{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:31:23Z","timestamp":1790317883391,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"4","funder":[{"DOI":"10.13039\/100011102","name":"European Union Seventh Framework Programme","doi-asserted-by":"crossref","award":["FP7-HEALTH-2011"],"award-info":[{"award-number":["FP7-HEALTH-2011"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100011102","name":"European Union Seventh Framework Programme","doi-asserted-by":"crossref","award":["282004"],"award-info":[{"award-number":["282004"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100011102","name":"European Union Seventh Framework Programme","doi-asserted-by":"crossref","award":["ANR-11-DPBS-0001"],"award-info":[{"award-number":["ANR-11-DPBS-0001"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,30]]},"DOI":"10.1093\/infdis\/jix604","type":"journal-article","created":{"date-parts":[[2017,11,19]],"date-time":"2017-11-19T07:06:48Z","timestamp":1511075208000},"page":"628-636","source":"Crossref","is-referenced-by-count":162,"title":["Protection of the Human Gut Microbiome From Antibiotics"],"prefix":"10.1093","volume":"217","author":[{"given":"Jean","family":"de Gunzburg","sequence":"first","affiliation":[{"name":"Da Volterra, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amine","family":"Ghozlane","sequence":"additional","affiliation":[{"name":"Metagenopolis, Institut National de la Recherche Agronomique, Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Ducher","sequence":"additional","affiliation":[{"name":"Da Volterra, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Le Chatelier","sequence":"additional","affiliation":[{"name":"Metagenopolis, Institut National de la Recherche Agronomique, Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Duval","sequence":"additional","affiliation":[{"name":"Bichat Claude Bernard Hospital, University Paris Diderot, Sorbonne Paris Cit\u00e9, Paris"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Infection Antimicrobials Modelling Evolution, Unit\u00e9 Mixte de Recherche, France"},{"name":"University Paris Diderot, Sorbonne Paris Cit\u00e9, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Rupp\u00e9","sequence":"additional","affiliation":[{"name":"Metagenopolis, Institut National de la Recherche Agronomique, Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Armand-Lefevre","sequence":"additional","affiliation":[{"name":"Bichat Claude Bernard Hospital, University Paris Diderot, Sorbonne Paris Cit\u00e9, Paris"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Infection Antimicrobials Modelling Evolution, Unit\u00e9 Mixte de Recherche, France"},{"name":"University Paris Diderot, Sorbonne Paris Cit\u00e9, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Sablier-Gallis","sequence":"additional","affiliation":[{"name":"Da Volterra, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Burdet","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Infection Antimicrobials Modelling Evolution, Unit\u00e9 Mixte de Recherche, France"},{"name":"University Paris Diderot, Sorbonne Paris Cit\u00e9, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loubna","family":"Alavoine","sequence":"additional","affiliation":[{"name":"Bichat Claude Bernard Hospital, University Paris Diderot, Sorbonne Paris Cit\u00e9, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Chachaty","sequence":"additional","affiliation":[{"name":"Institut Gustave-Roussy, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violaine","family":"Augustin","sequence":"additional","affiliation":[{"name":"Da Volterra, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Varastet","sequence":"additional","affiliation":[{"name":"Da Volterra, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Levenez","sequence":"additional","affiliation":[{"name":"Metagenopolis, Institut National de la Recherche Agronomique, Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Metagenopolis, Institut National de la Recherche Agronomique, Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Pons","sequence":"additional","affiliation":[{"name":"Metagenopolis, Institut National de la Recherche Agronomique, Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"France","family":"Mentr\u00e9","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Infection Antimicrobials Modelling Evolution, Unit\u00e9 Mixte de Recherche, France"},{"name":"University Paris Diderot, Sorbonne Paris Cit\u00e9, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Andremont","sequence":"additional","affiliation":[{"name":"Bichat Claude Bernard Hospital, University Paris Diderot, Sorbonne Paris Cit\u00e9, Paris"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Infection Antimicrobials Modelling Evolution, Unit\u00e9 Mixte de Recherche, France"},{"name":"University Paris Diderot, Sorbonne Paris Cit\u00e9, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,11,23]]},"reference":[{"key":"key\n\t\t\t\t20180328132500_CIT0001","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1099\/mic.0.040618-0","article-title":"Long-term impacts of antibiotic exposure on the human