{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:44:57Z","timestamp":1790624697074,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"7","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UG3 OD-023253"],"award-info":[{"award-number":["UG3 OD-023253"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AI-087881"],"award-info":[{"award-number":["U01 AI-087881"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI-114552"],"award-info":[{"award-number":["R01 AI-114552"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI-108588"],"award-info":[{"award-number":["R01 AI-108588"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 HL-129909"],"award-info":[{"award-number":["R21 HL-129909"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,13]]},"DOI":"10.1093\/infdis\/jix680","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T04:14:36Z","timestamp":1514088876000},"page":"1160-1169","source":"Crossref","is-referenced-by-count":60,"title":["Respiratory Syncytial Virus and Rhinovirus Bronchiolitis Are Associated With Distinct Metabolic Pathways"],"prefix":"10.1093","volume":"217","author":[{"given":"Christopher J","family":"Stewart","sequence":"first","affiliation":[{"name":"Alkek Center for Metagenomics and Microbiome Research, Houston, Texas"},{"name":"Department of Molecular Virology and Microbiology, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C","family":"Wong","sequence":"additional","affiliation":[{"name":"Alkek Center for Metagenomics and Microbiome Research, Houston, Texas"},{"name":"Department of Molecular Virology and Microbiology, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadim J","family":"Ajami","sequence":"additional","affiliation":[{"name":"Alkek Center for Metagenomics and Microbiome Research, Houston, Texas"},{"name":"Department of Molecular Virology and Microbiology, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F","family":"Petrosino","sequence":"additional","affiliation":[{"name":"Alkek Center for Metagenomics and Microbiome Research, Houston, Texas"},{"name":"Department of Molecular Virology and Microbiology, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro A","family":"Piedra","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology and Microbiology, Houston, Texas"},{"name":"Department of Pediatrics, Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice A","family":"Espinola","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney N","family":"Tierney","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Carlos A","family":"Camargo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M","family":"Mansbach","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,12,25]]},"reference":[{"key":"key\n\t\t\t\t20180803085117_CIT0001","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1586\/14787210.2014.906901","article-title":"Infectious pathogens and bronchiolitis outcomes","volume":"12","author":"Hasegawa","year":"2014","journal-title":"Expert Rev Anti Infect Ther"},{"key":"key\n\t\t\t\t20180803085117_CIT0002","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1001\/archpediatrics.2011.1669","article-title":"Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis","volume":"166","author":"Mansbach","year":"2012","journal-title":"Arch Pediatr Adolesc Med"},{"key":"key\n\t\t\t\t20180803085117_CIT0003","doi-asserted-by":"crossref","first-page":"e1474","DOI":"10.1542\/peds.2014-2742","article-title":"Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis","volume":"134","author":"Ralston","year":"2014","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t20180803085117_CIT0004","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1056\/NEJMoa071255","article-title":"A multicenter, randomized, controlled trial of dexamethasone for bronchiolitis","volume":"357","author":"Corneli","year":"2007","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180803085117_CIT0005","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1056\/NEJMoa0900544","article-title":"Epinephrine and dexamethasone in children with bronchiolitis","volume":"360","author":"Plint","year":"2009","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180803085117_CIT0006","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1136\/thoraxjnl-2016-208535","article-title":"A clustering approach to identify severe bronchiolitis profiles in children","volume":"71","author":"Dumas","year":"2016","journal-title":"Thorax"},{"key":"key\n\t\t\t\t20180803085117_CIT0007","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1164\/rccm.200802-309OC","article-title":"Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children","volume":"178","author":"Jackson","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20180803085117_CIT0008","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jaci.2016.03.049","article-title":"Early life rhinovirus wheezing, allergic sensitization, and asthma risk at adolescence","volume":"139","author":"Rubner","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"key\n\t\t\t\t20180803085117_CIT0009","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/j.jaci.2016.01.036","article-title":"Respiratory syncytial virus and rhinovirus severe bronchiolitis are associated with distinct nasopharyngeal