{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:46:46Z","timestamp":1791406006183,"version":"4.3.3"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6,1]]},"DOI":"10.1093\/infdis\/jit123","type":"journal-article","created":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T05:07:44Z","timestamp":1364360864000},"page":"1743-1752","source":"Crossref","is-referenced-by-count":194,"title":["Differential Cell Line Susceptibility to the Emerging Novel Human Betacoronavirus 2c EMC\/2012: Implications for Disease Pathogenesis and Clinical Manifestation"],"prefix":"10.1093","volume":"207","author":[{"given":"Jasper Fuk-Woo","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok-Hung","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garnet Kwan-Yue","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin Kai-Wang","family":"To","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Tse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Piao","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Lung","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent Chi-Chung","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yan","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna Kar-Pui","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick Chiu-Yat","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok-Yung","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,3,26]]},"reference":[{"key":"key\n\t\t\t\t20170702133744_JIT123C1","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3181\/0903-MR-94","article-title":"Coronavirus diversity, phylogeny and interspecies jumping","volume":"234","author":"Woo","year":"2009","journal-title":"Exp Biol Med (Maywood)"},{"key":"key\n\t\t\t\t20170702133744_JIT123C2","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0140-6736(66)92364-6","article-title":"Cultivation of viruses from a high proportion of patients with colds","volume":"1","author":"Tyrrell","year":"1966","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702133744_JIT123C3","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3181\/00379727-121-30734","article-title":"A new virus isolated from the human respiratory tract","volume":"121","author":"Hamre","year":"1966","journal-title":"Proc Soc Exp Biol Med"},{"key":"key\n\t\t\t\t20170702133744_JIT123C4","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1056\/NEJMra032498","article-title":"The severe acute respiratory syndrome","volume":"349","author":"Peiris","year":"2003","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170702133744_JIT123C5","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0140-6736(03)13077-2","article-title":"Coronavirus as a possible cause of severe acute respiratory syndrome","volume":"361","author":"Peiris","year":"2003","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702133744_JIT123C6","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/423240a","article-title":"Aetiology: Koch's postulates fulfilled for SARS virus","volume":"423","author":"Fouchier","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170702133744_JIT123C7","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1056\/NEJMoa030781","article-title":"A novel coronavirus associated with severe acute respiratory syndrome","volume":"348","author":"Ksiazek","year":"2003","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170702133744_JIT123C8","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1056\/NEJMoa030747","article-title":"Identification of a novel coronavirus in patients with severe acute respiratory syndrome","volume":"347","author":"Drosten","year":"2003","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170702133744_JIT123C9","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1128\/CMR.00023-07","article-title":"Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection","volume":"20","author":"Cheng","year":"2007","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20170702133744_JIT123C10","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0140-6736(04)15729-2","article-title":"Relative rates of non-pneumonic SARS coronavirus infection and SARS coronavirus pneumonia","volume":"363","author":"Woo","year":"2004","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702133744_JIT123C11","doi-asserted-by":"crossref","first-page":"6212","DOI":"10.1073\/pnas.0400762101","article-title":"A previously undescribed coronavirus associated with respiratory disease in humans","volume":"101","author":"Fouchier","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170702133744_JIT123C12","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nm1024","article-title":"Identification of a new human coronavirus","volume":"10","author":"van der Hoek","year":"2004","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170702133744_JIT123C13","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1128\/JVI.79.2.884-895.2005","article-title":"Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia","volume":"79","author":"Woo","year":"2005","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170702133744_JIT123C14","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jinf.2012.10.002","article-title":"Is the discovery of the novel human betacoronavirus 2c EMC\/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?","volume":"65","author":"Chan","year":"2012","journal-title":"J Infect."