{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:05:48Z","timestamp":1792674348269,"version":"4.5.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,15]]},"DOI":"10.1093\/infdis\/jit301","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T20:13:52Z","timestamp":1373400832000},"page":"1590-1597","source":"Crossref","is-referenced-by-count":66,"title":["Meningococcal Interaction to Microvasculature Triggers the Tissular Lesions of Purpura Fulminans"],"prefix":"10.1093","volume":"208","author":[{"given":"Olivier","family":"Join-Lambert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Lecuyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Lelievre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Jamet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Furio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Pelissier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Fraitag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Coureuil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Nassif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,7,9]]},"reference":[{"key":"key\n\t\t\t\t20170425160713_JIT301C1","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/S0140-6736(07)61016-2","article-title":"Epidemic meningitis, meningococcaemia, and Neisseria meningitidis","volume":"369","author":"Stephens","year":"2007","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170425160713_JIT301C2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-1-61779-346-2_2","article-title":"Classification and pathogenesis of meningococcal infections","volume":"799","author":"Brandtzaeg","year":"2012","journal-title":"Methods Mol Biol"},{"key":"key\n\t\t\t\t20170425160713_JIT301C3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0190-9622(97)70105-1","article-title":"Purpura in infants and children","volume":"37","author":"Baselga","year":"1997","journal-title":"J Am Acad Dermatol"},{"key":"key\n\t\t\t\t20170425160713_JIT301C4","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1136\/adc.66.4.485","article-title":"Features and outcome in meningococcal disease presenting with maculopapular rash","volume":"66","author":"Marzouk","year":"1991","journal-title":"Arch Dis Child"},{"key":"key\n\t\t\t\t20170425160713_JIT301C5","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/S0140-6736(88)91981-2","article-title":"Meningococcal rash","volume":"1","author":"Baxter","year":"1988","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170425160713_JIT301C6","first-page":"27","article-title":"Clinical, histopathologic & immunologic features of cutaneous lesions in acute meningococcaemia","volume":"91","author":"Ramesh","year":"1990","journal-title":"Indian J Med Res"},{"key":"key\n\t\t\t\t20170425160713_JIT301C7","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1128\/CMR.13.1.144-166.2000","article-title":"Update on meningococcal disease with emphasis on pathogenesis and clinical management","volume":"13","author":"van Deuren","year":"2000","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20170425160713_JIT301C8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1128\/MMBR.46.2.162-190.1982","article-title":"The meningococcus and mechanisms of pathogenicity","volume":"46","author":"DeVoe","year":"1982","journal-title":"Microbiol Rev"},{"key":"key\n\t\t\t\t20170425160713_JIT301C9","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1086\/514124","article-title":"Interaction of Neisseria meningitidis with the components of the blood-brain barrier correlates with an increased expression of PilC","volume":"176","author":"Pron","year":"1997","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425160713_JIT301C10","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/infdis\/133.5.506","article-title":"Pathogenesis of cutaneous lesions in acute meningococcemia in humans: light, immunofluorescent, and electron microscopic studies of skin biopsy specimens","volume":"133","author":"Sotto","year":"1976","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425160713_JIT301C11","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1093\/cid\/cis120","article-title":"Chronic meningococcemia cutaneous lesions involve meningococcal perivascular invasion through the remodeling of endothelial barriers","volume":"54","author":"Dupin","year":"2012","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170425160713_JIT301C12","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1128\/IAI.70.9.5193-5201.2002","article-title":"Analysis of pathogen-host cell interactions in purpura fulminans: expression of capsule, type IV pili, and PorA by Neisseria meningitidis in vivo","volume":"70","author":"Harrison","year":"2002","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170425160713_JIT301C13","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1001\/jama.1947.02880230023006","article-title":"The cutaneous lesions in acute meningococcemia; a clinical and pathologic study","volume":"134","author":"Hill","year":"1947","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20170425160713_JIT301C14","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1084\/jem.20060482","article-title":"Cerebral