microbiota","volume":"137","author":"Mansbach","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"key\n\t\t\t\t20180803085117_CIT0010","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1164\/rccm.201701-0071OC","article-title":"Associations of nasopharyngeal metabolome and microbiome with severity among infants with bronchiolitis. a multiomic analysis","volume":"196","author":"Stewart","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20180803085117_CIT0011","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1093\/infdis\/jiu658","article-title":"Respiratory syncytial virus genomic load and disease severity among children hospitalized with bronchiolitis: multicenter cohort studies in the United States and Finland","volume":"211","author":"Hasegawa","year":"2015","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180803085117_CIT0012","doi-asserted-by":"crossref","first-page":"6656","DOI":"10.1021\/ac901536h","article-title":"Integrated, nontargeted ultrahigh performance liquid chromatography\/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems","volume":"81","author":"Evans","year":"2009","journal-title":"Anal Chem"},{"key":"key\n\t\t\t\t20180803085117_CIT0013","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1183\/13993003.00152-2016","article-title":"Association of nasopharyngeal microbiota profiles with bronchiolitis severity in infants hospitalised for bronchiolitis","volume":"48","author":"Hasegawa","year":"2016","journal-title":"Eur Respir J"},{"key":"key\n\t\t\t\t20180803085117_CIT0014","first-page":"207","article-title":"A framework for human microbiome research","volume":"486","author":"Human","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180803085117_CIT0015","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/ismej.2012.8","article-title":"Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms","volume":"6","author":"Caporaso","year":"2012","journal-title":"ISME J"},{"key":"key\n\t\t\t\t20180803085117_CIT0016","doi-asserted-by":"crossref","first-page":"W251","DOI":"10.1093\/nar\/gkv380","article-title":"MetaboAnalyst 3.0\u2013making metabolomics more meaningful","volume":"43","author":"Xia","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20180803085117_CIT0017","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Ser B"},{"key":"key\n\t\t\t\t20180803085117_CIT0018","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1093\/bioinformatics\/btp515","article-title":"integrOmics: an R package to unravel relationships between two omics datasets","volume":"25","author":"L\u00ea Cao","year":"2009","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20180803085117_CIT0019","author":"Team RC","year":"2014"},{"key":"key\n\t\t\t\t20180803085117_CIT0020","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.chom.2016.12.014","article-title":"Systematic characterization and analysis of the taxonomic drivers of functional shifts in the human microbiome","volume":"21","author":"Manor","year":"2017","journal-title":"Cell Host Microbe"},{"key":"key\n\t\t\t\t20180803085117_CIT0021","doi-asserted-by":"crossref","first-page":"e00013","DOI":"10.1128\/mSystems.00013-15","article-title":"Metabolic model-based integration of microbiome taxonomic and metabolomic profiles elucidates mechanistic links between ecological and metabolic variation","volume":"1","author":"Noecker","year":"2016","journal-title":"mSystems"},{"key":"key\n\t\t\t\t20180803085117_CIT0022","first-page":"32","article-title":"A new method for non-parametric multivariate analysis of variance","volume":"26","author":"Anderson","year":"2001","journal-title":"Austral Ecol"},{"key":"key\n\t\t\t\t20180803085117_CIT0023","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1056\/NEJMra1413456","article-title":"Viral bronchiolitis in children","volume":"374","author":"Meissner","year":"2016","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180803085117_CIT0024","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1186\/s13104-015-1695-6","article-title":"Detection of respiratory syncytial virus and rhinovirus in healthy infants","volume":"8","author":"Hasegawa","year":"2015","journal-title":"BMC Res Notes"},{"key":"key\n\t\t\t\t20180803085117_CIT0025","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jpeds.2016.01.041","article-title":"Children hospitalized with rhinovirus bronchiolitis have asthma-like characteristics","volume":"172","author":"Mansbach","year":"2016","journal-title":"J Pediatr"},{"key":"key\n\t\t\t\t20180803085117_CIT0026","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1164\/rccm.201002-0221OC","article-title":"Viral load drives disease in humans experimentally infected with respiratory syncytial virus","volume":"182","author":"DeVincenzo","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20180803085117_CIT0027","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jaci.2015.02.021","article-title":"Rhinovirus-induced bronchiolitis: lack of association between virus genomic load and short-term outcomes","volume":"136","author":"Jartti","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"key\n\t\t\t\t20180803085117_CIT0028","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.bbapap.2016.06.007","article-title":"The