{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:29:17Z","timestamp":1788341357585,"version":"build-2803163510"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1093\/infdis\/jiu616","type":"journal-article","created":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T06:10:34Z","timestamp":1415340634000},"page":"1408-1417","source":"Crossref","is-referenced-by-count":55,"title":["Effect of Influenza A(H5N1) Vaccine Prepandemic Priming on CD4+ T-Cell Responses"],"prefix":"10.1093","volume":"211","author":[{"given":"Jennifer L.","family":"Nayak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Richards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Treanor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea J.","family":"Sant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,11,6]]},"reference":[{"key":"key\n\t\t\t\t20170702115150_JIU616C1","article-title":"Cumulative number of confirmed human cases for avian influenza A(H5N1) reported to WHO, 2003\u20132014"},{"key":"key\n\t\t\t\t20170702115150_JIU616C2","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0140-6736(08)60493-6","article-title":"Probable limited person-to-person transmission of highly pathogenic avian influenza A (H5N1) virus in China","volume":"371","author":"Wang","year":"2008","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702115150_JIU616C3","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.3201\/eid1309.070111","article-title":"Detecting human-to-human transmission of avian influenza A (H5N1)","volume":"13","author":"Yang","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20170702115150_JIU616C4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1056\/NEJMoa044021","article-title":"Probable person-to-person transmission of avian influenza A (H5N1)","volume":"352","author":"Ungchusak","year":"2005","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170702115150_JIU616C5","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1126\/science.1213362","article-title":"Airborne transmission of influenza A\/H5N1 virus between ferrets","volume":"336","author":"Herfst","year":"2012","journal-title":"Science"},{"key":"key\n\t\t\t\t20170702115150_JIU616C6","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nature10831","article-title":"Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA\/H1N1 virus in ferrets","volume":"486","author":"Imai","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170702115150_JIU616C7","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1126\/science.1222526","article-title":"The potential for respiratory droplet-transmissible A\/H5N1 influenza virus to evolve in a mammalian host","volume":"336","author":"Russell","year":"2012","journal-title":"Science"},{"key":"key\n\t\t\t\t20170702115150_JIU616C8","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1056\/NEJMoa055778","article-title":"Safety and immunogenicity of an inactivated subvirion influenza A (H5N1) vaccine","volume":"354","author":"Treanor","year":"2006","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170702115150_JIU616C9","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1016\/S0264-410X(00)00395-9","article-title":"Safety and immunogenicity of a recombinant hemagglutinin vaccine for H5 influenza in humans","volume":"19","author":"Treanor","year":"2001","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20170702115150_JIU616C10","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1086\/527489","article-title":"Effects of adjuvants on the safety and immunogenicity of an avian influenza H5N1 vaccine in adults","volume":"197","author":"Bernstein","year":"2008","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702115150_JIU616C11","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.vaccine.2011.12.009","article-title":"Safety and immunogenicity of an MF59((R))-adjuvanted A\/H5N1 pre-pandemic influenza vaccine in adults and the elderly","volume":"30","author":"Vesikari","year":"2012","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20170702115150_JIU616C12","doi-asserted-by":"crossref","first-page":"e762","DOI":"10.1542\/peds.2009-2628","article-title":"Immunogenicity and safety of MF59-adjuvanted H5N1 influenza vaccine from infancy to adolescence","volume":"126","author":"Vesikari","year":"2010","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t20170702115150_JIU616C13","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S1473-3099(09)70153-7","article-title":"Immunogenicity and adverse events of avian influenza A H5N1 vaccine in healthy adults: multiple-treatments meta-analysis","volume":"9","author":"Manzoli","year":"2009","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t20170702115150_JIU616C14","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/S0140-6736(00)05066-2","article-title":"Safety and antigenicity of non-adjuvanted and MF59-adjuvanted influenza A\/Duck\/Singapore\/97 (H5N3) vaccine: a randomised trial of two potential vaccines against H5N1 influenza","volume":"357","author":"Nicholson","year":"2001","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702115150_JIU616C15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/465161a","article-title":"Vaccinate before the next pandemic?","volume":"465","author":"Stohr","year":"2010","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170702115150_JIU616C16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-1-61779-621-0_9","article-title":"Influenza virus surveillance, vaccine strain selection, and manufacture","volume":"865","author":"Stohr","year":"2012","journal-title":"Methods