{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T08:19:49Z","timestamp":1782375589568,"version":"3.54.5"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11,15]]},"DOI":"10.1093\/infdis\/jis546","type":"journal-article","created":{"date-parts":[[2012,9,5]],"date-time":"2012-09-05T04:45:33Z","timestamp":1346820333000},"page":"1512-1520","source":"Crossref","is-referenced-by-count":26,"title":["High-Dimensional Gene Expression Profiling Studies in High and Low Responders to Primary Smallpox Vaccination"],"prefix":"10.1093","volume":"206","author":[{"given":"Iana H.","family":"Haralambieva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann L.","family":"Oberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam","family":"Dhiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna G.","family":"Ovsyannikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane E.","family":"Grill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Poland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,9,4]]},"reference":[{"key":"key\n\t\t\t\t20170425160110_JIS546C1","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1086\/498155","article-title":"Reemergence of monkeypox: prevalence, diagnostics, and countermeasures","volume":"41","author":"Nalca","year":"2005","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170425160110_JIS546C2","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.coi.2009.04.004","article-title":"The immunology of smallpox vaccines","volume":"21","author":"Kennedy","year":"2009","journal-title":"Curr Opin Immunol"},{"key":"key\n\t\t\t\t20170425160110_JIS546C3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1586\/1744666X.2.3.325","article-title":"Immunity to smallpox and vaccinia: the future of smallpox vaccines","volume":"2","author":"Lane","year":"2006","journal-title":"Expert Rev Clin Immunol"},{"key":"key\n\t\t\t\t20170425160110_JIS546C4","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.3201\/eid1610.100713","article-title":"Human monkeypox outbreak caused by novel virus belonging to Congo Basin clade, Sudan, 2005","volume":"16","author":"Formenty","year":"2010","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20170425160110_JIS546C5","doi-asserted-by":"crossref","first-page":"D65","DOI":"10.1016\/j.vaccine.2011.09.105","article-title":"Human and animal infections by vaccinia-like viruses in the state of Rio de Janeiro: a novel expanding zoonosis","volume":"29 Suppl 4","author":"Schatzmayr","year":"2011","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20170425160110_JIS546C6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.tim.2011.12.001","article-title":"Outbreaks of human monkeypox after cessation of smallpox vaccination","volume":"20","author":"Reynolds","year":"2012","journal-title":"Trends Microbiol"},{"key":"key\n\t\t\t\t20170425160110_JIS546C7","first-page":"156","article-title":"When good vaccines go wild: Feral Orthopoxvirus in developing countries and beyond","volume":"2","author":"Moussatche","year":"2008","journal-title":"J\u00a0Infect Dev Ctries"},{"key":"key\n\t\t\t\t20170425160110_JIS546C8","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.3201\/eid1309.070175","article-title":"Spectrum of infection and risk factors for human monkeypox, United States, 2003","volume":"13","author":"Reynolds","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20170425160110_JIS546C9","doi-asserted-by":"crossref","first-page":"12754","DOI":"10.1128\/JVI.01763-10","article-title":"Antiviral immunity following smallpox virus infection: a case-control study","volume":"84","author":"Hammarlund","year":"2010","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170425160110_JIS546C10","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1016\/j.vaccine.2009.01.086","article-title":"Gender effects on humoral immune response to smallpox vaccine","volume":"27","author":"Kennedy","year":"2008","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20170425160110_JIS546C11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/infdis\/jir268","article-title":"Common SNPs\/haplotypes in IL18R1 and IL18 genes are associated with variations in humoral immunity to smallpox vaccination in Caucasians and African Americans","volume":"204","author":"Haralambieva","year":"2011","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425160110_JIS546C12","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1128\/CVI.00109-09","article-title":"Statistical approach to estimate vaccinia-specific neutralizing antibody titers using a high-throughput assay","volume":"16","author":"Kennedy","year":"2009","journal-title":"Clin Vaccine Immunol"},{"key":"key\n\t\t\t\t20170425160110_JIS546C13","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1089\/vim.2011.0029","article-title":"Correlations between vaccinia-specific immune responses within a cohort of armed forces members","volume":"24","author":"Umlauf","year":"2011","journal-title":"Viral Immunol"},{"key":"key\n\t\t\t\t20170425160110_JIS546C14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jim.2011.01.011","article-title":"Optimizing high dimensional gene expression studies for immune response following smallpox vaccination using Taqman(R) Low density immune arrays","volume":"366","author":"Oberg","year":"2011","journal-title":"J Immunol