world of protein acetylation","volume":"1864","author":"Drazic","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20180803085117_CIT0029","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1365-2958.2010.07204.x","article-title":"Bacterial protein acetylation: the dawning of a new age","volume":"77","author":"Linda","year":"2010","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180803085117_CIT0030","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1183\/09031936.05.00117504","article-title":"Histone acetylation and deacetylation: importance in inflammatory lung diseases","volume":"25","author":"Barnes","year":"2005","journal-title":"Eur Respir J"},{"key":"key\n\t\t\t\t20180803085117_CIT0031","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.cll.2009.07.011","article-title":"Respiratory viruses in bronchiolitis and their link to recurrent wheezing and asthma","volume":"29","author":"Mansbach","year":"2009","journal-title":"Clin Lab Med"},{"key":"key\n\t\t\t\t20180803085117_CIT0032","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.prrv.2004.04.002","article-title":"Mechanisms of rhinovirus-induced asthma","volume":"5","author":"Papadopoulos","year":"2004","journal-title":"Paediatr Respir Rev"},{"key":"key\n\t\t\t\t20180803085117_CIT0033","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1128\/CVI.00414-15","article-title":"Understanding the association of human rhinovirus with asthma","volume":"23","author":"Stone","year":"2015","journal-title":"Clin Vaccine Immunol"},{"key":"key\n\t\t\t\t20180803085117_CIT0034","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1038\/ismej.2015.207","article-title":"Microbial, host and xenobiotic diversity in the cystic fibrosis sputum metabolome","volume":"10","author":"Quinn","year":"2016","journal-title":"ISME J"},{"key":"key\n\t\t\t\t20180803085117_CIT0035","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1074\/jbc.M111.304311","article-title":"Characterization of central carbon metabolism of Streptococcus pneumoniae by isotopologue profiling","volume":"287","author":"H\u00e4rtel","year":"2012","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180803085117_CIT0036","doi-asserted-by":"crossref","first-page":"e0154646","DOI":"10.1371\/journal.pone.0154646","article-title":"Composition and predicted metabolic capacity of upper and lower airway microbiota of healthy dogs in relation to the fecal microbiota","volume":"11","author":"Ericsson","year":"2016","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180803085117_CIT0037","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1001\/archpediatrics.2011.1669","article-title":"Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis","volume":"166","author":"Mansbach","year":"2012","journal-title":"Arch Pediatr Adolesc Med"},{"key":"key\n\t\t\t\t20180803085117_CIT0038","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1097\/INF.0000000000000313","article-title":"Hospital length-of-stay is associated with rhinovirus etiology of bronchiolitis","volume":"33","author":"Jartti","year":"2014","journal-title":"Pediatr Infect Dis J"},{"key":"key\n\t\t\t\t20180803085117_CIT0039","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1164\/rccm.201701-0071OC","article-title":"Associations of nasopharyngeal metabolome and microbiome with severity among infants with bronchiolitis. a multiomic analysis","volume":"196","author":"Stewart","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20180803085117_CIT0040","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/cid\/cix483","article-title":"Serum LL-37 levels associated with severity of bronchiolitis and viral etiology","volume":"65","author":"Mansbach","year":"2017","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180803085117_CIT0041","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1111\/all.13160","article-title":"The relationship between nasopharyngeal CCL5 and microbiota on disease severity among infants with bronchiolitis","volume":"72","author":"Hasegawa","year":"2017","journal-title":"Allergy"},{"key":"key\n\t\t\t\t20180803085117_CIT0042","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1164\/rccm.201104-0655OC","article-title":"Topographical continuity of bacterial populations in the healthy human respiratory tract","volume":"184","author":"Charlson","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20180803085117_CIT0043","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.jaci.2013.11.025","article-title":"Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease","volume":"133","author":"Poole","year":"2014","journal-title":"J Allergy Clin Immunol"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/217\/7\/1160\/25421802\/jix680.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T02:22:19Z","timestamp":1719714139000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/217\/7\/1160\/4774594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,25]]},"references-count":43,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,12,25]]},"published-print":{"date-parts":[[2018,3,13]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jix680","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,4,1]]},"published":{"date-parts":[[2017,12,25]]}}}