{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:15:06Z","timestamp":1782458106472,"version":"3.54.5"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7,1]]},"DOI":"10.1093\/infdis\/jiu662","type":"journal-article","created":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T04:28:41Z","timestamp":1418185721000},"page":"86-94","source":"Crossref","is-referenced-by-count":36,"title":["Seasonal Influenza Can Poise Hosts for CD4 T-Cell Immunity to H7N9 Avian Influenza"],"prefix":"10.1093","volume":"212","author":[{"given":"Katherine A.","family":"Richards","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco A.","family":"Chaves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"DiPiazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zackery A. G.","family":"Knowlden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabnam","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Treanor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea J.","family":"Sant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,12,9]]},"reference":[{"key":"key\n\t\t\t\t20170425161437_JIU662C1","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1038\/srep02318","article-title":"Towards a better understanding of the novel avian-origin H7N9 influenza A virus in China","volume":"3","author":"Wang","year":"2013","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t20170425161437_JIU662C2","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1056\/NEJMoa1304459","article-title":"Human infection with a novel avian-origin influenza A (H7N9) virus","volume":"368","author":"Gao","year":"2013","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170425161437_JIU662C3","doi-asserted-by":"crossref","first-page":"20453","DOI":"10.2807\/ese.18.15.20453-en","article-title":"Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013","volume":"18","author":"Kageyama","year":"2013","journal-title":"Euro Surveill"},{"key":"key\n\t\t\t\t20170425161437_JIU662C4","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1016\/S0140-6736(13)60938-1","article-title":"Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses","volume":"381","author":"Liu","year":"2013","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170425161437_JIU662C5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1126\/science.1239844","article-title":"Infectivity, transmission, and pathology of human-isolated H7N9 influenza virus in ferrets and pigs","volume":"341","author":"Zhu","year":"2013","journal-title":"Science"},{"key":"key\n\t\t\t\t20170425161437_JIU662C6","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1126\/science.1240532","article-title":"H7N9 influenza viruses are transmissible in ferrets by respiratory droplet","volume":"341","author":"Zhang","year":"2013","journal-title":"Science"},{"key":"key\n\t\t\t\t20170425161437_JIU662C7","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nature12392","article-title":"Characterization of H7N9 influenza A viruses isolated from humans","volume":"501","author":"Watanabe","year":"2013","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170425161437_JIU662C8","first-page":"4","article-title":"H7N9 avian influenza A virus and the perpetual challenge of potential human pandemicity","author":"Morens","year":"2013","journal-title":"MBio"},{"key":"key\n\t\t\t\t20170425161437_JIU662C9","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nature12455","article-title":"Influenza: pathways to human adaptation","volume":"499","author":"Steinhauer","year":"2013","journal-title":"Nature"},{"issue":"suppl 3","key":"key\n\t\t\t\t20170425161437_JIU662C10","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/irv.12180","article-title":"Influenza vaccines: an Asia-Pacific perspective","volume":"7","author":"Jennings","year":"2013","journal-title":"Influenza Other Respir Viruses"},{"key":"key\n\t\t\t\t20170425161437_JIU662C11","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1001\/jama.2013.6589","article-title":"Major challenges in providing an effective and timely pandemic vaccine for influenza A(H7N9)","volume":"309","author":"Osterholm","year":"2013","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20170425161437_JIU662C12","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1084\/jem.20121517","article-title":"Revealing the role of CD4+ T cells in viral immunity","volume":"209","author":"Sant","year":"2012","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170425161437_JIU662C13","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nri3152","article-title":"Expanding roles for CD4+ T cells in immunity to viruses","volume":"12","author":"Swain","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20170425161437_JIU662C14","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.coviro.2013.05.001","article-title":"Role of T cell immunity in recovery from influenza virus