{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:39:57Z","timestamp":1791225597441,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6,1]]},"DOI":"10.1093\/infdis\/jir084","type":"journal-article","created":{"date-parts":[[2011,5,18]],"date-time":"2011-05-18T01:37:29Z","timestamp":1305682649000},"page":"1574-1581","source":"Crossref","is-referenced-by-count":35,"title":["Fully Human Monoclonal Antibody Directed to Proteolytic Cleavage Site in Severe Acute Respiratory Syndrome (SARS) Coronavirus S Protein Neutralizes the Virus in a Rhesus Macaque SARS Model"],"prefix":"10.1093","volume":"203","author":[{"given":"Tohru","family":"Miyoshi-Akiyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Fukushi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keina","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Tsukahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seisuke","family":"Hatakeyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norikazu","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aki","family":"Morisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Yoshinaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Lianfeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Chuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruo","family":"Kirikae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Sasazuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,6,1]]},"reference":[{"key":"key\n\t\t\t\t20170702145922_bib1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1126\/science.1087139","article-title":"Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China","volume":"302","author":"Guan","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20170702145922_bib2","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1126\/science.1085953","article-title":"The Genome sequence of the SARS-associated coronavirus","volume":"300","author":"Marra","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20170702145922_bib3","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1126\/science.1085952","article-title":"Characterization of a novel coronavirus associated with severe acute respiratory syndrome","volume":"300","author":"Rota","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20170702145922_bib4","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.3201\/eid1212.060401","article-title":"Review of bats and SARS","volume":"12","author":"Wang","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20170702145922_bib5","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature02145","article-title":"Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus","volume":"426","author":"Li","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170702145922_bib6","doi-asserted-by":"crossref","first-page":"20836","DOI":"10.1074\/jbc.M400759200","article-title":"Structural characterization of the SARS-coronavirus spike S fusion protein core","volume":"279","author":"Tripet","year":"2004","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170702145922_bib7","doi-asserted-by":"crossref","first-page":"49414","DOI":"10.1074\/jbc.M408782200","article-title":"Crystal structure of severe acute respiratory syndrome coronavirus spike protein fusion core","volume":"279","author":"Xu","year":"2004","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170702145922_bib8","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1073\/pnas.0809524106","article-title":"Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites","volume":"106","author":"Belouzard","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170702145922_bib9","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/j.1399-0039.2004.00314.x","article-title":"Assessment of synthetic peptides of severe acute respiratory syndrome coronavirus recognized by long-lasting immunity","volume":"64","author":"Shichijo","year":"2004","journal-title":"Tissue Antigens"},{"key":"key\n\t\t\t\t20170702145922_bib10","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1086\/427242","article-title":"Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice","volume":"191","author":"Greenough","year":"2005","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702145922_bib11","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.bbrc.2004.09.106","article-title":"Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine","volume":"324","author":"He","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170702145922_bib12","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s11373-005-9004-3","article-title":"Characterization of neutralizing monoclonal antibodies recognizing a 15-residues epitope on the spike protein HR2 region of severe acute respiratory syndrome coronavirus (SARS-CoV)","volume":"12","author":"Lai","year":"2005","journal-title":"J Biomed Sci"},{"key":"key\n\t\t\t\t20170702145922_bib13","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1073\/pnas.0409065102","article-title":"Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses","volume":"102","author":"Yang","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170702145922_bib14","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.vaccine.2006.08.011","article-title":"Antibodies against trimeric S glycoprotein protect hamsters against SARS-CoV challenge despite their capacity to mediate FcgammaRII-dependent entry into B cells in vitro","volume":"25","author":"Kam","year":"2007","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20170702145922_bib15","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1371\/journal.pmed.0030237","article-title":"Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants","volume":"3","author":"ter