{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T10:11:05Z","timestamp":1793959865491,"version":"4.8.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,1]]},"DOI":"10.1093\/infdis\/jix086","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T08:54:58Z","timestamp":1487148898000},"page":"1376-1385","source":"Crossref","is-referenced-by-count":81,"title":["Higher T-Cell Responses Induced by DNA\/rAd5 HIV-1 Preventive Vaccine Are Associated With Lower HIV-1 Infection Risk in an Efficacy Trial"],"prefix":"10.1093","volume":"215","author":[{"given":"Holly E.","family":"Janes","sequence":"first","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen W.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Frahm","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"De Rosa","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hural","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig A.","family":"Magaret","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly","family":"Karuna","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carter","family":"Bentley","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Gottardo","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Finak","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Grove","sequence":"additional","affiliation":[{"name":"The Statistical Center for HIV\/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingchao","family":"Shen","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barney S.","family":"Graham","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Koup","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Mulligan","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center, Emory University, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beryl","family":"Koblin","sequence":"additional","affiliation":[{"name":"Laboratory of Infectious Disease Prevention, New York Blood Center, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan P.","family":"Buchbinder","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Epidemiology\/Biostatistics, University of California San Francisco;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Keefer","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center, School of Medicine and Dentistry, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Adams","sequence":"additional","affiliation":[{"name":"Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuka","family":"Anude","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Corey","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Sobieszczyk","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Columbia University College of Physicians and Surgeons, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Hammer","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Columbia University College of Physicians and Surgeons, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Juliana","family":"McElrath","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,2,12]]},"reference":[{"key":"key\n\t\t\t\t20180306103606_CIT0001","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1086\/428404","article-title":"Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection","volume":"191","author":"Flynn","year":"2005","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180306103606_CIT0002","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1086\/508748","article-title":"Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand","volume":"194","author":"Pitisuttithum","year":"2006","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180306103606_CIT0003","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/S0140-6736(08)61591-3","article-title":"Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial","volume":"372","author":"Buchbinder","year":"2008","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180306103606_CIT0004","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S1473-3099(11)70098-6","article-title":"Safety and efficacy of the HVTN 503\/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study","volume":"11","author":"Gray","year":"2011","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t20180306103606_CIT0005","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1056\/NEJMoa0908492","article-title":"Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand","volume":"361","author":"Rerks-Ngarm","year":"2009","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180306103606_CIT0006","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1056\/NEJMoa1310566","article-title":"Efficacy trial of a DNA\/rAd5 HIV-1 preventive vaccine","volume":"369","author":"Hammer","year":"2013","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180306103606_CIT0007","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/COH.0b013e32833d17ac","article-title":"HIV vaccines: lessons learned and the way forward","volume":"5","author":"Kim","year":"2010","journal-title":"Curr Opin HIV AIDS"},{"key":"key\n\t\t\t\t20180306103606_CIT0008","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2174\/1570162X113116660051","article-title":"Lessons learned from HIV vaccine clinical efficacy trials","volume":"11","author":"Day","year":"2013","journal-title":"Curr HIV Res"},{"key":"key\n\t\t\t\t20180306103606_CIT0009","doi-asserted-by":"crossref","first-page":"310rv7","DOI":"10.1126\/scitranslmed.aac7732","article-title":"Immune correlates of vaccine protection against HIV-1 acquisition","volume":"7","author":"Corey","year":"2015","journal-title":"Sci Transl Med"},{"key":"key\n\t\t\t\t20180306103606_CIT0010","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1086\/522428","article-title":"A framework for assessing immunological correlates of protection in vaccine trials","volume":"196","author":"Qin","year":"2007","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180306103606_CIT0011","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1111\/j.1541-0420.2008.01014.x","article-title":"Evaluating candidate principal surrogate endpoints","volume":"64","author":"Gilbert","year":"2008","journal-title":"Biometrics"},{"key":"key\n\t\t\t\t20180306103606_CIT0012","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1093\/cid\/cis238","article-title":"Nomenclature for immune correlates of protection after vaccination","volume":"54","author":"Plotkin","year":"2012","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180306103606_CIT0013","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1111\/j.1541-0420.2006.00569.x","article-title":"Augmented designs to assess immune response in vaccine trials","volume":"62","author":"Follmann","year":"2006","journal-title":"Biometrics"},{"key":"key\n\t\t\t\t20180306103606_CIT0014","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1056\/NEJMoa1113425","article-title":"Immune-correlates analysis of an HIV-1 vaccine efficacy trial","volume":"366","author":"Haynes","year":"2012","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180306103606_CIT0015","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nbt.3187","article-title":"COMPASS identifies T-cell subsets correlated with clinical outcomes","volume":"33","author":"Lin","year":"2015","journal-title":"Nat Biotechnol"},{"key":"key\n\t\t\t\t20180306103606_CIT0016","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jim.2007.03.002","article-title":"Optimization and validation of an 8-color intracellular cytokine staining (ICS) assay to quantify antigen-specific T cells induced by vaccination","volume":"323","author":"Horton","year":"2007","journal-title":"J Immunol Methods"},{"key":"key\n\t\t\t\t20180306103606_CIT0017","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1023\/A:1009661900674","article-title":"Exposure stratified case-cohort designs","volume":"6","author":"Borgan","year":"2000","journal-title":"Lifetime Data