{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:33:24Z","timestamp":1788910404068,"version":"build-2803163510"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,1]]},"DOI":"10.1093\/infdis\/jit826","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T03:54:27Z","timestamp":1387511667000},"page":"1792-1800","source":"Crossref","is-referenced-by-count":12,"title":["Posttreatment Changes in Cytokines Induced by Schistosoma mansoni Egg and Worm Antigens: Dissociation of Immunity- and Morbidity-Associated Type 2 Responses"],"prefix":"10.1093","volume":"209","author":[{"given":"Shona","family":"Wilson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances M.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee-Carol","family":"Kenty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph K.","family":"Mwatha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gachuhi","family":"Kimani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Curtis","family":"Kariuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Dunne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,12,19]]},"reference":[{"key":"key\n\t\t\t\t20170511122044_JIT826C1","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(05)66457-4","article-title":"Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis","volume":"365","author":"King","year":"2005","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170511122044_JIT826C2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri843","article-title":"The immunobiology of schistosomiasis","volume":"2","author":"Pearce","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20170511122044_JIT826C3","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/0035-9203(86)90268-3","article-title":"Immune responses and immunoregulation in relation to human schistosomiasis in Egypt. III. Immunity and longitudinal studies of in vitro responsiveness after treatment","volume":"80","author":"Colley","year":"1986","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"key\n\t\t\t\t20170511122044_JIT826C4","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1086\/517832","article-title":"Antigen-specific proliferation and interferon-gamma and interleukin-5 production are down-regulated during Schistosoma haematobium infection","volume":"177","author":"Grogan","year":"1998","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170511122044_JIT826C5","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1086\/510313","article-title":"Th2 cytokines are associated with persistent hepatic fibrosis in human Schistosoma japonicum infection","volume":"195","author":"Coutinho","year":"2007","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170511122044_JIT826C6","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1128\/IAI.72.6.3391-3397.2004","article-title":"Association of type 2 cytokines with hepatic fibrosis in human Schistosoma mansoni infection","volume":"72","author":"de Jesus","year":"2004","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170511122044_JIT826C7","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1128\/IAI.74.2.1215-1221.2006","article-title":"Cytokine production associated with periportal fibrosis during chronic schistosomiasis mansoni in humans","volume":"74","author":"Alves Oliveira","year":"2006","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170511122044_JIT826C8","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.4049\/jimmunol.160.4.1992","article-title":"High levels of TNF, soluble TNF receptors, soluble ICAM-1, and IFN-gamma, but low levels of IL-5, are associated with hepatosplenic disease in human schistosomiasis mansoni","volume":"160","author":"Mwatha","year":"1998","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170511122044_JIT826C9","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1128\/IAI.01433-07","article-title":"Hepatosplenomegaly is associated with low regulatory and Th2 responses to schistosome antigens in childhood schistosomiasis and malaria coinfection","volume":"76","author":"Wilson","year":"2008","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170511122044_JIT826C10","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1128\/IAI.72.2.728-734.2004","article-title":"Cytokine production in whole blood cultures from a fishing community in an area of high endemicity for Schistosoma mansoni in Uganda: the differential effect of parasite worm and egg antigens","volume":"72","author":"Joseph","year":"2004","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170511122044_JIT826C11","doi-asserted-by":"crossref","first-page":"5490","DOI":"10.4049\/jimmunol.177.8.5490","article-title":"Increased human IgE induced by killing Schistosoma mansoni in vivo is associated with pretreatment Th2 cytokine responsiveness to worm antigens","volume":"177","author":"Walter","year":"2006","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170511122044_JIT826C12","doi-asserted-by":"crossref","first-page":"e2149","DOI":"10.1371\/journal.pntd.0002149","article-title":"Rapidly boosted plasma IL-5 induced by treatment of human Schistosomiasis haematobium is dependent on antigen dose, IgE and eosinophils","volume":"7","author":"Wilson","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"key\n\t\t\t\t20170511122044_JIT826C13","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1128\/IAI.00641-12","article-title":"Progressive cross-reactivity in IgE responses: an explanation for the slow development of human immunity to schistosomiasis?","volume":"80","author":"Fitzsimmons","year":"2012","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170511122044_JIT826C14","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1002\/eji.1830260628","article-title":"Elevated proliferation and interleukin-4 release from CD4+ cells after chemotherapy in human Schistosoma haematobium infection","volume":"26","author":"Grogan","year":"1996","journal-title":"Eur J Immunol"},{"key":"key\n\t\t\t\t20170511122044_JIT826C15","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1086\/344352","article-title":"Immune responses induced by repeated treatment do not result in protective immunity to Schistosoma haematobium: interleukin (IL)-5 and IL-10 responses","volume":"186","author":"van den Biggelaar","year":"2002","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170511122044_JIT826C16","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1086\/422604","article-title":"Increases in human T helper 2 cytokine responses to Schistosoma mansoni worm and worm-tegument antigens are induced by treatment with praziquantel","volume":"190","author":"Joseph","year":"2004","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170511122044_JIT826C17","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.0105-2896.2004.00195.x","article-title":"Interleukin-13 