{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:56:00Z","timestamp":1791356160401,"version":"4.3.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,15]]},"DOI":"10.1093\/infdis\/jis230","type":"journal-article","created":{"date-parts":[[2012,3,28]],"date-time":"2012-03-28T20:24:02Z","timestamp":1332966242000},"page":"1501-1509","source":"Crossref","is-referenced-by-count":54,"title":["Severe Immune Dysregulation Affects CD4+CD25hiFoxP3+ Regulatory T Cells in HIV-Infected Patients With Low-level CD4 T-Cell Repopulation Despite Suppressive Highly Active Antiretroviral Therapy"],"prefix":"10.1093","volume":"205","author":[{"given":"Gema","family":"M\u00e9ndez-Lagares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Mar","family":"Pozo-Balado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Genebat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Garc\u00eda-Perga\u00f1eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda Mar\u00eda","family":"Pacheco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,3,28]]},"reference":[{"key":"key\n\t\t\t\t20170702142403_JIS230C1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.2174\/157016209789973673","article-title":"Risk factors, CD4 long-term evolution and mortality of HIV-infected patients who persistently maintain low CD4 counts, despite virological response to HAART","volume":"7","author":"Pacheco","year":"2009","journal-title":"Curr HIV Res"},{"key":"key\n\t\t\t\t20170702142403_JIS230C2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/QAI.0b013e3181ec28ff","article-title":"A CD4+ cell count <200 cells per cubic millimeter at 2 years after initiation of combination antiretroviral therapy is associated with increased mortality in HIV-infected individuals with viral suppression","volume":"55","author":"Loutfy","year":"2010","journal-title":"J Acquir Immune Defic Syndr"},{"key":"key\n\t\t\t\t20170702142403_JIS230C3","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/1471-2334-10-318","article-title":"Long-term mortality in HIV patients virally suppressed for more than three years with incomplete CD4 recovery: a cohort study","volume":"10","author":"Engsig","year":"2010","journal-title":"BMC Infect Dis"},{"key":"key\n\t\t\t\t20170702142403_JIS230C4","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1056\/NEJMoa0903175","article-title":"Interleukin-2 therapy in patients with HIV Infection","volume":"361","author":"Abrams","year":"2009","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170702142403_JIS230C5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1086\/695852","article-title":"The absence of CD4+ T cell count recovery despite receipt of virologically suppressive highly active antiretroviral therapy: clinical risk, immunological gaps and therapeutic options","volume":"48","author":"Gazzola","year":"2009","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170702142403_JIS230C6","first-page":"88","article-title":"Failure to reconstitute CD4+ T-cells despite suppression of HIV replication under HAART","volume":"8","author":"Aiuti","year":"2006","journal-title":"AIDS Rev"},{"key":"key\n\t\t\t\t20170702142403_JIS230C7","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/jac\/dkp248","article-title":"Premature immunosenescence in HIV-infected patients on highly active antiretroviral therapy with low-level CD4 T cell repopulation","volume":"64","author":"Molina-Pinelo","year":"2009","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20170702142403_JIS230C8","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2008.05.009","article-title":"Regulatory T Cells and Immune Tolerance","volume":"133","author":"Sakaguchi","year":"2008","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170702142403_JIS230C9","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.immuni.2009.04.010","article-title":"Mechanisms of Foxp3+ T regulatory cell-mediated suppression","volume":"30","author":"Shevach","year":"2009","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20170702142403_JIS230C10","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1097\/QAD.0b013e3282f466da","article-title":"Regulatory T cells in HIV infection: pathogenic or protective participants in the immune response?","volume":"22","author":"Fazekas de St Groth","year":"2008","journal-title":"AIDS"},{"key":"key\n\t\t\t\t20170702142403_JIS230C11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11904-008-0004-6","article-title":"Regulatory T cells in HIV infection: who's suppressing what?","volume":"5","author":"Seddiki","year":"2008","journal-title":"Curr HIV\/AIDS Rep"},{"key":"key\n\t\t\t\t20170702142403_JIS230C12","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1097\/01.aids.0000247588.69438.fd","article-title":"T-cell homeostasis alteration in HIV-1 infected subjects with low CD4 T-cell count despite undetectable virus load during HAART","volume":"20","author":"Marziali","year":"2006","journal-title":"AIDS"},{"key":"key\n\t\t\t\t20170702142403_JIS230C13","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1086\/649840","article-title":"CD4(+)CD25(+\/hi)CD127(lo) phenotype does not accurately identify regulatory T cells in all populations of HIV-infected persons","volume":"201","author":"Del Pozo-Balado","year":"2010","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702142403_JIS230C14","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1097\/01.aids.0000238415.98194.38","article-title":"Foxp3+ regulatory