{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:43:30Z","timestamp":1790120610657,"version":"4.0.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,15]]},"DOI":"10.1093\/infdis\/jit029","type":"journal-article","created":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T05:41:31Z","timestamp":1358314891000},"page":"1339-1347","source":"Crossref","is-referenced-by-count":119,"title":["The Mannoprotein Cig1 Supports Iron Acquisition From Heme and Virulence in the Pathogenic Fungus Cryptococcus neoformans"],"prefix":"10.1093","volume":"207","author":[{"given":"Brigitte","family":"Cadieux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshun","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanggan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Biondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Teti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E. P.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Louise","family":"Creagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Kronstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,1,15]]},"reference":[{"key":"key\n\t\t\t\t20170511122328_JIT029C1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/QAD.0b013e328322ffac","article-title":"Estimation of the current global burden of cryptococcal meningitis among persons living with HIV\/AIDS","volume":"23","author":"Park","year":"2009","journal-title":"AIDS"},{"key":"key\n\t\t\t\t20170511122328_JIT029C2","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1258\/ijsa.2010.010182","article-title":"An update on Cryptococcus among HIV-infected patients","volume":"21","author":"Warkentien","year":"2010","journal-title":"Int J STD AIDS"},{"key":"key\n\t\t\t\t20170511122328_JIT029C3","doi-asserted-by":"crossref","first-page":"e410","DOI":"10.1371\/journal.pbio.0040410","article-title":"Iron regulation of the major virulence factors in the AIDS-associated pathogen Cryptococcus neoformans","volume":"4","author":"Jung","year":"2006","journal-title":"PLoS Biol"},{"key":"key\n\t\t\t\t20170511122328_JIT029C4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1462-5822.2007.01077.x","article-title":"Iron and fungal pathogenesis: a case study with Cryptococcus neoformans","volume":"10","author":"Jung","year":"2008","journal-title":"Cell Microbiol"},{"key":"key\n\t\t\t\t20170511122328_JIT029C5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1099\/mic.0.2006\/000927-0","article-title":"The iron- and cAMP-regulated gene SIT1 influences ferrioxamine B utilization, melanization and cell wall structure in Cryptococcus neoformans","volume":"153","author":"Tangen","year":"2007","journal-title":"Microbiology"},{"key":"key\n\t\t\t\t20170511122328_JIT029C6","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1039\/c1mt00047k","article-title":"The theft of host heme by Gram-positive pathogenic bacteria","volume":"3","author":"Nobles","year":"2011","journal-title":"Metallomics"},{"key":"key\n\t\t\t\t20170511122328_JIT029C7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2008.10.013","article-title":"Bacterial heme-transport proteins and their heme-coordination modes","volume":"481","author":"Tong","year":"2009","journal-title":"Arch Biochem Biophys"},{"key":"key\n\t\t\t\t20170511122328_JIT029C8","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1139\/w02-037","article-title":"Utilization and cell-surface binding of hemin by Histoplasma capsulatum","volume":"48","author":"Foster","year":"2002","journal-title":"Can J Microbiol"},{"key":"key\n\t\t\t\t20170511122328_JIT029C9","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1111\/j.1365-2958.2004.04199.x","article-title":"A family of Candida cell surface haem-binding proteins involved in haemin and haemoglobin-iron utilization","volume":"53","author":"Weissman","year":"2004","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170511122328_JIT029C10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1365-2958.2008.06277.x","article-title":"An endocytic mechanism for haemoglobin-iron acquisition in Candida albicans","volume":"69","author":"Weissman","year":"2008","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170511122328_JIT029C11","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1371\/journal.ppat.0040045","article-title":"Iron source preference and regulation of iron uptake in Cryptococcus neoformans","volume":"4","author":"Jung","year":"2008","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20170511122328_JIT029C12","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1111\/j.1365-2958.2004.04474.x","article-title":"Iron-regulated transcription and capsule formation in the fungal pathogen Cryptococcus neoformans","volume":"55","author":"Lian","year":"2005","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170511122328_JIT029C13","doi-asserted-by":"crossref","first-page":"e1001209","DOI":"10.1371\/journal.ppat.1001209","article-title":"HapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans","volume":"6","author":"Jung","year":"2010","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20170511122328_JIT029C14","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1567-1364.2006.00043.x","article-title":"Identification of major proteins secreted by Cryptococcus neoformans","volume":"6","author":"Biondo","year":"2006","journal-title":"FEMS Yeast Res"},{"key":"key\n\t\t\t\t20170511122328_JIT029C15","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1567-1364.2006.00071.x","article-title":"The molecular basis for the immunogenicity of Cryptococcus neoformans mannoproteins","volume":"6","author":"Levitz","year":"2006","journal-title":"FEMS Yeast Res"},{"key":"key\n\t\t\t\t20170511122328_JIT029C16","doi-asserted-by":"crossref","first-page":"e1000776","DOI":"10.1371\/journal.ppat.1000776","article-title":"Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule","volume":"6","author":"O'Meara","year":"2010","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20170511122328_JIT029C17","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1128\/EC.00166-09","article-title":"Role of ferroxidases in iron uptake and virulence of Cryptococcus neoformans","volume":"8","author":"Jung","year":"2009","journal-title":"Eukaryot Cell"},{"key":"key\n\t\t\t\t20170511122328_JIT029C18","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/j.1365-2958.2012.08134.x","article-title":"Regulated expression of cyclic AMP-dependent protein kinase A reveals an influence on cell