Meulen","year":"2006","journal-title":"PLoS Med"},{"key":"key\n\t\t\t\t20170702145922_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jviromet.2005.03.021","article-title":"Monoclonal antibodies to SARS-associated coronavirus (SARS-CoV): identification of neutralizing and antibodies reactive to S, N, M and E viral proteins","volume":"128","author":"Tripp","year":"2005","journal-title":"J Virol Methods"},{"key":"key\n\t\t\t\t20170702145922_bib17","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/nm1080","article-title":"An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus","volume":"10","author":"Traggiai","year":"2004","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170702145922_bib18","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1086\/500143","article-title":"Therapy with a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden Syrian hamsters","volume":"193","author":"Roberts","year":"2006","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702145922_bib19","doi-asserted-by":"crossref","first-page":"5900","DOI":"10.1128\/JVI.79.10.5900-5906.2005","article-title":"Evaluation of human monoclonal antibody 80R for immunoprophylaxis of severe acute respiratory syndrome by an animal study, epitope mapping, and analysis of spike variants","volume":"79","author":"Sui","year":"2005","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170702145922_bib20","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1016\/S0140-6736(04)16506-9","article-title":"Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets","volume":"363","author":"ter Meulen","year":"2004","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702145922_bib21","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/path.1769","article-title":"An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus","volume":"206","author":"Qin","year":"2005","journal-title":"J Pathol"},{"key":"key\n\t\t\t\t20170702145922_bib22","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nm1280","article-title":"Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque","volume":"11","author":"Li","year":"2005","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170702145922_bib23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1089\/153623002753632084","article-title":"Production of human monoclonal and polyclonal antibodies in TransChromo animals","volume":"4","author":"Ishida","year":"2002","journal-title":"Cloning Stem Cells"},{"key":"key\n\t\t\t\t20170702145922_bib24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.virol.2008.07.012","article-title":"Dissection and identification of regions required to form pseudoparticles by the interaction between the nucleocapsid (N) and membrane (M) proteins of SARS coronavirus","volume":"380","author":"Hatakeyama","year":"2008","journal-title":"Virology"},{"key":"key\n\t\t\t\t20170702145922_bib25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s10616-007-9059-2","article-title":"pH Condition in temperature shift cultivation enhances cell longevity and specific hMab productivity in CHO culture","volume":"52","author":"Oguchi","year":"2006","journal-title":"Cytotechnology"},{"key":"key\n\t\t\t\t20170702145922_bib26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.virol.2008.08.016","article-title":"Rhesus angiotensin converting enzyme 2 supports entry of severe acute respiratory syndrome coronavirus in Chinese macaques","volume":"381","author":"Chen","year":"2008","journal-title":"Virology"},{"key":"key\n\t\t\t\t20170702145922_bib27","doi-asserted-by":"crossref","first-page":"12543","DOI":"10.1073\/pnas.0503203102","article-title":"Protease-mediated enhancement of severe acute respiratory syndrome coronavirus infection","volume":"102","author":"Matsuyama","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170702145922_bib28","doi-asserted-by":"crossref","first-page":"7411","DOI":"10.1128\/JVI.00079-09","article-title":"Characterization of a highly conserved domain within the severe acute respiratory syndrome coronavirus spike protein S2 domain with characteristics of a viral fusion peptide","volume":"83","author":"Madu","year":"2009","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170702145922_bib29","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.bbrc.2009.10.115","article-title":"Antibody-mediated synergy and interference in the neutralization of SARS-CoV at an epitope cluster on the spike protein","volume":"390","author":"Zhong","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170702145922_bib30","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0140-6736(03)13413-7","article-title":"Lung pathology of fatal severe acute respiratory syndrome","volume":"361","author":"Nicholls","year":"2003","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702145922_bib31","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/S0140-6736(03)13412-5","article-title":"Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study","volume":"361","author":"Peiris","year":"2003","journal-title":"Lancet"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/203\/11\/1574\/18063607\/jir084.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T17:46:51Z","timestamp":1560188811000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jir084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,1]]},"references-count":31,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2011,6,1]]},"published-print":{"date-parts":[[2011,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jir084","relation":{},"ISSN":["1537-6613","0022-1899"],"issn-type":[{"value":"1537-6613","type":"electronic"},{"value":"0022-1899","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6,1]]}}}