{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:29:06Z","timestamp":1791332946170,"version":"4.3.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"suppl_2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,15]]},"DOI":"10.1093\/infdis\/jit319","type":"journal-article","created":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T15:54:51Z","timestamp":1382457291000},"page":"S125-S130","source":"Crossref","is-referenced-by-count":138,"title":["Overcoming Current Limitations in Humanized Mouse Research"],"prefix":"10.1093","volume":"208","author":[{"given":"Michael A.","family":"Brehm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard D.","family":"Shultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Luban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale L.","family":"Greiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,11,15]]},"reference":[{"key":"key\n\t\t\t\t20170425160739_JIT319C1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/301527a0","article-title":"A severe combined immunodeficiency mutation in the mouse","volume":"301","author":"Bosma","year":"1983","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170425160739_JIT319C2","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1126\/science.2971269","article-title":"The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function","volume":"241","author":"McCune","year":"1988","journal-title":"Science"},{"key":"key\n\t\t\t\t20170425160739_JIT319C3","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/335256a0","article-title":"Transfer of a functional human immune system to mice with severe combined immunodeficiency","volume":"335","author":"Mosier","year":"1988","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170425160739_JIT319C4","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1742-4690-6-76","article-title":"The utilization of humanized mouse models for the study of human retroviral infections","volume":"6","author":"Van","year":"2009","journal-title":"Retrovirology"},{"key":"key\n\t\t\t\t20170425160739_JIT319C5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11427-010-0059-7","article-title":"Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis","volume":"53","author":"Zhang","year":"2010","journal-title":"Sci China Life Sci"},{"key":"key\n\t\t\t\t20170425160739_JIT319C6","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nri3311","article-title":"Humanized mice for immune system investigation: progress, promise and challenges","volume":"12","author":"Shultz","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C7","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nri2017","article-title":"Humanized mice in translational biomedical research","volume":"7","author":"Shultz","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C8","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1146\/annurev-immunol-032712-095921","article-title":"Human hemato-lymphoid system mice: current use and future potential for medicine","volume":"31","author":"Rongvaux","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C9","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.1093933","article-title":"Development of a human adaptive immune system in cord blood cell-transplanted mice","volume":"304","author":"Traggiai","year":"2004","journal-title":"Science"},{"key":"key\n\t\t\t\t20170425160739_JIT319C10","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1182\/blood-2001-12-0207","article-title":"NOD\/SCID\/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells","volume":"100","author":"Ito","year":"2002","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170425160739_JIT319C11","doi-asserted-by":"crossref","first-page":"6477","DOI":"10.4049\/jimmunol.174.10.6477","article-title":"Human lymphoid and myeloid cell development in NOD\/LtSz-scid IL2r\u03b3null mice engrafted with mobilized human hematopoietic stem cell","volume":"174","author":"Shultz","year":"2005","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C12","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nri2580","article-title":"New insights into the regulation of T cells by gamma(c) family cytokines","volume":"9","author":"Rochman","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C13","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.4049\/jimmunol.0901647","article-title":"The IL-7 signaling pathway regulates lymph node development independent of peripheral lymphocytes","volume":"184","author":"Chappaz","year":"2010","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C14","doi-asserted-by":"crossref","first-page":"15951","DOI":"10.1073\/pnas.0604493103","article-title":"Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-\/-gamma c-\/- mice","volume":"103","author":"Baenziger","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170425160739_JIT319C15","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/intimm\/dxp050","article-title":"The analysis of the functions of human B and T cells in humanized NOD\/shi-scid\/gammac(null) (NOG) mice (hu-HSC NOG mice)","volume":"21","author":"Watanabe","year":"2009","journal-title":"Int Immunol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C16","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.exphem.2006.05.006","article-title":"Development of human-human hybridoma from anti-Her-2 peptide-producing B cells in immunized NOG mouse","volume":"34","author":"Kametani","year":"2006","journal-title":"Exp