{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:20:38Z","timestamp":1791037238734,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN266200400066C"],"award-info":[{"award-number":["HHSN266200400066C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To determine genetic factors predisposing to neurological complications following West Nile virus infection, we analyzed a cohort of 560 neuroinvasive case patients and 950 control patients for 13\u200a371 mostly nonsynonymous single-nucleotide polymorphisms (SNPs). The top 3 SNPs on the basis of statistical significance were also in genes of biological plausibility: rs2066786 in RFC1 (replication factor C1) (P = 1.88 \u00d7 10\u22125; odds ratio [OR], 0.68 [95% confidence interval {CI}, .56\u2013.81]); rs2298771 in SCN1A (sodium channel, neuronal type I \u03b1 subunit) (P = 5.87 \u00d7 10\u22125; OR, 1.47 [95% CI, 1.21\u20131.77]); and rs25651 in ANPEP (ananyl aminopeptidase) (P = 1.44 \u00d7 10\u22124; OR, 0.69 [95% CI, .56\u2013.83]). Additional genotyping of these SNPs in a separate sample of 264 case patients and 296 control patients resulted in a lack of significance in the replication cohort; joint significance was as follows: rs2066786, P = .0022; rs2298771, P = .005; rs25651, P = .042. Using mostly nonsynonymous variants, we therefore did not identify genetic variants associated with neuroinvasive disease.<\/jats:p>","DOI":"10.1093\/infdis\/jir493","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T10:44:41Z","timestamp":1314873881000},"page":"1031-1037","source":"Crossref","is-referenced-by-count":38,"title":["Genetic Variants and Susceptibility to Neurological Complications Following West Nile Virus Infection"],"prefix":"10.1093","volume":"204","author":[{"given":"Mark","family":"Loeb","sequence":"first","affiliation":[{"name":"Department of Medicine, Clinical Epidemiology, and Biostatistics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha","family":"Eskandarian","sequence":"first","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Michael G DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, 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