{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:31:06Z","timestamp":1791419466643,"version":"4.3.3"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3,1]]},"DOI":"10.1093\/infdis\/jir845","type":"journal-article","created":{"date-parts":[[2012,2,3]],"date-time":"2012-02-03T01:27:27Z","timestamp":1328232447000},"page":"798-806","source":"Crossref","is-referenced-by-count":133,"title":["Methicillin Resistance Reduces the Virulence of Healthcare-Associated Methicillin-Resistant Staphylococcus aureus by Interfering With the agr Quorum Sensing System"],"prefix":"10.1093","volume":"205","author":[{"given":"Justine K.","family":"Rudkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G.","family":"Bowden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric L.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa","family":"Pozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine M.","family":"Waters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weng C.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"O\u2019Gara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth C.","family":"Massey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,3,1]]},"reference":[{"key":"key\n\t\t\t\t20170702133145_bib1","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1056\/NEJM199808203390806","article-title":"Staphylococcus aureus infections","volume":"339","author":"Lowy","year":"1998","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170702133145_bib2","doi-asserted-by":"crossref","first-page":"S350","DOI":"10.1086\/533591","article-title":"Pathogenesis of methicillin-resistant Staphylococcus aureus infection","volume":"46","author":"Gordon","year":"2008","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170702133145_bib3","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/S0140-6736(09)61999-1","article-title":"Community-associated meticillin-resistant Staphylococcus aureus","volume":"375","author":"Deleo","year":"2010","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702133145_bib4","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1128\/AAC.43.6.1449","article-title":"Cloning and nucleotide sequence determination of the entire mec DNA of pre-methicillin-resistant Staphylococcus aureus N315","volume":"43","author":"Ito","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170702133145_bib5","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0966-842X(01)02175-8","article-title":"The emergence and evolution of methicillin-resistant Staphylococcus aureus","volume":"9","author":"Hiramatsu","year":"2001","journal-title":"Trends Microbiol"},{"key":"key\n\t\t\t\t20170702133145_bib6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1078\/1438-4221-00192","article-title":"Molecular genetics of methicillin-resistant Staphylococcus aureus","volume":"292","author":"Hiramatsu","year":"2002","journal-title":"Int J Med Microbiol"},{"key":"key\n\t\t\t\t20170702133145_bib7","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1002\/(SICI)1096-9888(1998100)33:10<1009::AID-JMS717>3.0.CO;2-4","article-title":"Identification of the active site serine of penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus by electrospray mass spectrometry","volume":"33","author":"Sun","year":"1998","journal-title":"J Mass Spectrom"},{"key":"key\n\t\t\t\t20170702133145_bib8","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1128\/AAC.01255-08","article-title":"Functional characterization of the sigmaB-dependent yabJ-spoVG operon in Staphylococcus aureus: role in methicillin and glycopeptide resistance","volume":"53","author":"Schulthess","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170702133145_bib9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00203-002-0436-0","article-title":"Factors influencing methicillin resistance in staphylococci","volume":"178","author":"Berger-B\u00e4chi","year":"2002","journal-title":"Arch Microbiol"},{"key":"key\n\t\t\t\t20170702133145_bib10","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1089\/mdr.1999.5.163","article-title":"Antibiotic resistance as a stress response: complete sequencing of a large number of chromosomal loci in Staphylococcus aureus strain COL that impact on the expression of resistance to methicillin","volume":"5","author":"de Lencastre","year":"1999","journal-title":"Microb Drug Resist"},{"key":"key\n\t\t\t\t20170702133145_bib11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1086\/345476","article-title":"Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis","volume":"36","author":"Cosgrove","year":"2003","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170702133145_bib12","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s15010-005-3186-5","article-title":"Mortality risk factors with nosocomial Staphylococcus aureus infections in intensive care units: results from the German Nosocomial Infection Surveillance System (KISS)","volume":"33","author":"Gastmeier","year":"2005","journal-title":"Infection"},{"key":"key\n\t\t\t\t20170702133145_bib13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1086\/502523","article-title":"Costs and outcomes among hemodialysis-dependent patients with methicillin-resistant or methicillin-susceptible Staphylococcus aureus bacteremia","volume":"26","author":"Reed","year":"2005","journal-title":"Infect Control Hosp Epidemiol"},{"key":"key\n\t\t\t\t20170702133145_bib14","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev.micro.112408.134309","article-title":"Basis of virulence in community-associated methicillin-resistant Staphylococcus aureus","volume":"64","author":"Otto","year":"2010","journal-title":"Annu Rev Microbiol"},{"key":"key\n\t\t\t\t20170702133145_bib15","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.1073\/pnas.0900743106","article-title":"Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus","volume":"106","author":"Li","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170702133145_bib16","first-page":"1476","article-title":"Comparison of community-acquired pneumonia due to methicillin-resistant and methicillin-susceptible Staphylococcus aureus producing the Panton-Valentine leukocidin","volume":"13","author":"Vardakas","year":"2009","journal-title":"Int J Tuberc Lung Dis"},{"key":"key\n\t\t\t\t20170702133145_bib17","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1086\/511041","article-title":"A prospective investigation of outcomes after hospital discharge for endemic, community-acquired methicillin-resistant and -susceptible Staphylococcus aureus skin infection","volume":"44","author":"Miller","year":"2007","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170702133145_bib18","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/ismej.2009.151","article-title":"Offsetting virulence and antibiotic resistance costs by MRSA","volume":"4","author":"Collins","year":"2010","journal-title":"ISME J"},{"key":"key\n\t\t\t\t20170702133145_bib19","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1128\/JB.00167-08","article-title":"A novel Staphylococcus aureus biofilm phenotype mediated by the fibronectin-binding proteins, FnBPA and FnBPB","volume":"190","author":"O\u2019Neill","year":"2008","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20170702133145_bib20","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev.genet.42.110807.091640","article-title":"Quorum sensing in staphylococci","volume":"42","author":"Novick","year":"2008","journal-title":"Annu Rev Genet"},{"key":"key\n\t\t\t\t20170702133145_bib21","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1128\/jb.170.9.4365-4372.1988","article-title":"Cloning, characterization, and sequencing of an accessory gene regulator (agr) in Staphylococcus aureus","volume":"170","author":"Peng","year":"1988","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20170702133145_bib22","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1002\/j.1460-2075.1993.tb06074.x","article-title":"Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule","volume":"12","author":"Novick","year":"1993","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20170702133145_bib23","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0042-6822(67)90105-5","article-title":"Properties of a cryptic high-frequency transducing phage in Staphylococcus aureus","volume":"33","author":"Novick","year":"1967","journal-title":"Virology"},{"key":"key\n\t\t\t\t20170702133145_bib24","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1128\/JCM.38.3.1008-1015.2000","article-title":"Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus","volume":"38","author":"Enright","year":"2000","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20170702133145_bib25","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1128\/JCM.02402-06","article-title":"Evaluation of molecular typing methods in characterizing a European collection of epidemic methicillin-resistant Staphylococcus aureus strains: the HARMONY collection","volume":"45","author":"Cookson","year":"2007","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20170702133145_bib26","first-page":"654858","article-title":"Clinical and microbiological determinants of outcome in Staphylococcus aureus bacteraemia","author":"Price","year":"2010","journal-title":"Int J Microbiol"},{"key":"key\n\t\t\t\t20170702133145_bib27","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.plasmid.2008.10.001","article-title":"An improved tetracycline-inducible expression vector for Staphylococcus aureus","volume":"61","author":"Corrigan","year":"2009","journal-title":"Plasmid"},{"key":"key\n\t\t\t\t20170702133145_bib28","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0378-1119(92)90048-T","article-title":"A series of shuttle vectors for Bacillus subtilis and Escherichia coli","volume":"122","author":"Bruckner","year":"1992","journal-title":"Gene"},{"key":"key\n\t\t\t\t20170702133145_bib29","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1128\/IAI.69.11.7074-7082.2001","article-title":"Agr