{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T08:30:38Z","timestamp":1783672238883,"version":"3.55.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,13]]},"DOI":"10.1093\/infdis\/jiy013","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T22:05:42Z","timestamp":1515708342000},"page":"1078-1088","source":"Crossref","is-referenced-by-count":6,"title":["Kinetics of Serological Responses in Critically Ill Patients Hospitalized With 2009 Pandemic Influenza A(H1N1) Virus Infection in Canada, 2009\u20132011"],"prefix":"10.1093","volume":"217","author":[{"given":"Melissa A","family":"Rolfes","sequence":"first","affiliation":[{"name":"Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F Liaini","family":"Gross","sequence":"additional","affiliation":[{"name":"Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia"},{"name":"Battelle, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"Flannery","sequence":"additional","affiliation":[{"name":"Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne F A","family":"Meyers","sequence":"additional","affiliation":[{"name":"National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg"},{"name":"Department of Medical Microbiology and Infectious Diseases, Winnipeg"},{"name":"Department of Medical Microbiology, University of Nairobi, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma","family":"Luo","sequence":"additional","affiliation":[{"name":"National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Bastien","sequence":"additional","affiliation":[{"name":"National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Fowler","sequence":"additional","affiliation":[{"name":"Sunnybrook Hospital, Department of Critical Care Medicine, University of Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M","family":"Katz","sequence":"additional","affiliation":[{"name":"Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Z","family":"Levine","sequence":"additional","affiliation":[{"name":"Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Kumar","sequence":"additional","affiliation":[{"name":"Section of Critical Care Medicine, Winnipeg"},{"name":"Section of Infectious Diseases, University of Manitoba, Winnipeg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M","family":"Uyeki","sequence":"additional","affiliation":[{"name":"Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"CSIS and ROSII Study Groups","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vic","family":"Veguilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Influenza","family":"Division","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Dhingra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Winston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Bagshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Kutsogiannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Silverman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Herridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"McGeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary-Anne","family":"Aarts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauralyn","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Ahern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosar","family":"Khwaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Bandrauk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Rello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,12]]},"reference":[{"key":"key\n\t\t\t\t20180313074315_CIT0001","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S2213-2600(17)30174-1","article-title":"Immune plasma for the treatment of severe influenza: an open-label, multicentre, phase 2 randomised study","volume":"5","author":"Beigel","year":"2017","journal-title":"Lancet Respir Med"},{"key":"key\n\t\t\t\t20180313074315_CIT0002","doi-asserted-by":"crossref","first-page":"599","DOI":"10.7326\/0003-4819-145-8-200610170-00139","article-title":"Meta-analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment","volume":"145","author":"Luke","year":"2006","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t20180313074315_CIT0003","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2288-10-18","article-title":"Relationship between haemagglutination-inhibiting antibody titres and clinical protection against influenza: development and application of a bayesian random-effects model","volume":"10","author":"Coudeville","year":"2010","journal-title":"BMC Med Res Methodol"},{"key":"key\n\t\t\t\t20180313074315_CIT0004","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1017\/S0022172400022610","article-title":"The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B viruses","volume":"70","author":"Hobson","year":"1972","journal-title":"J Hyg (Lond)"},{"key":"key\n\t\t\t\t20180313074315_CIT0005","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.virusres.2004.02.025","article-title":"Immunogenicity and protective efficacy of influenza vaccination","volume":"103","author":"Hannoun","year":"2004","journal-title":"Virus Res"},{"key":"key\n\t\t\t\t20180313074315_CIT0006","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/oxfordjournals.bmb.a071545","article-title":"Determinants of immunity to influenza infection in man","volume":"35","author":"Potter","year":"1979","journal-title":"Br Med Bull"},{"key":"key\n\t\t\t\t20180313074315_CIT0007","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1164\/rccm.201311-2071OC","article-title":"Low titers of serum antibodies inhibiting hemagglutination predict fatal fulminant influenza A(H1N1) 2009 