in the skin and interferon-gamma in the liver are key players in immune protection in human schistosomiasis","volume":"201","author":"Dessein","year":"2004","journal-title":"Immunol Rev"},{"key":"key\n\t\t\t\t20170511122044_JIT826C18","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1365-3156.2004.01215.x","article-title":"Detailed clinical and ultrasound examination of children and adolescents in a Schistosoma mansoni endemic area in Kenya: hepatosplenic disease in the absence of portal fibrosis","volume":"9","author":"Vennervald","year":"2004","journal-title":"Trop Med Int Health"},{"key":"key\n\t\t\t\t20170511122044_JIT826C19","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.trstmh.2004.06.009","article-title":"Regression of hepatosplenomegaly in Kenyan school-aged children after praziquantel treatment and three years of greatly reduced exposure to Schistosoma mansoni","volume":"99","author":"Vennervald","year":"2005","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"key\n\t\t\t\t20170511122044_JIT826C20","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1756-3305-6-107","article-title":"Long term study on the effect of mollusciciding with niclosamide in stream habitats on the transmission of schistosomiasis mansoni after community-based chemotherapy in Makueni district, Kenya","volume":"6","author":"Kariuki","year":"2013","journal-title":"Parasit Vectors"},{"key":"key\n\t\t\t\t20170511122044_JIT826C21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0035-9203(03)00018-X","article-title":"Hepatosplenic morbidity in two neighbouring communities in Uganda with high levels of Schistosoma mansoni infection but very different durations of residence","volume":"98","author":"Booth","year":"2004","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"key\n\t\t\t\t20170511122044_JIT826C22","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1086\/382089","article-title":"Responses to Toll-like receptor ligands in children living in areas where schistosome infections are endemic","volume":"189","author":"van der Kleij","year":"2004","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170511122044_JIT826C23","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1016\/j.molimm.2006.12.012","article-title":"Schistosoma mansoni soluble egg antigens are internalized by human dendritic cells through multiple C-type lectins and suppress TLR-induced dendritic cell activation","volume":"44","author":"van Liempt","year":"2007","journal-title":"Mol Immunol"},{"key":"key\n\t\t\t\t20170511122044_JIT826C24","doi-asserted-by":"crossref","first-page":"e667","DOI":"10.1371\/journal.pntd.0000667","article-title":"Functional impairment of human myeloid dendritic cells during Schistosoma haematobium infection","volume":"4","author":"Everts","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"key\n\t\t\t\t20170511122044_JIT826C25","doi-asserted-by":"crossref","first-page":"e24393","DOI":"10.1371\/journal.pone.0024393","article-title":"Enhanced pro-inflammatory cytokine responses following Toll-like-receptor ligation in Schistosoma haematobium-infected schoolchildren from rural Gabon","volume":"6","author":"Meurs","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170511122044_JIT826C26","doi-asserted-by":"crossref","first-page":"e1149","DOI":"10.1371\/journal.pntd.0001149","article-title":"Chronic hepatosplenomegaly in African school children: a common but neglected morbidity associated with schistosomiasis and malaria","volume":"5","author":"Wilson","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"key\n\t\t\t\t20170511122044_JIT826C27","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1086\/315662","article-title":"Chronic schistosomiasis: dendritic cells generated from patients can overcome antigen-specific T cell hyporesponsiveness","volume":"182","author":"van Den Biggelaar","year":"2000","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170511122044_JIT826C28","doi-asserted-by":"crossref","first-page":"e1593","DOI":"10.1371\/journal.pntd.0001593","article-title":"The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses","volume":"6","author":"Fitzsimmons","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"key\n\t\t\t\t20170511122044_JIT826C29","doi-asserted-by":"crossref","first-page":"4984","DOI":"10.1128\/IAI.61.12.4984-4993.1993","article-title":"Immunity after treatment of human schistosomiasis: association between cellular responses and resistance to reinfection","volume":"61","author":"Roberts","year":"1993","journal-title":"Infect Immun"},{"issue":"pt 3","key":"key\n\t\t\t\t20170511122044_JIT826C30","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1017\/S0031182000080896","article-title":"A statistical approach to schistosome population dynamics and estimation of the life-span of Schistosoma mansoni in man","volume":"110","author":"Fulford","year":"1995","journal-title":"Parasitology"},{"issue":"pt 2","key":"key\n\t\t\t\t20170511122044_JIT826C31","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1017\/S0031182000053920","article-title":"Schistosoma mansoni: structural damage and tegumental repair after in vivo treatment with praziquantel","volume":"94","author":"Shaw","year":"1987","journal-title":"Parasitology"},{"key":"key\n\t\t\t\t20170511122044_JIT826C32","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S0140-6736(02)09781-7","article-title":"Resistance to reinfection with Schistosoma mansoni in occupationally exposed adults and effect of HIV-1 co-infection on susceptibility to schistosomiasis: a longitudinal study","volume":"360","author":"Karanja","year":"2002","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170511122044_JIT826C33","doi-asserted-by":"crossref","first-page":"e637","DOI":"10.1371\/journal.pntd.0000637","article-title":"Influence of exposure history on the immunology and development of resistance to human schistosomiasis mansoni","volume":"4","author":"Black","year":"2011","journal-title":"PLoS Negl Trop Dis"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/209\/11\/1792\/16867010\/jit826.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T06:50:22Z","timestamp":1688885422000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jit826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,19]]},"references-count":33,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,12,19]]},"published-print":{"date-parts":[[2014,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jit826","relation":{},"ISSN":["1537-6613","0022-1899"],"issn-type":[{"value":"1537-6613","type":"electronic"},{"value":"0022-1899","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12,19]]}}}