expression precedes escape of internalized Staphylococcus aureus from the host endosome","volume":"69","author":"Qazi","year":"2001","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170702133145_bib30","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1128\/JCM.00156-08","article-title":"Identification of factors contributing to T-cell toxicity of Staphylococcus aureus clinical isolates","volume":"46","author":"Collins","year":"2008","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20170702133145_bib31","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1046\/j.1365-2958.2001.02539.x","article-title":"Structure, activity and evolution of the group I thiolactone peptide quorum-sensing system of Staphylococcus aureus","volume":"41","author":"McDowell","year":"2001","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170702133145_bib32","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1086\/423145","article-title":"Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal protein","volume":"190","author":"Fowler","year":"2004","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702133145_bib33","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/BF00330517","article-title":"Regulation of exoprotein gene expression in Staphylococcus aureus by agr","volume":"202","author":"Recsei","year":"1986","journal-title":"Mol Gen Genet"},{"key":"key\n\t\t\t\t20170702133145_bib34","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1128\/JB.88.5.1304-1309.1964","article-title":"Purification and properties of staphylococcal beta-hemolysin","volume":"88","author":"Haque","year":"1964","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20170702133145_bib35","doi-asserted-by":"crossref","first-page":"e1000533","DOI":"10.1371\/journal.ppat.1000533","article-title":"Mobile genetic element-encoded cytolysin connects virulence to methicillin resistance in MRSA","volume":"5","author":"Queck","year":"2009","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20170702133145_bib36","doi-asserted-by":"crossref","first-page":"e1001267","DOI":"10.1371\/journal.ppat.1001267","article-title":"Transcription and translation products of the cytolysin gene psm-mec on the mobile genetic element SCCmec regulate Staphylococcus aureus virulence","volume":"7","author":"Kaito","year":"2011","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20170702133145_bib37","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1111\/j.1365-2958.2006.04986.x","article-title":"A slipped-mispairing mutation in AgrA of laboratory strains and clinical isolates results in delayed activation of agr and failure to translate delta- and alpha-haemolysins","volume":"59","author":"Traber","year":"2006","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170702133145_bib38","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1086\/656915","article-title":"Mutations in agr do not persist in natural populations of methicillin-resistant Staphylococcus aureus","volume":"202","author":"Shopsin","year":"2010","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702133145_bib39","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1128\/AAC.37.2.342","article-title":"Abnormal peptidoglycan produced in a methicillin-resistant strain of Staphylococcus aureus grown in the presence of methicillin: functional role for penicillin-binding protein 2A in cell wall synthesis","volume":"37","author":"de Jonge","year":"1993","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170702133145_bib40","doi-asserted-by":"crossref","first-page":"11248","DOI":"10.1016\/S0021-9258(19)49903-1","article-title":"Peptidoglycan composition of a highly methicillin-resistant Staphylococcus aureus strain","volume":"267","author":"de Jonge","year":"1992","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170702133145_bib41","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1128\/JCM.40.11.4289-4294.2002","article-title":"Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community","volume":"40","author":"Okuma","year":"2002","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20170702133145_bib42","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/305709a0","article-title":"The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage","volume":"305","author":"Kreiswirth","year":"1983","journal-title":"Nature"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/205\/5\/798\/18067388\/jir845.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T19:15:03Z","timestamp":1640632503000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jir845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,1]]},"references-count":42,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,3,1]]},"published-print":{"date-parts":[[2012,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jir845","relation":{},"ISSN":["1537-6613","0022-1899"],"issn-type":[{"value":"1537-6613","type":"electronic"},{"value":"0022-1899","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3,1]]}}}