{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:04:16Z","timestamp":1791295456604,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,1]]},"DOI":"10.1093\/infdis\/jir638","type":"journal-article","created":{"date-parts":[[2011,10,14]],"date-time":"2011-10-14T01:00:27Z","timestamp":1318554027000},"page":"1750-1761","source":"Crossref","is-referenced-by-count":40,"title":["Hemoglobin S and C Heterozygosity Enhances Neither the Magnitude nor Breadth of Antibody Responses to a Diverse Array of Plasmodium falciparum Antigens"],"prefix":"10.1093","volume":"204","author":[{"given":"Xiaolin","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boubacar","family":"Traore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassoum","family":"Kayentao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aissata","family":"Ongoiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safiatou","family":"Doumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Waisberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ogobara K.","family":"Doumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip L.","family":"Felgner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick M.","family":"Fairhurst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Crompton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,10,12]]},"reference":[{"key":"key\n\t\t\t\t20170702152559_bib1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/352595a0","article-title":"Common west African HLA antigens are associated with protection from severe malaria","volume":"352","author":"Hill","year":"1991","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170702152559_bib2","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(02)08273-9","article-title":"Protective effects of the sickle cell gene against malaria morbidity and mortality","volume":"359","author":"Aidoo","year":"2002","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702152559_bib3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/ng.388","article-title":"Genome-wide and fine-resolution association analysis of malaria in West Africa","volume":"41","author":"Jallow","year":"2009","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170702152559_bib4","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1182\/blood.V96.7.2358","article-title":"Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S","volume":"96","author":"Agarwal","year":"2000","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170702152559_bib5","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/35104556","article-title":"Haemoglobin C protects against clinical Plasmodium falciparum malaria","volume":"414","author":"Modiano","year":"2001","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170702152559_bib6","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1086\/422847","article-title":"Hemoglobin C and resistance to severe malaria in Ghanaian children","volume":"190","author":"Mockenhaupt","year":"2004","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702152559_bib7","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1086\/430744","article-title":"Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases","volume":"192","author":"Williams","year":"2005","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702152559_bib8","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1182\/blood-2009-09-241844","article-title":"Differing effects of HbS and HbC traits on uncomplicated falciparum malaria, anemia, and child growth","volume":"115","author":"Kreuels","year":"2010","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170702152559_bib9","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1073\/pnas.75.4.1994","article-title":"Erythrocytic mechanism of sickle cell resistance to malaria","volume":"75","author":"Friedman","year":"1978","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170702152559_bib10","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/274701a0","article-title":"Cellular mechanism for the protective effect of haemoglobin S against P. falciparum malaria","volume":"274","author":"Pasvol","year":"1978","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170702152559_bib11","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1182\/blood-2003-11-3820","article-title":"Enhanced phagocytosis of ring-parasitized mutant erythrocytes: A common mechanism that may explain protection against falciparum malaria in sickle trait and beta-thalassemia trait","volume":"104","author":"Ayi","year":"2004","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170702152559_bib12","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nature03631","article-title":"Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria","volume":"435","author":"Fairhurst","year":"2005","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170702152559_bib13","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1073\/pnas.0711401105","article-title":"Impaired cytoadherence of Plasmodium falciparum\u2013infected erythrocytes containing sickle hemoglobin","volume":"105","author":"Cholera","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170702152559_bib14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0306-9877(87)90193-9","article-title":"The sickle-cell trait modifies the intensity and specificity of the immune response against P. falciparum malaria and leads to acquired protective immunity","volume":"22","author":"Bayoumi","year":"1987","journal-title":"Med Hypotheses"},{"key":"key\n\t\t\t\t20170702152559_bib15","first-page":"270","article-title":"A new look at the protection of hemoglobin AS and AC genotypes against Plasmodium falciparum infection: A census tract approach","volume":"28","author":"Ringelhann","year":"1976","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t20170702152559_bib16","doi-asserted-by":"crossref","first-page":"e128","DOI":"10.1371\/journal.pmed.0020128","article-title":"An immune basis for malaria protection by the sickle cell trait","volume":"2","author":"Williams","year":"2005","journal-title":"PLoS Med"},{"key":"key\n\t\t\t\t20170702152559_bib17","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/192733a0","article-title":"Gamma-globulin and acquired immunity to human malaria","volume":"192","author":"Cohen","year":"1961","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170702152559_bib18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/00034983.1979.11687244","article-title":"Abnormal haemoglobins in the Sudan savanna of Nigeria. II. Immunological response to malaria in normals and subjects with sickle cell trait","volume":"73","author":"Cornille-Brogger","year":"1979","journal-title":"Ann Trop Med Parasitol"},{"key":"key\n\t\t\t\t20170702152559_bib19","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1136\/jcp.13.2.118","article-title":"The relationship of serum gamma-globulin concentration to malaria and sickling","volume":"13","author":"Edozien","year":"1960","journal-title":"J Clin Pathol"},{"key":"key\n\t\t\t\t20170702152559_bib20","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/ije\/28.4.793","article-title":"Longitudinal study of Plasmodium falciparum infection and immune responses in infants with or without the sickle cell trait","volume":"28","author":"Le Hesran","year":"1999","journal-title":"Int J Epidemiol"},{"key":"key\n\t\t\t\t20170702152559_bib21","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/0035-9203(92)90083-O","article-title":"Morbidity from malaria and immune responses to defined Plasmodium falciparum antigens in children with sickle cell trait in The