infection","volume":"3","author":"Sun","year":"2013","journal-title":"Curr Opin Virol"},{"key":"key\n\t\t\t\t20170425161437_JIU662C15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-1-4419-5632-3_6","article-title":"Control of innate immunity by memory CD4 T cells","volume":"780","author":"Strutt","year":"2011","journal-title":"Adv Exp Med Biol"},{"key":"key\n\t\t\t\t20170425161437_JIU662C16","doi-asserted-by":"crossref","first-page":"9217","DOI":"10.1128\/JVI.01069-10","article-title":"Memory CD4 T cells direct protective responses to influenza virus in the lungs through helper-independent mechanisms","volume":"84","author":"Teijaro","year":"2010","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170425161437_JIU662C17","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1084\/jem.20120994","article-title":"The origins, function, and regulation of T follicular helper cells","volume":"209","author":"Ma","year":"2012","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170425161437_JIU662C18","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/infdis\/jis684","article-title":"CD4+ T-cell expansion predicts neutralizing antibody responses to monovalent, inactivated 2009 pandemic influenza A(H1N1) virus subtype H1N1 vaccine","volume":"207","author":"Nayak","year":"2013","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425161437_JIU662C19","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005191","article-title":"Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination","volume":"5","author":"Bentebibel","year":"2013","journal-title":"Sci Transl Med"},{"key":"key\n\t\t\t\t20170425161437_JIU662C20","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1128\/JVI.02077-13","article-title":"CD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection","volume":"88","author":"Alam","year":"2014","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170425161437_JIU662C21","doi-asserted-by":"crossref","first-page":"6566","DOI":"10.1128\/JVI.00302-09","article-title":"Infection of HLA-DR1 transgenic mice with a human isolate of influenza a virus (H1N1) primes a diverse CD4 T-cell repertoire that includes CD4 T cells with heterosubtypic cross-reactivity to avian (H5N1) influenza virus","volume":"83","author":"Richards","year":"2009","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170425161437_JIU662C22","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.4049\/jimmunol.1001395","article-title":"Cutting edge: CD4 T cells generated from encounter with seasonal influenza viruses and vaccines have broad protein specificity and can directly recognize naturally generated epitopes derived from the live pandemic H1N1 virus","volume":"185","author":"Richards","year":"2010","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425161437_JIU662C23","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev.immunol.23.021704.115658","article-title":"How TCRs bind MHCs, peptides, and coreceptors","volume":"24","author":"Rudolph","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"key\n\t\t\t\t20170425161437_JIU662C24","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1365-2567.2010.03268.x","article-title":"MHC class II epitope predictive algorithms","volume":"130","author":"Nielsen","year":"2010","journal-title":"Immunology"},{"key":"key\n\t\t\t\t20170425161437_JIU662C25","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1038\/nm1210-1389","article-title":"Induction of unnatural immunity: prospects for a broadly protective universal influenza vaccine","volume":"16","author":"Nabel","year":"2010","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170425161437_JIU662C26","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1089\/vim.2009.0099","article-title":"Analyses of the specificity of CD4 T cells during the primary immune response to influenza virus reveals dramatic MHC-linked asymmetries in reactivity to individual viral proteins","volume":"23","author":"Nayak","year":"2010","journal-title":"Viral Immunol"},{"key":"key\n\t\t\t\t20170425161437_JIU662C27","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.vaccine.2012.10.039","article-title":"Trivalent inactivated influenza vaccines induce broad immunological reactivity to both internal virion components and influenza surface proteins","volume":"31","author":"Richards","year":"2012","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20170425161437_JIU662C28","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1001\/jama.2014.12854","article-title":"Serological responses to an avian influenza A\/H7N9 vaccine mixed at the point-of-use with MF59 adjuvant: a randomized clinical trial","volume":"312","author":"Mulligan","year":"2014","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20170425161437_JIU662C29","doi-asserted-by":"crossref","first-page":"e87962","DOI":"10.1371\/journal.pone.0087962","article-title":"Assessment of