Methods"},{"key":"key\n\t\t\t\t20170425160110_JIS546C15","first-page":"111","article-title":"Statistical methods for identifying genes with differential expression in replicated cDNA microarray experiments","volume":"12","author":"Dudoit","year":"2002","journal-title":"Statistica Sinica"},{"key":"key\n\t\t\t\t20170425160110_JIS546C16","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1093\/bioinformatics\/bth327","article-title":"Faster cyclic loess: normalizing RNA arrays via linear models","volume":"20","author":"Ballman","year":"2004","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20170425160110_JIS546C17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0025-5564(01)00107-9","article-title":"A systematic statistical linear modeling approach to oligonucleotide array experiments","volume":"176","author":"Chu","year":"2002","journal-title":"Math Biosci"},{"key":"key\n\t\t\t\t20170425160110_JIS546C18","volume-title":"SAS system for mixed models","author":"Littell","year":"2002"},{"key":"key\n\t\t\t\t20170425160110_JIS546C19","volume-title":"Mixed-Effects Models in S and S-PLUS","author":"Pinheiro","year":"2004"},{"key":"key\n\t\t\t\t20170425160110_JIS546C20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Series B"},{"key":"key\n\t\t\t\t20170425160110_JIS546C21","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies","volume":"100","author":"Storey","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170425160110_JIS546C22","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1086\/518794","article-title":"The immunogenetics of smallpox vaccination","volume":"196","author":"Stanley","year":"2007","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425160110_JIS546C23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/588670","article-title":"Genetic basis for adverse events after smallpox vaccination","volume":"198","author":"Reif","year":"2008","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425160110_JIS546C24","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1086\/505503","article-title":"Cytokine expression patterns associated with systemic adverse events following smallpox immunization","volume":"194","author":"McKinney","year":"2006","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425160110_JIS546C25","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/gene.2008.80","article-title":"Integrated analysis of genetic and proteomic data identifies biomarkers associated with adverse events following smallpox vaccination","volume":"10","author":"Reif","year":"2009","journal-title":"Genes Immun"},{"key":"key\n\t\t\t\t20170425160110_JIS546C26","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/gene.2010.37","article-title":"Surfing a genetic association interaction network to identify modulators of antibody response to smallpox vaccine","volume":"11","author":"Davis","year":"2010","journal-title":"Genes Immun"},{"key":"key\n\t\t\t\t20170425160110_JIS546C27","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1093\/infdis\/jir167","article-title":"Human leukocyte antigen genotypes in the genetic control of adaptive immune responses to smallpox vaccine","volume":"203","author":"Ovsyannikova","year":"2011","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425160110_JIS546C28","doi-asserted-by":"crossref","first-page":"15190","DOI":"10.1073\/pnas.0405759101","article-title":"The host response to smallpox: analysis of the gene expression program in peripheral blood cells in a nonhuman primate model","volume":"101","author":"Rubins","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170425160110_JIS546C29","doi-asserted-by":"crossref","first-page":"5004","DOI":"10.1016\/j.vaccine.2008.07.050","article-title":"Gene profiling analysis of ALVAC infected human monocyte derived dendritic cells","volume":"26","author":"Harenberg","year":"2008","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20170425160110_JIS546C30","doi-asserted-by":"crossref","first-page":"6458","DOI":"10.1016\/j.vaccine.2007.06.035","article-title":"Distinct gene expression profiles in peripheral blood mononuclear cells from patients infected with vaccinia virus, yellow fever 17D virus, or upper respiratory infections","volume":"25","author":"Scherer","year":"2007","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20170425160110_JIS546C31","doi-asserted-by":"crossref","first-page":"8707","DOI":"10.1128\/JVI.00444-07","article-title":"Distinct gene expression profiling after infection of immature human monocyte-derived dendritic cells by the attenuated poxvirus vectors MVA and NYVAC","volume":"81","author":"Guerra","year":"2007","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170425160110_JIS546C32","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.1128\/JVI.78.11.5820-5834.2004","article-title":"Microarray analysis reveals characteristic changes of host cell gene expression in response to attenuated modified vaccinia virus Ankara infection of human HeLa cells","volume":"78","author":"Guerra","year":"2004","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170425160110_JIS546C33","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1038\/sj.leu.2401865","article-title":"Death and decoy receptors and p53-mediated apoptosis","volume":"14","author":"Sheikh","year":"2000","journal-title":"Leukemia"},{"key":"key\n\t\t\t\t20170425160110_JIS546C34","doi-asserted-by":"crossref","first-page":"11513","DOI":"10.1073\/pnas.1006594107","article-title":"Simultaneous