{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:03:55Z","timestamp":1770887035378,"version":"3.50.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"4","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R37AI048793"],"award-info":[{"award-number":["R37AI048793"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,30]]},"DOI":"10.1093\/infdis\/jix538","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T15:09:51Z","timestamp":1507043391000},"page":"560-566","source":"Crossref","is-referenced-by-count":19,"title":["Polymorphisms in the Wilms Tumor Gene Are Associated With Interindividual Variations in Rubella Virus\u2013Specific Cellular Immunity After Measles-Mumps-Rubella II Vaccination"],"prefix":"10.1093","volume":"217","author":[{"given":"Emily A","family":"Voigt","sequence":"first","affiliation":[{"name":"Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iana H","family":"Haralambieva","sequence":"additional","affiliation":[{"name":"Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth L","family":"Larrabee","sequence":"additional","affiliation":[{"name":"Mayo Clinic Division of Biostatistics, Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard B","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna G","family":"Ovsyannikova","sequence":"additional","affiliation":[{"name":"Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J","family":"Schaid","sequence":"additional","affiliation":[{"name":"Mayo Clinic Division of Biostatistics, Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory A","family":"Poland","sequence":"additional","affiliation":[{"name":"Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"key":"key\n\t\t\t\t20180306104555_CIT0001","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0140-6736(82)92677-0","article-title":"Consequences of confirmed maternal rubella at successive stages of pregnancy","volume":"2","author":"Miller","year":"1982","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180306104555_CIT0002","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/S1473-3099(15)00102-4","article-title":"Rubella is eliminated from the Americas","volume":"15","author":"Kirby","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t20180306104555_CIT0003","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1016\/S0140-6736(14)60539-0","article-title":"Rubella","volume":"385","author":"Lambert","year":"2015","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180306104555_CIT0004","first-page":"258","article-title":"Vaccination of schoolgirls against rubella. Assessment of serological status and a comparative trial of Wistar RA 27\/3 and Cendehill strain live attenuated rubella vaccines in 13-year-old schoolgirls in Dudley","volume":"29","author":"Freestone","year":"1975","journal-title":"Br J Prev Soc Med"},{"key":"key\n\t\t\t\t20180306104555_CIT0005","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1086\/605410","article-title":"Persistence of rubella antibodies after 2 doses of measles-mumps-rubella vaccine","volume":"200","author":"LeBaron","year":"2009","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180306104555_CIT0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12026-013-8475-y","article-title":"Characterization of humoral and cellular immunity to rubella vaccine in four distinct cohorts","volume":"58","author":"Lambert","year":"2014","journal-title":"Immunol Res"},{"key":"key\n\t\t\t\t20180306104555_CIT0007","doi-asserted-by":"crossref","first-page":"6093","DOI":"10.1016\/j.vaccine.2015.06.113","article-title":"Rubella specific cell-mediated and humoral immunity following vaccination in college students with low antibody titers","volume":"33","author":"Terada","year":"2015","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20180306104555_CIT0008","doi-asserted-by":"crossref","first-page":"e1002344","DOI":"10.1371\/journal.ppat.1002344","article-title":"Vaccinomics and personalized vaccinology: is science leading us toward a new path of directed vaccine development and discovery","volume":"7","author":"Poland","year":"2011","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20180306104555_CIT0009","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1016\/j.vaccine.2013.02.070","article-title":"Personalized vaccinology: one size and dose might not fit both sexes","volume":"31","author":"Klein","year":"2013","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20180306104555_CIT0010","doi-asserted-by":"crossref","first-page":"6926","DOI":"10.1016\/j.vaccine.2009.08.109","article-title":"Replication of rubella vaccine population genetic studies: validation of HLA genotype and humoral response associations","volume":"27","author":"Ovsyannikova","year":"2009","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20180306104555_CIT0011","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00251-010-0423-6","article-title":"SNP\/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine","volume":"62","author":"Dhiman","year":"2010","journal-title":"Immunogenetics"},{"key":"key\n\t\t\t\t20180306104555_CIT0012","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1086\/649588","article-title":"Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination","volume":"201","author":"Ovsyannikova","year":"2010","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180306104555_CIT0013","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.humimm.2010.01.004","article-title":"2\u02b9-5\u02b9-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine","volume":"71","author":"Haralambieva","year":"2010","journal-title":"Hum Immunol"},{"key":"key\n\t\t\t\t20180306104555_CIT0014","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1093\/infdis\/jiu553","article-title":"Polymorphisms in HLA-DPB1 are associated with differences in rubella virus-specific humoral immunity after vaccination","volume":"211","author":"Lambert","year":"2015","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180306104555_CIT0015","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.humimm.2009.11.002","article-title":"Effect of human leukocyte antigen homozygosity on rubella vaccine-induced humoral and cell-mediated immune