{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:30:08Z","timestamp":1791282608865,"version":"4.1.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"suppl 3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dis."],"published-print":{"date-parts":[[2015,6,15]]},"DOI":"10.1093\/infdis\/jiu610","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T16:41:20Z","timestamp":1432572080000},"page":"S96-S106","source":"Crossref","is-referenced-by-count":101,"title":["Pharmacokinetic-Pharmacodynamic and Dose-Response Relationships of Antituberculosis Drugs: Recommendations and Standards for Industry and Academia"],"prefix":"10.1093","volume":"211","author":[{"given":"Tawanda","family":"Gumbo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1igo","family":"Angulo-Barturen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Ferrer-Bazaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,5,25]]},"reference":[{"key":"2015062616183371000_211.suppl_3.S96.1","unstructured":"Gumbo T . General principles of chemotherapy of infectious diseases. In: Brunton LL Chabner B Knollmann B , eds. Goodman & Gilman's the pharmacological basis of therapeutics. 12th ed. New York, NY: McGraw Hill Medical, 2011."},{"key":"2015062616183371000_211.suppl_3.S96.2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00749-10"},{"key":"2015062616183371000_211.suppl_3.S96.3","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00133-10"},{"key":"2015062616183371000_211.suppl_3.S96.4","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01687-10"},{"key":"2015062616183371000_211.suppl_3.S96.5","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00427-08"},{"key":"2015062616183371000_211.suppl_3.S96.6","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01433-10"},{"key":"2015062616183371000_211.suppl_3.S96.7","doi-asserted-by":"publisher","DOI":"10.1086\/510247"},{"key":"2015062616183371000_211.suppl_3.S96.8","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2010.58.5.421"},{"key":"2015062616183371000_211.suppl_3.S96.9","doi-asserted-by":"crossref","unstructured":"Greco WR Bravo G Parsons JC . The search for synergy: a critical review from a response surface perspective. Pharmacol Rev 1995; 47:331\u201385.","DOI":"10.1016\/S0031-6997(25)06847-4"},{"key":"2015062616183371000_211.suppl_3.S96.10","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.4.1051-1058.2000"},{"key":"2015062616183371000_211.suppl_3.S96.11","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00334-06"},{"key":"2015062616183371000_211.suppl_3.S96.12","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01681-08"},{"key":"2015062616183371000_211.suppl_3.S96.13","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00185-07"},{"key":"2015062616183371000_211.suppl_3.S96.14","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.8.2951-2957.2004"},{"key":"2015062616183371000_211.suppl_3.S96.15","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis353"},{"key":"2015062616183371000_211.suppl_3.S96.16","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-007-0305-5"},{"key":"2015062616183371000_211.suppl_3.S96.17","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.6.859"},{"key":"2015062616183371000_211.suppl_3.S96.18","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00763-10"},{"key":"2015062616183371000_211.suppl_3.S96.19","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.7.2118-2124.2003"},{"key":"2015062616183371000_211.suppl_3.S96.20","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01533-06"},{"key":"2015062616183371000_211.suppl_3.S96.21","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.47.553.737"},{"key":"2015062616183371000_211.suppl_3.S96.22","unstructured":"Verbist L . Rifampicin activity \"in vitro\" and in established tuberculosis in mice. Acta Tuberc Pneumol Belg 1969; 60:397\u2013412."},{"key":"2015062616183371000_211.suppl_3.S96.23","doi-asserted-by":"publisher","DOI":"10.1016\/0041-3879(76)90047-7"},{"key":"2015062616183371000_211.suppl_3.S96.24","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01520-08"},{"key":"2015062616183371000_211.suppl_3.S96.25","unstructured":"Kreis B Pretet S Birenbaum J Two three-month treatment regimens for pulmonary tuberculosis. Bull Int Union Tuberc 1976; 51:71\u20135."},{"key":"2015062616183371000_211.suppl_3.S96.26","unstructured":"Peloquin C . What is the \u2018right\u2019 dose of rifampin? Int J Tuberc Lung Dis 2003; 7:3\u20135."},{"key":"2015062616183371000_211.suppl_3.S96.27","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir184"},{"key":"2015062616183371000_211.suppl_3.S96.28","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01474-06"},{"key":"2015062616183371000_211.suppl_3.S96.29","unstructured":"Yeager RL Munroe WG Dessau FI . Pyrazinamide (aldinamide) in the treatment of pulmonary tuberculosis. Am Rev Tuberc 1952; 65:523\u201346."