Hematol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C17","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0301-472X(03)00193-0","article-title":"Functional CD5+ B cells develop predominantly in the spleen of NOD\/SCID\/gammac(null) (NOG) mice transplanted either with human umbilical cord blood, bone marrow, or mobilized peripheral blood CD34+ cells","volume":"31","author":"Matsumura","year":"2003","journal-title":"Exp Hematol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C18","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1365-2567.2012.03585.x","article-title":"Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice","volume":"136","author":"Jaiswal","year":"2012","journal-title":"Immunol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/intimm\/dxs045","article-title":"Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD\/Shi-scid\/gammacnull mouse","volume":"24","author":"Suzuki","year":"2012","journal-title":"Int Immunol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C20","doi-asserted-by":"crossref","first-page":"e19826","DOI":"10.1371\/journal.pone.0019826","article-title":"Expression of HLA class II molecules in humanized NOD.Rag1KO.IL2RgcKO mice is critical for development and function of human T and B cells","volume":"6","author":"Danner","year":"2011","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170425160739_JIT319C21","doi-asserted-by":"crossref","first-page":"5223","DOI":"10.4049\/jimmunol.1201789","article-title":"GM-CSF and IL-4 stimulate antibody responses in humanized mice by promoting T, B, and dendritic cell maturation","volume":"189","author":"Chen","year":"2012","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C22","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/nm1431","article-title":"Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1","volume":"12","author":"Melkus","year":"2006","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170425160739_JIT319C23","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1084\/jem.20062411","article-title":"Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1","volume":"204","author":"Sun","year":"2007","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170425160739_JIT319C24","doi-asserted-by":"crossref","first-page":"7582","DOI":"10.1128\/JVI.00537-11","article-title":"One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates","volume":"85","author":"Denton","year":"2011","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C25","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1371\/journal.pmed.0050016","article-title":"Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice","volume":"5","author":"Denton","year":"2008","journal-title":"PLoS Med"},{"key":"key\n\t\t\t\t20170425160739_JIT319C26","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.virol.2011.05.013","article-title":"Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2R \u03b3(-\/-) (NSG) BLT mice","volume":"417","author":"Stoddart","year":"2011","journal-title":"Virology"},{"key":"key\n\t\t\t\t20170425160739_JIT319C27","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/mi.2012.31","article-title":"IL-2 receptor \u03b3-chain molecule is critical for intestinal T-cell reconstitution in humanized mice","volume":"5","author":"Denton","year":"2012","journal-title":"Mucosal Immunol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C28","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1182\/blood-2012-04-422303","article-title":"Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice","volume":"120","author":"Hur","year":"2012","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170425160739_JIT319C29","doi-asserted-by":"crossref","first-page":"e1002732","DOI":"10.1371\/journal.ppat.1002732","article-title":"Human breast milk and antiretrovirals dramatically reduce oral HIV-1 transmission in BLT humanized mice","volume":"8","author":"Wahl","year":"2012","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20170425160739_JIT319C30","doi-asserted-by":"crossref","first-page":"e8829","DOI":"10.1371\/journal.pone.0008829","article-title":"Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice","volume":"5","author":"Denton","year":"2010","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170425160739_JIT319C31","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1172\/JCI45876","article-title":"Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras","volume":"121","author":"Wheeler","year":"2011","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170425160739_JIT319C32","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1128\/JVI.01777-12","article-title":"Inefficient vaginal transmission of tenofovir-resistant HIV-1","volume":"87","author":"Chateau","year":"2013","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C33","doi-asserted-by":"crossref","first-page":"e60024","DOI":"10.1371\/journal.pone.0060024","article-title":"Rectal transmission of transmitted\/founder HIV-1 is efficiently prevented by topical 1% tenofovir in BLT humanized mice","volume":"8","author":"Chateau","year":"2013","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170425160739_JIT319C34","doi-asserted-by":"crossref","first-page":"143ra98","DOI":"10.1126\/scitranslmed.3003984","article-title":"Rapid evolution of HIV-1 to functional CD8+ T cell responses in humanized BLT mice","volume":"4","author":"Dudek","year":"2012","journal-title":"Sci Transl Med"},{"key":"key\n\t\t\t\t20170425160739_JIT319C35","doi-asserted-by":"crossref","first-page":"e44664","DOI":"10.1371\/journal.pone.0044664","article-title":"Graft