{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:45:06Z","timestamp":1791308706875,"version":"4.3.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7,1]]},"DOI":"10.1093\/infdis\/jir198","type":"journal-article","created":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T17:44:08Z","timestamp":1306863848000},"page":"103-114","source":"Crossref","is-referenced-by-count":150,"title":["Progressive Multifocal Leukoencephalopathy (PML) Development Is Associated With Mutations in JC Virus Capsid Protein VP1 That Change Its Receptor Specificity"],"prefix":"10.1093","volume":"204","author":[{"given":"Leonid","family":"Gorelik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Testa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot","family":"Brickelmaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Bossolasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Pazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arabella","family":"Bestetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Carmillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"McAuliffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Tonkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Carulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Lugovskoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Lazzarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamil","family":"Sunyaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Cinque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,7,1]]},"reference":[{"key":"key\n\t\t\t\t20170511121016_bib1","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1056\/NEJMp0906248","article-title":"Reemergence of PML in natalizumab-treated patients\u2014new cases, same concerns","volume":"361","author":"Major","year":"2009","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170511121016_bib2","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1473-3099(09)70226-9","article-title":"Progressive multifocal leukoencephalopathy in HIV-1 infection","volume":"9","author":"Cinque","year":"2009","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t20170511121016_bib3","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1086\/597126","article-title":"Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors","volume":"199","author":"Egli","year":"2009","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170511121016_bib4","doi-asserted-by":"crossref","first-page":"e1000363","DOI":"10.1371\/journal.ppat.1000363","article-title":"Seroepidemiology of human polyomaviruses","volume":"5","author":"Kean","year":"2009","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20170511121016_bib5","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1128\/JVI.72.6.4643-4649.1998","article-title":"Infection of glial cells by the human polyomavirus JC is mediated by an N-linked glycoprotein containing terminal alpha(2-6)-linked sialic acids","volume":"72","author":"Liu","year":"1998","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170511121016_bib6","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.virol.2008.12.021","article-title":"The Polyomaviridae: contributions of virus structure to our understanding of virus receptors and infectious entry","volume":"384","author":"Neu","year":"2009","journal-title":"Virology"},{"key":"key\n\t\t\t\t20170511121016_bib7","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1006\/viro.2002.1522","article-title":"Construction of a novel JCV\/SV40 hybrid virus (JCVS) reveals a role for the JCV capsid in viral tropism","volume":"300","author":"Chen","year":"2002","journal-title":"Virology"},{"key":"key\n\t\t\t\t20170511121016_bib8","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/13550280152537201","article-title":"Predicted amino acid sequences for 100 JCV strains","volume":"7","author":"Cubitt","year":"2001","journal-title":"J Neurovirol"},{"key":"key\n\t\t\t\t20170511121016_bib9","doi-asserted-by":"crossref","first-page":"e1000368","DOI":"10.1371\/journal.pgen.1000368","article-title":"Adaptive mutations in the JC virus protein capsid are associated with progressive multifocal leukoencephalopathy (PML)","volume":"5","author":"Sunyaev","year":"2009","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t20170511121016_bib10","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1086\/427698","article-title":"Prognostic significance of JC virus DNA levels in cerebrospinal fluid of patients with HIV-associated progressive multifocal leukoencephalopathy","volume":"40","author":"Bossolasco","year":"2005","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170511121016_bib11","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1099\/vir.0.80863-0","article-title":"New sequence polymorphisms in the outer loops of the JC polyomavirus major capsid protein (VP1) possibly associated with progressive multifocal leukoencephalopathy","volume":"86","author":"Zheng","year":"2005","journal-title":"J Gen Virol"},{"key":"key\n\t\t\t\t20170511121016_bib12","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","article-title":"ClustalW and ClustalX version 2.0","volume":"23","author":"Larkin","year":"2007","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20170511121016_bib13","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1099\/00221287-12-2-241","article-title":"Particle counts of haemagglutinating viruses","volume":"12","author":"Isaacs","year":"1955","journal-title":"J Gen Microbiol"},{"key":"key\n\t\t\t\t20170511121016_bib14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1743-422X-3-3","article-title":"Comparison of real-time PCR and hemagglutination assay for quantitation of human polyomavirus JC","volume":"3","author":"Chapagain","year":"2006","journal-title":"Virol J"},{"key":"key\n\t\t\t\t20170511121016_bib15","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1128\/JVI.73.5.4465-4469.1999","article-title":"Molecular cloning and expression of major structural protein VP1 of the human polyomavirus JC virus: formation of