responses","volume":"71","author":"Kennedy","year":"2010","journal-title":"Hum Immunol"},{"key":"key\n\t\t\t\t20180306104555_CIT0016","doi-asserted-by":"crossref","first-page":"7883","DOI":"10.1016\/j.vaccine.2011.08.083","article-title":"Associations between single nucleotide polymorphisms and haplotypes in cytokine and cytokine receptor genes and immunity to measles vaccination","volume":"29","author":"Haralambieva","year":"2011","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20180306104555_CIT0017","doi-asserted-by":"crossref","first-page":"8988","DOI":"10.1016\/j.vaccine.2011.09.043","article-title":"Genetic polymorphisms in host antiviral genes: associations with humoral and cellular immunity to measles vaccine","volume":"29","author":"Haralambieva","year":"2011","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20180306104555_CIT0018","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1016\/j.vaccine.2012.01.025","article-title":"Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes","volume":"30","author":"Kennedy","year":"2012","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20180306104555_CIT0019","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1007\/s00439-012-1174-2","article-title":"Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients","volume":"131","author":"Kennedy","year":"2012","journal-title":"Hum Genet"},{"key":"key\n\t\t\t\t20180306104555_CIT0020","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1159\/000331585","article-title":"The association of CD46, SLAM and CD209 cellular receptor gene SNPs with variations in measles vaccine-induced immune responses: a replication study and examination of novel polymorphisms","volume":"72","author":"Ovsyannikova","year":"2011","journal-title":"Hum Hered"},{"key":"key\n\t\t\t\t20180306104555_CIT0021","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1016\/j.vaccine.2009.01.079","article-title":"Influence of host genetic variation on rubella-specific T cell cytokine responses following rubella vaccination","volume":"27","author":"Ovsyannikova","year":"2009","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20180306104555_CIT0022","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cyto.2009.12.002","article-title":"Predominant inflammatory cytokine secretion pattern in response to two doses of live rubella vaccine in healthy vaccinees","volume":"50","author":"Dhiman","year":"2010","journal-title":"Cytokine"},{"key":"key\n\t\t\t\t20180306104555_CIT0023","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nmeth.2307","article-title":"Improved whole-chromosome phasing for disease and population genetic studies","volume":"10","author":"Delaneau","year":"2013","journal-title":"Nat Methods"},{"key":"key\n\t\t\t\t20180306104555_CIT0024","doi-asserted-by":"crossref","first-page":"e1000529","DOI":"10.1371\/journal.pgen.1000529","article-title":"A flexible and accurate genotype imputation method for the next generation of genome-wide association studies","volume":"5","author":"Howie","year":"2009","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t20180306104555_CIT0025","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/gepi.20303","article-title":"Estimation of the multiple testing burden for genomewide association studies of nearly all common variants","volume":"32","author":"Pe\u2019er","year":"2008","journal-title":"Genet Epidemiol"},{"key":"key\n\t\t\t\t20180306104555_CIT0026","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1056\/NEJMra0905980","article-title":"Genomewide association studies and assessment of the risk of disease","volume":"363","author":"Manolio","year":"2010","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180306104555_CIT0027","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/ng.610","article-title":"Estimation of effect size distribution from genome-wide association studies and implications for future discoveries","volume":"42","author":"Park","year":"2010","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20180306104555_CIT0028","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nn.4228","article-title":"Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept","volume":"19","author":"Franke","year":"2016","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20180306104555_CIT0029","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0378-1119(01)00593-5","article-title":"WT1 proteins: functions in growth and differentiation","volume":"273","author":"Scharnhorst","year":"2001","journal-title":"Gene"},{"key":"key\n\t\t\t\t20180306104555_CIT0030","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0092-8674(91)90194-4","article-title":"Germline mutations in the Wilms\u2019 tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome","volume":"67","author":"Pelletier","year":"1991","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180306104555_CIT0031","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/hmg\/7.4.709","article-title":"Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +\/-KTS splice isoforms","volume":"7","author":"Klamt","year":"1998","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20180306104555_CIT0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-4023-3_1","article-title":"WT1 mutation in childhood cancer","volume":"1467","author":"Charlton","year":"2016","journal-title":"Methods Mol Biol"},{"key":"key\n\t\t\t\t20180306104555_CIT0033","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.2217\/imt-2016-0031","article-title":"Wilms\u2019 tumor 1 (WT1)-targeted cancer vaccines to extend survival for patients with pancreatic cancer","volume":"8","author":"Koido","year":"2016","journal-title":"Immunotherapy"},{"key":"key\n\t\t\t\t20180306104555_CIT0034","doi-asserted-by":"crossref","first-page":"8132","DOI":"10.1073\/pnas.94.15.8132","article-title":"Altered expression of the WT1 Wilms tumor suppressor gene in human breast cancer","volume":"94","author":"Silberstein","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20180306104555_CIT0035","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/ijc.10476","article-title":"Overexpression of the Wilms\u2019 tumor gene WT1 in de novo lung