intestinal microbiota","volume":"156","author":"Jernberg","year":"2010","journal-title":"Microbiology"},{"key":"key\n\t\t\t\t20180328132500_CIT0002","doi-asserted-by":"crossref","first-page":"4554","DOI":"10.1073\/pnas.1000087107","article-title":"Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation","volume":"108","author":"Dethlefsen","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20180328132500_CIT0003","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1136\/gutjnl-2012-303184","article-title":"Gut microbiota disturbance during antibiotic therapy: a multi-omic approach","volume":"62","author":"P\u00e9rez-Cobas","year":"2013","journal-title":"Gut"},{"key":"key\n\t\t\t\t20180328132500_CIT0004","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2014.03.011","article-title":"Role of the microbiota in immunity and inflammation","volume":"157","author":"Belkaid","year":"2014","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180328132500_CIT0005","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nrendo.2014.210","article-title":"Antibiotics in early life and obesity","volume":"11","author":"Cox","year":"2015","journal-title":"Nat Rev Endocrinol"},{"key":"key\n\t\t\t\t20180328132500_CIT0006","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.reaurg.2010.03.021","article-title":"Resistance to fluoroquinolones in 2010: what are the consequences for prescriptions in intensive care units","volume":"19","author":"de Lastours","year":"2010","journal-title":"R\u00e9animation"},{"key":"key\n\t\t\t\t20180328132500_CIT0007","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3390\/genes6041347","article-title":"Disruption of the gut microbiome: Clostridium difficile infection and the threat of antibiotic resistance","volume":"6","author":"Johanesen","year":"2015","journal-title":"Genes (Basel)"},{"key":"key\n\t\t\t\t20180328132500_CIT0008","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1056\/NEJMra1403772","article-title":"Clostridium difficile infection","volume":"372","author":"Leffler","year":"2015","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180328132500_CIT0009","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1128\/AAC.02176-12","article-title":"Meta-analysis of antibiotics and the risk of community-associated Clostridium difficile infection","volume":"57","author":"Brown","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180328132500_CIT0010","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1093\/jac\/dkt129","article-title":"Community-associated Clostridium difficile infection and antibiotics: a meta-analysis","volume":"68","author":"Deshpande","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180328132500_CIT0011","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1093\/jac\/dkt477","article-title":"Antibiotics and hospital-acquired Clostridium difficile infection: update of systematic review and meta-analysis","volume":"69","author":"Slimings","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180328132500_CIT0012","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1056\/NEJMra1600266","article-title":"The human intestinal microbiome in health and disease","volume":"375","author":"Lynch","year":"2016","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180328132500_CIT0013","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature18646","article-title":"Human gut microbes impact host serum metabolome and insulin sensitivity","volume":"535","author":"Pedersen","year":"2016","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180328132500_CIT0014","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.cell.2014.05.052","article-title":"Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences","volume":"158","author":"Cox","year":"2014","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180328132500_CIT0015","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature12506","article-title":"Richness of human gut microbiome correlates with metabolic markers","volume":"500","author":"Le Chatelier","year":"2013","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180328132500_CIT0016","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1093\/infdis\/160.2.274","article-title":"Use of beta-lactamase-producing anaerobes to prevent ceftriaxone from degrading intestinal resistance to colonization","volume":"160","author":"L\u00e9onard","year":"1989","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180328132500_CIT0017","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1086\/379153","article-title":"Oral administration of beta-lactamase preserves colonization resistance of piperacillin-treated mice","volume":"188","author":"Stiefel","year":"2003","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180328132500_CIT0018","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/jac\/dkn298","article-title":"Orally administered beta-lactamase enzymes represent a novel strategy to prevent colonization by Clostridium difficile","volume":"62","author":"Stiefel","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180328132500_CIT0019","first-page":"838","article-title":"IPSAT