{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:30:24Z","timestamp":1791192624029,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,5,1]]},"DOI":"10.1093\/infdis\/jit593","type":"journal-article","created":{"date-parts":[[2013,11,12]],"date-time":"2013-11-12T01:55:03Z","timestamp":1384221303000},"page":"1418-1428","source":"Crossref","is-referenced-by-count":14,"title":["Haemophilus influenzae Resides in Tonsils and Uses Immunoglobulin D Binding as an Evasion Strategy"],"prefix":"10.1093","volume":"209","author":[{"given":"Kalpana","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ther\u00e9se","family":"Nordstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"M\u00f6rgelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Brant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars-Olaf","family":"Cardell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Riesbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,11,11]]},"reference":[{"key":"key\n\t\t\t\t20170425161130_JIT593C1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/INF.0b013e318184dba2","article-title":"Nontypeable Haemophilus influenzae as a pathogen in children","volume":"28","author":"Murphy","year":"2009","journal-title":"Pediatr Infect Dis J"},{"key":"key\n\t\t\t\t20170425161130_JIT593C2","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1056\/NEJMra0800353","article-title":"Infection in the pathogenesis and course of chronic obstructive pulmonary disease","volume":"359","author":"Sethi","year":"2008","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170425161130_JIT593C3","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/infdis\/172.1.132","article-title":"Epidemiology of nasopharyngeal colonization with nontypeable Haemophilus influenzae in the first 2 years of life","volume":"172","author":"Faden","year":"1995","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425161130_JIT593C4","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1001\/jama.287.13.1699","article-title":"Nontypeable Haemophilus influenzae in carriage and disease: a difference in IgA1 protease activity levels","volume":"287","author":"Vitovski","year":"2002","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20170425161130_JIT593C5","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.tim.2010.03.007","article-title":"Haemophilus influenzae and the complement system","volume":"18","author":"Hallstrom","year":"2010","journal-title":"Trends Microbiol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1365-2958.2011.07678.x","article-title":"Haemophilus influenzae protein E recognizes the C-terminal domain of vitronectin and modulates the membrane attack complex","volume":"81","author":"Singh","year":"2011","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C7","doi-asserted-by":"crossref","first-page":"6316","DOI":"10.4049\/jimmunol.178.10.6316","article-title":"Characterization of the IgD binding site of encapsulated Haemophilus influenzae serotype b","volume":"178","author":"Samuelsson","year":"2007","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C8","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.4049\/jimmunol.167.4.2112","article-title":"Isolation and characterization of a novel IgD-binding protein from Moraxella catarrhalis","volume":"167","author":"Forsgren","year":"2001","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C9","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.4049\/jimmunol.140.4.1194","article-title":"Protein L. A novel bacterial cell wall protein with affinity for Ig L chains","volume":"140","author":"Bjorck","year":"1988","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1365-3083.1985.tb01414.x","article-title":"Non-immune IgG F(ab\u2019)2 binding to group C and G streptococci is mediated by structures on gamma chains","volume":"21","author":"Erntell","year":"1985","journal-title":"Scand J Immunol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C11","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1084\/jem.178.1.331","article-title":"The structural basis of germline-encoded VH3 immunoglobulin binding to staphylococcal protein A","volume":"178","author":"Hillson","year":"1993","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170425161130_JIT593C12","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1189\/jlb.1107788","article-title":"Moraxella catarrhalis-dependent tonsillar B cell activation does not lead to apoptosis but to vigorous proliferation resulting in nonspecific IgM production","volume":"83","author":"Jendholm","year":"2008","journal-title":"J Leukoc Biol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C13","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1615\/CritRevImmunol.v26.i4.40","article-title":"Structure and immunological action of the human pathogen Moraxella catarrhalis IgD-binding protein","volume":"26","author":"Riesbeck","year":"2006","journal-title":"Crit Rev Immunol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C14","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.4049\/jimmunol.0803032","article-title":"Superantigen- and TLR-dependent activation of tonsillar B cells after receptor-mediated endocytosis","volume":"182","author":"Jendholm","year":"2009","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C15","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.4049\/jimmunol.178.5.2803","article-title":"Staphylococcus aureus protein A triggers T