human immune responses to H7 avian influenza virus of pandemic potential: results from a placebo-controlled, randomized double-blind phase I study of live attenuated H7N3 influenza vaccine","volume":"9","author":"Rudenko","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170425161437_JIU662C30","doi-asserted-by":"crossref","first-page":"e49704","DOI":"10.1371\/journal.pone.0049704","article-title":"A randomized clinical trial of an inactivated avian influenza A (H7N7) vaccine","volume":"7","author":"Couch","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170425161437_JIU662C31","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1093\/infdis\/jiu616","article-title":"Effect of influenza A(H5N1) vaccine prepandemic priming on CD4+ T-cell responses","volume":"211","author":"Nayak","year":"2015","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425161437_JIU662C32","doi-asserted-by":"crossref","first-page":"W525","DOI":"10.1093\/nar\/gks438","article-title":"Immune epitope database analysis resource","volume":"40","author":"Kim","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20170425161437_JIU662C33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cell.2005.05.013","article-title":"How the T cell repertoire becomes peptide and MHC specific","volume":"122","author":"Huseby","year":"2005","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170425161437_JIU662C34","doi-asserted-by":"crossref","first-page":"7608","DOI":"10.1128\/JVI.02834-06","article-title":"Direct ex vivo analyses of HLA-DR1 transgenic mice reveal an exceptionally broad pattern of immunodominance in the primary HLA-DR1-restricted CD4 T-cell response to influenza virus hemagglutinin","volume":"81","author":"Richards","year":"2007","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170425161437_JIU662C35","doi-asserted-by":"crossref","first-page":"950","DOI":"10.4161\/hv.24939","article-title":"Low immunogenicity predicted for emerging avian-origin H7N9: implication for influenza vaccine design","volume":"9","author":"De Groot","year":"2013","journal-title":"Hum Vaccin Immunother"},{"key":"key\n\t\t\t\t20170425161437_JIU662C36","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.4049\/jimmunol.1103640","article-title":"The utility and limitations of current Web-available algorithms to predict peptides recognized by CD4 T cells in response to pathogen infection","volume":"188","author":"Chaves","year":"2012","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425161437_JIU662C37","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1186\/1471-2105-11-568","article-title":"Peptide binding predictions for HLA DR, DP and DQ molecules","volume":"11","author":"Wang","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t20170425161437_JIU662C38","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.4049\/jimmunol.164.5.2338","article-title":"Qualitative changes accompany memory T cell generation: faster, more effective responses at lower doses of antigen","volume":"164","author":"Rogers","year":"2000","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425161437_JIU662C39","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1365-2567.2010.03260.x","article-title":"Memory CD4 T cells: generation, reactivation and re-assignment","volume":"130","author":"MacLeod","year":"2010","journal-title":"Immunology"},{"key":"key\n\t\t\t\t20170425161437_JIU662C40","doi-asserted-by":"crossref","first-page":"265","DOI":"10.4049\/jimmunol.164.1.265","article-title":"Functional responses and costimulator dependence of memory CD4+ T cells","volume":"164","author":"London","year":"2000","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425161437_JIU662C41","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4049\/jimmunol.1002742","article-title":"Transcriptional control of rapid recall by memory CD4 T cells","volume":"187","author":"Lai","year":"2011","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170425161437_JIU662C42","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.immuni.2011.08.010","article-title":"Increased sensitivity of antigen-experienced T cells through the enrichment of oligomeric T cell receptor complexes","volume":"35","author":"Kumar","year":"2011","journal-title":"Immunity"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/212\/1\/86\/13805948\/jiu662.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T04:09:08Z","timestamp":1650773348000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jiu662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,9]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,12,9]]},"published-print":{"date-parts":[[2015,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiu662","relation":{},"ISSN":["1537-6613","0022-1899"],"issn-type":[{"value":"1537-6613","type":"electronic"},{"value":"0022-1899","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12,9]]}}}