{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:15:00Z","timestamp":1791846900283,"version":"4.3.4"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"3","funder":[{"name":"CDC"},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI095274"],"award-info":[{"award-number":["R01AI095274"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dis."],"published-print":{"date-parts":[[2016,2,1]]},"DOI":"10.1093\/infdis\/jiv327","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T20:15:08Z","timestamp":1434053708000},"page":"379-385","source":"Crossref","is-referenced-by-count":140,"title":["A Novel Botulinum Neurotoxin, Previously Reported as Serotype H, Has a Hybrid-Like Structure With Regions of Similarity to the Structures of Serotypes A and F and Is Neutralized With Serotype A Antitoxin"],"prefix":"10.1093","volume":"213","author":[{"given":"Susan E.","family":"Maslanka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"L\u00faquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet K.","family":"Dykes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Tepp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina L.","family":"Pier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Pellett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian H.","family":"Raphael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne R.","family":"Kalb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Barr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agam","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,6,10]]},"reference":[{"key":"2016012803022214000_213.3.379.1","doi-asserted-by":"crossref","unstructured":"Yu PA , Maslanka SE , St Louis ME , Swerdlow DL . Botulism. In: Abrutyn E , Brachman PS , eds. Bacterial infections in humans. New York: Springer, 2009:159\u201376.","DOI":"10.1007\/978-0-387-09843-2_7"},{"key":"2016012803022214000_213.3.379.2","first-page":"299","article-title":"Investigational heptavalent botulinum antitoxin (HBAT) to replace licensed botulinum antitoxin AB and investigational Botulinum antitoxin E","volume":"59","author":"CDC","year":"2010","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2016012803022214000_213.3.379.3","unstructured":"FDA approves first Botulism Antitoxin for use in neutralizing all seven known botulinum nerve toxin serotypes [news release]. 2013. http:\/\/www.fda.gov\/newsEvents\/Newsroom\/Press\/Announcements\/ucm345128.htm. Accessed 12 April 2014."},{"key":"2016012803022214000_213.3.379.4","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1056\/NEJMoa051926","article-title":"Human botulism immune globulin for the treatment of infant botulism","volume":"354","author":"Arnon","year":"2005","journal-title":"New Eng J Med"},{"key":"2016012803022214000_213.3.379.5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.7326\/0003-4819-129-3-199808010-00011","article-title":"Botulism in the United States: A clinical and epidemiologic review","volume":"123","author":"Shapiro","year":"1998","journal-title":"Annals of Internal Med"},{"key":"2016012803022214000_213.3.379.6","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90988-4"},{"key":"2016012803022214000_213.3.379.7","first-page":"535","article-title":"Botulinum neurotoxins: genetic, structural and mechanistic insights","volume":"12","author":"Rossetto","year":"2014","journal-title":"Nature"},{"key":"2016012803022214000_213.3.379.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.07.040"},{"key":"2016012803022214000_213.3.379.9","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01180-06"},{"key":"2016012803022214000_213.3.379.10","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0167-4781(96)00006-1","article-title":"Mosaic structures of neurotoxins produced from Clostridium botulinum types C and D organisms","volume":"1307","author":"Moriishi","year":"1996","journal-title":"Biochimica et Biophysica Acta"},{"key":"2016012803022214000_213.3.379.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.07.023"},{"key":"2016012803022214000_213.3.379.12","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.03109-09"},{"key":"2016012803022214000_213.3.379.13","doi-asserted-by":"publisher","DOI":"10.1021\/ac5001509"},{"key":"2016012803022214000_213.3.379.14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/infdis\/jit449","article-title":"A novel strain of Clostridium botulinum that produces type B and type H botulinum toxins","volume":"209","author":"Barash","year":"2013","journal-title":"J Infect Dis"},{"key":"2016012803022214000_213.3.379.15","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu211"},{"key":"2016012803022214000_213.3.379.16","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.01275-14"},{"key":"2016012803022214000_213.3.379.17","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1128\/JVI.73.1.152-160.1999","article-title":"Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination","volume":"73","author":"Lole","year":"1999","journal-title":"J Virol"},{"key":"2016012803022214000_213.3.379.18","unstructured":"Maslanka SE , Solomon HM , Sharma S , Johnson EA . Clostridium botulinum and its toxins. In: Tortorello ML , Downes FP , Doores S , Ito K , Salfinger Y , eds. Compendium of methods for the microbiological examination of foods. Washington, DC: American Public Health Association, 2013."