{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:57:39Z","timestamp":1792501059219,"version":"4.5.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,1]]},"DOI":"10.1093\/infdis\/jit432","type":"journal-article","created":{"date-parts":[[2013,9,8]],"date-time":"2013-09-08T00:11:45Z","timestamp":1378599105000},"page":"457-467","source":"Crossref","is-referenced-by-count":58,"title":["Poly(I:C)-Induced Protection of Neonatal Mice Against Intestinal Cryptosporidium parvum Infection Requires an Additional TLR5 Signal Provided by the Gut Flora"],"prefix":"10.1093","volume":"209","author":[{"given":"Louis","family":"Lantier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Drouet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Guesdon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roselyne","family":"Mancassola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"Metton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Lo-Man","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Werts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Laurent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Lacroix-Lamand\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,9,6]]},"reference":[{"key":"key\n\t\t\t\t20170522121120_JIT432C1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nri2075","article-title":"Innate immunity of the newborn: basic mechanisms and clinical correlates","volume":"7","author":"Levy","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20170522121120_JIT432C2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri1394","article-title":"Neonatal adaptive immunity comes of age","volume":"4","author":"Adkins","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20170522121120_JIT432C3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1086\/376530","article-title":"Differences in participation of innate and adaptive immunity to respiratory syncytial virus in adults and neonates","volume":"188","author":"Krishnan","year":"2003","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170522121120_JIT432C4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cell.2004.07.002","article-title":"Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis","volume":"118","author":"Rakoff-Nahoum","year":"2004","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522121120_JIT432C5","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/86373","article-title":"Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria","volume":"2","author":"Rescigno","year":"2001","journal-title":"Nat Immunol"},{"key":"key\n\t\t\t\t20170522121120_JIT432C6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000060371","article-title":"Host immune responses against Cryptosporidium","volume":"6","author":"McDonald","year":"2000","journal-title":"Contrib Microbiol"},{"key":"key\n\t\t\t\t20170522121120_JIT432C7","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1128\/IAI.69.3.1635-1642.2001","article-title":"Cryptosporidium parvum\u2013specific mucosal immune response in C57BL\/6 neonatal and gamma interferon-deficient mice: role of tumor necrosis factor alpha in protection","volume":"69","author":"Lacroix","year":"2001","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170522121120_JIT432C8","doi-asserted-by":"crossref","first-page":"263","DOI":"10.4049\/jimmunol.156.1.263","article-title":"IL-12 protects immunocompetent and immunodeficient neonatal mice against infection with Cryptosporidium parvum","volume":"156","author":"Urban","year":"1996","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170522121120_JIT432C9","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1128\/IAI.00377-09","article-title":"Roles for NK cells and an NK cell\u2013independent source of intestinal gamma interferon for innate immunity to Cryptosporidium parvum infection","volume":"77","author":"Barakat","year":"2009","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170522121120_JIT432C10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1053\/gast.2001.20907","article-title":"Interferon gamma induces enterocyte resistance against infection by the intracellular pathogen Cryptosporidium parvum","volume":"120","author":"Pollok","year":"2001","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170522121120_JIT432C11","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1086\/644601","article-title":"Cryptosporidium parvum infection rapidly induces a protective innate immune response involving type I interferon","volume":"200","author":"Barakat","year":"2009","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170522121120_JIT432C12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1443.020","article-title":"Toll-like receptor and RIG-I-like receptor signaling","volume":"1143","author":"Kawai","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t20170522121120_JIT432C13","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1128\/IAI.70.4.2090-2099.2002","article-title":"Role of gamma interferon in chemokine expression in the ileum of mice and in a murine intestinal epithelial cell line after Cryptosporidium parvum infection","volume":"70","author":"Lacroix-Lamande","year":"2002","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170522121120_JIT432C14","doi-asserted-by":"crossref","first-page":"7528","DOI":"10.1073\/pnas.0800152105","article-title":"Hyper innate responses in neonates lead to increased morbidity and mortality after infection","volume":"105","author":"Zhao","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170522121120_JIT432C15","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1084\/jem.20091181","article-title":"Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells","volume":"206","author":"McCartney","year":"2009","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170522121120_JIT432C16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1074-7613(02)00365-5","article-title":"In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens","volume":"17","author":"Jung","year":"2002","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20170522121120_JIT432C17","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1128\/IAI.65.11.4761-4769.1997","article-title":"Profiles of healing and nonhealing Cryptosporidium parvum infection in C57BL\/6 mice with functional B and T lymphocytes: the extent of gamma interferon modulation determines the outcome of infection","volume":"65","author":"Theodos","year":"1997","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170522121120_JIT432C18","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1128\/IAI.62.10.4506-4514.1994","article-title":"Cryptosporidium parvum infection of Caco-2 cell monolayers induces an apical monolayer defect, selectively increases transmonolayer permeability, and causes epithelial cell death","volume":"62","author":"Griffiths","year":"1994","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170522121120_JIT432C19","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1086\/503748","article-title":"Oral and