-title":"Aging impairs IFN Regulatory Factor 7 upregulation in plasmacytoid dendritic cells during TLR9 activation","volume":"181","author":"Stout-Delgado","year":"2008","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702153523_bib38","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jhep.2006.01.037","article-title":"Oxidative stress inhibits IFN-alpha-induced antiviral gene expression by blocking the JAK-STAT pathway","volume":"45","author":"Di Bona","year":"2006","journal-title":"J Hepatol"},{"key":"key\n\t\t\t\t20170702153523_bib39","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1084\/jem.20081582","article-title":"Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production","volume":"206","author":"Tzima","year":"2009","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170702153523_bib40","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1084\/jem.20090222","article-title":"Key role of T cell defects in age-related vulnerability to West Nile virus","volume":"206","author":"Brien","year":"2009","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170702153523_bib41","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1086\/516788","article-title":"Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older Adults","volume":"195","author":"van Duin","year":"2007","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702153523_bib42","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1046\/j.1365-3083.1999.00625.x","article-title":"Low levels of interferon-alpha induce CD86 (B7.2) expression and accelerates dendritic cell maturation from human peripheral blood mononuclear cells","volume":"50","author":"Radvanyi","year":"1999","journal-title":"Scand J Immunol"},{"key":"key\n\t\t\t\t20170702153523_bib43","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1084\/jem.20090247","article-title":"Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant","volume":"206","author":"Longhi","year":"2009","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170702153523_bib44","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1084\/jem.20021522","article-title":"Dendritic cell responses to early murine cytomegalovirus infection: subset functional specialization and differential regulation by interferon alpha\/beta","volume":"197","author":"Dalod","year":"2003","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170702153523_bib45","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0952-7915(97)80155-0","article-title":"Activation and function of natural killer cell responses during viral infections","volume":"9","author":"Biron","year":"1997","journal-title":"Curr Opin Immunol"},{"key":"key\n\t\t\t\t20170702153523_bib46","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S1074-7613(01)00126-1","article-title":"Type i interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo","volume":"14","author":"Le Bon","year":"2001","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20170702153523_bib47","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1128\/JVI.80.6.2913-2923.2006","article-title":"West Nile virus evades activation of interferon regulatory factor 3 through RIG-I-dependent and -independent pathways without antagonizing host defense signaling","volume":"80","author":"Fredericksen","year":"2006","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170702153523_bib48","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1126\/science.1139522","article-title":"TLR3 deficiency in patients with herpes simplex encephalitis","volume":"317","author":"Zhang","year":"2007","journal-title":"Science"},{"key":"key\n\t\t\t\t20170702153523_bib49","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1073\/pnas.0510801103","article-title":"Activation of anti-hepatitis C virus responses via Toll-like receptor 7","volume":"103","author":"Lee","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170702153523_bib50","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.4049\/jimmunol.176.5.2888","article-title":"TLR7\/8 triggering exerts opposing effects in acute versus latent HIV infection","volume":"176","author":"Schlaepfer","year":"2006","journal-title":"J Immunol"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/203\/10\/1415\/18063969\/jir048.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T03:01:07Z","timestamp":1560049267000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jir048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,15]]},"references-count":50,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2011,5,15]]},"published-print":{"date-parts":[[2011,5,15]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jir048","relation":{},"ISSN":["1537-6613","0022-1899"],"issn-type":[{"value":"1537-6613","type":"electronic"},{"value":"0022-1899","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5,15]]}}}