},{"key":"2016012803022214000_213.3.379.19","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22879"},{"key":"2016012803022214000_213.3.379.20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/978-1-4612-3898-0_12","article-title":"Botulism","volume-title":"Laboratory diagnosis of infectious diseases: principles and practice","volume":"Vol 1","author":"Hatheway","year":"1988"},{"key":"2016012803022214000_213.3.379.21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1385\/1-59259-052-7:27","article-title":"Purification of Clostridium botulinum type A neurotoxin","volume-title":"Bacterial toxins: methods and protocols, methods in molecular biology","volume":"Vol 145","author":"Malizio","year":"2000"},{"key":"2016012803022214000_213.3.379.22","doi-asserted-by":"publisher","DOI":"10.1021\/ac502948v"},{"key":"2016012803022214000_213.3.379.23","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfr354"},{"key":"2016012803022214000_213.3.379.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.08.078"},{"key":"2016012803022214000_213.3.379.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2010.01.003"},{"key":"2016012803022214000_213.3.379.26","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.resmic.2014.09.007","article-title":"Historical and current perspectives on Clostridium botulinum diversity","volume":"166","author":"Smith","year":"2014","journal-title":"Res Microbiol"},{"key":"2016012803022214000_213.3.379.27","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1128\/JCM.14.6.607-611.1981","article-title":"Atypical toxin variant of Clostridium botulinum type B associated with infant botulism","volume":"14","author":"Hatheway","year":"1981","journal-title":"J Clin Microbiol"},{"key":"2016012803022214000_213.3.379.28","first-page":"68","article-title":"Clostridium botulinum subtype Ba","volume":"257","author":"Gim\u00e9nez","year":"1984","journal-title":"Zbl Bakt Hyg A"},{"key":"2016012803022214000_213.3.379.29","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/infdis\/jit450","article-title":"Molecular characterization of a novel botulinum neurotoxin type H gene","volume":"209","author":"Dover","year":"2013","journal-title":"J Infect Dis"},{"key":"2016012803022214000_213.3.379.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.09.084"},{"key":"2016012803022214000_213.3.379.31","doi-asserted-by":"publisher","DOI":"10.1586\/erv.13.37"},{"key":"2016012803022214000_213.3.379.32","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00382-13"},{"key":"2016012803022214000_213.3.379.33","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1128\/JB.4.5.555-570.1.1919","article-title":"Notes on Bacillus botulinus","volume":"4","author":"Burke","year":"1919","journal-title":"J Bacteriol"},{"key":"2016012803022214000_213.3.379.34","first-page":"701","article-title":"Preparation and assay of the International standards for Clostridium botulinum types A, B, C, D, and E antitoxins","volume":"29","author":"Bowmer","year":"1963","journal-title":"Bull World Health Organ"},{"key":"2016012803022214000_213.3.379.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.biologicals.2005.11.009"},{"key":"2016012803022214000_213.3.379.36","first-page":"596","article-title":"Variaciones antigenicas en toxinas botulinicas del tipo F. Ensayo de definiciones para la tipificacion serologica y clasificacion de Clostridium botulinum","volume":"32","author":"Gim\u00e9nez","year":"1972","journal-title":"Medicina (Bs Aires)"},{"key":"2016012803022214000_213.3.379.37","doi-asserted-by":"crossref","unstructured":"Gim\u00e9nez DF , Gim\u00e9nez JA . Serological subtypes of botulinal neurotoxins. In: DasGupta BR , ed. Botulinum and tetanus neurotoxins. New York: Plenus Press, 1993:421\u201330.","DOI":"10.1007\/978-1-4757-9542-4_46"},{"key":"2016012803022214000_213.3.379.38","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.9.5450-5457.2005"},{"key":"2016012803022214000_213.3.379.39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005355"},{"key":"2016012803022214000_213.3.379.40","doi-asserted-by":"publisher","DOI":"10.1021\/ac504716v"},{"key":"2016012803022214000_213.3.379.41","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.11.4.352"},{"key":"2016012803022214000_213.3.379.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.biologicals.2003.08.001"},{"key":"2016012803022214000_213.3.379.43","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/150.3.407"}],"container-title":["Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/213\/3\/379\/7424439\/jiv327.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T05:40:34Z","timestamp":1599111634000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1093\/infdis\/jiv327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,10]]},"references-count":43,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,1,7]]},"published-print":{"date-parts":[[2016,2,1]]}},"alternative-id":["10.1093\/infdis\/jiv327"],"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiv327","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,10]]}}}