Anal"},{"key":"key\n\t\t\t\t20180306103606_CIT0018","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.2517-6161.1996.tb02080.x","article-title":"Regression Shrinkage and Selection via the Lasso","volume":"58","author":"Tibshirani","year":"1996","journal-title":"J R Stat Soc Series B Stat Methodol"},{"key":"key\n\t\t\t\t20180306103606_CIT0019","doi-asserted-by":"crossref","first-page":"13439","DOI":"10.1073\/pnas.1400446111","article-title":"Preferential infection of human Ad5-specific CD4 T cells by HIV in Ad5 naturally exposed and recombinant Ad5-HIV vaccinated individuals","volume":"111","author":"Hu","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180306103606_CIT0020","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1172\/JCI60202","article-title":"Human adenovirus-specific T cells modulate HIV-specific T cell responses to an Ad5-vectored HIV-1 vaccine","volume":"122","author":"Frahm","year":"2012","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180306103606_CIT0021","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1086\/428405","article-title":"Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase 3 HIV-1 preventive vaccine trial","volume":"191","author":"Gilbert","year":"2005","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180306103606_CIT0022","first-page":"255","article-title":"Nonhuman primate models in AIDS research","volume":"8","author":"Evans","year":"2013","journal-title":"Curr Opin HIV AIDS"},{"key":"key\n\t\t\t\t20180306103606_CIT0023","first-page":"187","article-title":"Predictive value of primate models for AIDS","volume":"6","author":"Haigwood","year":"2004","journal-title":"AIDS Rev"},{"key":"key\n\t\t\t\t20180306103606_CIT0024","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2174\/1568005054201508","article-title":"Non-human primate models for AIDS vaccine research","volume":"5","author":"Hu","year":"2005","journal-title":"Curr Drug Targets Infect Disord"},{"key":"key\n\t\t\t\t20180306103606_CIT0025","doi-asserted-by":"crossref","first-page":"81ra36","DOI":"10.1126\/scitranslmed.3002351","article-title":"Immune and genetic correlates of vaccine protection against mucosal infection by SIV in monkeys","volume":"3","author":"Letvin","year":"2011","journal-title":"Sci Transl Med"},{"key":"key\n\t\t\t\t20180306103606_CIT0026","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1126\/science.aab3886","article-title":"Protective efficacy of adenovirus\/protein vaccines against SIV challenges in rhesus monkeys","volume":"349","author":"Barouch","year":"2015","journal-title":"Science"},{"key":"key\n\t\t\t\t20180306103606_CIT0027","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.4049\/jimmunol.1202958","article-title":"Polyinosinic-polycytidylic acid is the most effective TLR adjuvant for SIV Gag protein-induced T cell responses in nonhuman primates","volume":"190","author":"Park","year":"2013","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20180306103606_CIT0028","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1038\/nm.2934","article-title":"Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines","volume":"18","author":"Fukazawa","year":"2012","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20180306103606_CIT0029","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature10003","article-title":"Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine","volume":"473","author":"Hansen","year":"2011","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180306103606_CIT0030","doi-asserted-by":"crossref","first-page":"6172","DOI":"10.4049\/jimmunol.1401504","article-title":"Antibody to the gp120 V1\/V2 loops and CD4+ and CD8+ T cell responses in protection from SIVmac251 vaginal acquisition and persistent viremia","volume":"193","author":"Gordon","year":"2014","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20180306103606_CIT0031","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1128\/JVI.02544-12","article-title":"Antibodies with high avidity to the gp120 envelope protein in protection from simian immunodeficiency virus SIV(mac251) acquisition in an immunization regimen that mimics the RV-144 Thai trial","volume":"87","author":"Pegu","year":"2013","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20180306103606_CIT0032","doi-asserted-by":"crossref","first-page":"10802","DOI":"10.1128\/JVI.01440-15","article-title":"Vaccine-induced simian immunodeficiency virus-specific CD8+ T-cell responses focused on a single Nef epitope select for escape variants shortly after infection","volume":"89","author":"Martins","year":"2015","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20180306103606_CIT0033","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1016\/j.vaccine.2012.04.082","article-title":"A trivalent recombinant Ad5 gag\/pol\/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challenge","volume":"30","author":"Reynolds","year":"2012","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20180306103606_CIT0034","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1128\/JVI.00969-09","article-title":"Efficacy of multivalent adenovirus-based vaccine against simian immunodeficiency virus challenge","volume":"84","author":"Casimiro","year":"2010","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20180306103606_CIT0035","doi-asserted-by":"crossref","first-page":"9190","DOI":"10.1128\/JVI.00041-10","article-title":"Macaques vaccinated with simian immunodeficiency virus SIVmac239Delta nef delay acquisition and control replication after repeated low-dose heterologous SIV challenge","volume":"84","author":"Reynolds","year":"2010","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20180306103606_CIT0036","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nm.4105","article-title":"Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition","volume":"22","author":"Vaccari","year":"2016","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20180306103606_CIT0037","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nature10766","article-title":"Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys","volume":"482","author":"Barouch","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180306103606_CIT0038","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nm.1935","article-title":"Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge","volume":"15","author":"Hansen","year":"2009","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20180306103606_CIT0039","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/S0140-6736(08)61592-5","article-title":"HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis","volume":"372","author":"McElrath","year":"2008","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180306103606_CIT0040","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1002\/sim.6439","article-title":"Calibration weighted estimation of semiparametric transformation models for two-phase sampling","volume":"34","author":"Fong","year":"2015","journal-title":"Stat Med"},{"key":"key\n\t\t\t\t20180306103606_CIT0041","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.vaccine.2008.11.071","article-title":"AIDSVAX immunization induces HIV-specific CD8+ T-cell responses in high-risk, HIV-negative volunteers who subsequently acquire HIV infection","volume":"27","author":"Jones","year":"2009","journal-title":"Vaccine"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/215\/9\/1376\/24262192\/jix086.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T13:41:41Z","timestamp":1719063701000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/215\/9\/1376\/2990220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,12]]},"references-count":41,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,2,12]]},"published-print":{"date-parts":[[2017,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jix086","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,5,1]]},"published":{"date-parts":[[2017,2,12]]}}}