versus host disease in the bone marrow, liver and thymus humanized mouse model","volume":"7","author":"Greenblatt","year":"2012","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170425160739_JIT319C36","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1182\/blood-2005-02-0516","article-title":"Development of functional human blood and immune systems in NOD\/SCID\/IL2 receptor gamma chain null mice","volume":"106","author":"Ishikawa","year":"2005","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170425160739_JIT319C37","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.4049\/jimmunol.1103660","article-title":"Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD\/SCID\/IL2rgammaKO mice","volume":"188","author":"Tanaka","year":"2012","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C38","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1182\/blood-2010-12-326926","article-title":"Efficient differentiation and function of human macrophages in humanized CSF-1 mice","volume":"118","author":"Rathinam","year":"2011","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170425160739_JIT319C39","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1073\/pnas.1019682108","article-title":"Human IL-3\/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung","volume":"108","author":"Willinger","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170425160739_JIT319C40","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0301-472X(03)00076-6","article-title":"Regulation of human short-term repopulating cell (STRC) engraftment in NOD\/SCID mice by host CD122+ cells","volume":"31","author":"Shultz","year":"2003","journal-title":"Exp Hematol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C41","first-page":"173","article-title":"Use of NOD\/LtSz-scid\/scid mice in biomedical research","volume-title":"NOD mice and related strains: research applications in diabetes, AIDS, cancer and other diseases","author":"Greiner","year":"1998"},{"key":"key\n\t\t\t\t20170425160739_JIT319C42","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/stem.160166","article-title":"SCID mouse models of human stem cell engraftment","volume":"16","author":"Greiner","year":"1998","journal-title":"Stem Cells"},{"key":"key\n\t\t\t\t20170425160739_JIT319C43","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1006\/cimm.1996.0193","article-title":"Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL\/6J-scid mice and in C57BL\/6J-scid bg mice","volume":"171","author":"Christianson","year":"1996","journal-title":"Cell Immunol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C44","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4049\/jimmunol.154.1.180","article-title":"Multiple defects in innate and adaptive immunologic function in NOD\/LtSz-scid mice","volume":"154","author":"Shultz","year":"1995","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C45","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1182\/blood.V88.10.3731.bloodjournal88103731","article-title":"Phenotype and function of human hematopoietic cells engrafting immune-deficient CB17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells","volume":"88","author":"Pflumio","year":"1996","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170425160739_JIT319C46","first-page":"888","article-title":"Improved engraftment of human spleen cells in NOD\/LtSz-scid\/scid mice as compared with C.B-17-scid\/scid mice","volume":"146","author":"Greiner","year":"1995","journal-title":"Am J Path"},{"key":"key\n\t\t\t\t20170425160739_JIT319C47","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1093\/infdis\/172.4.974","article-title":"High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD\/LtSz-scid\/scid mice","volume":"172","author":"Hesselton","year":"1995","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425160739_JIT319C48","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2249.2009.03933.x","article-title":"Hu-PBL-NOD-scid IL2rgnull mouse model of xenogeneic graft-versus-host-like disease and the role of host MHC","volume":"157","author":"King","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C49","doi-asserted-by":"crossref","first-page":"518","DOI":"10.4049\/jimmunol.165.1.518","article-title":"Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice","volume":"165","author":"Wagar","year":"2000","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425160739_JIT319C50","doi-asserted-by":"crossref","first-page":"3886","DOI":"10.1182\/blood-2004-02-0656","article-title":"Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2\u2212\/\u2212 gammac\u2212\/\u2212 mice: functional inactivation of p53 in developing T cells","volume":"104","author":"Gimeno","year":"2004","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170425160739_JIT319C51"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/208\/suppl_2\/S125\/13803990\/jit319.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T13:31:35Z","timestamp":1688563895000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jit319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,15]]},"references-count":51,"journal-issue":{"issue":"suppl_2","published-online":{"date-parts":[[2013,11,15]]},"published-print":{"date-parts":[[2013,11,15]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jit319","relation":{},"ISSN":["1537-6613","0022-1899"],"issn-type":[{"value":"1537-6613","type":"electronic"},{"value":"0022-1899","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11,15]]}}}