T cells in antiretroviral-naive HIV patients","volume":"20","author":"Montes","year":"2006","journal-title":"AIDS"},{"key":"key\n\t\t\t\t20170702142403_JIS230C15","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/eji.200838667","article-title":"High frequency and proliferation of CD4+FOXP3+ Treg in HIV-1-infected patients with low CD4 counts","volume":"39","author":"Bi","year":"2009","journal-title":"Eur J Immunol"},{"key":"key\n\t\t\t\t20170702142403_JIS230C16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.clim.2010.02.012","article-title":"Is it age or HIV that drives the regulatory T-cells expansion that occurs in older HIV-infected persons?","volume":"36","author":"M\u00e9ndez-Lagares","year":"2010","journal-title":"Clin Immunol"},{"key":"key\n\t\t\t\t20170702142403_JIS230C17","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1097\/QAD.0b013e32825eab8b","article-title":"Proportions of circulating T cells with a regulatory cell phenotype increase with HIV-associated immune activation and remain high on antiretroviral therapy","volume":"21","author":"Lim","year":"2007","journal-title":"AIDS"},{"key":"key\n\t\t\t\t20170702142403_JIS230C18","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1089\/aid.2008.0140","article-title":"Regulatory T cell expansion and immune activation during untreated HIV type 1 infection are associated with disease progression","volume":"25","author":"Cao","year":"2009","journal-title":"AIDS Res Hum Retroviruses"},{"key":"key\n\t\t\t\t20170702142403_JIS230C19","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/eji.200838630","article-title":"Proliferation of weakly suppressive regulatory CD4+ T cells is associated with over-active CD4+ T-cell responses in HIV-positive patients with mycobacterial immune restoration disease","volume":"39","author":"Seddiki","year":"2009","journal-title":"Eur J Immunol"},{"key":"key\n\t\t\t\t20170702142403_JIS230C20","article-title":"Increased frequency of CD25+FoxP3+CD4+ T cells in HIV-1 infected patients with low CD4 T cell recovery under ART despite undetectable viremia [abstract MOPEA02]","author":"Albuquerque","year":"2007"},{"key":"key\n\t\t\t\t20170702142403_JIS230C21","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/COH.0b013e328335c0c1","article-title":"Th17 and regulatory T cells: implications for AIDS pathogenesis","volume":"5","author":"Kanwar","year":"2010","journal-title":"Curr Opin HIV AIDS"},{"key":"key\n\t\t\t\t20170702142403_JIS230C22","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.4049\/jimmunol.169.9.4850","article-title":"Homeostasis of peripheral CD4+ T-cells: IL-2R\u03b1 and IL-2 shape a population of regulatory cells that controls CD4+ T-cell numbers","volume":"169","author":"Almeida","year":"2002","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702142403_JIS230C23","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4049\/jimmunol.177.1.192","article-title":"Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T-cells is indexed to the number of IL-2 producing cells","volume":"177","author":"Almeida","year":"2006","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702142403_JIS230C24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1074-7613(02)00367-9","article-title":"CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficientmice. Implications for the nonredundant function of IL-2","volume":"17","author":"Malek","year":"2002","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20170702142403_JIS230C25","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ni1263","article-title":"Function for interleukin 2 in Foxp3-expressing regulatory T cells","volume":"6","author":"Fontenot","year":"2005","journal-title":"Nat Immunol"},{"key":"key\n\t\t\t\t20170702142403_JIS230C26","doi-asserted-by":"crossref","first-page":"e10788","DOI":"10.1371\/journal.pone.0010788","article-title":"CD4+ T cell depletion, immune activation and increased production of regulatory T cells in the thymus of HIV-infected individuals","volume":"5","author":"Bandera","year":"2010","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170702142403_JIS230C27","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1084\/jem.20032069","article-title":"CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status","volume":"200","author":"Kinter","year":"2004","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170702142403_JIS230C28","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1097\/01.aids.0000171401.23243.56","article-title":"Relationship of CD4+CD25+ regulatory T cells to immune status in HIV-infected patients","volume":"19","author":"Tsunemi","year":"2005","journal-title":"AIDS"},{"key":"key\n\t\t\t\t20170702142403_JIS230C29","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1365-2249.2006.03319.x","article-title":"Peripheral CD4 loss of regulatory T cells is associated with persistent viraemia in chronic HIV infection","volume":"147","author":"Baker","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"key\n\t\t\t\t20170702142403_JIS230C30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-2567.2008.02813.x","article-title":"Mechanisms of regulatory T-cell suppression\u2014a diverse arsenal for a moving target","volume":"124","author":"Sojka","year":"2008","journal-title":"Immunology"},{"key":"key\n\t\t\t\t20170702142403_JIS230C31","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/ni1572","article-title":"The FoxP3+ regulatory T cell: a jack