},{"key":"2015062616183371000_211.suppl_3.S96.30","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01524-10"},{"key":"2015062616183371000_211.suppl_3.S96.31","doi-asserted-by":"publisher","DOI":"10.1016\/0041-3879(76)90046-5"},{"key":"2015062616183371000_211.suppl_3.S96.32","doi-asserted-by":"publisher","DOI":"10.1016\/0041-3879(69)90017-8"},{"key":"2015062616183371000_211.suppl_3.S96.33","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05988-11"},{"key":"2015062616183371000_211.suppl_3.S96.34","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01567-09"},{"key":"2015062616183371000_211.suppl_3.S96.35","doi-asserted-by":"publisher","DOI":"10.1016\/0007-0971(81)90046-2"},{"key":"2015062616183371000_211.suppl_3.S96.36","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit352"},{"key":"2015062616183371000_211.suppl_3.S96.37","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.13.0128"},{"key":"2015062616183371000_211.suppl_3.S96.38","doi-asserted-by":"publisher","DOI":"10.1086\/651377"},{"key":"2015062616183371000_211.suppl_3.S96.39","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-3879(68)80016-9"},{"key":"2015062616183371000_211.suppl_3.S96.40","doi-asserted-by":"publisher","DOI":"10.1086\/429321"},{"key":"2015062616183371000_211.suppl_3.S96.41","doi-asserted-by":"publisher","DOI":"10.1086\/599040"},{"key":"2015062616183371000_211.suppl_3.S96.42","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03931-14"},{"key":"2015062616183371000_211.suppl_3.S96.43","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00830-09"},{"key":"2015062616183371000_211.suppl_3.S96.44","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.3.548"},{"key":"2015062616183371000_211.suppl_3.S96.45","doi-asserted-by":"publisher","DOI":"10.1086\/424849"},{"key":"2015062616183371000_211.suppl_3.S96.46","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00414-06"},{"key":"2015062616183371000_211.suppl_3.S96.47","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.8.3178-3181.2005"},{"key":"2015062616183371000_211.suppl_3.S96.48","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69573-1"},{"key":"2015062616183371000_211.suppl_3.S96.49","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00139-10"},{"key":"2015062616183371000_211.suppl_3.S96.50","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01354-09"},{"key":"2015062616183371000_211.suppl_3.S96.51","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00849-10"},{"key":"2015062616183371000_211.suppl_3.S96.52","doi-asserted-by":"crossref","unstructured":"Rouan MC Lounis N Gevers T Pharmacokinetics-pharmacodynamics of TMC207 and its N-desmethyl metabolite in a murine model of tuberculosis. Antimicrob Agents Chemother 2011; 56:1444\u201351.","DOI":"10.1128\/AAC.00720-11"},{"key":"2015062616183371000_211.suppl_3.S96.53","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01204-07"},{"key":"2015062616183371000_211.suppl_3.S96.54","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02243-12"},{"key":"2015062616183371000_211.suppl_3.S96.55","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808427"},{"key":"2015062616183371000_211.suppl_3.S96.56","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.623"},{"key":"2015062616183371000_211.suppl_3.S96.57","unstructured":"Canetti G Froman S Grosset J Mycobacteria: laboratory methods for testing drug sensitivity and resistance. Bull World Health Organ 1963; 29:565\u201378."},{"key":"2015062616183371000_211.suppl_3.S96.58","unstructured":"Clinical and Laboratory Standards Institute. Susceptibility testing of mycobacteria, nocardiae, and other aerobic actinomycetes: approved standard. Wayne, PA: Clinical and Laboratory Standards Institute, 2003."},{"key":"2015062616183371000_211.suppl_3.S96.59","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.1.13-22.2001"},{"key":"2015062616183371000_211.suppl_3.S96.60","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01474-09"},{"key":"2015062616183371000_211.suppl_3.S96.61","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku136"},{"key":"2015062616183371000_211.suppl_3.S96.62","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01478-13"},{"key":"2015062616183371000_211.suppl_3.S96.63","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.10.0127"},{"key":"2015062616183371000_211.suppl_3.S96.64","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.11.0178"},{"key":"2015062616183371000_211.suppl_3.S96.65","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt284"},{"key":"2015062616183371000_211.suppl_3.S96.66","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03549-14"},{"key":"2015062616183371000_211.suppl_3.S96.67","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090569"},{"key":"2015062616183371000_211.suppl_3.S96.68","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108911"},{"key":"2015062616183371000_211.suppl_3.S96.69","doi-asserted-by":"publisher","DOI":"10.2307\/2280232"},{"key":"2015062616183371000_211.suppl_3.S96.70","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki079"}],"container-title":["Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/211\/suppl_3\/S96\/5106516\/jiu610.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T02:55:26Z","timestamp":1748400926000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jiu610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,25]]},"references-count":70,"journal-issue":{"issue":"suppl 3","published-online":{"date-parts":[[2015,5,25]]},"published-print":{"date-parts":[[2015,6,15]]}},"alternative-id":["10.1093\/infdis\/jiu610"],"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiu610","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,25]]}}}