cell-independent B cell proliferation by sensitizing B cells for TLR2 ligands","volume":"178","author":"Bekeredjian-Ding","year":"2007","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C16","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat Immunol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C17","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170425161130_JIT593C18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s004290100210","article-title":"Morphology and immunology of the human palatine tonsil","volume":"204","author":"Nave","year":"2001","journal-title":"Anat Embryol (Berl)"},{"issue":"suppl 1","key":"key\n\t\t\t\t20170425161130_JIT593C19","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/j.ijporl.2003.08.018","article-title":"Immunology of tonsils and adenoids: everything the ENT surgeon needs to know","volume":"67","author":"Brandtzaeg","year":"2003","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C20","first-page":"64","article-title":"Immunology and immunopathology of tonsils","volume":"47","author":"Brandtzaeg","year":"1992","journal-title":"Adv Otorhinolaryngol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C21","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1017\/S002221510011624X","article-title":"High recovery of Haemophilus influenzae and group A streptococci in recurrent tonsillar infection or hypertrophy as compared with normal tonsils","volume":"105","author":"Stjernquist-Desatnik","year":"1991","journal-title":"J Laryngol Otol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C22","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1080\/00016480310000395","article-title":"Does the tonsillar surface flora differ in children with and without tonsillar disease?","volume":"123","author":"Van Staaij","year":"2003","journal-title":"Acta Otolaryngol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C23","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1288\/00005537-198810000-00006","article-title":"The role of Haemophilus influenzae in the pathogenesis of tonsillar hypertrophy in children","volume":"98","author":"Brodsky","year":"1988","journal-title":"Laryngoscope"},{"key":"key\n\t\t\t\t20170425161130_JIT593C24","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1097\/MLG.0b013e31814543c8","article-title":"Bacteriologic comparison of tonsil core in recurrent tonsillitis and tonsillar hypertrophy","volume":"117","author":"Jeong","year":"2007","journal-title":"Laryngoscope"},{"key":"key\n\t\t\t\t20170425161130_JIT593C25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1136\/jcp.2006.037309","article-title":"Spatial organisation of microbiota in quiescent adenoiditis and tonsillitis","volume":"60","author":"Swidsinski","year":"2007","journal-title":"J Clin Pathol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C26","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1189\/jlb.0205065","article-title":"The IgD-binding domain of the Moraxella IgD-binding protein MID (MID962\u20131200) activates human B cells in the presence of T cell cytokines","volume":"79","author":"Nordstrom","year":"2006","journal-title":"J Leukoc Biol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C27","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.1128\/AAC.00415-12","article-title":"Increase of beta-lactam-resistant invasive Haemophilus influenzae in Sweden, 1997 to 2010","volume":"56","author":"Resman","year":"2012","journal-title":"Antimicrob Agents Chemothe"},{"key":"key\n\t\t\t\t20170425161130_JIT593C28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1086\/509824","article-title":"Haemophilus haemolyticus: a human respiratory tract commensal to be distinguished from Haemophilus influenzae","volume":"195","author":"Murphy","year":"2007","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425161130_JIT593C29","doi-asserted-by":"crossref","first-page":"e1000724","DOI":"10.1371\/journal.ppat.1000724","article-title":"B cell activation by outer membrane vesicles\u2014a novel virulence mechanism","volume":"6","author":"Vidakovics","year":"2010","journal-title":"PLoS Pathogens"},{"key":"key\n\t\t\t\t20170425161130_JIT593C30","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1002\/eji.200535594","article-title":"The IgD CH1 region contains the binding site for the human respiratory pathogen Moraxella catarrhalis IgD-binding protein MID","volume":"36","author":"Samuelsson","year":"2006","journal-title":"Eur J Immunol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C31","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1002\/eji.200425218","article-title":"Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner","volume":"34","author":"Rutz","year":"2004","journal-title":"Eur J Immunol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C32","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0002-9440(10)64841-9","article-title":"Human nasopharyngeal-associated lymphoreticular tissues. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils","volume":"157","author":"Boyaka","year":"2000","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C33","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.4049\/jimmunol.122.4.1468","article-title":"Many bacterial species bind human IgD","volume":"122","author":"Forsgren","year":"1979","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C34","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1182\/blood-2002-11-3569","article-title":"A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells","volume":"101","author":"Bernasconi","year":"2003","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170425161130_JIT593C35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2567.2009.03173.x","article-title":"Toll-like receptors\u2014sentries in the B-cell response","volume":"128","author":"Bekeredjian-Ding","year":"2009","journal-title":"Immunology"},{"key":"key\n\t\t\t\t20170425161130_JIT593C36","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1365-2567.2006.02392.x","article-title":"A distinct Toll-like receptor repertoire in human tonsillar B cells, directly activated by PamCSK, R-837 and CpG-2006 stimulation","volume":"118","author":"Mansson","year":"2006","journal-title":"Immunology"},{"key":"key\n\t\t\t\t20170425161130_JIT593C37","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.imlet.2003.10.016","article-title":"Down-modulation of the antigen receptor by a superantigen for human B cells","volume":"92","author":"Viau","year":"2004","journal-title":"Immunol Lett"},{"key":"key\n\t\t\t\t20170425161130_JIT593C38","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1128\/JCM.43.11.5721-5732.2005","article-title":"Defining the normal bacterial flora of the oral cavity","volume":"43","author":"Aas","year":"2005","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C39","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1288\/00005537-198801000-00019","article-title":"The immunology of tonsils in children: the effect of bacterial load on the presence of B- and T-cell subsets","volume":"98","author":"Brodsky","year":"1988","journal-title":"Laryngoscope"},{"key":"key\n\t\t\t\t20170425161130_JIT593C40","first-page":"382","article-title":"Immunoglobulin systems of human tonsils. II. Patients with chronic tonsillitis or tonsillar hyperplasia: quantification of Ig-producing cells, tonsillar morphometry and serum Ig concentrations","volume":"31","author":"Surjan","year":"1978","journal-title":"Clin Exp Immunol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C41","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0161-5890(01)00006-2","article-title":"Structural and functional properties of membrane and secreted IgD","volume":"37","author":"Preud'homme","year":"2000","journal-title":"Mol Immunol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C42","first-page":"21","article-title":"Production and secretion of immunoglobulins in the gastrointestinal tract","volume":"59","author":"Brandtzaeg","year":"1987","journal-title":"Ann Allergy"},{"key":"key\n\t\t\t\t20170425161130_JIT593C43","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/ni.1748","article-title":"Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils","volume":"10","author":"Chen","year":"2009","journal-title":"Nat Immunol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C44","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1164\/rccm.200403-354OC","article-title":"Persistent colonization by Haemophilus influenzae in chronic obstructive pulmonary disease","volume":"170","author":"Murphy","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20170425161130_JIT593C45","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1086\/322016","article-title":"The importance of a beta-glucan receptor in the nonopsonic entry of nontypeable Haemophilus influenzae into human monocytic and epithelial cells","volume":"184","author":"Ahren","year":"2001","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425161130_JIT593C46","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1006\/mpat.2001.0456","article-title":"Protein D expression promotes the adherence and internalization of non-typeable Haemophilus influenzae into human monocytic cells","volume":"31","author":"Ahren","year":"2001","journal-title":"Microb Pathog"},{"key":"key\n\t\t\t\t20170425161130_JIT593C47","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.micpath.2009.01.003","article-title":"Lymphocytes serve as a reservoir for Listeria monocytogenes growth during infection of mice","volume":"46","author":"McElroy","year":"2009","journal-title":"Microb Pathog"},{"key":"key\n\t\t\t\t20170425161130_JIT593C48","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.4049\/jimmunol.0802831","article-title":"B cell receptor-mediated internalization of salmonella: a novel pathway for autonomous B cell activation and antibody production","volume":"182","author":"Souwer","year":"2009","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425161130_JIT593C49","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1574-6968.2001.tb10820.x","article-title":"Survival of nontypeable Haemophilus influenzae in macrophages","volume":"203","author":"Craig","year":"2001","journal-title":"FEMS Microbiol Lett"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/209\/9\/1418\/13804718\/jit593.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T10:28:11Z","timestamp":1716114491000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jit593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,11]]},"references-count":49,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,11,11]]},"published-print":{"date-parts":[[2014,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jit593","relation":{},"ISSN":["1537-6613","0022-1899"],"issn-type":[{"value":"1537-6613","type":"electronic"},{"value":"0022-1899","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11,11]]}}}