P1A, a class A beta-lactamase therapy for the prevention of penicillin-induced disruption to the intestinal microflora","volume":"10","author":"Pitout","year":"2009","journal-title":"Curr Opin Investig Drugs Lond Engl 2000"},{"key":"key\n\t\t\t\t20180328132500_CIT0020","doi-asserted-by":"crossref","DOI":"10.1111\/jam.13432","article-title":"SYN-004 (ribaxamase), an oral beta-lactamase, mitigates antibiotic-mediated dysbiosis in a porcine gut microbiome model","volume-title":"J Appl Microbiol","author":"Connelly","year":"2017"},{"key":"key\n\t\t\t\t20180328132500_CIT0021","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ejps.2010.06.018","article-title":"Removal of residual colonic ciprofloxacin in the rat by activated charcoal entrapped within zinc-pectinate beads","volume":"41","author":"Khoder","year":"2010","journal-title":"Eur J Pharm Sci"},{"key":"key\n\t\t\t\t20180328132500_CIT0022","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/jcph.359","article-title":"Targeted adsorption of molecules in the colon with the novel adsorbent-based medicinal product, DAV132: a proof of concept study in healthy subjects","volume":"55","author":"de Gunzburg","year":"2015","journal-title":"J Clin Pharmacol"},{"key":"key\n\t\t\t\t20180328132500_CIT0023","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/00365540050164272","article-title":"Comparative effects of moxifloxacin and clarithromycin on the normal intestinal microflora","volume":"32","author":"Edlund","year":"2000","journal-title":"Scand J Infect Dis"},{"key":"key\n\t\t\t\t20180328132500_CIT0024","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1128\/AEM.63.7.2802-2813.1997","article-title":"Molecular microbial diversity of an anaerobic digestor as determined by small-subunit rDNA sequence analysis","volume":"63","author":"Godon","year":"1997","journal-title":"Appl Environ Microbiol"},{"key":"key\n\t\t\t\t20180328132500_CIT0025","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.1128\/AEM.65.11.4799-4807.1999","article-title":"Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut","volume":"65","author":"Suau","year":"1999","journal-title":"Appl Environ Microbiol"},{"key":"key\n\t\t\t\t20180328132500_CIT0026","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nbt.2939","article-title":"Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes","volume":"32","author":"Nielsen","year":"2014","journal-title":"Nat Biotechnol"},{"key":"key\n\t\t\t\t20180328132500_CIT0027","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nature12480","article-title":"Dietary intervention impact on gut microbial gene richness","volume":"500","author":"Cotillard","year":"2013","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180328132500_CIT0028","doi-asserted-by":"crossref","DOI":"10.1002\/0471250953.bi1107s32","article-title":"Aligning short sequencing reads with Bowtie","author":"Langmead","year":"2010","journal-title":"Curr Protoc Bioinforma"},{"key":"key\n\t\t\t\t20180328132500_CIT0029","volume-title":"Antibiotic assay. Antibiogram","author":"Kitzis","year":"2010"},{"key":"key\n\t\t\t\t20180328132500_CIT0030","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1365-2125.2005.02357.x","article-title":"Influence of activated charcoal on the pharmacokinetics of moxifloxacin following intravenous and oral administration of a 400 mg single dose to healthy males","volume":"59","author":"Stass","year":"2005","journal-title":"Br J Clin Pharmacol"},{"key":"key\n\t\t\t\t20180328132500_CIT0031","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrmicro3270","article-title":"Microbiological effects of sublethal levels of antibiotics","volume":"12","author":"Andersson","year":"2014","journal-title":"Nat Rev Microbiol"},{"key":"key\n\t\t\t\t20180328132500_CIT0032","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1086\/600122","article-title":"Ciprofloxacin dosage and emergence of resistance in human commensal bacteria","volume":"200","author":"Fantin","year":"2009","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180328132500_CIT0033","doi-asserted-by":"crossref","first-page":"e00543","DOI":"10.1128\/AAC.00543-17","article-title":"Protection of hamsters from mortality by reducing fecal moxifloxacin concentration with DAV131A in a model of moxifloxacin-induced Clostridium difficile colitis","volume":"61","author":"Burdet","year":"2017","journal-title":"Antimicrob Agents Chemother"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/217\/4\/628\/24263346\/jix604.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T23:46:40Z","timestamp":1603324000000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/217\/4\/628\/4653556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,23]]},"references-count":33,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,11,23]]},"published-print":{"date-parts":[[2018,1,30]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jix604","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/169813","asserted-by":"object"}]},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,2,15]]},"published":{"date-parts":[[2017,11,23]]}}}