{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:45:51Z","timestamp":1790624751518,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"8","funder":[{"DOI":"10.13039\/501100001659","name":"European Union projects the Deutsche Forschungsgemeinschaft (project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"European Union projects the Deutsche Forschungsgemeinschaft (project","doi-asserted-by":"publisher","award":["Health-F3-2009-241642"],"award-info":[{"award-number":["Health-F3-2009-241642"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"European Union projects the Deutsche Forschungsgemeinschaft (project","doi-asserted-by":"publisher","award":["Health-2009-242107"],"award-info":[{"award-number":["Health-2009-242107"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"European Union projects the Deutsche Forschungsgemeinschaft (project","doi-asserted-by":"publisher","award":["KR 1150\/6-1"],"award-info":[{"award-number":["KR 1150\/6-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10,15]]},"DOI":"10.1093\/infdis\/jiu257","type":"journal-article","created":{"date-parts":[[2014,5,2]],"date-time":"2014-05-02T22:21:36Z","timestamp":1399069296000},"page":"1207-1216","source":"Crossref","is-referenced-by-count":71,"title":["Interleukin 10 (IL-10)\u2013Producing CD1dhi Regulatory B Cells From Schistosoma Haematobium\u2013Infected Individuals Induce IL-10\u2013Positive T Cells and Suppress Effector T-Cell Cytokines"],"prefix":"10.1093","volume":"210","author":[{"given":"Luci\u00ebn E. P. M.","family":"van der Vlugt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannot F.","family":"Zinsou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arifa","family":"Ozir-Fazalalikhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Kremsner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Yazdanbakhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayola A.","family":"Adegnika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermelijn H.","family":"Smits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,5,1]]},"reference":[{"key":"key\n\t\t\t\t20170425185720_JIU257C1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/365797a0","article-title":"Immunological modulation and evasion by helminth parasites in human populations","volume":"365","year":"1993","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170425185720_JIU257C2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1084\/jem.173.1.159","article-title":"Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni","volume":"173","year":"1991","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170425185720_JIU257C3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1385\/CRIAI:26:1:15","article-title":"Parasites and the hygiene hypothesis: regulating the immune system?","volume":"26","year":"2004","journal-title":"Clin Rev Allergy Immunol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C4","doi-asserted-by":"crossref","first-page":"5374","DOI":"10.4049\/jimmunol.176.9.5374","article-title":"Naturally occurring CD4+Foxp3+ regulatory T cells are an essential, IL-10-independent part of the immunoregulatory network in Schistosoma mansoni egg-induced inflammation","volume":"176","year":"2006","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C5","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1128\/CMR.05040-11","article-title":"Helminth infections and host immune regulation","volume":"25","year":"2012","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20170425185720_JIU257C6","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1002\/eji.201141869","article-title":"Macrophage activation governs schistosomiasis-induced inflammation and fibrosis","volume":"41","year":"2011","journal-title":"Eur J Immunol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C7","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1089\/jir.2010.0020","article-title":"Allergen-specific transforming growth factor-beta-producing CD19+CD5+ regulatory B-cell (Br3) responses in human late eczematous allergic reactions to cow's milk","volume":"31","year":"2011","journal-title":"J Interferon Cytokine Res"},{"key":"key\n\t\t\t\t20170425185720_JIU257C8","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/mi.2012.42","article-title":"Regulatory B cells from hilar lymph nodes of tolerant mice in a murine model of allergic airway disease are CD5+, express TGF-beta, and co-localize with CD4+Foxp3+ T cells","volume":"5","year":"2012","journal-title":"Mucosal Immunol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C9","first-page":"177","article-title":"Regulatory B cells\u2014implications in autoimmune and allergic disorders","volume-title":"Recent advances in immunology to target cancer, inflammation and infections","year":"2012"},{"key":"key\n\t\t\t\t20170425185720_JIU257C10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev-immunol-020711-074934","article-title":"Immune regulatory function of B cells","volume":"30","year":"2012","journal-title":"Annu Rev Immunol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C11","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3109\/08916934.2012.665525","article-title":"B