{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:34:35Z","timestamp":1791056075164,"version":"4.1.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7,1]]},"DOI":"10.1093\/infdis\/jir080","type":"journal-article","created":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T21:44:08Z","timestamp":1306878248000},"page":"36-43","source":"Crossref","is-referenced-by-count":37,"title":["Endogenous IL-13 Plays a Crucial Role in Liver Granuloma Maturation During Leishmania donovani Infection, Independent of IL-4R\u03b1\u2013Responsive Macrophages and Neutrophils"],"prefix":"10.1093","volume":"204","author":[{"given":"Emma","family":"McFarlane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine C.","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N.","family":"McKenzie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Brombacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,7,1]]},"reference":[{"key":"key\n\t\t\t\t20170702153641_bib1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.0105-2896.2004.00188.x","article-title":"The immunopathology of experimental visceral leishmaniasis","volume":"201","author":"Kaye","year":"2004","journal-title":"Immunol Rev"},{"key":"key\n\t\t\t\t20170702153641_bib2","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1086\/315890","article-title":"Interleukin-12 regulates the response to chemotherapy in experimental visceral leishmaniasis","volume":"182","author":"Murray","year":"2000","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702153641_bib3","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1002\/1521-4141(2001010)31:10<2848::AID-IMMU2848>3.0.CO;2-T","article-title":"IL-10 mediates susceptibility to Leishmania donovani infection","volume":"31","author":"Murphy","year":"2001","journal-title":"Eur J Immunol"},{"key":"key\n\t\t\t\t20170702153641_bib4","doi-asserted-by":"crossref","first-page":"4804","DOI":"10.1128\/IAI.71.8.4804-4807.2003","article-title":"Both interleukin-4 (IL-4) and IL-4 receptor \u03b1 signaling contribute to the development of hepatic granulomas with optimal antileishmanial activity","volume":"71","author":"St\u00e4ger","year":"2003","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170702153641_bib5","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1002\/1521-4141(200010)30:10<2935::AID-IMMU2935>3.0.CO;2-Q","article-title":"Endogenous IL-4 is necessary for effective drug therapy against visceral leishmaniasis","volume":"30","author":"Alexander","year":"2000","journal-title":"Eur J Immunol"},{"key":"key\n\t\t\t\t20170702153641_bib6","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1128\/AAC.37.9.1842","article-title":"Antileishmanial activity of sodium stibogluconate fractions","volume":"37","author":"Roberts","year":"1993","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170702153641_bib7","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1172\/JCI114009","article-title":"Requirement for T cells and effect of lymphokines in successful chemotherapy for an intracellular infection:","volume":"83","author":"Murray","year":"1989","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170702153641_bib8","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1128\/IAI.74.4.2487-2490.2006","article-title":"Visceral Leishmania donovani infection in interleukin-13-\/- mice","volume":"74","author":"Murray","year":"2006","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170702153641_bib9","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1128\/IAI.73.7.3903-3911.2005","article-title":"Antagonizing deactivating cytokines to enhance host defense and chemotherapy in experimental visceral leishmaniasis","volume":"73","author":"Murray","year":"2005","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170702153641_bib10","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.4049\/jimmunol.164.3.1458","article-title":"IL-13 is a susceptibility factor for Leishmaniamajor infection","volume":"164","author":"Matthews","year":"2000","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702153641_bib11","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S1074-7613(04)00107-4","article-title":"Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology","volume":"20","author":"Herbert","year":"2004","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20170702153641_bib12","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1008942828960","article-title":"Conditional gene targeting in macrophages and granulocytes using LysMcre mice","volume":"8","author":"Clausen","year":"1999","journal-title":"Transgenic Res"},{"key":"key\n\t\t\t\t20170702153641_bib13","doi-asserted-by":"crossref","first-page":"7302","DOI":"10.4049\/jimmunol.162.12.7302","article-title":"Differences between IL-4- and IL-4 receptor \u03b1-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling","volume":"162","author":"Mohrs","year":"1999","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702153641_bib14","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1128\/AAC.47.5.1529-1535.2003","article-title":"The in vivo susceptibility of Leishmania donovani to