{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:53:22Z","timestamp":1793332402862,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7,1]]},"DOI":"10.1093\/infdis\/jiu813","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T10:24:39Z","timestamp":1418984679000},"page":"95-105","source":"Crossref","is-referenced-by-count":63,"title":["Host-pathogen Interaction at the Intestinal Mucosa Correlates With Zoonotic Potential of Streptococcus suis"],"prefix":"10.1093","volume":"212","author":[{"given":"Maria Laura","family":"Ferrando","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"de Greeff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willemien J. M.","family":"van Rooijen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Stockhofe-Zurwieden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Wichgers Schreur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Pannekoek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annet","family":"Heuvelink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie","family":"van der Ende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance","family":"Schultsz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,12,18]]},"reference":[{"key":"key\n\t\t\t\t20170425161511_JIU813C1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1086\/596763","article-title":"Streptococcus suis: an emerging human pathogen","volume":"48","author":"Wertheim","year":"2009","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170425161511_JIU813C2","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.3201\/eid2007.131594","article-title":"Epidemiology, clinical manifestations, and outcomes of Streptococcus suis infection in humans","volume":"20","author":"Huong","year":"2014","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20170425161511_JIU813C3","doi-asserted-by":"crossref","first-page":"e17604","DOI":"10.1371\/journal.pone.0017604","article-title":"Risk factors of Streptococcus suis infection in Vietnam. A case-control study","volume":"6","author":"Nghia","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170425161511_JIU813C4","doi-asserted-by":"crossref","first-page":"e31265","DOI":"10.1371\/journal.pone.0031265","article-title":"Population-based study of Streptococcus suis infection in humans in Phayao Province in northern Thailand","volume":"7","author":"Takeuchi","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170425161511_JIU813C5","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0034-5288(18)33808-6","article-title":"Streptococcal infection in piglets: the palatine tonsils as portals of entry for Streptococcus suis","volume":"15","author":"Williams","year":"1973","journal-title":"Res Vet Sci"},{"key":"key\n\t\t\t\t20170425161511_JIU813C6","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1574-6941.2008.00529.x","article-title":"Changes in abundance of Lactobacillus spp. and Streptococcus suis in the stomach, jejunum and ileum of piglets after weaning","volume":"66","author":"Su","year":"2008","journal-title":"FEMS Microbiol Ecol"},{"key":"key\n\t\t\t\t20170425161511_JIU813C7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.vetmic.2004.06.010","article-title":"Intestinal translocation of Streptococcus suis type 2 EF+ in pigs","volume":"103","author":"Swildens","year":"2004","journal-title":"Vet Microbiol"},{"key":"key\n\t\t\t\t20170425161511_JIU813C8","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/j.1462-5822.2004.00409.x","article-title":"Non-encapsulated strains reveal novel insights in invasion and survival of Streptococcus suis in epithelial cells","volume":"6","author":"Benga","year":"2004","journal-title":"Cell Microbiol"},{"key":"key\n\t\t\t\t20170425161511_JIU813C9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1574-695X.1999.tb01369.x","article-title":"Epithelial invasion and cell lysis by virulent strains of Streptococcus suis is enhanced by the presence of suilysin","volume":"26","author":"Norton","year":"1999","journal-title":"FEMS Immunol Med Microbiol"},{"key":"key\n\t\t\t\t20170425161511_JIU813C10","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4161\/viru.28595","article-title":"Streptococcus suis infection: an emerging\/reemerging challenge of bacterial infectious diseases?","volume":"5","author":"Feng","year":"2014","journal-title":"Virulence"},{"key":"key\n\t\t\t\t20170425161511_JIU813C11","doi-asserted-by":"crossref","first-page":"e33854","DOI":"10.1371\/journal.pone.0033854","article-title":"Differences in the population structure of invasive Streptococcus suis strains isolated from pigs and from humans in The Netherlands","volume":"7","author":"Schultsz","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170425161511_JIU813C12","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.micpath.2011.08.002","article-title":"The novel virulence-related gene stp of Streptococcus suis serotype 9 strain contributes to a significant reduction in mouse mortality","volume":"51","author":"Zhu","year":"2011","journal-title":"Microb