microcirculation shear stress levels determine Neisseria meningitidis attachment sites along the blood-brain barrier","volume":"203","author":"Mairey","year":"2006","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170425160713_JIT301C15","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1159\/000094054","article-title":"Type IV pilin structures: insights on shared architecture, fiber assembly, receptor binding and type II secretion","volume":"11","author":"Hansen","year":"2006","journal-title":"J Mol Microbiol Biotechnol"},{"key":"key\n\t\t\t\t20170425160713_JIT301C16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1128\/IAI.05837-11","article-title":"Two strikingly different signaling pathways are induced by meningococcal type IV pili on endothelial and epithelial cells","volume":"80","author":"Lecuyer","year":"2012","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170425160713_JIT301C17","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1242\/jcs.115.6.1231","article-title":"Microvilli-like structures are associated with the internalization of virulent capsulated Neisseria meningitidis into vascular endothelial cells","volume":"115","author":"Eugene","year":"2002","journal-title":"J Cell Sci"},{"key":"key\n\t\t\t\t20170425160713_JIT301C18","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1046\/j.1365-2958.1999.01459.x","article-title":"Type IV pili of pathogenic Neisseriae elicit cortical plaque formation in epithelial cells","volume":"32","author":"Merz","year":"1999","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170425160713_JIT301C19","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1365-2958.1992.tb01505.x","article-title":"Tumour necrosis factor alpha antibody protects against lethal meningococcaemia","volume":"6","author":"Nassif","year":"1992","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170425160713_JIT301C20","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1128\/IAI.05604-11","article-title":"Enhanced bacteremia in human factor H transgenic rats infected by Neisseria meningitidis","volume":"80","author":"Vu","year":"2012","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170425160713_JIT301C21","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1128\/IAI.24.2.545-551.1979","article-title":"Neisseria meningitidis infection in mice: influence of iron, variations in virulence among strains, and pathology","volume":"24","author":"Holbein","year":"1979","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170425160713_JIT301C22","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1172\/JCI116320","article-title":"Human\/severe combined immunodeficient mouse chimeras. An experimental in vivo model system to study the regulation of human endothelial cell-leukocyte adhesion molecules","volume":"91","author":"Yan","year":"1993","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170425160713_JIT301C23","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1365-2958.1993.tb01615.x","article-title":"Antigenic variation of pilin regulates adhesion of Neisseria meningitidis to human epithelial cells","volume":"8","author":"Nassif","year":"1993","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170425160713_JIT301C24","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/1523-1747.ep12475646","article-title":"New techniques for the grafting of cultured human epidermal cells onto athymic animals","volume":"91","author":"Barrandon","year":"1988","journal-title":"J Invest Dermatol"},{"key":"key\n\t\t\t\t20170425160713_JIT301C25","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1128\/IAI.25.3.880-890.1979","article-title":"Inhibition of the growth of Neisseria meningitidis by reduced ferritin and other iron-binding agents","volume":"25","author":"Calver","year":"1979","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170425160713_JIT301C26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1128\/IAI.36.1.107-113.1982","article-title":"Expression of a high-affinity mechanism for acquisition of transferrin iron by Neisseria meningitidis","volume":"36","author":"Simonson","year":"1982","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170425160713_JIT301C27","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1128\/iai.29.3.886-891.1980","article-title":"Iron-controlled infection with Neisseria meningitidis in mice","volume":"29","author":"Holbein","year":"1980","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170425160713_JIT301C28","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1128\/IAI.34.1.120-125.1981","article-title":"Enhancement of Neisseria meningitidis infection in mice by addition of iron bound to transferrin","volume":"34","author":"Holbein","year":"1981","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170425160713_JIT301C29","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1099\/0022-1317-50-10-847","article-title":"Cytokines, chemokines and other effector molecules involved in meningococcal disease","volume":"50","author":"Hackett","year":"2001","journal-title":"J Med Microbiol"},{"key":"key\n\t\t\t\t20170425160713_JIT301C30","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1128\/JCM.42.7.2980-2987.2004","article-title":"Use