Mol Biol"},{"key":"key\n\t\t\t\t20170702115150_JIU616C17","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1086\/590916","article-title":"Immune responses of healthy subjects to a single dose of intramuscular inactivated influenza A\/Vietnam\/1203\/2004 (H5N1) vaccine after priming with an antigenic variant","volume":"198","author":"Goji","year":"2008","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702115150_JIU616C18","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1093\/infdis\/jiq093","article-title":"Safety and immunogenicity of influenza A H5 subunit vaccines: effect of vaccine schedule and antigenic variant","volume":"203","author":"Belshe","year":"2011","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702115150_JIU616C19","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1093\/infdis\/jiu123","article-title":"A Live Attenuated Influenza A(H5N1) Vaccine Induces Long-Term Immunity in the Absence of a Primary Antibody Response","volume":"209","author":"Talaat","year":"2014","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702115150_JIU616C20","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1056\/NEJMc0805274","article-title":"Antigenically distinct MF59-adjuvanted vaccine to boost immunity to H5N1","volume":"359","author":"Stephenson","year":"2008","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170702115150_JIU616C21","doi-asserted-by":"crossref","first-page":"e95496","DOI":"10.1371\/journal.pone.0095496","article-title":"Heterologous prime-boost vaccination with MF59-adjuvanted H5 vaccines promotes antibody affinity maturation towards the hemagglutinin HA1 domain and broad H5N1 cross-clade neutralization","volume":"9","author":"Khurana","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170702115150_JIU616C22","doi-asserted-by":"crossref","first-page":"7962","DOI":"10.1073\/pnas.0903181106","article-title":"Fast rise of broadly cross-reactive antibodies after boosting long-lived human memory B cells primed by an MF59 adjuvanted prepandemic vaccine","volume":"106","author":"Galli","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170702115150_JIU616C23","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.vaccine.2009.11.002","article-title":"B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variant","volume":"28","author":"Baer","year":"2010","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20170702115150_JIU616C24","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev-immunol-031210-101400","article-title":"Follicular helper CD4 T cells (TFH)","volume":"29","author":"Crotty","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"key\n\t\t\t\t20170702115150_JIU616C25","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/ni.2019","article-title":"Germinal center B and follicular helper T cells: siblings, cousins or just good friends?","volume":"12","author":"Nutt","year":"2011","journal-title":"Nat Immunol"},{"key":"key\n\t\t\t\t20170702115150_JIU616C26","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/imr.12031","article-title":"T-cell subsets in the germinal center","volume":"252","author":"Ramiscal","year":"2013","journal-title":"Immunol Rev"},{"key":"key\n\t\t\t\t20170702115150_JIU616C27","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1084\/jem.20120994","article-title":"The origins, function, and regulation of T follicular helper cells","volume":"209","author":"Ma","year":"2012","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170702115150_JIU616C28","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/infdis\/jis684","article-title":"CD4 T-cell expansion predicts neutralizing antibody responses to monovalent inactivated pandemic H1N1 influenza vaccine","volume":"207","author":"Nayak","year":"2013","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702115150_JIU616C29","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1073\/pnas.0813390106","article-title":"Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels","volume":"106","author":"Galli","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170702115150_JIU616C30","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/infdis\/jis330","article-title":"T-Helper 1 Cells Elicited by H5N1 Vaccination Predict Seroprotection","volume":"206","author":"Pedersen","year":"2012","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170702115150_JIU616C31","doi-asserted-by":"crossref","first-page":"176ra32","DOI":"10.1126\/scitranslmed.3005191","article-title":"Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination","volume":"5","author":"Bentebibel","year":"2013","journal-title":"Sci Transl Med"},{"key":"key\n\t\t\t\t20170702115150_JIU616C32","doi-asserted-by":"crossref","first-page":"14330","DOI":"10.1073\/pnas.1311998110","article-title":"Human circulating influenza-CD4+ ICOS1+IL-21+ T cells expand after vaccination, exert helper function, and predict antibody responses","volume":"110","author":"Spensieri","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170702115150_JIU616C33","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.4049\/jimmunol.1203520","article-title":"Cutting edge: Heterosubtypic influenza infection antagonizes elicitation of immunological reactivity to hemagglutinin","volume":"191","author":"Nayak","year":"2013","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702115150_JIU616C34","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1128\/JVI.02077-13","article-title":"CD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection","volume":"88","author":"Alam","year":"2014","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170702115150_JIU616C35","doi-asserted-by":"crossref","first-page":"13310","DOI":"10.1128\/JVI.05728-11","article-title":"Infection