Gambia","volume":"86","author":"Allen","year":"1992","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"key\n\t\t\t\t20170702152559_bib22","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1128\/IAI.68.3.1252-1258.2000","article-title":"High immunoglobulin G2 (IgG2) and low IgG4 levels are associated with human resistance to Plasmodium falciparum malaria","volume":"68","author":"Aucan","year":"2000","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170702152559_bib23","doi-asserted-by":"crossref","first-page":"566","DOI":"10.4269\/ajtmh.2000.62.566","article-title":"Antibody responses to Plasmodium falciparum: Evolution according to the severity of a prior clinical episode and association with subsequent reinfection","volume":"62","author":"Luty","year":"2000","journal-title":"Am J Trop Med Hyg"},{"key":"key\n\t\t\t\t20170702152559_bib24","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1128\/IAI.61.1.103-108.1993","article-title":"Immunoglobulin M and G antibody responses to Plasmodium falciparum glutamate-rich protein: Correlation with clinical immunity in Gambian children","volume":"61","author":"Dziegiel","year":"1993","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170702152559_bib25","doi-asserted-by":"crossref","first-page":"e978","DOI":"10.1371\/journal.pone.0000978","article-title":"Haemoglobin C and S role in acquired immunity against Plasmodium falciparum malaria","volume":"2","author":"Verra","year":"2007","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170702152559_bib26","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature01097","article-title":"Genome sequence of the human malaria parasite Plasmodium falciparum","volume":"419","author":"Gardner","year":"2002","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170702152559_bib27","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0035-9203(89)90478-1","article-title":"Antibodies to blood stage antigens of Plasmodium falciparum in rural Gambians and their relation to protection against infection","volume":"83","author":"Marsh","year":"1989","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"key\n\t\t\t\t20170702152559_bib28","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1086\/429832","article-title":"The sickle cell trait is associated with enhanced immunoglobulin G antibody responses to Plasmodium falciparum variant surface antigens","volume":"191","author":"Cabrera","year":"2005","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702152559_bib29","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1086\/592224","article-title":"Sickle cell trait is associated with a delayed onset of malaria: implications for time-to-event analysis in clinical studies of malaria","volume":"198","author":"Crompton","year":"2008","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702152559_bib30","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1182\/blood-2003-11-3884","article-title":"The etiology of severe anemia in a village and a periurban area in Mali","volume":"104","author":"Dicko","year":"2004","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170702152559_bib31","doi-asserted-by":"crossref","first-page":"6958","DOI":"10.1073\/pnas.1001323107","article-title":"A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray","volume":"107","author":"Crompton","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170702152559_bib32","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1002\/pmic.200800194","article-title":"Profiling humoral immune responses to P. falciparum infection with protein microarrays","volume":"8","author":"Doolan","year":"2008","journal-title":"Proteomics"},{"key":"key\n\t\t\t\t20170702152559_bib33","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nature01107","article-title":"A proteomic view of the Plasmodium falciparum life cycle","volume":"419","author":"Florens","year":"2002","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170702152559_bib34","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1126\/science.1087025","article-title":"Discovery of gene function by expression profiling of the malaria parasite life cycle","volume":"301","author":"Le Roch","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20170702152559_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbiopara.2003.12.007","article-title":"Proteomics approach reveals novel proteins on the surface of malaria-infected erythrocytes","volume":"135","author":"Florens","year":"2004","journal-title":"Mol Biochem Parasitol"},{"key":"key\n\t\t\t\t20170702152559_bib36","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1126\/science.1102452","article-title":"Targeting malaria virulence and remodeling proteins to the host erythrocyte","volume":"306","author":"Marti","year":"2004","journal-title":"Science"},{"key":"key\n\t\t\t\t20170702152559_bib37","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1126\/science.1102737","article-title":"A host-targeting signal in virulence proteins reveals a secretome in malarial infection","volume":"306","author":"Hiller","year":"2004","journal-title":"Science"},{"key":"key\n\t\t\t\t20170702152559_bib38","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1128\/IAI.00593-10","article-title":"Hierarchical, domain type-specific acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 in Tanzanian children","volume":"78","author":"Cham","year":"2010","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170702152559_bib39","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/1475-2875-7-155","article-title":"Acquisition of naturally occurring antibody responses to recombinant protein domains of Plasmodium falciparum erythrocyte membrane protein 1","volume":"7","author":"Mackintosh","year":"2008","journal-title":"Malar J"},{"key":"key\n\t\t\t\t20170702152559_bib40","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0092-8674(95)90055-1","article-title":"The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes","volume":"82","author":"Su","year":"1995","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170702152559_bib41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0165-2478(02)00131-1","article-title":"Sickle cell trait carriage: imbalanced distribution of IgG subclass antibodies reactive to Plasmodium falciparum family\u2013specific MSP2 peptides in serum samples from Gabonese children","volume":"84","author":"Ntoumi","year":"2002","journal-title":"Immunol Lett"},{"key":"key\n\t\t\t\t20170702152559_bib42","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.exppara.2005.09.014","article-title":"Distribution of IgG subclass antibodies specific for Plasmodium falciparum glutamate-rich-protein molecule in sickle cell trait children with asymptomatic infections","volume":"112","author":"Matondo Maya","year":"2006","journal-title":"Exp Parasitol"},{"key":"key\n\t\t\t\t20170702152559_bib43","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.cell.2011.03.049","article-title":"Sickle hemoglobin confers tolerance to Plasmodium infection","volume":"145","author":"Ferreira","year":"2011","journal-title":"Cell"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/204\/11\/1750\/18065057\/jir638.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:02:49Z","timestamp":1593129769000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jir638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,12]]},"references-count":43,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2011,10,12]]},"published-print":{"date-parts":[[2011,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jir638","relation":{},"ISSN":["1537-6613","0022-1899"],"issn-type":[{"value":"1537-6613","type":"electronic"},{"value":"0022-1899","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10,12]]}}}