Pathog"},{"key":"key\n\t\t\t\t20170425161511_JIU813C13","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1128\/JCM.40.10.3671-3680.2002","article-title":"Development of a multilocus sequence typing scheme for the pig pathogen Streptococcus suis: identification of virulent clones and potential capsular serotype exchange","volume":"40","author":"King","year":"2002","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20170425161511_JIU813C14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/1471-2180-11-161","article-title":"Genetic diversity of Streptococcus suis isolates as determined by comparative genome hybridization","volume":"11","author":"de Greeff","year":"2011","journal-title":"BMC Microbiol"},{"key":"key\n\t\t\t\t20170425161511_JIU813C15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1053\/rvsc.2001.0448","article-title":"Thirty minutes transport causes small intestinal acidosis in pigs","volume":"70","author":"Nabuurs","year":"2001","journal-title":"Res Vet Sci"},{"key":"key\n\t\t\t\t20170425161511_JIU813C16","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1128\/IAI.60.2.550-556.1992","article-title":"Virulence of Streptococcus suis type 2 strains in newborn germfree pigs depends on phenotype","volume":"60","author":"Vecht","year":"1992","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170425161511_JIU813C17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0165-2427(03)00031-X","article-title":"Association of lymphopenia with porcine circovirus type 2 induced postweaning multisystemic wasting syndrome (PMWS)","volume":"92","author":"Nielsen","year":"2003","journal-title":"Vet Immunol Immunopathol"},{"key":"key\n\t\t\t\t20170425161511_JIU813C18","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1472-765X.2010.02804.x","article-title":"A versatile internal control for use as DNA in real-time PCR and as RNA in real-time reverse transcription PCR assays","volume":"50","author":"Deer","year":"2010","journal-title":"Lett Appl Microbiol"},{"key":"key\n\t\t\t\t20170425161511_JIU813C19","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.diagmicrobio.2010.12.015","article-title":"Real-time PCR for detection of Streptococcus suis serotype 2 in cerebrospinal fluid of human patients with meningitis","volume":"70","author":"Nga","year":"2011","journal-title":"Diagn Microbiol Infect Dis"},{"key":"key\n\t\t\t\t20170425161511_JIU813C20","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1128\/IAI.69.4.2732-2735.2001","article-title":"Generation and characterization of a defined mutant of Streptococcus suis lacking suilysin","volume":"69","author":"Allen","year":"2001","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170425161511_JIU813C21","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1128\/IAI.67.4.1750-1756.1999","article-title":"Identification and characterization of the cps locus of Streptococcus suis serotype 2: the capsule protects against phagocytosis and is an important virulence factor","volume":"67","author":"Smith","year":"1999","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170425161511_JIU813C22","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1128\/MMBR.00064-12","article-title":"Pathogenesis of human enterovirulent bacteria: lessons from cultured, fully differentiated human colon cancer cell lines","volume":"77","author":"Lievin-Le Moal","year":"2013","journal-title":"Microbiol Mol Biol Rev"},{"key":"key\n\t\t\t\t20170425161511_JIU813C23","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.vetmic.2011.10.017","article-title":"Porcine IPEC-J2 intestinal epithelial cells in microbiological investigations","volume":"156","author":"Brosnahan","year":"2012","journal-title":"Vet Microbiol"},{"key":"key\n\t\t\t\t20170425161511_JIU813C24","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1006\/plas.2001.1532","article-title":"Thermosensitive suicide vectors for gene replacement in Streptococcus suis","volume":"46","author":"Takamatsu","year":"2001","journal-title":"Plasmid"},{"key":"key\n\t\t\t\t20170425161511_JIU813C25","doi-asserted-by":"crossref","first-page":"e89334","DOI":"10.1371\/journal.pone.0089334","article-title":"Carbohydrate Availability Regulates Virulence Gene Expression in Streptococcus suis","volume":"9","author":"Ferrando","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170425161511_JIU813C26","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1099\/mic.0.037960-0","article-title":"ApuA, a multifunctional alpha-glucan-degrading enzyme of Streptococcus suis, mediates adhesion to porcine epithelium and mucus","volume":"156","author":"Ferrando","year":"2010","journal-title":"Microbiology"},{"key":"key\n\t\t\t\t20170425161511_JIU813C27","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1086\/498982","article-title":"Group B Streptococcus crosses human epithelial cells by a paracellular route","volume":"193","author":"Soriani","year":"2006","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425161511_JIU813C28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0091-679X(08)61707-0","article-title":"Chapter 