cells in allergic diseases: bad or better?","volume":"45","year":"2012","journal-title":"Autoimmunity"},{"key":"key\n\t\t\t\t20170425185720_JIU257C12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2119\/molmed.2011.00333","article-title":"Multiple mechanisms of immune suppression by B lymphocytes","volume":"18","year":"2012","journal-title":"Mol Med"},{"key":"key\n\t\t\t\t20170425185720_JIU257C13","doi-asserted-by":"crossref","first-page":"705","DOI":"10.4049\/jimmunol.176.2.705","article-title":"A case for regulatory B cells","volume":"176","year":"2006","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C14","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.jaci.2011.05.012","article-title":"Regulatory B-cell induction by helminths: Implications for allergic disease","volume":"128","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C15","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.it.2007.10.004","article-title":"The \u2018short\u2019 history of regulatory B cells","volume":"29","year":"2008","journal-title":"Trends Immunol"},{"issue":"suppl 1","key":"key\n\t\t\t\t20170425185720_JIU257C16","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/ar3907","article-title":"IL-10-producing regulatory B cells (B10 cells) in autoimmune disease","volume":"15","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"key\n\t\t\t\t20170425185720_JIU257C17","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nri2315","article-title":"Not always the bad guys: B cells as regulators of autoimmune pathology","volume":"8","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C18","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.4049\/jimmunol.167.2.1081","article-title":"Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice","volume":"167","year":"2001","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C19","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.jaci.2010.01.018","article-title":"Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model","volume":"125","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C20","doi-asserted-by":"crossref","first-page":"e30883","DOI":"10.1371\/journal.pone.0030883","article-title":"Schistosomes induce regulatory features in human and mouse CD1d(hi) B cells: inhibition of allergic inflammation by IL-10 and regulatory T cells","volume":"7","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170425185720_JIU257C21","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1002\/eji.200939721","article-title":"Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation","volume":"40","year":"2010","journal-title":"Eur J Immunol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C22","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.4049\/jimmunol.1103139","article-title":"IL-10-producing regulatory B cells in the pathogenesis of chronic hepatitis B virus infection","volume":"189","year":"2012","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C23","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.immuni.2009.11.009","article-title":"CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients","volume":"32","year":"2010","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20170425185720_JIU257C24","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1189\/jlb.0912436","article-title":"Regulatory B cell frequency correlates with markers of HIV disease progression and attenuates anti-HIV CD8(+) T cell function in vitro","volume":"93","year":"2013","journal-title":"J Leukoc Biol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C25","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1182\/blood-2010-07-294249","article-title":"Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells","volume":"117","year":"2011","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170425185720_JIU257C26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cellimm.2012.01.007","article-title":"CD19(+)CD1d(+)CD5(+) B cell frequencies are increased in patients with tuberculosis and suppress Th17 responses","volume":"274","year":"2012","journal-title":"Cell Immunol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/ana.21438","article-title":"Helminth infections associated with multiple sclerosis induce regulatory B cells","volume":"64","year":"2008","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C28","article-title":"Assessment of the effect of Schistosoma haematobium co-infection on malaria parasites and immune responses in rural populations in Gabon: study protocol","year":"2014","journal-title":"BMC Infect Dis"},{"key":"key\n\t\t\t\t20170425185720_JIU257C29","doi-asserted-by":"crossref","first-page":"798","DOI":"10.4269\/ajtmh.2006.75.798","article-title":"Microscopic and sub-microscopic Plasmodium falciparum infection, but not inflammation caused by infection, is associated with low birth weight","volume":"75","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"key\n\t\t\t\t20170425185720_JIU257C30","doi-asserted-by":"crossref","first-page":"e1329","DOI":"10.1371\/journal.pntd.0001329","article-title":"Epidemiology of concomitant infection due to Loa loa and Mansonella