high-resolution analysis of vaccinia virus and host cell transcriptomes by deep RNA sequencing","volume":"107","author":"Yang","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170425160110_JIS546C35","doi-asserted-by":"crossref","first-page":"10467","DOI":"10.1128\/JVI.00983-10","article-title":"Viral cell death inhibitor MC159 enhances innate immunity against vaccinia virus infection","volume":"84","author":"Challa","year":"2010","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170425160110_JIS546C36","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.immunol.15.1.155","article-title":"The role of the Ikaros gene in lymphocyte development and homeostasis","volume":"15","author":"Georgopoulos","year":"1997","journal-title":"Annu Rev Immunol"},{"key":"key\n\t\t\t\t20170425160110_JIS546C37","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/viro.2002.1400","article-title":"Interleukin 17 modulates the immune response to vaccinia virus infection","volume":"299","author":"Patera","year":"2002","journal-title":"Virology"},{"key":"key\n\t\t\t\t20170425160110_JIS546C38","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nm.1968","article-title":"Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion","volume":"15","author":"Yao","year":"2009","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170425160110_JIS546C39","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1126\/science.1113401","article-title":"Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function","volume":"309","author":"Peng","year":"2005","journal-title":"Science"},{"key":"key\n\t\t\t\t20170425160110_JIS546C40","doi-asserted-by":"crossref","first-page":"5601","DOI":"10.4049\/jimmunol.173.9.5601","article-title":"The B lymphocyte adaptor molecule of 32 kilodaltons (Bam32) regulates B cell antigen receptor internalization","volume":"173","author":"Niiro","year":"2004","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425160110_JIS546C41","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1186\/1743-422X-8-384","article-title":"Lysosome-associated membrane glycoprotein 3 is involved in influenza A virus replication in human lung epithelial (A549) cells","volume":"8","author":"Zhou","year":"2011","journal-title":"Virol J"},{"issue":"Pt 1","key":"key\n\t\t\t\t20170425160110_JIS546C42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1099\/vir.0.83391-0","article-title":"Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures","volume":"89","author":"Randall","year":"2008","journal-title":"J Gen Virol"},{"key":"key\n\t\t\t\t20170425160110_JIS546C43","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nri2314","article-title":"Interferon-inducible antiviral effectors","volume":"8","author":"Sadler","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20170425160110_JIS546C44","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1182\/blood-2006-06-027136","article-title":"Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-beta","volume":"109","author":"Zhu","year":"2007","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170425160110_JIS546C45","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1086\/649588","article-title":"Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination","volume":"201","author":"Ovsyannikova","year":"2010","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425160110_JIS546C46","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00439-009-0763-1","article-title":"Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes","volume":"127","author":"Ovsyannikova","year":"2010","journal-title":"Hum Genet"},{"key":"key\n\t\t\t\t20170425160110_JIS546C47","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.humimm.2010.01.004","article-title":"2\u2032-5\u2032-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine","volume":"71","author":"Haralambieva","year":"2010","journal-title":"Hum Immunol"},{"key":"key\n\t\t\t\t20170425160110_JIS546C48","doi-asserted-by":"crossref","first-page":"8988","DOI":"10.1016\/j.vaccine.2011.09.043","article-title":"Genetic polymorphisms in host antiviral genes: associations with humoral and cellular immunity to measles vaccine","volume":"29","author":"Haralambieva","year":"2011","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20170425160110_JIS546C49","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.2217\/fmb.10.146","article-title":"Vaccinomics, predictive vaccinology and the future of vaccine development","volume":"5","author":"Haralambieva","year":"2010","journal-title":"Future Microbiol"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/206\/10\/1512\/13803532\/jis546.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T23:01:31Z","timestamp":1714345291000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jis546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,4]]},"references-count":49,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2012,9,4]]},"published-print":{"date-parts":[[2012,11,15]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jis546","relation":{},"ISSN":["1537-6613","0022-1899"],"issn-type":[{"value":"1537-6613","type":"electronic"},{"value":"0022-1899","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9,4]]}}}