},{"key":"key\n\t\t\t\t20170702133744_JIT123C15","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1056\/NEJMoa1211721","article-title":"Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia","volume":"367","author":"Zaki","year":"2012","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170702133744_JIT123C16","doi-asserted-by":"crossref","DOI":"10.2807\/ese.17.40.20290-en","article-title":"Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012","volume":"17","author":"Bermingham","year":"2012","journal-title":"Euro Surveill"},{"key":"key\n\t\t\t\t20170702133744_JIT123C17","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1038\/emi.2012.45","article-title":"Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5","volume":"1","author":"Woo","year":"2012","journal-title":"Emerg Microbes Infect"},{"key":"key\n\t\t\t\t20170702133744_JIT123C18","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00473-12","article-title":"Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans","volume":"3","author":"van Boheemen","year":"2012","journal-title":"MBio"},{"key":"key\n\t\t\t\t20170702133744_JIT123C19","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1128\/JVI.02182-06","article-title":"Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features","volume":"81","author":"Woo","year":"2007","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170702133744_JIT123C20","author":"World Health Organization","journal-title":"Global alert and response: novel coronavirus infection\u2014update"},{"key":"key\n\t\t\t\t20170702133744_JIT123C21","article-title":"Novel coronavirus\u2014Saudi Arabia (12): request for information","author":"ProMED-mail"},{"key":"key\n\t\t\t\t20170702133744_JIT123C22","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0140-6736(98)01182-9","article-title":"Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus","volume":"351","author":"Yuen","year":"1998","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702133744_JIT123C23","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1056\/NEJMra052211","article-title":"Avian influenza A (H5N1) infection in humans","volume":"353","author":"Beigel","year":"2005","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170702133744_JIT123C24","doi-asserted-by":"crossref","first-page":"8091","DOI":"10.1073\/pnas.0711942105","article-title":"Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A\/H5N1 virus","volume":"105","author":"Zheng","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170702133744_JIT123C25","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jcv.2009.09.013","article-title":"Differential susceptibility of different cell lines to swine-origin influenza A H1N1, seasonal human influenza A H1N1, and avian influenza A H5N1 viruses","volume":"46","author":"Li","year":"2009","journal-title":"J Clin Virol"},{"key":"key\n\t\t\t\t20170702133744_JIT123C26","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1136\/pgmj.2009.096206","article-title":"Concurrent comparison of epidemiology, clinical presentation and outcome between adult patients suffering from the pandemic influenza A (H1N1) 2009 virus and the seasonal influenza A virus infection","volume":"86","author":"To","year":"2010","journal-title":"Postgrad Med J"},{"key":"key\n\t\t\t\t20170702133744_JIT123C27","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1073\/pnas.1119972109","article-title":"Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats","volume":"109","author":"Woo","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170702133744_JIT123C28","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/1743-422X-5-138","article-title":"Plaque assay for human coronavirus NL63 using human colon carcinoma cells","volume":"5","author":"Herzog","year":"2008","journal-title":"Virol J"},{"key":"key\n\t\t\t\t20170702133744_JIT123C29","doi-asserted-by":"crossref","first-page":"11255","DOI":"10.1128\/JVI.00947-10","article-title":"Culturing the unculturable: human coronavirus HKU1 infects, replicates, and produces progeny virions in human ciliated airway epithelial cell cultures","volume":"84","author":"Pyrc","year":"2010","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170702133744_JIT123C30","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1084\/jem.20070462","article-title":"A novel subset of putative stem\/progenitor CD34+Oct-4+ cells is the major target for SARS coronavirus in human lung","volume":"204","author":"Chen","year":"2007","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170702133744_JIT123C31","doi-asserted-by":"crossref","first-page":"9530","DOI":"10.1073\/pnas.0510232103","article-title":"Identification of pulmonary Oct-4+ stem\/progenitor cells and demonstration of their susceptibility to SARS coronavirus (SARS-CoV) infection in vitro","volume":"103","author":"Ling","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170702133744_JIT123C32","doi-asserted-by":"crossref","first-page":"e8729","DOI":"10.1371\/journal.pone.0008729","article-title":"Dynamic innate immune responses of human bronchial epithelial cells to severe acute respiratory syndrome-associated coronavirus infection","volume":"5","author":"Yoshikawa","year":"2010","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170702133744_JIT123C33","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1165\/ajrcmb.20.3.3383","article-title":"Respiratory carcinoma cell lines. MUC genes and glycoconjugates","volume":"20","author":"Berger","year":"1999","journal-title":"Am J respire Cell Mol Biol"},{"key":"key\n\t\t\t\t20170702133744_JIT123C34","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1086\/497151","article-title":"Clinical and molecular epidemiological features of coronavirus HKU1-associated community-acquired