intraperitoneal administration of phosphorothioate oligodeoxynucleotides leads to control of Cryptosporidium parvum infection in neonatal mice","volume":"193","author":"Barrier","year":"2006","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170522121120_JIT432C20","doi-asserted-by":"crossref","first-page":"7967","DOI":"10.1128\/IAI.73.12.7967-7976.2005","article-title":"Synergistic effect of Nod1 and Nod2 agonists with Toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells","volume":"73","author":"Tada","year":"2005","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170522121120_JIT432C21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1297-9716-42-19","article-title":"Mesenteric lymph node cells from neonates present a prominent IL-12 response to CpG oligodeoxynucleotide via an IL-15 feedback loop of amplification","volume":"42","author":"Ferret-Bernard","year":"2011","journal-title":"Vet Res"},{"key":"key\n\t\t\t\t20170522121120_JIT432C22","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.dci.2008.03.011","article-title":"Neonatal goats display a stronger TH1-type cytokine response to TLR ligands than adults","volume":"32","author":"Tourais-Esteves","year":"2008","journal-title":"Dev Comp Immunol"},{"key":"key\n\t\t\t\t20170522121120_JIT432C23","doi-asserted-by":"crossref","first-page":"e8291","DOI":"10.1371\/journal.pone.0008291","article-title":"Neonate intestinal immune response to CpG oligodeoxynucleotide stimulation","volume":"4","author":"Lacroix-Lamande","year":"2009","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170522121120_JIT432C24","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/icb.2011.7","article-title":"A critical role for IL-15 in TLR-mediated innate antiviral immunity against genital HSV-2 infection","volume":"89","author":"Thatte","year":"2011","journal-title":"Immunol Cell Biol"},{"key":"key\n\t\t\t\t20170522121120_JIT432C25","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1084\/jem.20110547","article-title":"Host innate recognition of an intestinal bacterial pathogen induces TRIF-dependent protective immunity","volume":"208","author":"Sotolongo","year":"2011","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170522121120_JIT432C26","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1086\/425079","article-title":"Toll-like receptor (TLR)-3, but not TLR4, agonist protects against genital herpes infection in the absence of inflammation seen with CpG DNA","volume":"190","author":"Ashkar","year":"2004","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170522121120_JIT432C27","doi-asserted-by":"crossref","first-page":"e1002670","DOI":"10.1371\/journal.ppat.1002670","article-title":"Age-dependent TLR3 expression of the intestinal epithelium contributes to rotavirus susceptibility","volume":"8","author":"Pott","year":"2012","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20170522121120_JIT432C28","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.4049\/jimmunol.179.8.5425","article-title":"Activation of innate immune defense mechanisms by signaling through RIG-I\/IPS-1 in intestinal epithelial cells","volume":"179","author":"Hirata","year":"2007","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170522121120_JIT432C29","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.4049\/jimmunol.1002862","article-title":"RIG-I\/MDA5\/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epithelium","volume":"186","author":"Broquet","year":"2011","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170522121120_JIT432C30","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.micinf.2007.01.026","article-title":"Involvement of intestinal epithelial cells in dendritic cell recruitment during C. parvum infection","volume":"9","author":"Auray","year":"2007","journal-title":"Microbes Infect"},{"key":"key\n\t\t\t\t20170522121120_JIT432C31","doi-asserted-by":"crossref","first-page":"6287","DOI":"10.4049\/jimmunol.1004036","article-title":"A new subset of CD103+ CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity","volume":"186","author":"Fujimoto","year":"2011","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170522121120_JIT432C32","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1189\/jlb.0408228","article-title":"Release of IL-12 by dendritic cells activated by TLR ligation is dependent on MyD88 signaling, whereas TRIF signaling is indispensable for TLR synergy","volume":"88","author":"Krummen","year":"2010","journal-title":"J Leukoc Biol"},{"key":"key\n\t\t\t\t20170522121120_JIT432C33","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1002\/eji.200526286","article-title":"Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists","volume":"35","author":"Fritz","year":"2005","journal-title":"Eur J Immunol"},{"key":"key\n\t\t\t\t20170522121120_JIT432C34","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.4049\/jimmunol.167.4.1882","article-title":"Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression","volume":"167","author":"Gewirtz","year":"2001","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170522121120_JIT432C35","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/35074106","article-title":"The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5","volume":"410","author":"Hayashi","year":"2001","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522121120_JIT432C36","doi-asserted-by":"crossref","first-page":"e9125","DOI":"10.1371\/journal.pone.0009125","article-title":"The induction of colitis and ileitis in mice is associated with marked increases in intestinal concentrations of stimulants of TLRs 2, 4, and 5","volume":"5","author":"Erridge","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170522121120_JIT432C37","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1097\/MPG.0b013e31815ce599","article-title":"Molecular studies of fecal anaerobic commensal bacteria in acute diarrhea in children","volume":"46","author":"Balamurugan","year":"2008","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"key\n\t\t\t\t20170522121120_JIT432C38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1574-6941.2008.00604.x","article-title":"Pattern extraction of structural responses of gut microbiota to rotavirus infection via multivariate statistical analysis of clone library data","volume":"70","author":"Zhang","year":"2009","journal-title":"FEMS Microbiol Ecol"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/209\/3\/457\/17409809\/jit432.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T11:17:39Z","timestamp":1688469459000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jit432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,6]]},"references-count":38,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,9,6]]},"published-print":{"date-parts":[[2014,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jit432","relation":{},"ISSN":["1537-6613","0022-1899"],"issn-type":[{"value":"1537-6613","type":"electronic"},{"value":"0022-1899","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9,6]]}}}