sodium stibogluconate is drug specific and can be reversed by inhibiting glutathione biosynthesis","volume":"47","author":"Carter","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170702153641_bib15","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.2042-7158.1988.tb05271.x","article-title":"The therapeutic effect of sodium stibogluconate in BALB\/c mice infected with Leishmania donovani is organ-dependent","volume":"40","author":"Carter","year":"1988","journal-title":"J Pharm Pharmacol"},{"key":"key\n\t\t\t\t20170702153641_bib16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1046\/j.1365-2613.2001.00199.x","article-title":"Tissue granuloma structure-function in experimental visceral leishmaniasis","volume":"82","author":"Murray","year":"2001","journal-title":"Int J Exp Pathol"},{"key":"key\n\t\t\t\t20170702153641_bib17","first-page":"189","article-title":"Interleukin-13 effects on activated monocytes lead to novel cytokine secretion profiles intermediate between those induced by interleukin-10 and by interferon-\u03b3","volume":"8","author":"Minty","year":"1997","journal-title":"Eur Cytokine Netw"},{"key":"key\n\t\t\t\t20170702153641_bib18","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/intimm\/9.4.467","article-title":"Effects of IL-13 on murine listeriosis","volume":"9","author":"Flesch","year":"1997","journal-title":"Int Immunol"},{"key":"key\n\t\t\t\t20170702153641_bib19","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1371\/journal.ppat.0030068","article-title":"Deletion of IL-4R\u03b1 on CD4 T cells renders BALB\/c mice resistant to Leishmania major infection","volume":"3","author":"Radwanska","year":"2007","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20170702153641_bib20","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/ni725","article-title":"IL-4 instructs Th1 responses and resistance to Leishmania major in susceptible BALB\/c mice","volume":"2","author":"Biedermann","year":"2001","journal-title":"Nat Immunol"},{"key":"key\n\t\t\t\t20170702153641_bib21","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.4049\/jimmunol.176.2.1115","article-title":"Impairment of alternative macrophage activation delays cutaneous leishmaniasis in nonhealing BALB\/c mice","volume":"176","author":"H\u00f6lscher","year":"2006","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702153641_bib22","doi-asserted-by":"crossref","first-page":"5486","DOI":"10.4049\/jimmunol.176.9.5486","article-title":"Loss of dendritic cell migration and impaired resistance to Leishmania donovani infection in mice deficient in CCL19 and CCL21","volume":"176","author":"Ato","year":"2006","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702153641_bib23","doi-asserted-by":"crossref","first-page":"5625","DOI":"10.4049\/jimmunol.170.11.5625","article-title":"Dendritic cell-based immunotherapy combined with antimony-based chemotherapy cures established murine visceral leishmaniasis","volume":"170","author":"Ghosh","year":"2003","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702153641_bib24","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1126\/science.282.5397.2258","article-title":"Interleukin-13: Central mediator of allergic asthma","volume":"282","author":"Wills-Karp","year":"1998","journal-title":"Science"},{"key":"key\n\t\t\t\t20170702153641_bib25","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1053\/jhep.2001.26376","article-title":"Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis","volume":"34","author":"Chiaramonte","year":"2001","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170702153641_bib26","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0960-9822(98)70134-4","article-title":"A distinct role for interleukin-13 in Th2-cell-mediated immune responses","volume":"8","author":"McKenzie","year":"1998","journal-title":"Curr Biol"},{"key":"key\n\t\t\t\t20170702153641_bib27","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1126\/science.282.5397.2261","article-title":"Requirement for IL-13 independently of IL-4 in experimental asthma","volume":"282","author":"Gr\u00fcnig","year":"1998","journal-title":"Science"},{"key":"key\n\t\t\t\t20170702153641_bib28","doi-asserted-by":"crossref","first-page":"943","DOI":"10.2353\/ajpath.2006.051319","article-title":"The Schistosoma mansoni hepatic egg granuloma provides a favorable microenvironment for sustained growth of Leishmania donovani","volume":"169","author":"Hassan","year":"2006","journal-title":"Am J Pathol"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/204\/1\/36\/18064583\/jir080.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T04:32:32Z","timestamp":1686112352000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jir080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,1]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,7,1]]},"published-print":{"date-parts":[[2011,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jir080","relation":{},"ISSN":["1537-6613","0022-1899"],"issn-type":[{"value":"1537-6613","type":"electronic"},{"value":"0022-1899","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7,1]]}}}