of robotized DNA isolation and real-time PCR to quantify and identify close correlation between levels of Neisseria meningitidis DNA and lipopolysaccharides in plasma and cerebrospinal fluid from patients with systemic meningococcal disease","volume":"42","author":"Ovstebo","year":"2004","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20170425160713_JIT301C31","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/0002-9343(69)90093-X","article-title":"Fatal intravascular consumption coagulopathy in meningococcal sepsis","volume":"46","author":"Evans","year":"1969","journal-title":"Am J Med"},{"key":"key\n\t\t\t\t20170425160713_JIT301C32","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1111\/j.1365-2958.1991.tb00807.x","article-title":"The role of pili in the interactions of pathogenic Neisseria with cultured human endothelial cells","volume":"5","author":"Virji","year":"1991","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170425160713_JIT301C33","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0378-1119(96)00802-5","article-title":"Type-4 pili and meningococcal adhesiveness","volume":"192","author":"Nassif","year":"1997","journal-title":"Gene"},{"key":"key\n\t\t\t\t20170425160713_JIT301C34","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1111\/j.1365-2958.1992.tb00848.x","article-title":"Variations in the expression of pili: the effect on adherence of Neisseria meningitidis to human epithelial and endothelial cells","volume":"6","author":"Virji","year":"1992","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170425160713_JIT301C35","first-page":"28","article-title":"Experimental study of purpuric meningococcemia in relation to the Shwartzmann phenomenon; with discussion of meningococcic purpura, the Waterhouse-Friderichsen syndrome and bilateral renal cortical necrosis","volume":"43","author":"Black-Schaffer","year":"1947","journal-title":"Arch Pathol"},{"key":"key\n\t\t\t\t20170425160713_JIT301C36","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1084\/jem.93.1.49","article-title":"Studies on the mechanism of the Shwartzman-phenomenon; evidence for the participation of polymorphonuclear leucocytes in the phenomenon","volume":"93","author":"Stetson","year":"1951","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170425160713_JIT301C37","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1083\/jcb.200507128","article-title":"Neisseria meningitidis infection of human endothelial cells interferes with leukocyte transmigration by preventing the formation of endothelial docking structures","volume":"173","author":"Doulet","year":"2006","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170425160713_JIT301C38","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1086\/338269","article-title":"Complement activation induced by purified Neisseria meningitidis lipopolysaccharide (LPS), outer membrane vesicles, whole bacteria, and an LPS-free mutant","volume":"185","author":"Bjerre","year":"2002","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425160713_JIT301C39","first-page":"401","article-title":"Neisseria meningitidis lipopolysaccharides in human pathology","volume":"7","author":"Brandtzaeg","year":"2001","journal-title":"J Endotoxin Res"},{"key":"key\n\t\t\t\t20170425160713_JIT301C40","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0882-4010(95)90085-3","article-title":"Investigations into the molecular basis of meningococcal toxicity for human endothelial and epithelial cells: the synergistic effect of LPS and pili","volume":"18","author":"Dunn","year":"1995","journal-title":"Microb Pathog"},{"key":"key\n\t\t\t\t20170425160713_JIT301C41","doi-asserted-by":"crossref","first-page":"e1000874","DOI":"10.1371\/journal.ppat.1000874","article-title":"Neisseria meningitidis induces brain microvascular endothelial cell detachment from the matrix and cleavage of occludin: a role for MMP-8","volume":"6","author":"Schubert-Unkmeir","year":"2010","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20170425160713_JIT301C42","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1006\/mpat.1996.0112","article-title":"Induction of human endothelial tissue factor expression by Neisseria meningitidis: the influence of bacterial killing and adherence to the endothelium","volume":"22","author":"Heyderman","year":"1997","journal-title":"Microb Pathog"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/208\/10\/1590\/13803923\/jit301.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T19:29:05Z","timestamp":1645990145000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jit301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,9]]},"references-count":42,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,7,9]]},"published-print":{"date-parts":[[2013,11,15]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jit301","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727797216.793534151","asserted-by":"object"}]},"ISSN":["1537-6613","0022-1899"],"issn-type":[{"value":"1537-6613","type":"electronic"},{"value":"0022-1899","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7,9]]}}}