with seasonal influenza virus elicits CD4 T cells specific for genetically conserved epitopes that can be rapidly mobilized for protective immunity to pandemic H1N1 influenza virus","volume":"85","author":"Alam","year":"2011","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170702115150_JIU616C36","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.4049\/jimmunol.1001395","article-title":"Cutting edge: CD4 T cells generated from encounter with seasonal influenza viruses and vaccines have broad protein specificity and can directly recognize naturally generated epitopes derived from the live pandemic H1N1 virus","volume":"185","author":"Richards","year":"2010","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702115150_JIU616C37","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1128\/JCM.37.4.937-943.1999","article-title":"Detection of antibody to avian influenza A (H5N1) virus in human serum by using a combination of serologic assays","volume":"37","author":"Rowe","year":"1999","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20170702115150_JIU616C38","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.immuni.2008.04.018","article-title":"Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities","volume":"28","author":"Sette","year":"2008","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20170702115150_JIU616C39","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1600-065X.2012.01124.x","article-title":"Germinal center selection and the development of memory B and plasma cells","volume":"247","author":"Shlomchik","year":"2012","journal-title":"Immunol Rev"},{"key":"key\n\t\t\t\t20170702115150_JIU616C40","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nri3128","article-title":"Molecular programming of B cell memory","volume":"12","author":"McHeyzer-Williams","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20170702115150_JIU616C41","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.4049\/jimmunol.180.3.1758","article-title":"Healthy human subjects have CD4+ T cells directed against H5N1 influenza virus","volume":"180","author":"Roti","year":"2008","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702115150_JIU616C42","doi-asserted-by":"crossref","first-page":"7578","DOI":"10.4049\/jimmunol.162.12.7578","article-title":"Human CD8+ and CD4+ T lymphocyte memory to influenza A viruses of swine and avian species","volume":"162","author":"Jameson","year":"1999","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702115150_JIU616C43","doi-asserted-by":"crossref","first-page":"6566","DOI":"10.1128\/JVI.00302-09","article-title":"Infection of HLA-DR1 transgenic mice with a human isolate of influenza a virus (H1N1) primes a diverse CD4 T-cell repertoire that includes CD4 T cells with heterosubtypic cross-reactivity to avian (H5N1) influenza virus","volume":"83","author":"Richards","year":"2009","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170702115150_JIU616C44","doi-asserted-by":"crossref","first-page":"6432","DOI":"10.4049\/jimmunol.0901617","article-title":"In vitro responses to avian influenza H5 by human CD4 T cells","volume":"183","author":"Cusick","year":"2009","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170702115150_JIU616C45","first-page":"3478","article-title":"Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals","volume":"118","author":"Lee","year":"2008","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170702115150_JIU616C46","doi-asserted-by":"crossref","first-page":"e49704","DOI":"10.1371\/journal.pone.0049704","article-title":"A randomized clinical trial of an inactivated avian influenza A (H7N7) vaccine","volume":"7","author":"Couch","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170702115150_JIU616C47","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1016\/j.vaccine.2009.01.116","article-title":"A phase I clinical trial of a PER.C6 cell grown influenza H7 virus vaccine","volume":"27","author":"Cox","year":"2009","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20170702115150_JIU616C48","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nm.2612","article-title":"Preexisting influenza-specific CD4(+) T cells correlate with disease protection against influenza challenge in humans","volume":"18","author":"Wilkinson","year":"2012","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170702115150_JIU616C49","doi-asserted-by":"crossref","first-page":"5935","DOI":"10.1073\/pnas.0601266103","article-title":"Mitigation strategies for pandemic influenza in the United States","volume":"103","author":"Germann","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170702115150_JIU616C50","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature04795","article-title":"Strategies for mitigating an influenza pandemic","volume":"442","author":"Ferguson","year":"2006","journal-title":"Nature"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/211\/9\/1408\/18082580\/jiu616.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T23:38:16Z","timestamp":1689637096000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jiu616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,6]]},"references-count":50,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,11,6]]},"published-print":{"date-parts":[[2015,5]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiu616","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,6]]}}}