of all trades, master of regulation","volume":"9","author":"Tang","year":"2008","journal-title":"Nat Immunol"},{"key":"key\n\t\t\t\t20170702142403_JIS230C32","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.4049\/jimmunol.0803123","article-title":"Cutting edge: regulatory T cells do not require stimulation through their TCR to suppress","volume":"182","author":"Szymczak-Workman","year":"2009","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702142403_JIS230C33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.it.2004.11.006","article-title":"The new paradigm of T-cell homeostatic proliferation-induced autoimmunity","volume":"26","author":"Baccala","year":"2005","journal-title":"Trends Immunol"},{"key":"key\n\t\t\t\t20170702142403_JIS230C34","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.4049\/jimmunol.177.7.4558","article-title":"CD25+CD4+ regulatory T cells and memory T cells prevent lymphopenia-induced proliferation of naive T cells in transient states of lymphopenia","volume":"177","author":"Bourgeois","year":"2006","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702142403_JIS230C35","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.4049\/jimmunol.0904076","article-title":"CD4+CD25+FoxP3+ regulatory T cells optimize diversity of the conventional T cell repertoire during reconstitution from lymphopenia","volume":"184","author":"Winstead","year":"2010","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702142403_JIS230C36","doi-asserted-by":"crossref","first-page":"7305","DOI":"10.4049\/jimmunol.180.11.7305","article-title":"Regulatory CD4+CD25+FoxP3+ T cells selectively inhibit the spontaneous form of lymphopenia-induced proliferation of naive T cells","volume":"180","author":"Winstead","year":"2008","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702142403_JIS230C37","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.4049\/jimmunol.1002000","article-title":"CD4 and CD8 T cell immune activation during chronic HIV infection: roles of homeostasis, HIV, type I IFN and IL-7","volume":"186","author":"Catalfamo","year":"2011","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702142403_JIS230C38","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1097\/01.aids.0000242819.72839.db","article-title":"Comparative analysis of T-cell turnover and homeostatic parameters in HIV-infected patients with discordant immune-virological responses to HAART","volume":"20","author":"Marchetti","year":"2006","journal-title":"AIDS"},{"key":"key\n\t\t\t\t20170702142403_JIS230C39","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1002\/eji.201040600","article-title":"CD4+CD25+ Treg regulate the contribution of CD8+ T-cell subsets in repopulation of the lymphopenic environment","volume":"40","author":"Almeida","year":"2010","journal-title":"Eur J Immunol"},{"key":"key\n\t\t\t\t20170702142403_JIS230C40","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/QAI.0b013e3181ca3f7c","article-title":"T-cell dysfunction in HIV-1-infected patients with impaired recovery of CD4 cells despite suppression of viral replication","volume":"53","author":"Erikstrup","year":"2010","journal-title":"J Acquir Immune Defic Syndr"},{"key":"key\n\t\t\t\t20170702142403_JIS230C41","doi-asserted-by":"crossref","DOI":"10.1093\/jac\/dkr594","article-title":"Differential alterations of the CD4 and CD8 T cell subsets in HIV-infected patients on highly active antiretroviral therapy with low CD4 T cell restoration","author":"M\u00e9ndez-Lagares","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20170702142403_JIS230C42","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1097\/QAD.0b013e328339cf40","article-title":"Skewed T-cell maturation and function in HIV-infected patients failing CD4+ recovery upon long-term virologically suppressive HAART","volume":"24","author":"Marchetti","year":"2010","journal-title":"AIDS"},{"key":"key\n\t\t\t\t20170702142403_JIS230C43","doi-asserted-by":"crossref","first-page":"6039","DOI":"10.4049\/jimmunol.174.10.6039","article-title":"Spontaneous and homeostatic proliferation of CD4 T-cells are regulated by different mechanisms","volume":"174","author":"Min","year":"2005","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702142403_JIS230C44","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/eji.200838603","article-title":"CTLA-4 is required by CD4+CD25+ Treg to control CD4+ T-cell lymphopenia-induced proliferation","volume":"39","author":"Sojka","year":"2009","journal-title":"Eur J Immunol"},{"key":"key\n\t\t\t\t20170702142403_JIS230C45","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1097\/QAD.0b013e328337b957","article-title":"CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART","volume":"24","author":"Massanella","year":"2010","journal-title":"AIDS"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/205\/10\/1501\/18066244\/jis230.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T12:49:50Z","timestamp":1503492590000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jis230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,28]]},"references-count":45,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2012,3,28]]},"published-print":{"date-parts":[[2012,5,15]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jis230","relation":{},"ISSN":["1537-6613","0022-1899"],"issn-type":[{"value":"1537-6613","type":"electronic"},{"value":"0022-1899","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3,28]]}}}