2: Assays of Cell Viability: Discrimination of Cells Dying by Apoptosis Original","volume":"41","author":"Darzynkiewic","year":"1994","journal-title":"Methods Cell Biol"},{"key":"key\n\t\t\t\t20170425161511_JIU813C29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nri3608","article-title":"Intestinal epithelial cells: regulators of barrier function and immune homeostasis","volume":"14","author":"Peterson","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20170425161511_JIU813C30","doi-asserted-by":"crossref","first-page":"e1003015","DOI":"10.1371\/journal.ppat.1003015","article-title":"InlA promotes dissemination of Listeria monocytogenes to the mesenteric lymph nodes during food borne infection of mice","volume":"8","author":"Bou Ghanem","year":"2012","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20170425161511_JIU813C31","doi-asserted-by":"crossref","first-page":"e35849","DOI":"10.1371\/journal.pone.0035849","article-title":"Immunomodulatory effects of Streptococcus suis capsule type on human dendritic cell responses, phagocytosis and intracellular survival","volume":"7","author":"Meijerink","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170425161511_JIU813C32","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.vetmic.2012.09.004","article-title":"A novel fibronectin-binding protein of Streptococcus suis serotype 2 contributes to epithelial cell invasion and in vivo dissemination","volume":"162","author":"Li","year":"2013","journal-title":"Vet Microbiol"},{"key":"key\n\t\t\t\t20170425161511_JIU813C33","doi-asserted-by":"crossref","first-page":"38854","DOI":"10.1074\/jbc.M111.260992","article-title":"Identification of a novel streptococcal adhesin P (SadP) protein recognizing galactosyl-alpha1\u20134-galactose-containing glycoconjugates: convergent evolution of bacterial pathogens to binding of the same host receptor","volume":"286","author":"Kouki","year":"2011","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170425161511_JIU813C34","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1172\/JCI118168","article-title":"Maturational regulation of globotriaosylceramide, the Shiga-like toxin 1 receptor, in cultured human gut epithelial cells","volume":"96","author":"Jacewicz","year":"1995","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170425161511_JIU813C35","doi-asserted-by":"crossref","first-page":"4461","DOI":"10.1128\/AEM.00182-10","article-title":"Verotoxin 2 enhances adherence of enterohemorrhagic Escherichia coli O157:H7 to intestinal epithelial cells and expression of \u03b21-integrin by IPEC-J2 cells","volume":"76","author":"Liu","year":"2010","journal-title":"Appl Environ Microbiol"},{"key":"key\n\t\t\t\t20170425161511_JIU813C36","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1478-811X-11-72","article-title":"Transmigration route of Campylobacter jejuni across polarized intestinal epithelial cells: paracellular, transcellular or both?","volume":"11","author":"Backert","year":"2013","journal-title":"Cell Commun Signal"},{"key":"key\n\t\t\t\t20170425161511_JIU813C37","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1757-4749-5-16","article-title":"Secreted Listeria adhesion protein (Lap) influences Lap-mediated Listeria monocytogenes paracellular translocation through epithelial barrier","volume":"5","author":"Kim","year":"2013","journal-title":"Gut Pathog"},{"key":"key\n\t\t\t\t20170425161511_JIU813C38","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1086\/591182","article-title":"Pilus backbone contributes to group B Streptococcus paracellular translocation through epithelial cells","volume":"198","author":"Pezzicoli","year":"2008","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425161511_JIU813C39","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/infdis\/jiq169","article-title":"Novel clues on the specific association of Streptococcus gallolyticus subsp gallolyticus with colorectal cancer","volume":"203","author":"Boleij","year":"2011","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425161511_JIU813C40","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S1473-3099(07)70001-4","article-title":"Streptococcus suis: an emerging zoonotic pathogen","volume":"7","author":"Lun","year":"2007","journal-title":"Lancet Infect Dis"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/212\/1\/95\/13805986\/jiu813.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T02:34:19Z","timestamp":1598582059000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jiu813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,18]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,12,18]]},"published-print":{"date-parts":[[2015,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiu813","relation":{},"ISSN":["1537-6613","0022-1899"],"issn-type":[{"value":"1537-6613","type":"electronic"},{"value":"0022-1899","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12,18]]}}}