virus-like particles useful for immunological and therapeutic studies","volume":"73","author":"Goldmann","year":"1999","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170511121016_bib16","doi-asserted-by":"crossref","first-page":"12992","DOI":"10.1128\/JVI.76.24.12992-13000.2002","article-title":"Oligosaccharides as receptors for JC virus","volume":"76","author":"Komagome","year":"2002","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170511121016_bib17","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/ana.1004","article-title":"Cellular and humoral immune response in progressive multifocal leukoencephalopathy","volume":"49","author":"Weber","year":"2001","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20170511121016_bib18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0009-3084(70)90017-4","article-title":"On the discovery and chemistry of neuraminic acid and gangliosides","volume":"5","author":"Klenk","year":"1970","journal-title":"Chem Phys Lipids"},{"key":"key\n\t\t\t\t20170511121016_bib19","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/j.febslet.2009.12.010","article-title":"Sphingolipids and gangliosides of the nervous system in membrane function and dysfunction","volume":"584","author":"Posse de Chaves","year":"2010","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20170511121016_bib20","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/jmv.1890110406","article-title":"Progressive multifocal leucoencephalopathy: detection of papovavirus JC in kidney tissue","volume":"11","author":"Dorries","year":"1983","journal-title":"J Med Virol"},{"key":"key\n\t\t\t\t20170511121016_bib21","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1097\/00007890-200105150-00020","article-title":"JC virus infection in allograft kidneys: analysis by polymerase chain reaction and immunohistochemistry","volume":"71","author":"Randhawa","year":"2001","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t20170511121016_bib22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1128\/CMR.5.1.49","article-title":"Pathogenesis and molecular biology of progressive multifocal leukoencephalopathy, the JC virus\u2013induced demyelinating disease of the human brain","volume":"5","author":"Major","year":"1992","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20170511121016_bib23","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/0042-6822(92)90909-9","article-title":"Interaction of the human polyomavirus, JCV, with human B-lymphocytes","volume":"190","author":"Atwood","year":"1992","journal-title":"Virology"},{"key":"key\n\t\t\t\t20170511121016_bib24","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/ana.410180412","article-title":"Progressive multifocal leukoencephalopathy: investigation of three cases using in situ hybridization with JC virus biotinylated DNA probe","volume":"18","author":"Aksamit","year":"1985","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20170511121016_bib25","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1073\/pnas.82.4.1257","article-title":"Establishment of a line of human fetal glial cells that supports JC virus multiplication","volume":"82","author":"Major","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170511121016_bib26","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF00685273","article-title":"Virus\u2013cell interaction in oligodendroglia, astroglia and phagocyte in progressive multifocal leukoencephalopathy. An electron microscopic study","volume":"36","author":"Watanabe","year":"1976","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20170511121016_bib27","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.chom.2010.09.004","article-title":"Structure\u2013function analysis of the human JC polyomavirus establishes the LSTc pentasaccharide as a functional receptor motif","volume":"8","author":"Neu","year":"2010","journal-title":"Cell Host Microbe"},{"key":"key\n\t\t\t\t20170511121016_bib28","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/BF00211765","article-title":"Cellular sialoglycoconjugates: a histochemical perspective","volume":"25","author":"Roth","year":"1993","journal-title":"Histochem J"},{"key":"key\n\t\t\t\t20170511121016_bib29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/glycob\/2.1.25","article-title":"Diversity in the sialic acids","volume":"2","author":"Varki","year":"1992","journal-title":"Glycobiology"},{"key":"key\n\t\t\t\t20170511121016_bib30","doi-asserted-by":"crossref","first-page":"7925","DOI":"10.1128\/JVI.69.12.7925-7931.1995","article-title":"Genetic and structural analysis of a virulence determinant in polyomavirus VP1","volume":"69","author":"Bauer","year":"1995","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170511121016_bib31","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s11481-006-9025-3","article-title":"Blood-brain barrier: structural components and function under physiologic and pathologic conditions","volume":"1","author":"Persidsky","year":"2006","journal-title":"J Neuroimmune Pharmacol"},{"key":"key\n\t\t\t\t20170511121016_bib32","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/ana.410320509","article-title":"Blood-brain barrier abnormalities in the acquired immunodeficiency syndrome: immunohistochemical localization of serum proteins in postmortem brain","volume":"32","author":"Petito","year":"1992","journal-title":"Ann Neurol"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/204\/1\/103\/16865398\/jir198.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T03:26:56Z","timestamp":1712460416000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jir198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,1]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,7,1]]},"published-print":{"date-parts":[[2011,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jir198","relation":{},"ISSN":["1537-6613","0022-1899"],"issn-type":[{"value":"1537-6613","type":"electronic"},{"value":"0022-1899","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7,1]]}}}