infection","volume":"189","author":"Guihot","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20180313074315_CIT0008","doi-asserted-by":"crossref","first-page":"20657","DOI":"10.2807\/1560-7917.ES2013.18.50.20657","article-title":"Kinetics of serological responses in influenza A(H7N9)-infected patients correlate with clinical outcome in China, 2013","volume":"18","author":"Zhang","year":"2013","journal-title":"Euro Surveill"},{"key":"key\n\t\t\t\t20180313074315_CIT0009","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1001\/jama.2009.1496","article-title":"Critically ill patients with 2009 influenza A(H1N1) infection in Canada","volume":"302","author":"Kumar","year":"2009","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20180313074315_CIT0010","first-page":"59","article-title":"Serological diagnosis of influenza by haemagglutination inhibition testing","volume-title":"Manual for the laboratory diagnosis and virological surveillance of influenza","author":"WHO Global Influenza Surveillance Network"},{"key":"key\n\t\t\t\t20180313074315_CIT0011","author":"Kane"},{"key":"key\n\t\t\t\t20180313074315_CIT0012","doi-asserted-by":"crossref","first-page":"R167","DOI":"10.1186\/cc9259","article-title":"Host adaptive immunity deficiency in severe pandemic influenza","volume":"14","author":"Bermejo-Martin","year":"2010","journal-title":"Crit Care"},{"key":"key\n\t\t\t\t20180313074315_CIT0013","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/S0140-6736(09)62126-7","article-title":"Incidence of 2009 pandemic influenza A H1N1 infection in England: a cross-sectional serological study","volume":"375","author":"Miller","year":"2010","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180313074315_CIT0014","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1128\/JCM.00229-11","article-title":"Sensitivity and specificity of serologic assays for detection of human infection with 2009 pandemic H1N1 virus in U.S. populations","volume":"49","author":"Veguilla","year":"2011","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20180313074315_CIT0015","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jcv.2015.11.019","article-title":"Serum and mucosal antibodies fail as prognostic markers during critical influenza A infection","volume":"74","author":"Grund","year":"2016","journal-title":"J Clin Virol"},{"key":"key\n\t\t\t\t20180313074315_CIT0016","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1164\/rccm.201101-0135OC","article-title":"Early corticosteroids in severe influenza A\/H1N1 pneumonia and acute respiratory distress syndrome","volume":"183","author":"Brun-Buisson","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20180313074315_CIT0017","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13054-016-1230-8","article-title":"The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness","volume":"20","author":"Delaney","year":"2016","journal-title":"Crit Care"},{"key":"key\n\t\t\t\t20180313074315_CIT0018","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1164\/rccm.201101-0110OC","article-title":"Corticosteroid treatment in critically ill patients with pandemic influenza A\/H1N1 2009 infection: analytic strategy using propensity scores","volume":"183","author":"Kim","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20180313074315_CIT0019","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s00134-010-2078-z","article-title":"Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection","volume":"37","author":"Martin-Loeches","year":"2011","journal-title":"Intensive Care Med"},{"key":"key\n\t\t\t\t20180313074315_CIT0020","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/irv.12456","article-title":"Effect of low-to-moderate-dose corticosteroids on mortality of hospitalized adolescents and adults with influenza A(H1N1)pdm09 viral pneumonia","volume":"11","author":"Li","year":"2017","journal-title":"Influenza Other Respir Viruses"},{"key":"key\n\t\t\t\t20180313074315_CIT0021","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nm.2262","article-title":"Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes","volume":"17","author":"Monsalvo","year":"2011","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20180313074315_CIT0022","doi-asserted-by":"crossref","first-page":"R148","DOI":"10.1186\/cc8044","article-title":"Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain","volume":"13","author":"Rello","year":"2009","journal-title":"Crit Care"},{"key":"key\n\t\t\t\t20180313074315_CIT0023","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1097\/CCM.0b013e3182416f23","article-title":"Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States","volume":"40","author":"Rice","year":"2012","journal-title":"Crit Care Med"},{"key":"key\n\t\t\t\t20180313074315_CIT0024","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.ajpath.2013.06.023","article-title":"Cytokine and chemokine profiles in lung tissues from fatal cases of 2009 pandemic influenza A (H1N1): role of the host immune response in pathogenesis","volume":"183","author":"Gao","year":"2013","journal-title":"Am J Pathol"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/217\/7\/1078\/24326524\/jiy013.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T07:43:39Z","timestamp":1520927019000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/217\/7\/1078\/4803439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,12]]},"references-count":24,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,1,12]]},"published-print":{"date-parts":[[2018,3,13]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiy013","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,4,1]]},"published":{"date-parts":[[2018,1,12]]}}}