cancers","volume":"100","author":"Oji","year":"2002","journal-title":"Int J Cancer"},{"key":"key\n\t\t\t\t20180306104555_CIT0036","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.3892\/mco.2015.647","article-title":"Association of Wilms\u2019 tumor 1 gene single-nucleotide polymorphism rs16754 with colorectal cancer","volume":"3","author":"Sangkhathat","year":"2015","journal-title":"Mol Clin Oncol"},{"key":"key\n\t\t\t\t20180306104555_CIT0037","doi-asserted-by":"crossref","first-page":"8588","DOI":"10.1074\/jbc.271.15.8588","article-title":"Differential function of Wilms\u2019 tumor gene WT1 splice isoforms in transcriptional regulation","volume":"271","author":"Hewitt","year":"1996","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180306104555_CIT0038","doi-asserted-by":"crossref","first-page":"e0130578","DOI":"10.1371\/journal.pone.0130578","article-title":"Identification of a novel C-terminal truncated WT1 isoform with antagonistic effects against major WT1 isoforms","volume":"10","author":"Tatsumi","year":"2015","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180306104555_CIT0039","doi-asserted-by":"crossref","first-page":"10878","DOI":"10.1074\/jbc.270.18.10878","article-title":"WT1-mediated transcriptional activation is inhibited by dominant negative mutant proteins","volume":"270","author":"Reddy","year":"1995","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180306104555_CIT0040","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/343774a0","article-title":"Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping","volume":"343","author":"Gessler","year":"1990","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180306104555_CIT0041","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-1-4939-4023-3_17","article-title":"Methods to identify and validate WT1-RNA interaction","volume":"1467","author":"Bharathavikru","year":"2016","journal-title":"Methods Mol Biol"},{"key":"key\n\t\t\t\t20180306104555_CIT0042","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.leukres.2015.10.014","article-title":"The hematopoietic tumor suppressor interferon regulatory factor 8 (IRF8) is upregulated by the antimetabolite cytarabine in leukemic cells involving the zinc finger protein ZNF224, acting as a cofactor of the Wilms\u2019 tumor gene 1 (WT1) protein","volume":"40","author":"Montano","year":"2016","journal-title":"Leuk Res"},{"key":"key\n\t\t\t\t20180306104555_CIT0043","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/leu.2010.33","article-title":"Wilms\u2019 tumor gene 1 protein represses the expression of the tumor suppressor interferon regulatory factor 8 in human hematopoietic progenitors and in leukemic cells","volume":"24","author":"Vidovic","year":"2010","journal-title":"Leukemia"},{"key":"key\n\t\t\t\t20180306104555_CIT0044","doi-asserted-by":"crossref","first-page":"8049","DOI":"10.1158\/0008-5472.CAN-06-1172","article-title":"Wilms\u2019 tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms\u2019 tumor","volume":"66","author":"Rong","year":"2006","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20180306104555_CIT0045","doi-asserted-by":"crossref","first-page":"e68837","DOI":"10.1371\/journal.pone.0068837","article-title":"WT1 promotes cell proliferation in non-small cell lung cancer cell lines through up-regulating cyclin D1 and p-pRb in vitro and in vivo","volume":"8","author":"Xu","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180306104555_CIT0046","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1016\/j.febslet.2010.10.045","article-title":"Wilms\u2019 tumor protein Wt1 regulates the interleukin-10 (IL-10) gene","volume":"584","author":"Sciesielski","year":"2010","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20180306104555_CIT0047","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/978-1-4939-4023-3_16","article-title":"WT1-associated protein-protein interaction networks","volume":"1467","author":"Bharathavikru","year":"2016","journal-title":"Methods Mol Biol"},{"key":"key\n\t\t\t\t20180306104555_CIT0048","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1101\/gad.12.20.3217","article-title":"WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes","volume":"12","author":"Davies","year":"1998","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20180306104555_CIT0049","doi-asserted-by":"crossref","first-page":"36520","DOI":"10.1074\/jbc.274.51.36520","article-title":"Presence of WT1, the Wilm\u2019s tumor suppressor gene product, in nuclear poly(A)(+) ribonucleoprotein","volume":"274","author":"Ladomery","year":"1999","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180306104555_CIT0050","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1074\/jbc.M115.678029","article-title":"Wilms tumor suppressor, WT1, cooperates with microRNA-26a and microRNA-101 to suppress translation of the polycomb protein, EZH2, in mesenchymal stem cells","volume":"291","author":"Akpa","year":"2016","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180306104555_CIT0051","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13046-015-0233-7","article-title":"WT1-AS promotes cell apoptosis in hepatocellular carcinoma through down-regulating of WT1","volume":"34","author":"Lv","year":"2015","journal-title":"J Exp Clin Cancer Res"},{"key":"key\n\t\t\t\t20180306104555_CIT0052","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1086\/587844","article-title":"Immune response during adverse events after 17D-derived yellow fever vaccination in Europe","volume":"197","author":"Bae","year":"2008","journal-title":"J Infect Dis"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/217\/4\/560\/24263001\/jix538.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T10:46:40Z","timestamp":1520333200000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/217\/4\/560\/4743250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,14]]},"references-count":52,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,12,14]]},"published-print":{"date-parts":[[2018,1,30]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jix538","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,2,15]]},"published":{"date-parts":[[2017,12,14]]}}}