size and the secretion of virulence factors in Cryptococcus neoformans","volume":"85","author":"Choi","year":"2012","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170511122328_JIT029C19","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/infdis\/167.1.186","article-title":"Regulation of cryptococcal capsular polysaccharide by iron","volume":"167","author":"Vartivarian","year":"1993","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170511122328_JIT029C20","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key\n\t\t\t\t20170511122328_JIT029C21","doi-asserted-by":"crossref","first-page":"5443","DOI":"10.1021\/bi200369p","article-title":"Unique heme-iron coordination by the hemoglobin receptor IsdB of Staphylococcus aureus","volume":"50","author":"Gaudin","year":"2011","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170511122328_JIT029C22","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3389\/fmicb.2012.00096","article-title":"Redox transformations of iron at extremely low pH: fundamental and applied aspects","volume":"3","author":"Johnson","year":"2012","journal-title":"Front Microbiol"},{"key":"key\n\t\t\t\t20170511122328_JIT029C23","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1128\/MMBR.66.3.426-446.2002","article-title":"Regulation of gene expression by ambient pH in filamentous fungi and yeasts","volume":"66","author":"Penalva","year":"2002","journal-title":"Microbiol Mol Biol Rev"},{"key":"key\n\t\t\t\t20170511122328_JIT029C24","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.micro.58.030603.123715","article-title":"Recent advances in the characterization of ambient pH regulation of gene expression in filamentous fungi and yeasts","volume":"58","author":"Penalva","year":"2004","journal-title":"Annu Rev Microbiol"},{"key":"key\n\t\t\t\t20170511122328_JIT029C25","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1046\/j.1365-2958.1999.01175.x","article-title":"Non-iron metalloporphyrins: potent antibacterial compounds that exploit haem\/Hb uptake systems of pathogenic bacteria","volume":"31","author":"Stojiljkovic","year":"1999","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170511122328_JIT029C26","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1365-2958.2012.08136.x","article-title":"Haemophore functions revisited","volume":"85","author":"Wandersman","year":"2012","journal-title":"Mol Microbiol."},{"key":"key\n\t\t\t\t20170511122328_JIT029C27","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10534-006-9050-y","article-title":"Heme acquisition by hemophores","volume":"20","author":"Cescau","year":"2007","journal-title":"Biometals"},{"key":"key\n\t\t\t\t20170511122328_JIT029C28","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1078\/1438-4221-00103","article-title":"Iron uptake mechanisms and their regulation in pathogenic bacteria","volume":"291","author":"Braun","year":"2001","journal-title":"Int J Med Microbiol"},{"key":"key\n\t\t\t\t20170511122328_JIT029C29","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1099\/mic.0.26108-0","article-title":"Haemin uptake and use as an iron source by Candida albicans: role of CaHMX1-encoded haem oxygenase","volume":"149","author":"Santos","year":"2003","journal-title":"Microbiology"},{"key":"key\n\t\t\t\t20170511122328_JIT029C30","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/genetics\/156.1.31","article-title":"Identification and characterization of TUP1-regulated genes in Candida albicans","volume":"156","author":"Braun","year":"2000","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170511122328_JIT029C31","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.288.5468.1062","article-title":"A high-affinity iron permease essential for Candida albicans virulence","volume":"288","author":"Ramanan","year":"2000","journal-title":"Science"},{"key":"key\n\t\t\t\t20170511122328_JIT029C32","doi-asserted-by":"crossref","first-page":"research0047.1","DOI":"10.1186\/gb-2002-3-9-research0047","article-title":"NEAT: a domain duplicated in genes near the components of a putative Fe3+ siderophore transporter from Gram-positive pathogenic bacteria","volume":"3","author":"Andrade","year":"2002","journal-title":"Genome Biol"},{"key":"key\n\t\t\t\t20170511122328_JIT029C33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-2958.2006.05502.x","article-title":"Haem recognition by a Staphylococus aureus NEAT domain","volume":"63","author":"Grigg","year":"2007","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170511122328_JIT029C34","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/0003-2697(82)90475-4","article-title":"Affinity chromatography of heme-binding proteins: an improved method for the synthesis of hemin-agarose","volume":"121","author":"Tsutsui","year":"1982","journal-title":"Anal Biochem"},{"key":"key\n\t\t\t\t20170511122328_JIT029C35","doi-asserted-by":"crossref","first-page":"e1000132","DOI":"10.1371\/journal.ppat.1000132","article-title":"Bacillus anthracis secretes proteins that mediate heme acquisition from hemoglobin","volume":"4","author":"Maresso","year":"2008","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20170511122328_JIT029C36","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1111\/j.1365-2958.2004.04350.x","article-title":"Transcriptional profiling in Candida albicans reveals new adaptive responses to extracellular pH and functions for Rim101p","volume":"54","author":"Bensen","year":"2004","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170511122328_JIT029C37","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1111\/j.1462-5822.2008.01198.x","article-title":"Candida albicans transcription factor Rim101 mediates pathogenic interactions through cell wall functions","volume":"10","author":"Nobile","year":"2008","journal-title":"Cell Microbiol"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/207\/8\/1339\/16867761\/jit029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T01:45:51Z","timestamp":1644111951000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jit029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,15]]},"references-count":37,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,1,15]]},"published-print":{"date-parts":[[2013,4,15]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jit029","relation":{},"ISSN":["1537-6613","0022-1899"],"issn-type":[{"value":"1537-6613","type":"electronic"},{"value":"0022-1899","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1,15]]}}}