perstans in Gabon","volume":"5","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"key\n\t\t\t\t20170425185720_JIU257C31","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/COH.0b013e3283524d90","article-title":"Epidemiology of malaria and helminth interaction: a review from 2001 to 2011","volume":"7","year":"2012","journal-title":"Curr Opin HIV AIDS"},{"key":"key\n\t\t\t\t20170425185720_JIU257C32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/jmcb\/mjr033","article-title":"TGF-beta: the sword, the wand, and the shield of FOXP3(+) regulatory T cells","volume":"4","year":"2012","journal-title":"J Mol Cell Biol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C33","doi-asserted-by":"crossref","first-page":"7459","DOI":"10.4049\/jimmunol.0900270","article-title":"The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals","volume":"182","year":"2009","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C34","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1749-6632.2009.05137.x","article-title":"B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer","volume":"1183","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t20170425185720_JIU257C35","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1111\/all.12218","article-title":"Tolerogenic CX3CR1+ B cells suppress food allergy-induced intestinal inflammation in mice","volume":"68","year":"2013","journal-title":"Allergy"},{"key":"key\n\t\t\t\t20170425185720_JIU257C36","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cellimm.2010.05.013","article-title":"Characterisation of allergen-specific responses of IL-10-producing regulatory B cells (Br1) in cow milk allergy","volume":"264","year":"2010","journal-title":"Cell Immunol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C37","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.autrev.2011.11.018","article-title":"Human CD19(+)CD25(high) B regulatory cells suppress proliferation of CD4(+) T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells","volume":"11","year":"2012","journal-title":"Autoimmun Rev"},{"key":"key\n\t\t\t\t20170425185720_JIU257C38","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/sj.icb.7100014","article-title":"Immunopathology of schistosomiasis","volume":"85","year":"2007","journal-title":"Immunol Cell Biol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C39","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1182\/blood-2012-05-432575","article-title":"Defective regulatory B-cell compartment in patients with immune thrombocytopenia","volume":"120","year":"2012","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170425185720_JIU257C40","doi-asserted-by":"crossref","first-page":"173ra23","DOI":"10.1126\/scitranslmed.3005407","article-title":"CD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation","volume":"5","year":"2013","journal-title":"Sci Transl Med"},{"key":"key\n\t\t\t\t20170425185720_JIU257C41","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1006\/expr.1996.0102","article-title":"B-cell outgrowth and ligand-specific production of IL-10 correlate with Th2 dominance in certain parasitic diseases","volume":"84","year":"1996","journal-title":"Exp Parasitol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C42","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1073\/pnas.91.1.18","article-title":"Oligosaccharide-specific induction of interleukin 10 production by B220+ cells from schistosome-infected mice: a mechanism for regulation of CD4+ T-cell subsets","volume":"91","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170425185720_JIU257C43","doi-asserted-by":"crossref","first-page":"5999","DOI":"10.4049\/jimmunol.0900897","article-title":"Helminth antigens modulate immune responses in cells from multiple sclerosis patients through TLR2-dependent mechanisms","volume":"183","year":"2009","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C44","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jneuroim.2011.08.019","article-title":"Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naive\/memory Breg ratio during a relapse but not in remission","volume":"239","year":"2011","journal-title":"J Neuroimmunol"},{"key":"key\n\t\t\t\t20170425185720_JIU257C45","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1136\/annrheumdis-2012-202986","article-title":"Regulatory B cells in ANCA-associated vasculitis","volume":"72","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t20170425185720_JIU257C46","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.jaci.2013.01.014","article-title":"IgG4 production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses","volume":"131","year":"2013","journal-title":"J Allergy Clin Immunol"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T22:43:33Z","timestamp":1565390613000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jiu257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,1]]},"references-count":46,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,5,1]]},"published-print":{"date-parts":[[2014,10,15]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiu257","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,1]]}}}