pneumonia","volume":"192","author":"Woo","year":"2005","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702133744_JIT123C35","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1128\/JCM.02614-05","article-title":"Coronavirus HKU1 and other coronavirus infections in Hong Kong","volume":"44","author":"Lau","year":"2006","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20170702133744_JIT123C36","doi-asserted-by":"crossref","first-page":"6180","DOI":"10.1128\/JVI.79.10.6180-6193.2005","article-title":"Comparative host gene transcription by microarray analysis early after infection of the Huh7 cell line by severe acute respiratory syndrome coronavirus and human coronavirus 229E","volume":"79","author":"Tang","year":"2005","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170702133744_JIT123C37","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/357420a0","article-title":"Human aminopeptidase N is a receptor for human coronavirus 229E","volume":"357","author":"Yeager","year":"1992","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170702133744_JIT123C38","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1099\/vir.0.038414-0","article-title":"Infection of human alveolar macrophages by human coronavirus strain 229E","volume":"93","author":"Funk","year":"2012","journal-title":"J Gen Virol"},{"key":"key\n\t\t\t\t20170702133744_JIT123C39","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1128\/JVI.73.4.3326-3337.1999","article-title":"Persistent infection of human oligodendrocytic and neuroglial cell lines by human coronavirus 229E","volume":"73","author":"Arbour","year":"1999","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170702133744_JIT123C40","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1128\/JVI.73.4.3338-3350.1999","article-title":"Acute and persistent infection of human neural cell lines by human coronavirus OC43","volume":"73","author":"Arbour","year":"1999","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170702133744_JIT123C41","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3201\/eid1201.050496","article-title":"SARS\u2013associated coronavirus replication in cell lines","volume":"12","author":"Kaye","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20170702133744_JIT123C42","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1086\/382681","article-title":"Viral replication in the nasopharynx is associated with diarrhea in patients with severe acute respiratory syndrome","volume":"38","author":"Cheng","year":"2004","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170702133744_JIT123C43","doi-asserted-by":"crossref","first-page":"e00515","DOI":"10.1128\/mBio.00515-12","article-title":"Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines","volume":"3","author":"M\u00fcller","year":"2012","journal-title":"MBio"},{"key":"key\n\t\t\t\t20170702133744_JIT123C44","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/j.1523-1755.2005.67130.x","article-title":"Acute renal impairment in coronavirus-associated severe acute respiratory syndrome","volume":"67","author":"Chu","year":"2005","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20170702133744_JIT123C45","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1637\/0005-2086(2002)046[0847:NIBIPC]2.0.CO;2","article-title":"Nephropathogenic infectious bronchitis in Pennsylvania chickens 1997\u20132000","volume":"45","author":"Ziegler","year":"2002","journal-title":"Avian Dis"},{"key":"key\n\t\t\t\t20170702133744_JIT123C46","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.3201\/eid1009.040058","article-title":"Viral loads in clinical specimens and SARS manifestations","volume":"10","author":"Hung","year":"2004","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20170702133744_JIT123C47","doi-asserted-by":"crossref","first-page":"14040","DOI":"10.1073\/pnas.0506735102","article-title":"Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats","volume":"102","author":"Lau","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170702133744_JIT123C48","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1128\/JVI.01977-08","article-title":"Comparative analysis of complete genome sequences of three avian coronaviruses reveals a novel group 3c coronavirus","volume":"83","author":"Woo","year":"2009","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170702133744_JIT123C49","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1128\/JVI.06540-11","article-title":"Discovery of seven novel mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltavoronavirus","volume":"86","author":"Woo","year":"2012","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170702133744_JIT123C50","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1128\/JVI.06927-11","article-title":"Isolation and characterization of a novel betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits","volume":"86","author":"Lau","year":"2012","journal-title":"J Virol"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/207\/11\/1743\/18068093\/jit123.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T13:17:20Z","timestamp":1644671840000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jit123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,26]]},"references-count":50,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,3,26]]},"published-print":{"date-parts":[[2013,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jit123","relation":{},"ISSN":["1537-6613","0022-1899"],"issn-type":[{"value":"1537-6613","type":"electronic"},{"value":"0022-1899","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3,26]]}}}